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  1. AU="Jay Patel"
  2. AU="Iacob, Nicusor"
  3. AU="Guo, Dengyang"
  4. AU="Galacho-Harriero, Ana María"
  5. AU="Awoyelu, E H"
  6. AU="Tinajero, Jose"
  7. AU=Vashishtha Vipin M AU=Vashishtha Vipin M
  8. AU="D'Agostino, Nicole"
  9. AU="Lunetta, Kathryn L"
  10. AU="Tirschmann, Felix"
  11. AU="Adetuyi, B.O."

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  1. Artikel ; Online: Spinal Cord Herniation into a Pseudomeningocele—A Delayed Presentation following a Traumatic Cervical Root Avulsion Injury

    Jay Patel / James Stewart / Shubhabrata Biswas / Sarsam Zaid

    Indian Journal of Radiology and Imaging, Vol 33, Iss 02, Pp 264-

    2023  Band 266

    Abstract: Background Spinal cord herniation into a traumatic pseudomeningocele is a rare clinical entity. We present the sixth known case and describe surgical management. Case Presentation A 44-year-old male presented with Brown-Sequard syndrome three decades ... ...

    Abstract Background Spinal cord herniation into a traumatic pseudomeningocele is a rare clinical entity. We present the sixth known case and describe surgical management. Case Presentation A 44-year-old male presented with Brown-Sequard syndrome three decades after a cervical nerve root avulsion injury. Imaging revealed hemicord herniation into a C7/T1 pseudomeningocele in addition to extra-axial cord compression from further pseudomeningoceles. Significant clinical improvement was achieved following surgical repair. The radiological findings and technique for operative repair are described. Conclusion The case highlights this rare pathology and presentation, describes the surgical measures for repair of cord herniation, and provides evidence for the favorable outcome that can be achieved by surgical intervention.
    Schlagwörter pseudomeningocele ; herniation ; spinal cord ; trauma ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2023-04-01T00:00:00Z
    Verlag Thieme Medical and Scientific Publishers Pvt. Ltd.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Atrial Fibrillation and Reperfusion Therapy in Acute Ischaemic Stroke Patients

    Jay Patel / Sonu M. M. Bhaskar

    Neurology International, Vol 15, Iss 65, Pp 1014-

    Prevalence and Outcomes—A Comprehensive Systematic Review and Meta-Analysis

    2023  Band 1043

    Abstract: Atrial fibrillation (AF) significantly contributes to acute ischaemic stroke (AIS), yet its precise influence on clinical outcomes post-intravenous thrombolysis (IVT) and post-endovascular thrombectomy (EVT) has remained elusive. Furthermore, the overall ...

    Abstract Atrial fibrillation (AF) significantly contributes to acute ischaemic stroke (AIS), yet its precise influence on clinical outcomes post-intravenous thrombolysis (IVT) and post-endovascular thrombectomy (EVT) has remained elusive. Furthermore, the overall prevalence of AF in AIS patients undergoing reperfusion therapy has not been clearly determined. Employing random-effects meta-analyses, this research aimed to estimate the pooled prevalence of AF among AIS patients undergoing reperfusion therapy, while also examining the association between AF and clinical outcomes such as functional outcomes, symptomatic intracerebral haemorrhage (sICH) and mortality. Studies comparing AF and non-AF patient groups undergoing reperfusion therapy were identified and included following an extensive database search. Forty-nine studies (n = 66,887) were included. Among IVT patients, the prevalence of AF was 31% (Effect Size [ES] 0.31 [95%CI 0.28–0.35], p < 0.01), while in EVT patients, it reached 42% (ES 0.42 [95%CI 0.38–0.46], p < 0.01), and in bridging therapy (BT) patients, it stood at 36% (ES 0.36 [95%CI 0.28–0.43], p < 0.01). AF was associated with significantly lower odds of favourable 90-day functional outcomes post IVT (Odds Ratio [OR] 0.512 [95%CI 0.376–0.696], p < 0.001), but not post EVT (OR 0.826 [95%CI 0.651–1.049], p = 0.117). Our comprehensive meta-analysis highlights the varying prevalence of AF among different reperfusion therapies and its differential impact on patient outcomes. The highest pooled prevalence of AF was observed in EVT patients, followed by BT and IVT patients. Interestingly, our analysis revealed that AF was significantly associated with poorer clinical outcomes following IVT. Such an association was not observed following EVT.
    Schlagwörter atrial fibrillation ; stroke ; prevalence ; outcomes ; reperfusion therapy ; thrombolysis ; Medicine ; R ; Internal medicine ; RC31-1245 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: We should learn from the Asia–Pacific responses to COVID-19

    Jay Patel / Devi Sridhar

    The Lancet Regional Health. Western Pacific, Vol 5, Iss , Pp 100062- (2020)

    2020  

    Schlagwörter COVID-19 ; Epidemiology ; Health policy ; Public health ; Public aspects of medicine ; RA1-1270
    Sprache Englisch
    Erscheinungsdatum 2020-12-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: The role of oral bacteria in COVID-19

    Jay Patel / Victoria Sampson

    The Lancet Microbe, Vol 1, Iss 3, Pp e105- (2020)

    2020  

    Schlagwörter Medicine (General) ; R5-920 ; Microbiology ; QR1-502
    Sprache Englisch
    Erscheinungsdatum 2020-07-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Obstructed hemivagina with ipsilateral renal agenesis (OHVIRA) syndrome

    Bhavana Devanabanda, MD / Bradley Chatterton, BS / Irfan Nazir Hassan, MD / Jay Patel, MD

    Radiology Case Reports, Vol 18, Iss 7, Pp 2437-

    Typical presentation of a rare syndrome

    2023  Band 2440

    Abstract: Obstructed hemivagina with ipsilateral renal agenesis (OHVIRA) syndrome is a rare congenital malformation of the Mullerian duct. We report on a 34-year-old female who presented to the emergency department for cramping lower abdominal pain and pelvic ... ...

    Abstract Obstructed hemivagina with ipsilateral renal agenesis (OHVIRA) syndrome is a rare congenital malformation of the Mullerian duct. We report on a 34-year-old female who presented to the emergency department for cramping lower abdominal pain and pelvic pressure with vaginal spotting. Physical exam showed marked swelling in the right adnexa, and laboratory exams were within normal limits except for positive Coronavirus disease 2019 (COVID-19) status. Transvaginal ultrasound revealed 3 well circumscribed, round hypoechoic complex cystic lesions with arterial doppler detected within the peripheral walls. Magnetic resonance imaging of the abdomen and pelvis showed a right hemivagina, right hematosalpinx, right hematometra and right renal agenesis, compatible with OHVIRA syndrome. The patient was informed of elective surgical procedure but was unable to undergo surgery at this time secondary to COVID status. The patient was therefore recommended oral contraceptive therapy for suppression of menses and protection of endometrial lining.
    Schlagwörter OHVIRA syndrome ; Herlyn-Werner-Wunderlich Syndrome ; Mullerian aplasia ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2023-07-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: An Epidemiological Investigation of the Diphtheria Outbreaks Reported in a District of Gujarat

    Harsh Shah / Jay Patel / Aniket Rana / Anish Sinha / Manish Fancy

    Healthline, Vol 12, Iss 4, Pp 39-

    2021  Band 45

    Abstract: Introduction: Mortality and morbidity due to infectious disease have got reduced in the last couple of decades. Diphtheria is one of the infectious diseases which can be preventable with a complete immunization. Objective: To understand trends and ... ...

    Abstract Introduction: Mortality and morbidity due to infectious disease have got reduced in the last couple of decades. Diphtheria is one of the infectious diseases which can be preventable with a complete immunization. Objective: To understand trends and identify factors affecting the outbreak of diphtheria in Banaskantha district of Gujarat. Method: A retrospective study based on the available case records for the years 2019, 2020 and 2021(till June). The study was conducted after the reported diphtheria cases in a district. The study was a public health response and intended to provide specific geographical recommendations to the district. The data was recorded from the reported case record and immunization registers. The data were analyzed for defined variables. Results: Out of the 366 cases identified during years 2019-2021.Almost 74% cases have occurred during 2019, with a 7.7% mortality rate. Total 48% of cases were among the age group of 5-10 years, with an increasing number of cases during August-December with specific geographical distribution. Among all the cases, 164 (44.5%) have never taken any vaccine in their lifetime or are unaware of the vaccination status, and 87.9% of cases have not taken third dose of DPT or Pentavalent Vaccine, which is associated statistically with the mortality. Conclusion: The prevalence of diphtheria cases was high in children who have not taken all three doses of DPT or Pentavalent vaccine. These have shown an essential role of immunization, focusing on the vaccine for all doses and need to create a customized awareness communication plan.
    Schlagwörter diphtheria ; dpt vaccine ; epidemiology ; immunization ; pentavalent vaccine ; Medicine ; R ; Public aspects of medicine ; RA1-1270
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag Indian Association of Preventive and Social Medicine
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Segmentation of Dental Restorations on Panoramic Radiographs Using Deep Learning

    Csaba Rohrer / Joachim Krois / Jay Patel / Hendrik Meyer-Lueckel / Jonas Almeida Rodrigues / Falk Schwendicke

    Diagnostics, Vol 12, Iss 1316, p

    2022  Band 1316

    Abstract: Convolutional Neural Networks (CNNs) such as U-Net have been widely used for medical image segmentation. Dental restorations are prominent features of dental radiographs. Applying U-Net on the panoramic image is challenging, as the shape, size and ... ...

    Abstract Convolutional Neural Networks (CNNs) such as U-Net have been widely used for medical image segmentation. Dental restorations are prominent features of dental radiographs. Applying U-Net on the panoramic image is challenging, as the shape, size and frequency of different restoration types vary. We hypothesized that models trained on smaller, equally spaced rectangular image crops (tiles) of the panoramic would outperform models trained on the full image. A total of 1781 panoramic radiographs were annotated pixelwise for fillings, crowns, and root canal fillings by dental experts. We used different numbers of tiles for our experiments. Five-times-repeated three-fold cross-validation was used for model evaluation. Training with more tiles improved model performance and accelerated convergence. The F1-score for the full panoramic image was 0.7, compared to 0.83, 0.92 and 0.95 for 6, 10 and 20 tiles, respectively. For root canals fillings, which are small, cone-shaped features that appear less frequently on the radiographs, the performance improvement was even higher (+294%). Training on tiles and pooling the results thereafter improved pixelwise classification performance and reduced the time to model convergence for segmenting dental restorations. Segmentation of panoramic radiographs is biased towards more frequent and extended classes. Tiling may help to overcome this bias and increase accuracy.
    Schlagwörter machine learning ; deep learning ; image segmentation ; dental restorations ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 006
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Effects of Exercise Preconditioning on Doxorubicin-Induced Liver and Kidney Toxicity in Male and Female Rats

    Franccesco P. Boeno / Jay Patel / Ryan N. Montalvo / Stephanie S. Lapierre-Nguyen / Claire M. Schreiber / Ashley J. Smuder

    International Journal of Molecular Sciences, Vol 24, Iss 10222, p

    2023  Band 10222

    Abstract: Doxorubicin (DOX) is a highly effective chemotherapy agent prescribed for cancer treatment. However, the clinical use of DOX is limited due to off-target toxicity in healthy tissues. In this regard, hepatic and renal metabolic clearance results in DOX ... ...

    Abstract Doxorubicin (DOX) is a highly effective chemotherapy agent prescribed for cancer treatment. However, the clinical use of DOX is limited due to off-target toxicity in healthy tissues. In this regard, hepatic and renal metabolic clearance results in DOX accumulation within these organ systems. Within the liver and kidneys, DOX causes inflammation and oxidative stress, which promotes cytotoxic cellular signaling. While there is currently no standard of care to treat DOX hepatic- and nephrotoxicity, endurance exercise preconditioning may be an effective intervention to prevent elevations in liver alanine transaminase (ALT) and aspartate aminotransferase (AST) and to improve kidney creatinine clearance. To determine whether exercise preconditioning is sufficient to reduce liver and kidney toxicity resulting from acute exposure to DOX chemotherapy treatment, male and female Sprague–Dawley rats remained sedentary or were exercise trained prior to saline or DOX exposure. Our findings demonstrate that DOX treatment elevated AST and AST/ALT in male rats, with no effects of exercise preconditioning to prevent these increases. We also showed increased plasma markers of renin–angiotensin–aldosterone system (RAAS) activation and urine markers of proteinuria and proximal tubule damage, with male rats revealing greater differences compared to females. Exercise preconditioning showed improved urine creatinine clearance and reduced cystatin c in males, while females had reduced plasma angiotensin II (AngII) levels. Our results demonstrate both tissue- and sex-specific responses related to the effects of exercise preconditioning and DOX treatment on markers of liver and kidney toxicity.
    Schlagwörter hepatotoxicity ; nephrotoxicity ; anthracycline ; exercise preconditioning ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 590 ; 610
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Exploring private sector perspectives on barriers and facilitators in availing tuberculosis care cascade services

    Harsh D Shah / Shalu Chaudhary / Bharat Desai / Jay Patel / Sandul Yasobant / Priya Bhavsar / Somen Saha / Anish K Sinha / Deepak Saxena / Yogesh Patel / Bhavesh Modi

    BMC Primary Care, Vol 25, Iss 1, Pp 1-

    a qualitative study from the Indian state

    2024  Band 11

    Abstract: Abstract Introduction The private sector plays an important role in tuberculosis (TB) elimination by providing access to quality TB care services like diagnosis and treatment, advocacy for preventive measures, innovation to address challenges in TB ... ...

    Abstract Abstract Introduction The private sector plays an important role in tuberculosis (TB) elimination by providing access to quality TB care services like diagnosis and treatment, advocacy for preventive measures, innovation to address challenges in TB elimination, vaccines etc. The study aims to understand the perspectives of private practitioners on patients’ TB care cascade to reinforce existing interventions by assuring the quality of care to TB patients. Methods The study utilized a qualitative design through in-depth interviews of private practitioners and was conducted in Ranchi and Purbi Singhbhum District of Jharkhand State from March-August 2021. The pilot-tested, semi-structured, open-ended interview guide questionnaire collected information from private practitioners on various aspects of the TB care cascade. The data from the provider interviews were transcribed into multiple codes and themes on the TB program. An inductive analysis was carried out with a focus on content credibility to eliminate bias. Ethical approval was received from the Institutional Ethics Committee of the Indian Institute of Public Health Gandhinagar (IIPHG), India. Written consent was taken from the private practitioners involved in the study. Result In-depth interviews of 17 private practitioners reveal various factors contributing to delays in TB care cascades, especially delay in access to TB diagnosis and TB Care, delay in providing treatment once after diagnosis and poor adherence to the TB treatment. According to the perception of private practitioners, there was an array of client, provider and system side factors affecting the TB care cascade gaps positively and negatively. Positive aspects mainly emerged from interviews: strong governance, consistent supply chain management, innovative PPP models and financial schemes reducing out-of-pocket expenditure (OOPE). Various factors affecting the TB care cascade negatively include awareness among the patient, socio-economic status, approach and decision-making power of ...
    Schlagwörter Tuberculosis ; Public Private Partnership ; TB elimination ; TB Care Cascade ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Comparison of Light Emitting Diode Phototherapy vs Conventional Phototherapy for Neonatal Hyperbilirubinemia

    CHARUL MEHTA / K GAYATRI / DHRUVIKA G CHAUDHARI / BHAVIN PATEL / SHASHANK BANSAL / JAY PATEL

    Journal of Clinical and Diagnostic Research, Vol 15, Iss 07, Pp 08-

    A Quasi-experimental Study

    2021  Band 10

    Abstract: Introduction: Neonatal hyperbilirubinemia is one of the most common problem encountered during the neonatal period. Phototherapy is a widely accepted, cheap, non-invasive relatively safe and effective method of treatment for neonatal hyperbilirubinemia. ... ...

    Abstract Introduction: Neonatal hyperbilirubinemia is one of the most common problem encountered during the neonatal period. Phototherapy is a widely accepted, cheap, non-invasive relatively safe and effective method of treatment for neonatal hyperbilirubinemia. Aim: To compare the efficacy of Light Emitting Diode (LED) phototherapy vs Conventional Phototherapy for treatment of neonatal hyperbilirubinemia in healthy term neonates. Materials and Methods: A quasi experimental study was conducted in Neonatal Intensive Care Unit and Post-natal wards in a tertiary care hospital affiliated to Medical College and Hospital, Ahmedabad, Gujarat from July 2018 to April 2019 with a sample size of 135 in each group. They were assessed clinically by Kramers method just before initiation of phototherapy, then using Transcutaneous Bilirubinometer (TCB) Total Serum Bilirubin (TSB) level was measured. Bilirubin assessment by these methods were done for every neonate before initiation of phototherapy and then again repeated after 24 and 48 hours of phototherapy. Data was collected and analysed in Microsoft (MS) excel Statistical Package for the Social Sciences (SPSS) 0.26. Chi-square test was used for comparison. Results: In the present study, 158 (58.51%) babies were male and 112 (41.48%) babies were female. Initially, LED was found to be better than Compact Fluorescent (CFL) conventional phototherapy on comparing the average fall in the serum bilirubin level from baseline during the first 24 hours however no such difference in the efficacy between the two light sources was seen after a period of 48 hours. Total 9 (6.66%) patients developed rebound hyperbilirubinemia after completion of conventional phototherapy whereas 14 (10.37%) developed rebound hyperbilirubinemia after completion of 48 hours of LED phototherapy. Conclusion: LED and conventional phototherapy were equally efficacious in managing non haemolytic hyperbilirubinemia in healthy term neonates.
    Schlagwörter kramers staging ; transcutaneous bilirubinometer ; total serum bilirubin ; Medicine ; R
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2021-07-01T00:00:00Z
    Verlag JCDR Research and Publications Private Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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