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Book: Identifying and treating foot ulcers in patients with diabetes: saving feet, legs and lives

Ousey, Karen / Chadwick, Paul / Jawien, Arkadiusz / Tariq, Gulnaz / Nair, Harikrishna K. Ragavan / Lázaro Martínez, José Luis / Sandy-Hodgetts, Kylie / Alves, Paulo / Wu, Stephanie / Moore, Zena

(Journal of wound care ; 27, 5, suppl. 5B (2018) ; JWC international consensus document)

2018

Author's details	autors: Karen Ousey, Paul Chadwick, Arkadiusz Jawien, Gulnaz Tariq, Harikrishna K. Ragavan Nair, José Luis Lázaro Martínez, Kylie Sandy-Hodgetts, Paulo Alves, Stephanie Wu, Zena Moore
Series title	Journal of wound care ; 27, 5, suppl. 5B (2018) JWC international consensus document
Collection
Language	English
Size	S51 Seiten, Illustrationen
Publisher	MA Healthcare Ltd
Publishing place	London
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT019803311
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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Zs A 4572 -27,5,Suppl.5b-	not available for loan	Zeitschriften-Lesesaal

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Article: New insight into biology, molecular diagnostics and treatment options of unstable carotid atherosclerotic plaque: a narrative review.

Migdalski, Arkadiusz / Jawien, Arkadiusz

Annals of translational medicine

2021 Volume 9, Issue 14, Page(s) 1207

Abstract: Indications for intervention in hemodynamically relevant carotid artery stenosis (carotid endarterectomy or stenting) are primarily based on a degree of stenosis and symptomatology. To date the plaque vulnerability is rarely taken into account in ... ...

Abstract	Indications for intervention in hemodynamically relevant carotid artery stenosis (carotid endarterectomy or stenting) are primarily based on a degree of stenosis and symptomatology. To date the plaque vulnerability is rarely taken into account in clinical decision making although development of molecular imaging allows a better understanding of plaque biology and provides new techniques detecting potentially vulnerable plaque at risk. A significant number of reports describing the mechanisms of unstable plaque formation suggest that it is a multifactorial process. Inflammation, lipid accumulation, apoptosis, proteolysis, the thrombotic process and angiogenesis are among the main factors of carotid plaque destabilization. Although inflammation is a key process in development of plaque vulnerability, the hemostasis and neoangiogenesis should be regarded as equally important. Only a small group of asymptomatic patients may benefit from the invasive treatment and it remains a challenge to determine whether initially asymptomatic carotid plaque become unstable or vulnerable. Currently, the main task of research on atherosclerotic lesion imaging is focused on functional state of the plaque. The presence of one or more features such as stenosis progression, large plaque area, large juxta-luminal black area, plaque echolucency, intra-plaque hemorrhage, impaired cerebral vascular reserve and spontaneous embolization may indicate patients at higher risk for stroke suitable for revascularization. Treatment of carotid stenosis as one of the manifestations of generalized atherosclerosis requires a broad approach. Nowadays pharmacological treatment options for the atherosclerotic process are largely aimed at stimulating the plaque stabilization, but in symptomatic patients and selected asymptomatic patients, carotid plaque should be removed as a potential source of embolism.
Language	English
Publishing date	2021-08-21
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-20-7197
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Enhancing Functional Efficiency and Quality of Life through Revascularization Surgery in Peripheral Arterial Disease: A Comparative Analysis of Objective and Subjective Indicators.

Nowaczyk, Anna / Cwajda-Białasik, Justyna / Jawień, Arkadiusz / Szewczyk, Maria Teresa

Medical science monitor : international medical journal of experimental and clinical research

2023 Volume 29, Page(s) e941673

Abstract: BACKGROUND This study aimed to compare the ankle-brachial index (ABI), maximal claudication distance (MCD), pain-free walking distance (PFWD), claudication pain, and quality of life (intermittent claudication questionnaire [ICQ]) before and 3 months ... ...

Abstract	BACKGROUND This study aimed to compare the ankle-brachial index (ABI), maximal claudication distance (MCD), pain-free walking distance (PFWD), claudication pain, and quality of life (intermittent claudication questionnaire [ICQ]) before and 3 months after revascularization surgery in 98 patients diagnosed with peripheral arterial disease (PAD) at a single center in Poland. MATERIAL AND METHODS Ninety-eight patients were examined (77% men, 23% women, 65.65±7.27 years old), diagnosed with PAD, and qualified for revascularization. The diagnosis of PAD was made on the basis of ABI ≤0.9 and medical records. The patients underwent a noninvasive examination, including measurement of ABI (by Doppler with the EZ8 probe), assessment of the quality of life by ICQ, distance of intermittent claudication on a treadmill using the Gardner-Skinner protocol (including PFWD and MCD), and pain intensity during walking (numeric rating scale [NRS11]). The assessment was carried out twice: 1 to 5 days before surgery and 3 months after surgery. RESULTS There was an increase of ABI (0.4 vs 0.62, P<0.001), PFWD (26.64 vs 80.21, P<0.001), MCD (60.08 vs 181.85, P<0.001), and ICQ (79.92 vs 60.23, P<0.001) and reduction of PFWD pain (7.26 vs 6.05, P<0.001) and MCD pain (9.24 vs 8.11, P<0.001). CONCLUSIONS Revascularization surgery improved the ABI and patients functional efficiency expressed in the improvement of subjective indicators PFWD, MCD, NRS11, and ICQ. Patients who had a longer duration of disease had worse outcomes after revascularization. More attention should be paid to increasing access to preventive examinations aimed at early detection of PAD and the possibility of implementing conservative treatment.
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Aged ; Intermittent Claudication/surgery ; Quality of Life ; Peripheral Arterial Disease/surgery ; Ankle Brachial Index ; Conservative Treatment ; Pain
Language	English
Publishing date	2023-09-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.941673
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4924: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Fluorescence - modern method of the diagnosis of chronic wounds on the example of venous leg ulcer.

Mościcka, Paulina / Cwajda-Białasik, Justyna / Jawień, Arkadiusz / Szewczyk, Maria T

Postepy dermatologii i alergologii

2022 Volume 40, Issue 1, Page(s) 66–71

Abstract: Introduction: Fluorescence imaging has become a method for bacterial visualisation in chronic wounds for the last few years. MolecuLight i:X (MolecuLight, Inc, ON, Canada) is a handheld device, which enables quick diagnostics to determine both the type ... ...

Abstract	Introduction: Fluorescence imaging has become a method for bacterial visualisation in chronic wounds for the last few years. MolecuLight i:X (MolecuLight, Inc, ON, Canada) is a handheld device, which enables quick diagnostics to determine both the type and location of pathogens present in the wound and on the skin. By means of fluorescent light illumination the tissues populated by pathogenic bacteria emit red or cyan fluorescent signatures, depending on the type of the pathogen: red fluorescence signal is emitted by Staphylococcus and Escherichia coli among others, while Pseudomonas aeruginosa produce cyan fluorescence. The fluorescence image also presents the spatial pattern of bacterial load, which creates bacterial mapping of the wound and may be used by a clinician for targeted sampling or debridement, among others. Aim: This study presents the method of microbiological fluorescent imaging and two case studies of patients with venous leg ulcers. Material and methods: In both cases, the sample for microbiological testing was obtained by means of a swab stick. Results: The results obtained from fluorescent imaging showed moderate-to-heavy bacterial load, which corresponded with the results from microbiology laboratory. Thanks to quick diagnostics with the use of MolecuLight i:X device, instant implementation of targeted topical actions such as wound hygiene, skin disinfection, appropriate dressing choice and curative treatment among others was possible. Conclusions: Our observations are consistent with the reports from other facilities.
Language	English
Publishing date	2022-09-09
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2596142-1
ISSN	1642-395X
ISSN	1642-395X
DOI	10.5114/ada.2022.119419
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Article ; Online: Healing Process, Pain, and Health-Related Quality of Life in Patients with Venous Leg Ulcers Treated with Fish Collagen Gel: A 12-Week Randomized Single-Center Study.

Mościcka, Paulina / Cwajda-Białasik, Justyna / Szewczyk, Maria Teresa / Jawień, Arkadiusz

International journal of environmental research and public health

2022 Volume 19, Issue 12

Abstract: The aim of the study was to assess the effectiveness of fish skin collagen and its impact on healing, pain intensity, and quality of life in patients with venous leg ulcers (VLUs). This study included 100 adults with VLUs. Eligible patients were ... ...

Abstract	The aim of the study was to assess the effectiveness of fish skin collagen and its impact on healing, pain intensity, and quality of life in patients with venous leg ulcers (VLUs). This study included 100 adults with VLUs. Eligible patients were randomized to either tropocollagen gel treatment (group A,
MeSH term(s)	Collagen/therapeutic use ; Humans ; Pain/drug therapy ; Quality of Life ; Tropocollagen ; Varicose Ulcer/drug therapy
Chemical Substances	Tropocollagen ; Collagen (9007-34-5)
Language	English
Publishing date	2022-06-09
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19127108
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Article: Clinical Perspectives and Management of Edema in Chronic Venous Disease-What about Ruscus?

Bihari, Imre / Guex, Jean-Jérôme / Jawien, Arkadiusz / Szolnoky, Gyozo

Medicines (Basel, Switzerland)

2022 Volume 9, Issue 8

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-07-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2777965-8
ISSN	2305-6320
ISSN	2305-6320
DOI	10.3390/medicines9080041
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Article ; Online: Lower extremity arterial disease perspective: IUA consensus document on "lead management". Part 1.

Antignani, Pier Luigi / Gargiulo, Mauro / Gastaldi, Giacomo / Jawien, Arkadiusz / Mansilha, Armando / Poredos, Pavel

International angiology : a journal of the International Union of Angiology

2023 Volume 42, Issue 5, Page(s) 382–395

Abstract: Atherosclerotic cardiovascular disease (ASCVD) is defined as coronary heart disease (CHD), cerebrovascular disease, or lower extremity arterial disease (LEAD) also named peripheral arterial disease (PAD). ASCVD is considered to be of atherosclerotic ... ...

Abstract	Atherosclerotic cardiovascular disease (ASCVD) is defined as coronary heart disease (CHD), cerebrovascular disease, or lower extremity arterial disease (LEAD) also named peripheral arterial disease (PAD). ASCVD is considered to be of atherosclerotic origin and is the leading cause of morbidity and mortality mainly for individuals with diabetes mellitus (DM). In this consensus document of the International Union of Angiology the authors discuss epidemiology, risk factors, primary and secondary prophylaxis, the correlation between diabetes mellitus and LEAD, conservative and surgical treatment.
MeSH term(s)	Humans ; Consensus ; Diabetes Mellitus/epidemiology ; Risk Factors ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/therapy ; Peripheral Arterial Disease/epidemiology ; Lower Extremity/blood supply ; Atherosclerosis/epidemiology
Language	English
Publishing date	2023-10-12
Publishing country	Italy
Document type	Journal Article
ZDB-ID	604910-2
ISSN	1827-1839 ; 0392-9590
ISSN (online)	1827-1839
ISSN	0392-9590
DOI	10.23736/S0392-9590.23.05110-6
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Zs.A 1833: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Evaluation of factors affecting the healing process of venous ulcers: A 12-week longitudinal study.

Mościcka, Paulina / Cwajda-Białasik, Justyna / Jawień, Arkadiusz / Jaraczewski, Wojciech / Szewczyk, Maria T

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

2023 Volume 31, Issue 6, Page(s) 783–792

Abstract: The process of healing venous ulcers is complex and influenced by many factors. By identifying the risk factors that influence a slower healing process, it is possible to predict impending delays and plan an individualised care plan. We analysed our ... ...

Abstract	The process of healing venous ulcers is complex and influenced by many factors. By identifying the risk factors that influence a slower healing process, it is possible to predict impending delays and plan an individualised care plan. We analysed our database of patients with venous ulcers and identified clinical and demographic factors that delay the healing process. The research analysed the medical records of 754 patients with VLUs at Chronic Wound Treatment Unit of the University Hospital treated between 2001 and 2019. In study, the majority (64.3%) were women, the mean age was 65.7 years. The median duration of Chronic Venous Insufficiency was 24 years, 52% patients had had the disease >20 years, and 296 (39.3%) had experienced ulceration >12 months. Most of the patients (85.8%) had comorbidities, 84% were obese. At 12-week follow-up, 432 of the 754 ulcers had healed. Identified independent predictors of slower ulcer healing rates: wound area greater than 8.25 cm
MeSH term(s)	Humans ; Male ; Female ; Aged ; Wound Healing ; Varicose Ulcer/drug therapy ; Longitudinal Studies ; Ulcer ; Risk Factors
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1174873-4
ISSN	1524-475X ; 1067-1927
ISSN (online)	1524-475X
ISSN	1067-1927
DOI	10.1111/wrr.13140
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3890: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Microbiological Status of Venous Leg Ulcers and Its Predictors: A Single-Center Cross-Sectional Study.

Cwajda-Białasik, Justyna / Mościcka, Paulina / Jawień, Arkadiusz / Szewczyk, Maria Teresa

International journal of environmental research and public health

2021 Volume 18, Issue 24

Abstract: Venous leg ulcers are frequently colonized by microbes. This can be particularly devastating if the ulcer is infected with alert pathogens, i.e., highly virulent microorganisms with well-developed mechanisms of antibiotic resistance. We analyzed the ... ...

Abstract	Venous leg ulcers are frequently colonized by microbes. This can be particularly devastating if the ulcer is infected with alert pathogens, i.e., highly virulent microorganisms with well-developed mechanisms of antibiotic resistance. We analyzed the microbiological status of venous leg ulcers and identified the clinicodemographic predictors of culture-positive ulcers, especially in ulcers with colonization by alert pathogens. Methods: This study included 754 patients with chronic venous leg ulcers. Material for microbiological analysis was collected by swabbing only from patients who did not receive any antibiotic treatment. Results: A total of 636 (84.3%) patients presented with culture-positive ulcers. Alert pathogens, primarily Pseudomonas aeruginosa, were detected in 28.6% of the positive cultures. In a logistic regression model, culture-positive ulcers were predicted independently by age > 65 years, current ulcer duration > 12 months, and ulceration area greater than 8.25 cm Conclusions: Colonization/infection is particularly likely in older persons with chronic and/or large ulcers. Concomitant atherosclerosis was an independent predictor of culture-negative ulcers.
MeSH term(s)	Aged ; Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Cross-Sectional Studies ; Humans ; Logistic Models ; Varicose Ulcer ; Wound Healing
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2021-12-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph182412965
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Article: Complex treatment of venous leg ulcers including the use of oral nutritional supplementation: results of 12-week prospective study.

Mościcka, Paulina / Cwajda-Białasik, Justyna / Jawień, Arkadiusz / Szewczyk, Maria T

Postepy dermatologii i alergologii

2021 Volume 39, Issue 2, Page(s) 336–346

Abstract: Introduction: Malnutrition is known to impair the wound healing process, contributing to wound chronicity. Venous leg ulcers (VLU) represent the most common chronic leg wounds and become epidemiologically relevant in an ageing society.: Aim: This ... ...

Abstract	Introduction: Malnutrition is known to impair the wound healing process, contributing to wound chronicity. Venous leg ulcers (VLU) represent the most common chronic leg wounds and become epidemiologically relevant in an ageing society. Aim: This study investigated the effects of a complex treatment, including a specialized oral nutritional supplementation, on the dynamics of the VLU healing. Material and methods: This 12-week prospective study included 35 individuals with VLU. The patients received professional wound care including specialized dressings. To ensure an optimal nutritional status for wound healing, the patients were asked to drink three times per day 200 ml of an energy-dense protein-rich formula containing arginine, zinc, and vitamins. The healing dynamics were assessed by planimetry. Results: Complete wound healing was achieved in 6 patients, and the median ulcer area decreased from 26.5 cm Conclusions: This study shows that a complex intervention involving nutritional support contributes to a significant progress in VLU healing and promotes the well-being of affected individuals.
Language	English
Publishing date	2021-04-18
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2596142-1
ISSN	1642-395X
ISSN	1642-395X
DOI	10.5114/ada.2021.104730
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