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  1. Article ; Online: Newer therapies in ANCA associated vasculitis.

    Jayne, D

    Revista clinica espanola

    2020  Volume 220, Issue 3, Page(s) 179–181

    Title translation Nuevas terapias en las vasculitis asociadas a ANCA.
    Language Spanish
    Publishing date 2020-03-31
    Publishing country Spain
    Document type Editorial
    ISSN 2254-8874
    ISSN (online) 2254-8874
    DOI 10.1016/j.rce.2019.12.001
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  2. Article: Antineutrophil Cytoplasmic Antibody-associated Vasculitis Management 2020: Where Are We Now?

    Jayne, David

    The Journal of rheumatology

    2021  Volume 48, Issue 4, Page(s) 479–481

    MeSH term(s) Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Antibodies, Antineutrophil Cytoplasmic ; Humans
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic
    Language English
    Publishing date 2021-03-01
    Publishing country Canada
    Document type Editorial ; Comment
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.201351
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    Zs.A 1168: Show issues Location:
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    Zs.MO 135: Show issues

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  3. Article ; Online: Response to: Correspondence on 'EULAR recommendations for the management of ANCA-associated vasculitis: 2022 update' by Hellmich

    Hellmich, Bernhard / Jayne, David

    Annals of the rheumatic diseases

    2024  

    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard-2024-225606
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    Zs.MO 167: Show issues

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  4. Article ; Online: ANCA-associated vasculitis - Treatment Standard.

    Chalkia, Aglaia / Jayne, David

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2023  

    Abstract: ANCA-associated Vasculitides (AAV) are characterized by small vessel necrotizing inflammation and prior to the advent of immunosuppressive therapy frequently had a fatal outcome. Treatment has transformed AAV into a relapsing/remitting disease with ... ...

    Abstract ANCA-associated Vasculitides (AAV) are characterized by small vessel necrotizing inflammation and prior to the advent of immunosuppressive therapy frequently had a fatal outcome. Treatment has transformed AAV into a relapsing/remitting disease with increased drug-related toxicities and organ damage. The use of glucocorticoids, cyclophosphamide and immunosuppressives (including azathioprine, mycophenolate, methotrexate) was optimised through a sequence of clinical trials establishing a standard of care against which subsequent targeted therapies could be developed. Improved understanding of pathophysiology has supported the development of B cell depletion and complement inhibition, in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), and interleukin 5 inhibition for eosinophilic granulomatosis with polyangiitis (EGPA), leading to the approval of newer agents for these conditions. There has been an increased attention on minimising the adverse effects of treatment and of understanding the epidemiology of co-morbidities in AAV. This review will focus on recent evidence from clinical trials, especially with respect to glucocorticoids, avacopan, plasma exchange, rituximab and mepolizumab, and their interpretation in the 2022 management recommendations by the European League of Associations of Rheumatology (EULAR).
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfad237
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    Zs.A 2198: Show issues Location:
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    Zs.MO 329: Show issues

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  5. Article ; Online: Efficacy and safety of low- versus high-dose glucocorticoid regimens for induction of remission of anti-neutrophil cytoplasm antibody-associated vasculitis: a systematic review and meta-analysis.

    Alchi, M B / Lever, R / Flossmann, O / Jayne, D

    Scandinavian journal of rheumatology

    2023  Volume 52, Issue 5, Page(s) 564–573

    Abstract: Objective: Glucocorticoids (GCs) remain a cornerstone of the initial management of anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV), but have several dose-dependent side effects, in particular infections. The optimal dosing and ... ...

    Abstract Objective: Glucocorticoids (GCs) remain a cornerstone of the initial management of anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV), but have several dose-dependent side effects, in particular infections. The optimal dosing and tapering of oral GCs for remission induction are unknown. A systematic review and meta-analysis was undertaken to determine the efficacy and safety of low- versus high-dose GC regimens.
    Method: A systematic search of MEDLINE, Embase, and PubMed databases was conducted. Clinical studies using a GC-based induction protocol were selected. A daily dose of 0.5 mg/kg or < 30 mg/day oral prednisolone equivalent by the start of week 4 of the induction tapering schedule marked the threshold between high- and low-dose GCs. Risk ratios (RRs) were calculated by the random effects model for outcomes of remission and infection. Relapse events were summarized using risk differences with 95% confidence intervals (CIs).
    Results: In total, 1145 participants were included in three randomized controlled trials and two observational studies, of whom 543 were assigned to the low-dose GC group and 602 to the high-dose GC group. A low-dose GC regimen was non-inferior to high-dose GCs with respect to outcomes of remission (RR 0.98, 95% CI 0.95-1.02, p = 0.37; I
    Conclusion: Studies with low-dose GC regimens in AAV are associated with fewer infections while obtaining equivalent efficacy.
    MeSH term(s) Humans ; Glucocorticoids/therapeutic use ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Remission Induction ; Recurrence ; Cytoplasm ; Randomized Controlled Trials as Topic
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2023-06-20
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 121265-5
    ISSN 1502-7732 ; 0300-9742
    ISSN (online) 1502-7732
    ISSN 0300-9742
    DOI 10.1080/03009742.2023.2211387
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    Zs.A 832: Show issues Location:
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  6. Article ; Online: Wearable Sensors as a Preoperative Assessment Tool: A Review.

    Syversen, Aron / Dosis, Alexios / Jayne, David / Zhang, Zhiqiang

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 2

    Abstract: Surgery is a common first-line treatment for many types of disease, including cancer. Mortality rates after general elective surgery have seen significant decreases whilst postoperative complications remain a frequent occurrence. Preoperative assessment ... ...

    Abstract Surgery is a common first-line treatment for many types of disease, including cancer. Mortality rates after general elective surgery have seen significant decreases whilst postoperative complications remain a frequent occurrence. Preoperative assessment tools are used to support patient risk stratification but do not always provide a precise and accessible assessment. Wearable sensors (WS) provide an accessible alternative that offers continuous monitoring in a non-clinical setting. They have shown consistent uptake across the perioperative period but there has been no review of WS as a preoperative assessment tool. This paper reviews the developments in WS research that have application to the preoperative period. Accelerometers were consistently employed as sensors in research and were frequently combined with photoplethysmography or electrocardiography sensors. Pre-processing methods were discussed and missing data was a common theme; this was dealt with in several ways, commonly by employing an extraction threshold or using imputation techniques. Research rarely processed raw data; commercial devices that employ internal proprietary algorithms with pre-calculated heart rate and step count were most commonly employed limiting further feature extraction. A range of machine learning models were used to predict outcomes including support vector machines, random forests and regression models. No individual model clearly outperformed others. Deep learning proved successful for predicting exercise testing outcomes but only within large sample-size studies. This review outlines the challenges of WS and provides recommendations for future research to develop WS as a viable preoperative assessment tool.
    MeSH term(s) Humans ; Algorithms ; Biological Transport ; Electrocardiography ; Exercise Test ; Wearable Electronic Devices
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24020482
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  7. Article ; Online: Complement inhibition in ANCA vasculitis.

    Jayne, David

    Nephrologie & therapeutique

    2019  Volume 15, Issue 6, Page(s) 409–412

    Abstract: A role for the alternative complement pathway has emerged in the understanding of ANCA vasculitis pathogenesis. Current therapies of ANCA vasculitis are limited by partial efficacy and toxicity and many patients pursue a relapsing course. Improved ... ...

    Abstract A role for the alternative complement pathway has emerged in the understanding of ANCA vasculitis pathogenesis. Current therapies of ANCA vasculitis are limited by partial efficacy and toxicity and many patients pursue a relapsing course. Improved therapies are needed. Inhibition of the alternative complement pathway component C5a is attractive due to its role in neutrophil activation and migration, and engagement of other inflammatory and thrombotic mechanisms. Two inhibitors of C5a are in clinical development for ANCA vasculitis: avacopan, an oral C5a receptor inhibitor has demonstrated efficacy, safety and steroid sparing in two Phase II trials; and IFX-1, a monoclonal antibody to C5a which is entering Phase II development. Complement inhibition has the potential to contribute to remission induction protocols achieving a higher quality of remission as well as replacing steroids. Confirmation of safety, especially infective risk, and the potential to replace steroids depends on further studies and a role in relapse prevention needs to be explored.
    MeSH term(s) Aniline Compounds/pharmacology ; Aniline Compounds/therapeutic use ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/immunology ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; Clinical Trials, Phase II as Topic ; Complement C5a/antagonists & inhibitors ; Complement C5a/immunology ; Complement Inactivating Agents/pharmacology ; Complement Inactivating Agents/therapeutic use ; Complement Pathway, Alternative/drug effects ; Humans ; Neutrophil Activation/drug effects ; Nipecotic Acids/pharmacology ; Nipecotic Acids/therapeutic use
    Chemical Substances Aniline Compounds ; Antibodies, Monoclonal ; Complement Inactivating Agents ; Nipecotic Acids ; Complement C5a (80295-54-1) ; vilobelimab (F5T0RF9ZJA) ; avacopan (O880NM097T)
    Language English
    Publishing date 2019-10-17
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/j.nephro.2019.04.001
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    Zs.A 6298: Show issues Location:
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  8. Article ; Online: Roboterunterstützte kolorektale Chirurgie : Entwicklungen und Perspektiven.

    Jayne, D

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen

    2013  Volume 84, Issue 8, Page(s) 635–642

    Abstract: Robotic assistance has the potential to compensate for the limitations inherent in standard laparoscopic surgery. The daVinci® surgical system remains the only currently available commercial robotic system. It has found popularity in rectal cancer ... ...

    Title translation Robotic colorectal surgery: current status and future developments.
    Abstract Robotic assistance has the potential to compensate for the limitations inherent in standard laparoscopic surgery. The daVinci® surgical system remains the only currently available commercial robotic system. It has found popularity in rectal cancer surgery where its application has consistently been shown to reduce the need to convert to open surgery. With this exception, the technological advances of the robotic system have not so far translated into any reproducible patient benefit. The first part of this manuscript presents an overview of the current daVinci® platform, its applications, the evidence base and future developments in colorectal surgery. The second part of the manuscript looks at other robot systems in development and the different innovations and strategies taken to advance minimally invasive surgery.The English full-text version of this article is available at SpringerLink (under supplemental).
    MeSH term(s) Case-Control Studies ; Colonoscopy/instrumentation ; Colonoscopy/trends ; Colorectal Neoplasms/surgery ; Equipment Design ; Evidence-Based Medicine ; Forecasting ; Germany ; Humans ; Inventions ; Laparoscopy/instrumentation ; Minimally Invasive Surgical Procedures/instrumentation ; Minimally Invasive Surgical Procedures/trends ; Robotics/instrumentation ; Robotics/trends ; Treatment Outcome
    Language German
    Publishing date 2013-08-13
    Publishing country Germany
    Document type Comparative Study ; English Abstract ; Journal Article ; Review
    ZDB-ID 1521-0
    ISSN 1433-0385 ; 0009-4722
    ISSN (online) 1433-0385
    ISSN 0009-4722
    DOI 10.1007/s00104-013-2499-7
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  9. Article ; Online: Anti-GBM disease in pregnancy.

    Kafagi, Abdul Hadi / Li, Anna S / Jayne, David / Brix, Silke R

    BMJ case reports

    2024  Volume 17, Issue 4

    Abstract: We present the case of a pregnant woman in her 20s who presented in her second trimester with severe pulmonary haemorrhage and dialysis-dependent acute kidney failure due to antiglomerular basement membrane (GBM) disease. Responding to therapy, she ... ...

    Abstract We present the case of a pregnant woman in her 20s who presented in her second trimester with severe pulmonary haemorrhage and dialysis-dependent acute kidney failure due to antiglomerular basement membrane (GBM) disease. Responding to therapy, she recovered kidney function and delivered a baby. During her pregnancy, she developed cytomegalovirus viraemia, gestational diabetes and pre-eclampsia. Here, we report the first combined use of cyclophosphamide, rituximab and intensified plasma exchange in anti-GBM disease in pregnancy, allowing minimal exposure to cytotoxic medication, resulting in live birth and dialysis independence.
    MeSH term(s) Humans ; Female ; Pregnancy ; Anti-Glomerular Basement Membrane Disease/diagnosis ; Anti-Glomerular Basement Membrane Disease/complications ; Anti-Glomerular Basement Membrane Disease/therapy ; Pregnancy Complications/drug therapy ; Cyclophosphamide/therapeutic use ; Adult ; Plasma Exchange/methods ; Rituximab/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Acute Kidney Injury/etiology
    Chemical Substances Cyclophosphamide (8N3DW7272P) ; Rituximab (4F4X42SYQ6) ; Immunosuppressive Agents
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-257767
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  10. Article ; Online: Relationship between surgeons and industry.

    Jayne, D G

    The British journal of surgery

    2019  Volume 106, Issue 8, Page(s) 965–967

    MeSH term(s) Biotechnology/economics ; Biotechnology/organization & administration ; General Surgery/economics ; General Surgery/organization & administration ; Health Care Costs ; Health Care Sector/economics ; Health Care Sector/organization & administration ; Humans ; Inventions ; Surgeons/organization & administration ; Technology Assessment, Biomedical
    Language English
    Publishing date 2019-07-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.11241
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