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  1. AU="Jean-Pierre Thomé"
  2. AU=Narayanan Naveen
  3. AU=Azam Faizul
  4. AU="Özdog˘ru, Asil Ali"
  5. AU="Emami, Hajar"
  6. AU="Cimino, R."
  7. AU="Judith R. Stabel"
  8. AU="Takeuchi, Kazuto"
  9. AU="Mirzaei, Samira"
  10. AU="Carolina Salgado"
  11. AU="Mate, Sebastian"
  12. AU="Hou, Tian-Yang Liu"
  13. AU=Nino Gustavo
  14. AU="Lydon, Myra"
  15. AU="Jain, Nibha"
  16. AU="David A Schwartz"
  17. AU="Swart, Jonathan"
  18. AU="Karol, Agnieszka"
  19. AU="Reilly, Brittni"
  20. AU="Arfaatabar, Maryam"
  21. AU="Kumar Pandey, Anand"

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  1. Artikel ; Online: Prenatal and childhood exposure to chlordecone and adiposity of seven-year-old children in the Timoun mother–child cohort study in Guadeloupe (French West Indies)

    Nathalie Costet / Antoine Lafontaine / Florence Rouget / Léah Michineau / Christine Monfort / Jean-Pierre Thomé / Philippe Kadhel / Luc Multigner / Sylvaine Cordier

    Environmental Health, Vol 21, Iss 1, Pp 1-

    2022  Band 13

    Abstract: Abstract Background Exposure to persistent environmental organic pollutants may contribute to the development of obesity among children. Chlordecone is a persistent organochlorine insecticide with estrogenic properties that was used in the French West ... ...

    Abstract Abstract Background Exposure to persistent environmental organic pollutants may contribute to the development of obesity among children. Chlordecone is a persistent organochlorine insecticide with estrogenic properties that was used in the French West Indies (1973–1993) and is still present in the soil and the water and food consumed by the local population. We studied the association between prenatal and childhood exposure to chlordecone and the adiposity of prepubertal children. Methods Within the Timoun Mother–Child Cohort Study in Guadeloupe (French West Indies), 575 children had a medical examination at seven years of age, including adiposity measurements. A Structural Equation Modeling approach was used to create a global adiposity score from four adiposity indicators: the BMI z-score, percentage of fat mass, sum of the tricipital and subscapular skinfold thickness, and waist-to-height ratio. Chlordecone concentrations were measured in cord blood at birth and in the children’s blood at seven years of age. Models were adjusted for prenatal and postnatal covariates. Sensitivity analyses accounted for co-exposure to PCB-153 and pp’-DDE. Mediation analyses, including intermediate birth outcomes, were conducted. Results Prenatal chlordecone exposure tended to be associated with increased adiposity at seven years of age, particularly in boys. However, statistical significance was only reached in the third quartile of exposure and neither linear nor non-linear trends could be formally identified. Consideration of preterm birth or birth weight in mediation analyses did not modify the results, as adjustment for PCB-153 and pp’-DDE co-exposures. Conclusion Globally, we found little evidence of an association between chlordecone exposure during the critical in utero or childhood periods of development and altered body-weight homeostasis in childhood. Nevertheless, some associations we observed at seven years of age, although non-significant, were consistent with those observed at earlier ages and would be worth ...
    Schlagwörter Adiposity ; Obesity ; Chlordecone ; Organochlorine pesticides ; Prenatal exposure ; Childhood exposure ; Industrial medicine. Industrial hygiene ; RC963-969 ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2022-04-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: High pollutant exposure level of the largest European community of bottlenose dolphins in the English Channel

    Cyrielle Zanuttini / François Gally / Georges Scholl / Jean-Pierre Thomé / Gauthier Eppe / Krishna Das

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Band 10

    Abstract: Abstract The objective of this study was to assess the levels of persistent organic pollutants (POPs) and mercury (T-Hg) in the blubber and skin, respectively, of the free-ranging bottlenose dolphins, Tursiops truncatus, from the Normanno-Breton Gulf, ... ...

    Abstract Abstract The objective of this study was to assess the levels of persistent organic pollutants (POPs) and mercury (T-Hg) in the blubber and skin, respectively, of the free-ranging bottlenose dolphins, Tursiops truncatus, from the Normanno-Breton Gulf, one of the largest identified coastal population in Europe. Among all the POPs analysed in this study, the ∑NDL-PCBs were the most abundant compounds found in the blubber (mean: 1.33 × 105–0.65 × 105 ng.g−1 lipid weight (lw) for males and females respectively), followed by ∑DDX (1.11 × 104–4.67 × 103 ng.g−1 lw) > ∑DL-PCBs (8.06 × 103–2.62 × 103ng.g−1 lw) > ∑PBDEs (1.95 × 103–0.64 × 103ng.g−1 lw) > dieldrin (1.86 × 103–0.18 × 103 ng.g−1 lw) > ∑endosulfan (405–62 ng.g−1 lw) > HCB (86–52 ng.g−1 lw) > ∑HCHs (47–60 ng.g−1 lw) > ∑chlordane (24–0.97 ng.g−1 lw) > ∑PCDFs (0.3–0.1 ng.g−1 lw) > ∑PCDDs (0.06–0.05 ng.g−1 lw). The T-Hg concentrations were highly variable between individuals (2.45 × 103 ng.g−1 to 21.3 × 103 ng.g−1 dry weight, dw). The reported concentrations are among the highest reported for cetaceans. We strongly recommend that the Normanno-Breton Gulf be a special area of conservation (cSAC) candidate because it contains the last large European population of bottlenose dolphins (rare or threatened within a European context) designated under the EC Habitats Directive.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2019-09-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Predicting consequences of POP-induced disruption of blubber glucose uptake, mass gain rate and thyroid hormone levels for weaning mass in grey seal pups

    Kimberley A. Bennett / Kelly J. Robinson / Holly C. Armstrong / Simon E.W. Moss / Georges Scholl / Alexandra Tranganida / Gauthier Eppe / Jean-Pierre Thomé / Cathy Debier / Ailsa J. Hall

    Environment International, Vol 152, Iss , Pp 106506- (2021)

    2021  

    Abstract: Persistent organic pollutants (POPs) are endocrine disruptors that alter adipose tissue development, regulation and function. Top marine predators are particularly vulnerable because they possess large fat stores that accumulate POPs. However, links ... ...

    Abstract Persistent organic pollutants (POPs) are endocrine disruptors that alter adipose tissue development, regulation and function. Top marine predators are particularly vulnerable because they possess large fat stores that accumulate POPs. However, links between endocrine or adipose tissue function disruption and whole animal energetics have rarely been investigated. We predicted the impact of alterations to blubber metabolic characteristics and circulating thyroid hormone (TH) levels associated with polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides (OCPs) on suckling mass gain and weaning mass in wild grey seal pups. Glucose uptake by inner blubber was a strong predictor of whole animal mass gain rate, which in turn, resulted in heavier weaning mass. Weaning mass was predicted to increase by 3.7 ± 1.59 (sem) %, through increased mass gain rate, in the absence of the previously reported suppressive effect of dioxin-like PCB (DL-PCBs) on blubber glucose uptake. PBDEs were, conversely, associated with faster mass gain. Alleviation of this effect was predicted to reduce weaning mass by 6.02 ± 1.86% (sem). To better predict POPs effects on energy balance, it is crucial to determine if and how PBDEs promote mass gain in grey seal pups. Weaning mass was negatively related to total T3 (TT3) levels. A 20% (range = 9.3–31.7%) reduction in TT3 by DL-PCBs partially overcame the effect of DL-PCB -mediated reduction in blubber glucose uptake. Overall, DL-PCBs were thus predicted to reduce weaning mass by 1.86 ± 1.60%. Organohalogen impacts on whole-animal energy balance in grey seal pups appear to partially offset each other through opposing effects on different mechanisms. POP effects were generally minor, but the largest POP-induced reductions in weaning mass were predicted to occur in pups that were already small. Since weaning mass is positively related to first-year survival, POPs may disproportionately affect smaller individuals, and could continue to have ...
    Schlagwörter Adipose ; Endocrine disruption energetics ; Metabolic disruption ; Contaminants ; Marine mammal ; Environmental sciences ; GE1-350
    Sprache Englisch
    Erscheinungsdatum 2021-07-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: Persistent Organic Pollutant Burden, Experimental POP Exposure, and Tissue Properties Affect Metabolic Profiles of Blubber from Gray Seal Pups

    Robinson, Kelly J / Ailsa J. Hall / Cathy Debier / Gauthier Eppe / Jean-Pierre Thomé / Kimberley A. Bennett

    Environmental science & technology. 2018 Oct. 19, v. 52, no. 22

    2018  

    Abstract: Persistent organic pollutants (POPs) are toxic, ubiquitous, resist breakdown, bioaccumulate in living tissue, and biomagnify in food webs. POPs can also alter energy balance in humans and wildlife. Marine mammals experience high POP concentrations, but ... ...

    Abstract Persistent organic pollutants (POPs) are toxic, ubiquitous, resist breakdown, bioaccumulate in living tissue, and biomagnify in food webs. POPs can also alter energy balance in humans and wildlife. Marine mammals experience high POP concentrations, but consequences for their tissue metabolic characteristics are unknown. We used blubber explants from wild, gray seal (Halichoerus grypus) pups to examine impacts of intrinsic tissue POP burden and acute experimental POP exposure on adipose metabolic characteristics. Glucose use, lactate production, and lipolytic rate differed between matched inner and outer blubber explants from the same individuals and between feeding and natural fasting. Glucose use decreased with blubber dioxin-like PCBs (DL-PCB) and increased with acute experimental POP exposure. Lactate production increased with DL-PCBs during feeding, but decreased with DL-PCBs during fasting. Lipolytic rate increased with blubber dichlorodiphenyltrichloroethane and its metabolites (DDX) in fasting animals, but declined with DDX when animals were feeding. Our data show that POP burdens are high enough in seal pups to alter adipose function early in life, when fat deposition and mobilization are vital. Such POP-induced alterations to adipose metabolic properties may significantly alter energy balance regulation in marine top predators, with the potential for long-term impacts on fitness and survival.
    Schlagwörter DDT (pesticide) ; Halichoerus grypus ; bioaccumulation ; blubber ; energy balance ; explants ; fasting ; food webs ; glucose ; humans ; lactic acid ; metabolites ; persistent organic pollutants ; polychlorinated biphenyls ; predators ; pups ; seals ; toxicity ; wildlife
    Sprache Englisch
    Erscheinungsverlauf 2018-1019
    Umfang p. 13523-13534.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    ISSN 1520-5851
    DOI 10.1021/acs.est.8b04240
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel: Toxicokinetics of chlordecone in goats: Implications for risk management in French West Indies

    Fournier, Agnès / Cyril Feidt / Guido Rychen / Harry Archimede / Jean-Pierre Thome / Marie-Laure Lastel / Maurice Mahieu

    Chemosphere. 2017 Mar., v. 171

    2017  

    Abstract: The former use of chlordecone (CLD) in the French West Indies has resulted in long-term pollution of soils. CLD is known to be potentially transferred towards animal products of animals reared outdoors, mainly through accidental soil ingestion. Several ... ...

    Abstract The former use of chlordecone (CLD) in the French West Indies has resulted in long-term pollution of soils. CLD is known to be potentially transferred towards animal products of animals reared outdoors, mainly through accidental soil ingestion. Several studies indicate that soil bound CLD is bioavailable when administered to farm animals. Currently there is a need to quantify the level of CLD absorption and its toxicokinetic characteristics in the ruminant and particularly in the goat. These are considered as important farm species in the French West Indies. The objective of this study was to evaluate the absorption rate and the half-life of CLD in the non-lactating goat. The goats were administered either intravenously (i.v., n = 6) or orally (p.o., n = 6) one dose (1 mg kg−1 body weight) of CLD. Blood samples were collected at defined times up to 160 days post-dosing. CLD was analyzed in serum by high-resolution gas chromatography. A comparison of the area under the serum concentration-time curves (AUC) showed that the i.v. route is equivalent to the oral route. Thus, CLD is considered almost completely absorbed after p.o. administration, as shown by the mean absolute bioavailability. The comparison between the pharmacokinetic profiles of CLD following oral and intravenous dose showed a difference during the first 14 days and a similar kinetic after this period. The half-life of CLD in serum was close to 20 days. These results highlight a possible strategy of decontamination due to the short half-life of CLD, obtained in dry goats that did not excrete fat matter.
    Schlagwörter absorption ; animal products ; bioavailability ; blood sampling ; blood serum ; body weight ; chlordecone ; decontamination ; farms ; gas chromatography ; geophagia ; goats ; half life ; intravenous injection ; pharmacokinetics ; rearing ; risk management ; soil ; soil pollution ; French West Indies
    Sprache Englisch
    Erscheinungsverlauf 2017-03
    Umfang p. 564-570.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2016.12.054
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  6. Artikel ; Online: PCB-153 shows different dynamics of mobilisation from differentiated rat adipocytes during lipolysis in comparison with PCB-28 and PCB-118.

    Caroline Louis / Gilles Tinant / Eric Mignolet / Jean-Pierre Thomé / Cathy Debier

    PLoS ONE, Vol 9, Iss 9, p e

    2014  Band 106495

    Abstract: BACKGROUND: Polychlorinated biphenyls (PCBs) are persistent organic pollutants. Due to their lipophilic character, they are preferentially stored within the adipose tissue. During the mobilisation of lipids, PCBs might be released from adipocytes into ... ...

    Abstract BACKGROUND: Polychlorinated biphenyls (PCBs) are persistent organic pollutants. Due to their lipophilic character, they are preferentially stored within the adipose tissue. During the mobilisation of lipids, PCBs might be released from adipocytes into the bloodstream. However, the mechanisms associated with the release of PCBs have been poorly studied. Several in vivo studies followed their dynamics of release but the complexity of the in vivo situation, which is characterised by a large range of pollutants, does not allow understanding precisely the behaviour of individual congeners. The present in vitro experiment studied the impact of (i) the number and position of chlorine atoms of PCBs on their release from adipocytes and (ii) the presence of other PCB congeners on the mobilisation rate of such molecules. METHODOLOGY/PRINCIPAL FINDINGS: Differentiated rat adipocytes were used to compare the behaviour of PCB-28, -118 and -153. Cells were contaminated with the three congeners, alone or in cocktail, and a lipolysis was then induced with isoproterenol during 12 hours. Our data indicate that the three congeners were efficiently released from adipocytes and accumulated in the medium during the lipolysis. Interestingly, for a same level of cell lipids, PCB-153, a hexa-CB with two chlorine atoms in ortho-position, was mobilised slower than PCB-28, a tri-CB, and PCB-118, a penta-CB, which are both characterised by one chlorine atom in ortho-position. It suggests an impact of the chemical properties of pollutants on their mobilisation during periods of negative energy balance. Moreover, the mobilisation of PCB congeners, taken individually, did not seem to be influenced by the presence of other congeners within adipocytes. CONCLUSION/SIGNIFICANCE: These results not only highlight the obvious mobilisation of PCBs from adipocytes during lipolysis, in parallel to lipids, but also demonstrate that the structure of congeners defines their rate of release from adipocytes.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2014-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel: High hydrostatic pressure influences the in vitro response to xenobiotics in Dicentrarchus labrax liver

    Lemaire, Benjamin / Cathy Debier / Eric Mignolet / Jean François Rees / Jean Pierre Thomé / Pedro Buc Calderon

    Aquatic toxicology. 2016 Apr., v. 173

    2016  

    Abstract: Hydrostatic pressure (HP) increases by about 1 atmosphere (0.1MPa) for each ten-meter depth increase in the water column. This thermodynamical parameter could well influence the response to and effects of xenobiotics in the deep-sea biota, but this ... ...

    Abstract Hydrostatic pressure (HP) increases by about 1 atmosphere (0.1MPa) for each ten-meter depth increase in the water column. This thermodynamical parameter could well influence the response to and effects of xenobiotics in the deep-sea biota, but this possibility remains largely overlooked. To grasp the extent of HP adaptation in deep-sea fish, comparative studies with living cells of surface species exposed to chemicals at high HP are required. We initially conducted experiments with precision-cut liver slices of a deep-sea fish (Coryphaenoides rupestris), co-exposed for 15h to the aryl hydrocarbon receptor (AhR) agonist 3-methylcholanthrene at HP levels representative of the surface (0.1MPa) and deep-sea (5–15MPa; i.e., 500–1500m depth) environments. The transcript levels of a suite of stress-responsive genes, such as the AhR battery CYP1A, were subsequently measured (Lemaire et al., 2012; Environ. Sci. Technol. 46, 10310–10316). Strikingly, the AhR agonist-mediated increase of CYP1A mRNA content was pressure-dependently reduced in C. rupestris. Here, the same co-exposure scenario was applied for 6 or 15h to liver slices of a surface fish, Dicentrarchus labrax, a coastal species presumably not adapted to high HP. Precision-cut liver slices of D. labrax were also used in 1h co-exposure studies with the pro-oxidant tert-butylhydroperoxide (tBHP) as to investigate the pressure-dependence of the oxidative stress response (i.e., reactive oxygen production, glutathione and lipid peroxidation status). Liver cells remained viable in all experiments (adenosine triphosphate content). High HP precluded the AhR agonist-mediated increase of CYP1A mRNA expression in D. labrax, as well as that of glutathione peroxidase, and significantly reduced that of heat shock protein 70. High HP (1h) also tended per se to increase the level of oxidative stress in liver cells of the surface fish. Trends to an increased resistance to tBHP were also noted. Whether the latter observation truly reflects a protective response to oxidative stress will be addressed in future co-exposure studies with both surface and deep-sea fish liver cells, using additional pro-oxidant chemicals. Altogether, data on CYP1A inducibility with D. labrax and C. rupestris support the view that high HP represses AhR signaling in marine fishes, and that only species adapted to thrive in the deep-sea have evolved the molecular adaptations necessary to counteract to some extent this inhibition.
    Schlagwörter adenosine triphosphate ; agonists ; batteries ; Coryphaenoides rupestris ; Dicentrarchus labrax ; gene expression ; genes ; glutathione ; glutathione peroxidase ; heat-shock protein 70 ; hepatocytes ; high pressure treatment ; lipid peroxidation ; liver ; marine fish ; messenger RNA ; oxidative stress ; oxygen production ; stress response ; xenobiotics
    Sprache Englisch
    Erscheinungsverlauf 2016-04
    Umfang p. 43-52.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 782699-0
    ISSN 1879-1514 ; 0166-445X
    ISSN (online) 1879-1514
    ISSN 0166-445X
    DOI 10.1016/j.aquatox.2016.01.004
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  8. Artikel: Transcriptome analysis of the copepod Eurytemora affinis upon exposure to endocrine disruptor pesticides: Focus on reproduction and development

    Legrand, Eléna / Aurélie Duflot / Céline Boulangé-Lecomte / Jean-Michel Danger / Jean-Pierre Thomé / Joëlle Forget-Leray / Stéphanie Olivier

    Aquatic toxicology. 2016 July, v. 176

    2016  

    Abstract: Copepods—which include freshwater and marine species—represent the most abundant group of aquatic invertebrates. Among them, the calanoid copepod Eurytemora affinis is widely represented in the northern hemisphere estuaries and has become a species of ... ...

    Abstract Copepods—which include freshwater and marine species—represent the most abundant group of aquatic invertebrates. Among them, the calanoid copepod Eurytemora affinis is widely represented in the northern hemisphere estuaries and has become a species of interest in ecotoxicology. Like other non-target organisms, E. affinis may be exposed to a wide range of chemicals such as endocrine disruptors (EDs). This study investigated the gene expression variation in E. affinis after exposure to ED pesticides—chosen as model EDs—in order to (i) improve the knowledge on their effects in crustaceans, and (ii) highlight relevant transcripts for further development of potential biomarkers of ED exposure/effect. The study focused on the reproduction function in response to ED. Copepods were exposed to sublethal concentrations of pyriproxyfen (PXF) and chlordecone (CLD) separately. After 48h, males and females (400 individuals each) were sorted for RNA extraction. Their transcriptome was pyrosequenced using the Illumina® technology. Contigs were blasted and functionally annotated using Blast2GO®. The differential expression analysis between ED- and acetone-exposed organisms was performed according to sexes and contaminants. Half of the 19,721 contigs provided by pyrosequencing were annotated, mostly (80%) from arthropod sequences. Overall, 2,566 different genes were differentially expressed after ED exposures in comparison with controls. As many genes were differentially expressed after PXF exposure as after CLD exposure. In contrast, more genes were differentially expressed in males than in females after both exposures. Ninety-seven genes overlapped in all conditions. Finally, 31 transcripts involved in reproduction, growth and development, and changed in both chemical exposures were selected as potential candidates for future development of biomarkers.
    Schlagwörter aquatic invertebrates ; arthropods ; biomarkers ; chlordecone ; ecotoxicology ; endocrine-disrupting chemicals ; estuaries ; Eurytemora affinis ; females ; freshwater ; gene expression ; gene expression regulation ; genes ; growth and development ; males ; nontarget organisms ; pyriproxyfen ; reproduction ; RNA ; sequence analysis ; transcriptome ; transcriptomics
    Sprache Englisch
    Erscheinungsverlauf 2016-07
    Umfang p. 64-75.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 782699-0
    ISSN 1879-1514 ; 0166-445X
    ISSN (online) 1879-1514
    ISSN 0166-445X
    DOI 10.1016/j.aquatox.2016.04.010
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  9. Artikel: Bioaccumulation of polybrominated diphenyl ethers (PBDEs) in Gammarus pulex: Relative importance of different exposure routes and multipathway modeling

    Lebrun, Jérémie D / Arnaud Giusti / Catherine Gourlay-Francé / Delphine Leroy / Jean-Pierre Thomé

    Aquatic toxicology. 2014 Sept., v. 154

    2014  

    Abstract: Characterizing the exposure routes of an organism and its ability to regulate accumulated contaminants is a crucial step toward developing a biomonitor. To date, very little data are available on the bioaccumulation kinetics of PBDEs in freshwater biota. ...

    Abstract Characterizing the exposure routes of an organism and its ability to regulate accumulated contaminants is a crucial step toward developing a biomonitor. To date, very little data are available on the bioaccumulation kinetics of PBDEs in freshwater biota. This study aims at investigating the potential use of a litter-degrader widely distributed in European freshwaters, Gammarus pulex, as an indicator of exposure to PBDEs. In aquatic microcosms, gammarids were exposed to a mixture of brominated congeners (BDE-28, 47, 66, 85, 99, 100, 153, 154 and 183) to assess their ability to bioconcentrate PBDEs. Results show that all tested congeners are highly internalized by G. pulex and uptake rates of PBDEs are closely related to their partition coefficients (Kow). The determination of the elimination rate of BDE-47, the congener most readily accumulated by gammarids, indicated that metabolism and excretion of this congener are low in G. pulex, which argues in favor of its use as a quantitative biomonitor. Finally, bioaccumulation experiments were performed using contaminated leaves to determine the relative importance of dietary uptake in the contamination of gammarids. Even though water is the preeminent exposure route, a significant uptake of BDE-47 through food was observed (27%). We propose a biodynamic model that takes into account both exposure routes to describe BDE-47 bioaccumulation. This study supports the use of this ubiquitous amphipod as an early warning monitor of the bioavailable contamination of freshwaters by PBDEs.
    Schlagwörter bioaccumulation ; excretion ; exposure pathways ; freshwater ; Gammarus pulex ; leaves ; metabolism ; models ; partition coefficients ; polybrominated diphenyl ethers
    Sprache Englisch
    Erscheinungsverlauf 2014-09
    Umfang p. 107-113.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 782699-0
    ISSN 1879-1514 ; 0166-445X
    ISSN (online) 1879-1514
    ISSN 0166-445X
    DOI 10.1016/j.aquatox.2014.05.015
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  10. Artikel: Pollutant exposure in green and hawksbill marine turtles from the Caribbean region

    Dyc, Christelle / Adrian Covaci / Cathy Debier / Céline Leroy / Eric Delcroix / Jean-Pierre Thomé / Krishna Das

    Regional studies in marine science. 2015 Nov., v. 2

    2015  

    Abstract: Despite their common occurrence in Guadeloupe, little is known about levels and effects of pollutants in free-ranging green (Chelonia mydas) and hawksbill (Eretmochelys imbricata) turtles. The aims of this study were (1) to evaluate levels of persistent ... ...

    Abstract Despite their common occurrence in Guadeloupe, little is known about levels and effects of pollutants in free-ranging green (Chelonia mydas) and hawksbill (Eretmochelys imbricata) turtles. The aims of this study were (1) to evaluate levels of persistent organic pollutants and trace elements in Guadeloupian marine turtles, (2) to assess the risk for turtle embryo facing chemical exposure. Eggs and dermis were collected from 11 green and 4 hawksbill turtles and analysed for inorganic and organic pollutants. Chemical risks were evaluated for turtle embryos through a screening risk assessment (SRA). ∑PCBs and chlordecone were the main contaminant groups in green and hawksbill turtles. Contaminant levels were lower in the tissues of the Guadeloupean turtles compared to other geographic locations. p,p’-DDE, selenium, mercury and cadmium could affect the marine turtle embryos. This study is the first to provide levels of pollutants in marine turtles from Guadeloupe.
    Schlagwörter cadmium ; Chelonia mydas ; chlordecone ; dermis ; eggs ; Eretmochelys imbricata ; mercury ; persistent organic pollutants ; polychlorinated biphenyls ; risk ; risk assessment ; sea turtles ; selenium ; Caribbean ; Guadeloupe
    Sprache Englisch
    Erscheinungsverlauf 2015-11
    Umfang p. 158-170.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ISSN 2352-4855
    DOI 10.1016/j.rsma.2015.09.004
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