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  1. Article ; Online: Extensively Drug-Resistant Pseudomonas and Eye Drops-Stay Vigilant.

    Jeang, Lauren J / Tuli, Sonal S

    JAMA ophthalmology

    2024  

    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2024.0219
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    In stock of ZB MED Cologne/Königswinter

    Ul I Zs.26: Show issues Location:
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  2. Article ; Online: Reticular epithelial edema after penetrating keratoplasty in a patient taking netarsudil.

    Jeang, Lauren J / Shah, Ankit S / Hammer, Jon D / Tuli, Sonal S

    Digital journal of ophthalmology : DJO

    2022  Volume 28, Issue 8, Page(s) 34–37

    Abstract: Netarsudil is a relatively new medication for the treatment of primary open-angle glaucoma and ocular hypertension. It has been associated with red eyes and burning after instillation. Reticular epitheliopathy is a relatively rare complication of ... ...

    Abstract Netarsudil is a relatively new medication for the treatment of primary open-angle glaucoma and ocular hypertension. It has been associated with red eyes and burning after instillation. Reticular epitheliopathy is a relatively rare complication of netarsudil that has been described in patients with preexisting corneal edema. We report the case of a healthy 76-year-old woman who developed reticular epitheliopathy after full-thickness penetrating keratoplasty that completely resolved following discontinuation of the medication. In cases where netarsudil is initiated for treatment of glaucoma or, off-label, endothelial dysfunction, reticular epithelial edema should be considered in patients complaining of a decline in vision and severe pain.
    MeSH term(s) Aged ; Benzoates ; Edema/complications ; Female ; Glaucoma/etiology ; Glaucoma, Open-Angle/complications ; Glaucoma, Open-Angle/drug therapy ; Glaucoma, Open-Angle/surgery ; Humans ; Intraocular Pressure ; Keratoplasty, Penetrating/adverse effects ; beta-Alanine/analogs & derivatives
    Chemical Substances Benzoates ; beta-Alanine (11P2JDE17B) ; netarsudil (W6I5QDT7QI)
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2030129-7
    ISSN 1542-8958 ; 1542-8958
    ISSN (online) 1542-8958
    ISSN 1542-8958
    DOI 10.5693/djo.02.2022.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Diseases of the corneal endothelium.

    Jeang, Lauren J / Margo, Curtis E / Espana, Edgar M

    Experimental eye research

    2021  Volume 205, Page(s) 108495

    Abstract: The corneal endothelial monolayer and associated Descemet's membrane (DM) complex is a unique structure that plays an essential role in corneal function. Endothelial cells are neural crest derived cells that rest on a special extracellular matrix and ... ...

    Abstract The corneal endothelial monolayer and associated Descemet's membrane (DM) complex is a unique structure that plays an essential role in corneal function. Endothelial cells are neural crest derived cells that rest on a special extracellular matrix and play a major role in maintaining stromal hydration within a narrow physiologic range necessary for clear vision. A number of diseases affect the endothelial cells and DM complex and can impair corneal function and vision. This review addresses different human corneal endothelial diseases characterized by loss of endothelial function including: Fuchs endothelial corneal dystrophy (FECD), posterior polymorphous corneal dystrophy (PPCD), congenital hereditary endothelial dystrophy (CHED), bullous keratopathy, iridocorneal endothelial (ICE) syndrome, post-traumatic fibrous downgrowth, glaucoma and diabetes mellitus.
    MeSH term(s) Blister/complications ; Blister/pathology ; Corneal Dystrophies, Hereditary/complications ; Corneal Dystrophies, Hereditary/pathology ; Corneal Edema/etiology ; Corneal Stroma/pathology ; Endothelium, Corneal/pathology ; Fuchs' Endothelial Dystrophy/complications ; Fuchs' Endothelial Dystrophy/pathology ; Humans ; Iridocorneal Endothelial Syndrome/complications ; Iridocorneal Endothelial Syndrome/pathology ; Vision Disorders/etiology
    Language English
    Publishing date 2021-02-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 80122-7
    ISSN 1096-0007 ; 0014-4835
    ISSN (online) 1096-0007
    ISSN 0014-4835
    DOI 10.1016/j.exer.2021.108495
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 163: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Rate of Posterior Capsule Rupture in Phacoemulsification Cataract Surgery by Residents with Institution of a Wet Laboratory Course.

    Jeang, Lauren J / Liechty, Jacob J / Powell, Asyvia / Schwartz, Christopher / DiSclafani, Mark / Drucker, Mitchell D / McDowell, William M

    Journal of academic ophthalmology (2017)

    2022  Volume 14, Issue 1, Page(s) e70–e73

    Abstract: ... ...

    Abstract Purpose
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2897840-7
    ISSN 2475-4757 ; 2475-4757
    ISSN (online) 2475-4757
    ISSN 2475-4757
    DOI 10.1055/s-0042-1744270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Emergence of ocular toxicities associated with novel anticancer therapeutics: What the oncologist needs to know.

    Ali, Azka / Shah, Ankit A / Jeang, Lauren J / Fallgatter, Kyle S / George, Thomas J / DeRemer, David L

    Cancer treatment reviews

    2022  Volume 105, Page(s) 102376

    Abstract: As cancer treatment evolves in the era of precision oncology, molecularly targeted agents (MTAs) have become frontline therapy for many cancers. MTAs are biologically targeted and thought to have less off-target toxicity; however, the eye is particularly ...

    Abstract As cancer treatment evolves in the era of precision oncology, molecularly targeted agents (MTAs) have become frontline therapy for many cancers. MTAs are biologically targeted and thought to have less off-target toxicity; however, the eye is particularly susceptible to off-target toxicities given its unique microenvironment. In this review, we present commonly used FDA-approved MTAs, any associated ocular toxicities and review the mechanisms, frequency, severity, and management. Increased awareness and communication between clinicians caring for cancer patients is needed for individualized risk assessment, earlier diagnosis, and mitigation of ocular toxicities.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Humans ; Molecular Targeted Therapy ; Neoplasms/drug therapy ; Oncologists ; Precision Medicine ; Tumor Microenvironment
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2022-03-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 125102-8
    ISSN 1532-1967 ; 0305-7372
    ISSN (online) 1532-1967
    ISSN 0305-7372
    DOI 10.1016/j.ctrv.2022.102376
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    Zs.A 1022: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 611: Show issues

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  6. Article: Rate of Posterior Capsule Rupture in Phacoemulsification Cataract Surgery by Residents with Institution of a Wet Laboratory Course

    Jeang, Lauren J. / Liechty, Jacob J. / Powell, Asyvia / Schwartz, Christopher / DiSclafani, Mark / Drucker, Mitchell D. / McDowell, William M.

    Journal of Academic Ophthalmology

    2022  Volume 14, Issue 01, Page(s) e70–e73

    Abstract: Purpose: To determine if a structured surgical wet laboratory curriculum for ophthalmology residents reduced the rate of posterior capsule rupture (PCR) in phacoemulsification cataract surgery.: Setting: James A. Haley Veterans' Hospital, Tampa, FL.!# ...

    Abstract Purpose: To determine if a structured surgical wet laboratory curriculum for ophthalmology residents reduced the rate of posterior capsule rupture (PCR) in phacoemulsification cataract surgery.
    Setting: James A. Haley Veterans' Hospital, Tampa, FL.
    Design: Retrospective cohort study.
    Methods: The study assessed resident-performed phacoemulsification cataract cases from 2011 to 2017, after the creation of a wet laboratory course. Primary outcome measure was PCR. If present, timing of complication, dropped lens fragments, and the need for anterior vitrectomies were noted. Self-reported rates of PCR prior to institution of a wet laboratory course (2010–2011) were compared with cases done by residents who completed the course (2011–2017).
    Results: A total of 3,445 cases were reviewed of which 2.44% (84 cases) noted PCR. Of these, 19% (16) had dropped lens fragments, and 60.7% (51) required anterior vitrectomy. Sixty-nine cases documented timing of PCR with the majority, 58%, occurring during phacoemulsification. When comparing rates of PCR in cases done prior to the presence of a wet laboratory course versus after, there was a significant reduction observed (5.20% before vs. 2.44% after).
    Conclusion: In the presence of a wet laboratory curriculum, the rate of PCR decreased dramatically. The average rate was lower than those reported at other training programs (2.6–9.9%). Most PCR occurred during phacoemulsification, suggesting need for further focused instruction in this step.
    Keywords cataract surgery ; posterior capsular rupture ; ophthalmology ; resident ; phacoemulsification ; wet lab
    Language English
    Publishing date 2022-01-01
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2897840-7
    ISSN 2475-4757 ; 2475-4757
    ISSN (online) 2475-4757
    ISSN 2475-4757
    DOI 10.1055/s-0042-1744270
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  7. Article: Widespread Ocular Surface Squamous Neoplasia Treated with Topical Interferon Alpha-2b.

    Patel, Hershel / Jeang, Lauren J / Shah, Ankit / Espana, Edgar M / Margo, Curtis E

    Ocular oncology and pathology

    2018  Volume 4, Issue 5, Page(s) 298–303

    Abstract: Purpose: To emphasize the importance of staging ocular surface squamous neoplasia when contemplating use of topical interferon alpha-2b alone.: Cases: Two patients with 360 degrees of limbal involvement.: Results: Two patients with in situ ... ...

    Abstract Purpose: To emphasize the importance of staging ocular surface squamous neoplasia when contemplating use of topical interferon alpha-2b alone.
    Cases: Two patients with 360 degrees of limbal involvement.
    Results: Two patients with in situ squamous cell carcinoma of the conjunctiva and clinical involvement of the entire limbus were treated with topical interferon alpha-2b. Thorough examination and multiple biopsies excluded invasive disease. The patients had complete response to therapy.
    Conclusion: Widespread intraepithelial squamous neoplasia involving the entire limbus can be successfully treated with topical therapies. Biopsy plays a role in excluding invasive disease. Interferon alpha-2b is a preferable agent to start with because it is well tolerated. Since long-term risks of recurrence are unknown, appropriate monitoring is essential.
    Language English
    Publishing date 2018-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2806965-1
    ISSN 2296-4657 ; 2296-4681
    ISSN (online) 2296-4657
    ISSN 2296-4681
    DOI 10.1159/000486339
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  8. Article ; Online: Rapidly progressing glaucoma associated with monoclonal gammopathy.

    Jeang, Lauren J / Chang, Peter T / Frankfort, Benjamin J

    Journal of glaucoma

    2014  Volume 24, Issue 5, Page(s) e139–41

    Abstract: A 63 year old woman with surgically controlled primary open-angle glaucoma developed sudden visual field deterioration and subjective visual loss despite stable intraocular pressure in both eyes. An extensive systemic workup was performed which revealed ... ...

    Abstract A 63 year old woman with surgically controlled primary open-angle glaucoma developed sudden visual field deterioration and subjective visual loss despite stable intraocular pressure in both eyes. An extensive systemic workup was performed which revealed a diagnosis of monoclonal gammopathy of undetermined significance. Further work-up should be considered when the extent of a patient's vision changes is not consistent with a known preexisting disease such as glaucoma.
    MeSH term(s) Antihypertensive Agents/therapeutic use ; Disease Progression ; Drug Therapy, Combination ; Female ; Glaucoma, Open-Angle/diagnosis ; Glaucoma, Open-Angle/drug therapy ; Glaucoma, Open-Angle/immunology ; Humans ; Immunoglobulin lambda-Chains/immunology ; Intraocular Pressure/physiology ; Middle Aged ; Paraproteinemias/diagnosis ; Paraproteinemias/drug therapy ; Paraproteinemias/immunology ; Tonometry, Ocular ; Vision Disorders/diagnosis ; Visual Fields
    Chemical Substances Antihypertensive Agents ; Immunoglobulin lambda-Chains
    Language English
    Publishing date 2014-05-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 913494-3
    ISSN 1536-481X ; 1057-0829
    ISSN (online) 1536-481X
    ISSN 1057-0829
    DOI 10.1097/IJG.0000000000000053
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    Zs.A 3795: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Occult Fungal Scleritis.

    Jeang, Lauren J / Davis, Aaron / Madow, Brian / Espana, Edgar M / Margo, Curtis E

    Ocular oncology and pathology

    2016  Volume 3, Issue 1, Page(s) 41–44

    Abstract: Purpose: To heighten awareness of occult fungal scleritis.: Method: Case report and review of the literature.: Results: A 73-year-old woman with diabetes mellitus was diagnosed for 3 months with immune-mediated scleritis and subsequently treated ... ...

    Abstract Purpose: To heighten awareness of occult fungal scleritis.
    Method: Case report and review of the literature.
    Results: A 73-year-old woman with diabetes mellitus was diagnosed for 3 months with immune-mediated scleritis and subsequently treated with corticosteroids. On referral, the patient had a scleral nodule with contiguous corneal infiltrate and hypopyon. Culture grew
    Conclusion: Fungal scleritis can develop in persons without a history of foreign body injury, minor trauma, or evidence of endogenous fungemia. A high index of suspicion for infectious scleritis must be maintained in persons with presumed immune-mediated scleritis who fail to respond to conventional therapy, particularly if they present with decreased visual acuity.
    Language English
    Publishing date 2016-09-14
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2806965-1
    ISSN 2296-4657 ; 2296-4681
    ISSN (online) 2296-4657
    ISSN 2296-4681
    DOI 10.1159/000449103
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  10. Article: Widespread Ocular Surface Squamous Neoplasia Treated with Topical Interferon Alpha-2b

    Patel, Hershel / Jeang, Lauren J. / Shah, Ankit / Espana, Edgar M. / Margo, Curtis E.

    Ocular Oncology and Pathology

    2018  Volume 4, Issue 5, Page(s) 298–303

    Abstract: Purpose: To emphasize the importance of staging ocular surface squamous neoplasia when contemplating use of topical interferon alpha-2b alone. Cases: Two patients with 360 degrees of limbal involvement. Results: Two patients with in situ squamous cell ... ...

    Institution Department of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA
    Department of Ophthalmology, University of Florida College of Medicine, Gainesville, Florida, USA
    Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA
    Department of Pathology and Cell Biology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA
    Abstract Purpose: To emphasize the importance of staging ocular surface squamous neoplasia when contemplating use of topical interferon alpha-2b alone. Cases: Two patients with 360 degrees of limbal involvement. Results: Two patients with in situ squamous cell carcinoma of the conjunctiva and clinical involvement of the entire limbus were treated with topical interferon alpha-2b. Thorough examination and multiple biopsies excluded invasive disease. The patients had complete response to therapy. Conclusion: Widespread intraepithelial squamous neoplasia involving the entire limbus can be successfully treated with topical therapies. Biopsy plays a role in excluding invasive disease. Interferon alpha-2b is a preferable agent to start with because it is well tolerated. Since long-term risks of recurrence are unknown, appropriate monitoring is essential.
    Keywords Conjunctival intraepithelial neoplasia ; Interferon alpha-2b ; Ocular surface squamous neoplasia ; Cytokine immunotherapy ; Ocular surface
    Language English
    Publishing date 2018-02-13
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Novel Insights from Clinical Practice
    ZDB-ID 2806965-1
    ISSN 2296-4657 ; 2296-4681
    ISSN (online) 2296-4657
    ISSN 2296-4681
    DOI 10.1159/000486339
    Database Karger publisher's database

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