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  1. Article ; Online: Can selenium be a modifier of cancer risk in CHEK2 mutation carriers?

    Gupta, Satish / Jaworska-Bieniek, Katarzyna / Lubinski, Jan / Jakubowska, Anna

    Mutagenesis

    2013  Volume 28, Issue 6, Page(s) 625–629

    Abstract: Selenium is an essential trace element for humans, playing an important role in various major metabolic pathways. Selenium helps to protect the body from the poisonous effects of heavy metals and other harmful substances. Medical studies have provided ... ...

    Abstract Selenium is an essential trace element for humans, playing an important role in various major metabolic pathways. Selenium helps to protect the body from the poisonous effects of heavy metals and other harmful substances. Medical studies have provided evidence of selenium supplementation in preventing certain cancers. Low and too high selenium (Se) status correlates with increased risk of e.g. lung, larynx, colorectal and prostate cancers. A higher level of selenium and supplementation with selenium has been shown to be associated with substantially reduced cancer mortality. Selenium exerts its biological roles through selenoproteins, which are involved in oxidoreductions, redox signalling, antioxidant defence, thyroid hormone metabolism and immune responses. Checkpoint kinase 2 (CHEK2) is an important signal transducer of cellular responses to DNA damage and acts as a tumour suppressor gene. Mutations in the CHEK2 gene have been shown to be associated with increased risks of several cancers. Four common mutations in CHEK2 gene (1100delC, IVS2+1G>A, del5395 and I157T) have been identified in the Polish population. Studies have provided evidence that CHEK2-truncating and/or missense mutations are associated with increased risk of breast, prostate, thyroid, colon and kidney cancers. The variability in penetrance and cancer expression in CHEK2 mutation carriers can probably be explained by the influence of other genetic or environmental factors. One of the possible candidates is Se, which together with genetic variations in selenoprotein genes may influence susceptibility to cancer risk.
    MeSH term(s) Checkpoint Kinase 2/genetics ; Checkpoint Kinase 2/metabolism ; Dietary Supplements ; Humans ; Mutation ; Neoplasms/enzymology ; Neoplasms/genetics ; Neoplasms/prevention & control ; Selenium/administration & dosage ; Selenium/physiology ; Selenoproteins/metabolism ; Signal Transduction
    Chemical Substances Selenoproteins ; Checkpoint Kinase 2 (EC 2.7.1.11) ; CHEK2 protein, human (EC 2.7.11.1) ; Selenium (H6241UJ22B)
    Language English
    Publishing date 2013-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632903-2
    ISSN 1464-3804 ; 0267-8357
    ISSN (online) 1464-3804
    ISSN 0267-8357
    DOI 10.1093/mutage/get050
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  2. Article ; Online: Methylation of the BRCA1 promoter in peripheral blood DNA is associated with triple-negative and medullary breast cancer.

    Gupta, Satish / Jaworska-Bieniek, Katarzyna / Narod, Steven A / Lubinski, Jan / Wojdacz, Tomasz K / Jakubowska, Anna

    Breast cancer research and treatment

    2014  Volume 148, Issue 3, Page(s) 615–622

    Abstract: It has been proposed that methylation signatures in blood-derived DNA may correlate with cancer risk. In this study, we evaluated whether methylation of the promoter region of the BRCA1 gene detectable in DNA from peripheral blood cells is a risk factor ... ...

    Abstract It has been proposed that methylation signatures in blood-derived DNA may correlate with cancer risk. In this study, we evaluated whether methylation of the promoter region of the BRCA1 gene detectable in DNA from peripheral blood cells is a risk factor for breast cancer, in particular for tumors with pathologic features characteristic for cancers with BRCA1 gene mutations. We conducted a case-control study of 66 breast cancer cases and 36 unaffected controls. Cases were triple-negative or of medullary histology, or both; 30 carried a constitutional BRCA1 mutation and 36 did not carry a mutation. Blood for DNA methylation analysis was taken within three months of diagnosis. Methylation of the promoter of the BRCA1 gene was measured in cases and controls using methylation-sensitive high-resolution melting (MS-HRM). A sample with any detectable level of methylation was considered to be positive. Methylation of the BRCA1 promoter was detected in 15 of 66 cases and in 2 of 36 controls (OR 5.0, p = 0.03). Methylation was present in 15 of 36 women with breast cancer and without germline BRCA1 mutation, but in none of 30 women with breast cancer and a germline mutation (p < 0.01). The association between methylation and breast cancer was restricted to women with no constitutional BRCA1 mutation (OR 12.1, p = 0.0006). Methylation of the promoter of the BRCA1 gene detectable in peripheral blood DNA may be a marker of increased susceptibility to triple-negative or medullary breast cancer.
    MeSH term(s) Adult ; BRCA1 Protein/blood ; BRCA1 Protein/genetics ; Carcinoma, Medullary/blood ; Carcinoma, Medullary/genetics ; Carcinoma, Medullary/pathology ; Case-Control Studies ; DNA Methylation/genetics ; DNA-Cytosine Methylases/genetics ; Female ; Germ-Line Mutation ; Humans ; Promoter Regions, Genetic ; Triple Negative Breast Neoplasms/blood ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/pathology
    Chemical Substances BRCA1 Protein ; DNA-Cytosine Methylases (EC 2.1.1.-)
    Language English
    Publishing date 2014-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-014-3179-0
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  3. Article: Polymorphisms in

    Białkowska, Katarzyna / Marciniak, Wojciech / Muszyńska, Magdalena / Baszuk, Piotr / Gupta, Satish / Jaworska-Bieniek, Katarzyna / Sukiennicki, Grzegorz / Durda, Katarzyna / Gromowski, Tomasz / Lener, Marcin / Prajzendanc, Karolina / Łukomska, Alicja / Cybulski, Cezary / Huzarski, Tomasz / Gronwald, Jacek / Dębniak, Tadeusz / Lubiński, Jan / Jakubowska, Anna

    Hereditary cancer in clinical practice

    2020  Volume 18, Page(s) 16

    Abstract: Background: Matrix metalloproteinases (MMPs) and metallothioneins (MTs) are Zinc-related proteins which are involved in processes crucial for carcinogenesis such as angiogenesis, proliferation and apoptosis. Several single nucleotide polymorphisms (SNPs) ...

    Abstract Background: Matrix metalloproteinases (MMPs) and metallothioneins (MTs) are Zinc-related proteins which are involved in processes crucial for carcinogenesis such as angiogenesis, proliferation and apoptosis. Several single nucleotide polymorphisms (SNPs) in MMPs and MTs that affect genes expression have been associated with cancer risk, including breast, lung and colon.
    Methods: The study group consisted of 648 unselected patients (299 with breast cancer, 199 with lung cancer, 150 with colon cancer) and 648 unaffected individuals. Five SNPs, rs1799750 in
    Results: None of the 5 tested polymorphisms showed a correlation with cancer risk in studied groups, although for
    Conclusions: Analyses of polymorphisms, rs1799750 in
    Language English
    Publishing date 2020-07-31
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2252512-9
    ISSN 1897-4287 ; 1731-2302
    ISSN (online) 1897-4287
    ISSN 1731-2302
    DOI 10.1186/s13053-020-00147-w
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  4. Article: BRCA1 founder mutations do not contribute to increased risk of gastric cancer in the Polish population.

    Ławniczak, Małgorzata / Jakubowska, Anna / Białek, Andrzej / Lubiński, Jan / Jaworska-Bieniek, Katarzyna / Kaczmarek, Katarzyna / Starzyńska, Teresa

    Hereditary cancer in clinical practice

    2016  Volume 14, Page(s) 3

    Abstract: Background: Gastric cancer (GC) is part of the spectrum of diseases linked to BRCA1 and BRCA2 mutations that increase the risk of breast and ovarian cancer. Data suggesting an increased risk of developing GC among BRCA1 and BRCA2 mutation carriers are ... ...

    Abstract Background: Gastric cancer (GC) is part of the spectrum of diseases linked to BRCA1 and BRCA2 mutations that increase the risk of breast and ovarian cancer. Data suggesting an increased risk of developing GC among BRCA1 and BRCA2 mutation carriers are based almost exclusively on indirect studies. The objective was to assess in a direct study whether there is a relationship between GC and selected recurrent BRCA1 and BRCA2 mutations in the Polish population.
    Methods: Three hundred seventeen GC patients (193 males and 124 females; mean age 59.5 ± 12.8 y) diagnosed at the Department of Gastroenterology at the Pomeranian Medical University were included in this retrospective study. All patients were genotyped for 3 BRCA1 Polish founder mutations (5382insC, C61G and 4153delA) as well as for 9 known recurrent mutations in BRCA1 and BRCA2 genes. Genotyping was performed using allele-specific oligonucleotide polymerase chain reaction (ASA-PCR) for 4153delA and 5382insC, restriction fragment length polymorphism (PCR-RFLP) for C61G and TaqMan real-time PCR for 185delAG, 3819del5, 3875del4, 5370C > T, 886delGT, 4075delGT, 5467insT, 6174delT and 8138del5.
    Results: Among tested mutations one founder BRCA1 mutation 5382insC was detected in two of 317 (0.63 %) GC cases. A comparison of frequency of detected BRCA1 founder mutations in GC patients to previously described 4570 Polish controls (0.63 % vs. 0.48 %) failed to indicate an increased risk of GC in the mutation carriers (OR = 1.3; 95 % CI 0.3-5.6, p = 0.71). A comparison of frequency of GC male cases and male controls (1.0 % vs. 0.43 %,OR = 1.5; 95 % CI 0.3-6.4, p = 0.61) allowed to formulate the same conclusion that there is no increased risk for GC for males. None of the 9 recurrent BRCA1 and BRCA2 mutations has been detected in tested GC patients.
    Conclusion: The current study indicates that founder BRCA1 mutations reported in Polish breast/ovarian cancer patients do not contribute to increased GC risk. The nine tested recurrent BRCA1 and BRCA2 mutations were not detected in GC patients which may suggests that they are rare in GC patients in the Polish population. Further analyses, including sequencing of entire sequences of BRCA1 and BRCA2 genes, are necessary to ultimately determine the role of these two genes in GC in Poland.
    Language English
    Publishing date 2016-01-15
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2252512-9
    ISSN 1897-4287 ; 1731-2302
    ISSN (online) 1897-4287
    ISSN 1731-2302
    DOI 10.1186/s13053-015-0043-0
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  5. Article ; Online: Prevalence of Germline Mutations in Genes Engaged in DNA Damage Repair by Homologous Recombination in Patients with Triple-Negative and Hereditary Non-Triple-Negative Breast Cancers.

    Domagala, Pawel / Jakubowska, Anna / Jaworska-Bieniek, Katarzyna / Kaczmarek, Katarzyna / Durda, Katarzyna / Kurlapska, Agnieszka / Cybulski, Cezary / Lubinski, Jan

    PloS one

    2015  Volume 10, Issue 6, Page(s) e0130393

    Abstract: Purpose: This study sought to assess the prevalence of common germline mutations in several genes engaged in the repair of DNA double-strand break by homologous recombination in patients with triple-negative breast cancers and hereditary non-triple- ... ...

    Abstract Purpose: This study sought to assess the prevalence of common germline mutations in several genes engaged in the repair of DNA double-strand break by homologous recombination in patients with triple-negative breast cancers and hereditary non-triple-negative breast cancers. Tumors deficient in this type of DNA damage repair are known to be especially sensitive to DNA cross-linking agents (e.g., platinum drugs) and to poly(ADP-ribose) polymerase (PARP) inhibitors.
    Methods: Genetic testing was performed for 36 common germline mutations in genes engaged in the repair of DNA by homologous recombination, i.e., BRCA1, BRCA2, CHEK2, NBN, ATM, PALB2, BARD1, and RAD51D, in 202 consecutive patients with triple-negative breast cancers and hereditary non-triple-negative breast cancers.
    Results: Thirty five (22.2%) of 158 patients in the triple-negative group carried mutations in genes involved in DNA repair by homologous recombination, while 10 (22.7%) of the 44 patients in the hereditary non-triple-negative group carried such mutations. Mutations in BRCA1 were most frequent in patients with triple-negative breast cancer (18.4%), and mutations in CHEK2 were most frequent in patients with hereditary non-triple-negative breast cancers (15.9%). In addition, in the triple-negative group, mutations in CHEK2, NBN, and ATM (3.8% combined) were found, while mutations in BRCA1, NBN, and PALB2 (6.8% combined) were identified in the hereditary non-triple-negative group.
    Conclusions: Identifying mutations in genes engaged in DNA damage repair by homologous recombination other than BRCA1/2 can substantially increase the proportion of patients with triple-negative breast cancer and hereditary non-triple-negative breast cancer who may be eligible for therapy using PARP inhibitors and platinum drugs.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/genetics ; Breast Neoplasms/epidemiology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Carcinoma, Ductal, Breast/epidemiology ; Carcinoma, Ductal, Breast/genetics ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Lobular/epidemiology ; Carcinoma, Lobular/genetics ; Carcinoma, Lobular/pathology ; Cohort Studies ; DNA Damage/genetics ; DNA Repair/genetics ; Female ; Genetic Testing ; Germ-Line Mutation/genetics ; Homologous Recombination ; Humans ; Middle Aged ; Neoplasm Grading ; Poland/epidemiology ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Triple Negative Breast Neoplasms/epidemiology ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/pathology ; Young Adult
    Chemical Substances Biomarkers, Tumor ; Receptors, Estrogen ; Receptors, Progesterone ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2015-06-17
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0130393
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  6. Article: Serum selenium level and cancer risk: a nested case-control study.

    Narod, Steven A / Huzarski, Tomasz / Jakubowska, Anna / Gronwald, Jacek / Cybulski, Cezary / Oszurek, Oleg / Dębniak, Tadeusz / Jaworska-Bieniek, Katarzyna / Lener, Marcin / Białkowska, Katarzyna / Sukiennicki, Grzegorz / Muszyńska, Magdalena / Marciniak, Wojciech / Sun, Ping / Kotsopoulos, Joanne / Lubiński, Jan

    Hereditary cancer in clinical practice

    2019  Volume 17, Page(s) 33

    Abstract: Background: Epidemiologic studies have demonstrated a relationship between selenium status and cancer risk among those with low selenium levels. It is of interest to prospectively evaluate the relationship between selenium and cancer among women who ... ...

    Abstract Background: Epidemiologic studies have demonstrated a relationship between selenium status and cancer risk among those with low selenium levels. It is of interest to prospectively evaluate the relationship between selenium and cancer among women who reside in a region with ubiquitously low selenium levels.
    Methods: We performed a nested case-control study of baseline serum selenium levels and cancer risk using data and biological samples from 19,573 females that were participants in a biobanking initiative between 2010 and 2014 in Szczecin Poland. Cases included women with any incident cancer (
    Results: The odds ratio associated being below the cutoff of 70.0 μg/L compared to a level above 70.0 μg/L was 2.29 (95% CI 1.26-4.19;
    Conclusions: Results from this study suggest that suggest that the optimum serum level of selenium in women living in Poland should be between 70 μg/L and 90 μg/L.
    Language English
    Publishing date 2019-12-23
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2252512-9
    ISSN 1897-4287 ; 1731-2302
    ISSN (online) 1897-4287
    ISSN 1731-2302
    DOI 10.1186/s13053-019-0131-7
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  7. Article ; Online: Iron levels, genes involved in iron metabolism and antioxidative processes and lung cancer incidence.

    Sukiennicki, Grzegorz Mariusz / Marciniak, Wojciech / Muszyńska, Magdalena / Baszuk, Piotr / Gupta, Satish / Białkowska, Katarzyna / Jaworska-Bieniek, Katarzyna / Durda, Katarzyna / Lener, Marcin / Pietrzak, Sandra / Gromowski, Tomasz / Prajzendanc, Karolina / Łukomska, Alicja / Waloszczyk, Piotr / Wójcik, Janusz Zenon / Scott, Rodney / Lubiński, Jan / Jakubowska, Anna

    PloS one

    2019  Volume 14, Issue 1, Page(s) e0208610

    Abstract: Background: Lung cancer is the most common adult malignancy accounting for the largest proportion of cancer related deaths. Iron (Fe) is an essential trace element and is a component of several major metabolic pathways playing an important role in many ... ...

    Abstract Background: Lung cancer is the most common adult malignancy accounting for the largest proportion of cancer related deaths. Iron (Fe) is an essential trace element and is a component of several major metabolic pathways playing an important role in many physiological processes. In this study we evaluated the association between Fe concentration in serum, iron metabolism parameters and genetic variaton in 7 genes involved in iron metabolism and anti-oxidative processes with the incidence of lung cancer in Poland.
    Materials and methods: The study included 200 lung cancer patients and 200 matched healthy control subjects. We analyzed serum iron concentration and iron metabolism parameters (TIBC, UIBC, serum ferritin and transferrin saturation), and genotyped seven variants in seven genes: HFE, TFR1, HAMP, TF, SOD2, CAT and GPX1.
    Results: Lung cancer patients compared to their matched controls had significantly higher mean serum iron level (p = 0.01), ferritin level (p = 0.007) and TIBC (p = 0.006). Analysis revealed that higher concentration of iron and ferritin (IVth quartile) compared to the lower concentration (Ist quartile) was associated with over 2-fold increased lung cancer incidence. We also found that higher transferrin saturation (p = 0.01) and lower TIBC (p<0.01) are associated with better survival of lung cancer patients. The analysis of polymorphisms in iron related genes did not reveal a significant difference between lung cancer patients and controls. However, rs10421768 in HAMP showed a borderline statistically significant correlation with lung cancer risk (OR = 2.83, p = 0.05).
    Conclusions: The results of this case control study indicate that higher body iron represented by higher Fe and ferritin levels may be associated with lung cancer incidence. Rs10421768 in HAMP may be associated with about 3-times higher lung cancer risk. Higher Fe body content may be associated with better survival of lung cancer patients.
    MeSH term(s) Antioxidants/metabolism ; Genetic Variation ; Humans ; Incidence ; Iron/blood ; Iron/metabolism ; Lung Neoplasms/blood ; Lung Neoplasms/epidemiology ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Neoplasm Staging ; Risk Factors ; Survival Analysis
    Chemical Substances Antioxidants ; Iron (E1UOL152H7)
    Language English
    Publishing date 2019-01-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0208610
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  8. Article ; Online: Serum folate concentration and the incidence of lung cancer.

    Durda, Katarzyna / Kąklewski, Krzysztof / Gupta, Satish / Szydłowski, Michał / Baszuk, Piotr / Jaworska-Bieniek, Katarzyna / Sukiennicki, Grzegorz / Kaczmarek, Katarzyna / Waloszczyk, Piotr / Narod, Steven / Lubiński, Jan / Jakubowska, Anna

    PloS one

    2017  Volume 12, Issue 5, Page(s) e0177441

    Abstract: Background: Lung cancer is a leading cause of cancer-related mortality globally. Folate helps to maintain DNA integrity and to regulate gene expression. Serum folate levels may affect the risk of several cancers, including lung cancer. In this study we ... ...

    Abstract Background: Lung cancer is a leading cause of cancer-related mortality globally. Folate helps to maintain DNA integrity and to regulate gene expression. Serum folate levels may affect the risk of several cancers, including lung cancer. In this study we evaluated the association between serum folate concentration and variations in genes involved in folate metabolism with lung cancer incidence in Poland.
    Methods: The study included 366 lung cancer patients and 366 control subjects. We measured serum folate concentration and genotyped six variants in MTHFR, MTR and MTRR genes. The odds ratios of being diagnosed with lung cancer were calculated using conditional univariable and multivariable logistic regression with respect to folate level and genotypes.
    Results: The mean serum folate level was lower in lung cancer cases than in control group (20.07 nmol/l vs. 22.52 nmol/l, p = 0.002). The odds ratio for lung cancer declined with increasing serum content of the folate. The folate concentration of >25.71 nmol/l (IVth quartile) in comparison to <15.92 nmol/l (Ist quartile) was associated with an odds ratio of 0.61 (95%CI 0.40-0.95, p = 0.03). The analysis of variations in MTHFR, MTR and MTRR genes did not reveal any significant difference between lung cancer cases and controls in univariable and multivariable analyses.
    Conclusion: In this case-control study, lower serum folate concentrations were associated with a higher risk of lung cancer diagnosis. Although previous findings have been somewhat mixed, our results add to the evidence that circulating folate levels may be an indicator of lung cancer risk.
    MeSH term(s) 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/genetics ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Female ; Ferredoxin-NADP Reductase/genetics ; Folic Acid/blood ; Genotype ; Humans ; Incidence ; Logistic Models ; Lung Neoplasms/blood ; Lung Neoplasms/epidemiology ; Lung Neoplasms/genetics ; Methylenetetrahydrofolate Reductase (NADPH2)/genetics ; Middle Aged ; Odds Ratio ; Polymorphism, Single Nucleotide/genetics ; Risk Factors
    Chemical Substances Folic Acid (935E97BOY8) ; methionine synthase reductase (EC 1.18.1.-) ; Ferredoxin-NADP Reductase (EC 1.18.1.2) ; MTHFR protein, human (EC 1.5.1.20) ; Methylenetetrahydrofolate Reductase (NADPH2) (EC 1.5.1.20) ; 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (EC 2.1.1.13) ; MTR protein, human (EC 2.1.1.13.)
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0177441
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  9. Article ; Online: Arsenic (As) and breast cancer risk

    Muszyńska Magdalena / Jaworska-Bieniek Katarzyna / Durda Katarzyna / Sukiennicki Grzegorz / Gromowski Tomasz / Jakubowska Anna / Morawski Antoni / Lubiński Jan

    Hereditary Cancer in Clinical Practice , Vol 10, Iss Suppl 4, p A

    2012  Volume 8

    Abstract: Abstract The study was conducted to determine the correlations between serum concentration of arsenic (As) with increased or decreased predisposition to breast and ovarian cancer. ...

    Abstract Abstract The study was conducted to determine the correlations between serum concentration of arsenic (As) with increased or decreased predisposition to breast and ovarian cancer.
    Keywords Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2012-12-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Association of zinc level and polymorphism in MMP-7 gene with prostate cancer in Polish population.

    Białkowska, Katarzyna / Marciniak, Wojciech / Muszyńska, Magdalena / Baszuk, Piotr / Gupta, Satish / Jaworska-Bieniek, Katarzyna / Sukiennicki, Grzegorz / Durda, Katarzyna / Gromowski, Tomasz / Prajzendanc, Karolina / Cybulski, Cezary / Huzarski, Tomasz / Gronwald, Jacek / Dębniak, Tadeusz / Scott, Rodney J / Lubiński, Jan / Jakubowska, Anna

    PloS one

    2018  Volume 13, Issue 7, Page(s) e0201065

    Abstract: Introduction: Prostate cancer is one of the most commonly diagnosed malignancies among men in Western populations. Evidence reported in the literature suggests that zinc may be related to prostate cancer. In this study we evaluated the association of ... ...

    Abstract Introduction: Prostate cancer is one of the most commonly diagnosed malignancies among men in Western populations. Evidence reported in the literature suggests that zinc may be related to prostate cancer. In this study we evaluated the association of serum zinc levels and polymorphisms in genes encoding zinc-dependent proteins with prostate cancer in Poland.
    Methods: The study group consisted of 197 men affected with prostate cancer and 197 healthy men. Serum zinc levels were measured and 5 single nucleotide polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13, MT2A genes were genotyped.
    Results: The mean serum zinc level was higher in prostate cancer patients than in healthy controls (898.9±12.01 μg/l vs. 856.6±13.05 μg/l, p<0.01). When compared in quartiles a significant association of higher zinc concentration with the incidence of prostate cancer was observed. The highest OR (OR = 4.41, 95%CI 2.07-9.37, p<0.01) was observed in 3rd quartile (>853.0-973.9 μg/l). Among five analyzed genetic variants, rs11568818 in MMP-7 appeared to be correlated with 2-fold increased prostate cancer risk (OR = 2.39, 95% CI = 1.19-4.82, p = 0.015).
    Conclusion: Our results suggest a significant correlation of higher serum zinc levels with the diagnosis of prostate cancer. The polymorphism rs11568818 in MMP-7 gene was also associated with an increased prostate cancer risk in Poland.
    MeSH term(s) Case-Control Studies ; European Continental Ancestry Group/genetics ; Genetic Predisposition to Disease ; Humans ; Incidence ; Male ; Matrix Metalloproteinase 1/genetics ; Matrix Metalloproteinase 13/genetics ; Matrix Metalloproteinase 2/genetics ; Matrix Metalloproteinase 7/genetics ; Metallothionein/genetics ; Poland/epidemiology ; Polymorphism, Single Nucleotide ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/genetics ; Retrospective Studies ; Zinc/blood
    Chemical Substances MT2A protein, human ; Metallothionein (9038-94-2) ; MMP13 protein, human (EC 3.4.24.-) ; Matrix Metalloproteinase 13 (EC 3.4.24.-) ; MMP7 protein, human (EC 3.4.24.23) ; Matrix Metalloproteinase 7 (EC 3.4.24.23) ; MMP2 protein, human (EC 3.4.24.24) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; MMP1 protein, human (EC 3.4.24.7) ; Matrix Metalloproteinase 1 (EC 3.4.24.7) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2018-07-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0201065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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