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Article ; Online: Decoding the autoantibody reactome.

Jaycox, Jillian R / Dai, Yile / Ring, Aaron M

2024 Volume 383, Issue 6684, Page(s) 705–707

Abstract: Autoantibodies influence a wide range of conditions beyond autoimmune diseases. ...

Abstract	Autoantibodies influence a wide range of conditions beyond autoimmune diseases.
MeSH term(s)	Humans ; Autoantibodies/genetics ; Autoantibodies/immunology ; Autoimmune Diseases/immunology ; Neoplasms/immunology ; Antigens, Neoplasm/immunology ; COVID-19/immunology ; Interferon Type I/immunology
Chemical Substances	Autoantibodies ; Antigens, Neoplasm ; Interferon Type I
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.abn1034
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Article ; Online: SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity.

Jaycox, Jillian R / Lucas, Carolina / Yildirim, Inci / Dai, Yile / Wang, Eric Y / Monteiro, Valter / Lord, Sandra / Carlin, Jeffrey / Kita, Mariko / Buckner, Jane H / Ma, Shuangge / Campbell, Melissa / Ko, Albert / Omer, Saad / Lucas, Carrie L / Speake, Cate / Iwasaki, Akiko / Ring, Aaron M

Nature communications

2023 Volume 14, Issue 1, Page(s) 1299

Abstract: mRNA-based vaccines dramatically reduce the occurrence and severity of COVID-19, but are associated with rare vaccine-related adverse effects. These toxicities, coupled with observations that SARS-CoV-2 infection is associated with autoantibody ... ...

Abstract	mRNA-based vaccines dramatically reduce the occurrence and severity of COVID-19, but are associated with rare vaccine-related adverse effects. These toxicities, coupled with observations that SARS-CoV-2 infection is associated with autoantibody development, raise questions whether COVID-19 vaccines may also promote the development of autoantibodies, particularly in autoimmune patients. Here we used Rapid Extracellular Antigen Profiling to characterize self- and viral-directed humoral responses after SARS-CoV-2 mRNA vaccination in 145 healthy individuals, 38 patients with autoimmune diseases, and 8 patients with mRNA vaccine-associated myocarditis. We confirm that most individuals generated robust virus-specific antibody responses post vaccination, but that the quality of this response is impaired in autoimmune patients on certain modes of immunosuppression. Autoantibody dynamics are remarkably stable in all vaccinated patients compared to COVID-19 patients that exhibit an increased prevalence of new autoantibody reactivities. Patients with vaccine-associated myocarditis do not have increased autoantibody reactivities relative to controls. In summary, our findings indicate that mRNA vaccines decouple SARS-CoV-2 immunity from autoantibody responses observed during acute COVID-19.
MeSH term(s)	Humans ; Antibodies, Viral/immunology ; Autoantibodies/immunology ; Autoimmune Diseases/immunology ; Autoimmunity/immunology ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/therapeutic use ; Drug-Related Side Effects and Adverse Reactions/immunology ; Immunity, Humoral/immunology ; Myocarditis/immunology ; RNA, Messenger ; SARS-CoV-2 ; Vaccination ; Vaccines, Synthetic/adverse effects ; Vaccines, Synthetic/immunology ; Vaccines, Synthetic/therapeutic use ; mRNA Vaccines/adverse effects ; mRNA Vaccines/immunology ; mRNA Vaccines/therapeutic use
Chemical Substances	Antibodies, Viral ; Autoantibodies ; COVID-19 Vaccines ; RNA, Messenger ; Vaccines, Synthetic ; mRNA Vaccines
Language	English
Publishing date	2023-03-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-36686-8
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Article: Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID.

Grady, Connor B / Bhattacharjee, Bornali / Silva, Julio / Jaycox, Jillian / Lee, Lik Wee / Monteiro, Valter Silva / Sawano, Mitsuaki / Massey, Daisy / Caraballo, César / Gehlhausen, Jeff R / Tabachnikova, Alexandra / Mao, Tianyang / Lucas, Carolina / Peña-Hernandez, Mario A / Xu, Lan / Tzeng, Tiffany J / Takahashi, Takehiro / Herrin, Jeph / Güthe, Diana Berrent /

Akrami, Athena / Assaf, Gina / Davis, Hannah / Harris, Karen / McCorkell, Lisa / Schulz, Wade L / Grffin, Daniel / Wei, Hannah / Ring, Aaron M / Guan, Leying / Cruz, Charles Dela / Iwasaki, Akiko / Krumholz, Harlan M

medRxiv : the preprint server for health sciences

2024

Abstract: Background: Long COVID contributes to the global burden of disease. Proposed root cause hypotheses include the persistence of SARS-CoV-2 viral reservoir, autoimmunity, and reactivation of latent herpesviruses. Patients have reported various changes in ... ...

Abstract	Background: Long COVID contributes to the global burden of disease. Proposed root cause hypotheses include the persistence of SARS-CoV-2 viral reservoir, autoimmunity, and reactivation of latent herpesviruses. Patients have reported various changes in Long COVID symptoms after COVID-19 vaccinations, leaving uncertainty about whether vaccine-induced immune responses may alleviate or worsen disease pathology. Methods: In this prospective study, we evaluated changes in symptoms and immune responses after COVID-19 vaccination in 16 vaccine-naïve individuals with Long COVID. Surveys were administered before vaccination and then at 2, 6, and 12 weeks after receiving the first vaccine dose of the primary series. Simultaneously, SARS-CoV-2-reactive TCR enrichment, SARS-CoV-2-specific antibody responses, antibody responses to other viral and self-antigens, and circulating cytokines were quantified before vaccination and at 6 and 12 weeks after vaccination. Results: Self-report at 12 weeks post-vaccination indicated 10 out of 16 participants had improved health, 3 had no change, 1 had worse health, and 2 reported marginal changes. Significant elevation in SARS-CoV-2-specific TCRs and Spike protein-specific IgG were observed 6 and 12 weeks after vaccination. No changes in reactivities were observed against herpes viruses and self-antigens. Within this dataset, higher baseline sIL-6R was associated with symptom improvement, and the two top features associated with non-improvement were high IFN-β and CNTF, among soluble analytes. Conclusions: Our study showed that in this small sample, vaccination improved the health or resulted in no change to the health of most participants, though few experienced worsening. Vaccination was associated with increased SARS-CoV-2 Spike protein-specific IgG and T cell expansion in most individuals with Long COVID. Symptom improvement was observed in those with baseline elevated sIL-6R, while elevated interferon and neuropeptide levels were associated with a lack of improvement.
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.11.24300929
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Article ; Online: Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine-associated myocarditis.

Science immunology

2023 Volume 8, Issue 83, Page(s) eadh3455

Abstract: Rare immune-mediated cardiac tissue inflammation can occur after vaccination, including after SARS-CoV-2 mRNA vaccines. However, the underlying immune cellular and molecular mechanisms driving this pathology remain poorly understood. Here, we ... ...

Abstract	Rare immune-mediated cardiac tissue inflammation can occur after vaccination, including after SARS-CoV-2 mRNA vaccines. However, the underlying immune cellular and molecular mechanisms driving this pathology remain poorly understood. Here, we investigated a cohort of patients who developed myocarditis and/or pericarditis with elevated troponin, B-type natriuretic peptide, and C-reactive protein levels as well as cardiac imaging abnormalities shortly after SARS-CoV-2 mRNA vaccination. Contrary to early hypotheses, patients did not demonstrate features of hypersensitivity myocarditis, nor did they have exaggerated SARS-CoV-2-specific or neutralizing antibody responses consistent with a hyperimmune humoral mechanism. We additionally found no evidence of cardiac-targeted autoantibodies. Instead, unbiased systematic immune serum profiling revealed elevations in circulating interleukins (IL-1β, IL-1RA, and IL-15), chemokines (CCL4, CXCL1, and CXCL10), and matrix metalloproteases (MMP1, MMP8, MMP9, and TIMP1). Subsequent deep immune profiling using single-cell RNA and repertoire sequencing of peripheral blood mononuclear cells during acute disease revealed expansion of activated CXCR3
MeSH term(s)	Humans ; Myocarditis/etiology ; SARS-CoV-2 ; Leukocytes, Mononuclear ; COVID-19 Vaccines/adverse effects ; Contrast Media ; COVID-19/prevention & control ; Gadolinium ; Antineoplastic Agents ; Killer Cells, Natural ; Cytokines
Chemical Substances	COVID-19 Vaccines ; Contrast Media ; Gadolinium (AU0V1LM3JT) ; Antineoplastic Agents ; Cytokines
Language	English
Publishing date	2023-05-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2470-9468
ISSN (online)	2470-9468
DOI	10.1126/sciimmunol.adh3455
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Article ; Online: Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID

Grady, Connor B / Bhattacharjee, Bornali / Silva, Julio / Jaycox, Jillian / Lee, Lik Wee / Monteiro, Valter Silva / Sawano, Mitsuaki / Massey, Daisy / Caraballo, César / Gehlhausen, Jeff R. / Tabachnikova, Alexandra / Mao, Tianyang / Lucas, Carolina / Peña-Hernandez, Mario A. / Xu, Lan / Tzeng, Tiffany J. / Takahashi, Takehiro / Herrin, Jeph / Güthe, Diana Berrent /

medRxiv

Abstract	Background: Long COVID contributes to the global burden of disease. Proposed root cause hypotheses include the persistence of SARS-CoV-2 viral reservoir, autoimmunity, and reactivation of latent herpesviruses. Patients have reported various changes in Long COVID symptoms after COVID-19 vaccinations, leaving uncertainty about whether vaccine-induced immune responses may alleviate or worsen disease pathology. Methods: In this prospective study, we evaluated changes in symptoms and immune responses after COVID-19 vaccination in 16 vaccine-naïve individuals with Long COVID. Surveys were administered before vaccination and then at 2, 6, and 12 weeks after receiving the first vaccine dose of the primary series. Simultaneously, SARS-CoV-2-reactive TCR enrichment, SARS-CoV-2-specific antibody responses, antibody responses to other viral and self-antigens, and circulating cytokines were quantified before vaccination and at 6 and 12 weeks after vaccination. Results: Self-report at 12 weeks post-vaccination indicated 10 out of 16 participants had improved health, 3 had no change, 1 had worse health, and 2 reported marginal changes. Significant elevation in SARS-CoV-2-specific TCRs and Spike protein-specific IgG were observed 6 and 12 weeks after vaccination. No changes in reactivities were observed against herpes viruses and self-antigens. Within this dataset, higher baseline sIL-6R was associated with symptom improvement, and the two top features associated with non-improvement were high IFN-β and CNTF, among soluble analytes. Conclusions: Our study showed that in this small sample, vaccination improved the health or resulted in no change to the health of most participants, though few experienced worsening. Vaccination was associated with increased SARS-CoV-2 Spike protein-specific IgG and T cell expansion in most individuals with Long COVID. Symptom improvement was observed in those with baseline elevated sIL-6R, while elevated interferon and neuropeptide levels were associated with a lack of improvement.
Keywords	covid19
Language	English
Publishing date	2024-01-12
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2024.01.11.24300929
Database	COVID19

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Article: Distinguishing features of Long COVID identified through immune profiling.

Klein, Jon / Wood, Jamie / Jaycox, Jillian / Lu, Peiwen / Dhodapkar, Rahul M / Gehlhausen, Jeff R / Tabachnikova, Alexandra / Tabacof, Laura / Malik, Amyn A / Kamath, Kathy / Greene, Kerrie / Monteiro, Valter Silva / Peña-Hernandez, Mario / Mao, Tianyang / Bhattacharjee, Bornali / Takahashi, Takehiro / Lucas, Carolina / Silva, Julio / Mccarthy, Dayna /

Breyman, Erica / Tosto-Mancuso, Jenna / Dai, Yile / Perotti, Emily / Akduman, Koray / Tzeng, Tiffany J / Xu, Lan / Yildirim, Inci / Krumholz, Harlan M / Shon, John / Medzhitov, Ruslan / Omer, Saad B / van Dijk, David / Ring, Aaron M / Putrino, David / Iwasaki, Akiko

medRxiv : the preprint server for health sciences

2022

Abstract: SARS-CoV-2 infection can result in the development of a constellation of persistent sequelae following acute disease called post-acute sequelae of COVID-19 (PASC) or Long ... ...

Abstract	SARS-CoV-2 infection can result in the development of a constellation of persistent sequelae following acute disease called post-acute sequelae of COVID-19 (PASC) or Long COVID
Language	English
Publishing date	2022-08-10
Publishing country	United States
Document type	Preprint
DOI	10.1101/2022.08.09.22278592
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Article ; Online: Lack of association between pandemic chilblains and SARS-CoV-2 infection.

Gehlhausen, Jeff R / Little, Alicia J / Ko, Christine J / Emmenegger, Marc / Lucas, Carolina / Wong, Patrick / Klein, Jon / Lu, Peiwen / Mao, Tianyang / Jaycox, Jillian / Wang, Eric / Ugwu, Nelson / Muenker, Cate / Mekael, Dilgash / Klein, Rhonda Q / Patrignelli, Robert / Antaya, Richard / McNiff, Jennifer / Damsky, William /

Kamath, Kathy / Shon, John / Ring, Aaron M / Yildirim, Inci / Omer, Saad / Ko, Albert I / Aguzzi, Adriano / Iwasaki, Akiko

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 9

Abstract: An increased incidence of chilblains has been observed during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and attributed to viral infection. Direct evidence of this relationship has been limited, however, as most cases do ... ...

Abstract	An increased incidence of chilblains has been observed during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and attributed to viral infection. Direct evidence of this relationship has been limited, however, as most cases do not have molecular evidence of prior SARS-CoV-2 infection with PCR or antibodies. We enrolled a cohort of 23 patients who were diagnosed and managed as having SARS-CoV-2-associated skin eruptions (including 21 pandemic chilblains [PC]) during the first wave of the pandemic in Connecticut. Antibody responses were determined through endpoint titration enzyme-linked immunosorbent assay and serum epitope repertoire analysis. T cell responses to SARS-CoV-2 were assessed by T cell receptor sequencing and in vitro SARS-CoV-2 antigen-specific peptide stimulation assays. Immunohistochemical and PCR studies of PC biopsies and tissue microarrays for evidence of SARS-CoV-2 were performed. Among patients diagnosed and managed as "covid toes" during the pandemic, we find a percentage of prior SARS-CoV-2 infection (9.5%) that approximates background seroprevalence (8.5%) at the time. Immunohistochemistry studies suggest that SARS-CoV-2 staining in PC biopsies may not be from SARS-CoV-2. Our results do not support SARS-CoV-2 as the causative agent of pandemic chilblains; however, our study does not exclude the possibility of SARS-CoV-2 seronegative abortive infections.
MeSH term(s)	Adult ; COVID-19/complications ; COVID-19/epidemiology ; Chilblains/epidemiology ; Chilblains/immunology ; Chilblains/virology ; Connecticut/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2/immunology ; Young Adult
Language	English
Publishing date	2022-02-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2122090119
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Article ; Online: Signaling through IL-17C/IL-17RE is dispensable for immunity to systemic, oral and cutaneous candidiasis.

Conti, Heather R / Whibley, Natasha / Coleman, Bianca M / Garg, Abhishek V / Jaycox, Jillian R / Gaffen, Sarah L

PloS one

2015 Volume 10, Issue 4, Page(s) e0122807

Abstract: Candida albicans is a commensal fungal microbe of the human orogastrointestinal tract and skin. C. albicans causes multiple forms of disease in immunocompromised patients, including oral, vaginal, dermal and disseminated candidiasis. The cytokine IL-17 ( ... ...

Abstract	Candida albicans is a commensal fungal microbe of the human orogastrointestinal tract and skin. C. albicans causes multiple forms of disease in immunocompromised patients, including oral, vaginal, dermal and disseminated candidiasis. The cytokine IL-17 (IL-17A) and its receptor subunits, IL-17RA and IL-17RC, are required for protection to most forms of candidiasis. The importance of the IL-17R pathway has been observed not only in knockout mouse models, but also in humans with rare genetic mutations that impact generation of Th17 cells or the IL-17 signaling pathway, including Hyper-IgE Syndrome (STAT3 or TYK2 mutations) or IL17RA or ACT1 gene deficiency. The IL-17 family of cytokines is a distinct subclass of cytokines with unique structural and signaling properties. IL-17A is the best-characterized member of the IL-17 family to date, but far less is known about other IL-17-related cytokines. In this study, we sought to determine the role of a related IL-17 cytokine, IL-17C, in protection against oral, dermal and disseminated forms of C. albicans infection. IL-17C signals through a heterodimeric receptor composed of the IL-17RA and IL-17RE subunits. We observed that IL-17C mRNA was induced following oral C. albicans infection. However, mice lacking IL-17C or IL-17RE cleared C. albicans infections in the oral mucosa, skin and bloodstream at rates similar to WT littermate controls. Moreover, these mice demonstrated similar gene transcription profiles and recovery kinetics as WT animals. These findings indicate that IL-17C and IL-17RE are dispensable for immunity to the forms of candidiasis evaluated, and illustrate a surprisingly limited specificity of the IL-17 family of cytokines with respect to systemic, oral and cutaneous Candida infections.
MeSH term(s)	Animals ; Candidiasis/immunology ; Candidiasis/metabolism ; Candidiasis/pathology ; Candidiasis, Cutaneous/immunology ; Candidiasis, Cutaneous/metabolism ; Candidiasis, Cutaneous/pathology ; Candidiasis, Oral/immunology ; Candidiasis, Oral/metabolism ; Candidiasis, Oral/pathology ; Disease Resistance ; Female ; Interleukin-17/deficiency ; Interleukin-17/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Protein Subunits/deficiency ; Protein Subunits/metabolism ; Receptors, Interleukin-17/deficiency ; Receptors, Interleukin-17/metabolism ; Signal Transduction/immunology
Chemical Substances	Il17c protein, mouse ; Interleukin-17 ; Protein Subunits ; Receptors, Interleukin-17
Language	English
Publishing date	2015-04-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0122807
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Article ; Online: Distinguishing features of long COVID identified through immune profiling.

Klein, Jon / Wood, Jamie / Jaycox, Jillian R / Dhodapkar, Rahul M / Lu, Peiwen / Gehlhausen, Jeff R / Tabachnikova, Alexandra / Greene, Kerrie / Tabacof, Laura / Malik, Amyn A / Silva Monteiro, Valter / Silva, Julio / Kamath, Kathy / Zhang, Minlu / Dhal, Abhilash / Ott, Isabel M / Valle, Gabrielee / Peña-Hernández, Mario / Mao, Tianyang /

Bhattacharjee, Bornali / Takahashi, Takehiro / Lucas, Carolina / Song, Eric / McCarthy, Dayna / Breyman, Erica / Tosto-Mancuso, Jenna / Dai, Yile / Perotti, Emily / Akduman, Koray / Tzeng, Tiffany J / Xu, Lan / Geraghty, Anna C / Monje, Michelle / Yildirim, Inci / Shon, John / Medzhitov, Ruslan / Lutchmansingh, Denyse / Possick, Jennifer D / Kaminski, Naftali / Omer, Saad B / Krumholz, Harlan M / Guan, Leying / Dela Cruz, Charles S / van Dijk, David / Ring, Aaron M / Putrino, David / Iwasaki, Akiko

Nature

2023 Volume 623, Issue 7985, Page(s) 139–148

Abstract: Post-acute infection syndromes may develop after acute viral ... ...

Abstract	Post-acute infection syndromes may develop after acute viral disease
MeSH term(s)	Humans ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Biomarkers/blood ; Cross-Sectional Studies ; Herpesvirus 4, Human/immunology ; Hydrocortisone/blood ; Immunophenotyping ; Lymphocytes/immunology ; Machine Learning ; Myeloid Cells/immunology ; Post-Acute COVID-19 Syndrome/diagnosis ; Post-Acute COVID-19 Syndrome/immunology ; Post-Acute COVID-19 Syndrome/physiopathology ; Post-Acute COVID-19 Syndrome/virology ; SARS-CoV-2/immunology
Chemical Substances	Antibodies, Viral ; Biomarkers ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2023-09-25
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-06651-y
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Diverse functional autoantibodies in patients with COVID-19.

Wang, Eric Y / Mao, Tianyang / Klein, Jon / Dai, Yile / Huck, John D / Jaycox, Jillian R / Liu, Feimei / Zhou, Ting / Israelow, Benjamin / Wong, Patrick / Coppi, Andreas / Lucas, Carolina / Silva, Julio / Oh, Ji Eun / Song, Eric / Perotti, Emily S / Zheng, Neil S / Fischer, Suzanne / Campbell, Melissa /

Fournier, John B / Wyllie, Anne L / Vogels, Chantal B F / Ott, Isabel M / Kalinich, Chaney C / Petrone, Mary E / Watkins, Anne E / Dela Cruz, Charles / Farhadian, Shelli F / Schulz, Wade L / Ma, Shuangge / Grubaugh, Nathan D / Ko, Albert I / Iwasaki, Akiko / Ring, Aaron M

Nature

2021 Volume 595, Issue 7866, Page(s) 283–288

Abstract: COVID-19 manifests with a wide spectrum of clinical phenotypes that are characterized by exaggerated and misdirected host immune ... ...

Abstract	COVID-19 manifests with a wide spectrum of clinical phenotypes that are characterized by exaggerated and misdirected host immune responses
MeSH term(s)	Animals ; Antigens, Surface/immunology ; Autoantibodies/analysis ; Autoantibodies/immunology ; COVID-19/immunology ; COVID-19/metabolism ; COVID-19/pathology ; COVID-19/physiopathology ; Case-Control Studies ; Complement System Proteins/immunology ; Cytokines/immunology ; Disease Models, Animal ; Disease Progression ; Female ; Humans ; Male ; Mice ; Organ Specificity/immunology ; Proteome/immunology ; Proteome/metabolism
Chemical Substances	Antigens, Surface ; Autoantibodies ; Cytokines ; Proteome ; Complement System Proteins (9007-36-7)
Language	English
Publishing date	2021-05-19
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-021-03631-y
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