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  1. Article ; Online: Non-alcoholic fatty liver disease biomarkers estimate cardiovascular risk based on coronary artery calcium score in type 2 diabetes: a cross-sectional study with two independent cohorts.

    Denimal, Damien / Ponnaiah, Maharajah / Jeannin, Anne-Caroline / Phan, Franck / Hartemann, Agnès / Boussouar, Samia / Charpentier, Etienne / Redheuil, Alban / Foufelle, Fabienne / Bourron, Olivier

    Cardiovascular diabetology

    2024  Volume 23, Issue 1, Page(s) 69

    Abstract: Background: Studies have demonstrated that coronary artery calcification on one hand and non-alcoholic fatty liver disease (NAFLD) on the other hand are strongly associated with cardiovascular events. However, it remains unclear whether NAFLD biomarkers ...

    Abstract Background: Studies have demonstrated that coronary artery calcification on one hand and non-alcoholic fatty liver disease (NAFLD) on the other hand are strongly associated with cardiovascular events. However, it remains unclear whether NAFLD biomarkers could help estimate cardiovascular risk in individuals with type 2 diabetes (T2D). The primary objective of the present study was to investigate whether the biomarkers of NAFLD included in the FibroMax® panels are associated with the degree of coronary artery calcification in patients with T2D.
    Methods: A total of 157 and 460 patients with T2D were included from the DIACART and ACCoDiab cohorts, respectively. The coronary artery calcium score (CACS) was measured in both cohorts using computed tomography. FibroMax® panels (i.e., SteatoTest®, FibroTest®, NashTest®, and ActiTest®) were determined from blood samples as scores and stages in the DIACART cohort and as stages in the ACCoDiab cohort.
    Results: CACS significantly increased with the FibroTest® stages in both the DIACART and ACCoDiab cohorts (p-value for trend = 0.0009 and 0.0001, respectively). In DIACART, the FibroTest® score was positively correlated with CACS in univariate analysis (r = 0.293, p = 0.0002) and remained associated with CACS independently of the traditional cardiovascular risk factors included in the SCORE2-Diabetes model [β = 941 ± 425 (estimate ± standard error), p = 0.028]. In the ACCoDiab cohort, the FibroTest® F3-F4 stage was positively correlated with CACS in point-biserial analysis (r
    Conclusions: FibroTest® is independently and positively associated with the degree of coronary artery calcification in patients with T2D, suggesting that FibroTest® could be a relevant biomarker of coronary calcification and cardiovascular risk.
    Trial registration: ClinicalTrials.gov identifiers NCT02431234 and NCT03920683.
    MeSH term(s) Humans ; Biomarkers ; Calcium ; Cardiovascular Diseases/complications ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/epidemiology ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Heart Disease Risk Factors ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/epidemiology ; Risk Factors ; Vascular Calcification/diagnostic imaging ; Vascular Calcification/epidemiology
    Chemical Substances Biomarkers ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Clinical Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2093769-6
    ISSN 1475-2840 ; 1475-2840
    ISSN (online) 1475-2840
    ISSN 1475-2840
    DOI 10.1186/s12933-024-02161-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Prevalence and severity of malnutrition in hospitalized COVID-19 patients

    Bedock, Dorothée / Bel Lassen, Pierre / Mathian, Alexis / Moreau, Pauline / Couffignal, Julie / Ciangura, Cécile / Poitou-Bernert, Christine / Jeannin, Anne-Caroline / Mosbah, Helena / Fadlallah, Jehane / Amoura, Zahir / Oppert, Jean-Michel / Faucher, Pauline

    European Society for Clinical Nutrition and Metabolism Clinical nutrition ESPEN. 2020 Dec., v. 40

    2020  

    Abstract: Nutritional knowledge in patients with SARS-Cov2 infection (COVID-19) is limited. Our objectives were: i) to assess malnutrition in hospitalized COVID-19 patients, ii) to investigate the links between malnutrition and disease severity at admission, iii) ... ...

    Abstract Nutritional knowledge in patients with SARS-Cov2 infection (COVID-19) is limited. Our objectives were: i) to assess malnutrition in hospitalized COVID-19 patients, ii) to investigate the links between malnutrition and disease severity at admission, iii) to study the impact of malnutrition on clinical outcomes such as transfer to an intensive care unit (ICU) or death.Consecutive patients hospitalized in a medicine ward at a university hospital were included from March 21st to April 24th 2020 (n = 114, 60.5% males, age: 59.9 ± 15.9 years). Nutritional status was defined using Global Leadership Initiative on Malnutrition (GLIM) criteria. Clinical, radiological and biological characteristics of COVID-19 patients were compared according to the presence of malnutrition. Logistic regression was used to assess associations between nutritional parameters and unfavourable outcomes such as transfer to intensive care unit (ICU) or death.The overall prevalence of malnutrition was 42.1% (moderate: 23.7%, severe: 18.4%). The prevalence of malnutrition reached 66.7% in patients admitted from ICU. No significant association was found between nutritional status and clinical signs of COVID-19. Lower albumin levels were associated with a higher risk of transfer to ICU (for 10 g/l of albumin, OR [95%CI]: 0.31 [0.1; 0.7]; p < 0.01) and this association was independent of age and CRP levels.COVID-19 in medical units dedicated to non-intensive care is associated with a high prevalence of malnutrition, especially for patients transferred from ICU. These data emphasize the importance of early nutritional screening in these patients to adapt management accordingly.
    Keywords Coronavirus infections ; age ; albumins ; clinical nutrition ; disease severity ; hospitals ; infection ; leadership ; males ; malnutrition ; medicine ; nutrition assessment ; nutrition knowledge ; nutritional status ; objectives ; patients ; prevalence ; regression analysis ; risk ; signs and symptoms (animals and humans)
    Language English
    Dates of publication 2020-12
    Size p. 214-219.
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-light
    ISSN 2405-4577
    DOI 10.1016/j.clnesp.2020.09.018
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Correction: Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes.

    Jeannin, Anne-Caroline / Salem, Joe-Elie / Massy, Ziad / Aubert, Carole Elodie / Vemeer, Cees / Amouyal, Chloé / Phan, Franck / Halbron, Marine / Funck-Brentano, Christian / Hartemann, Agnès / Bourron, Olivier

    PloS one

    2020  Volume 15, Issue 5, Page(s) e0232996

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0229145.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0229145.].
    Language English
    Publishing date 2020-05-05
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0232996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes.

    Jeannin, Anne-Caroline / Salem, Joe-Elie / Massy, Ziad / Aubert, Carole Elodie / Vermeer, Cees / Amouyal, Chloé / Phan, Franck / Halbron, Marine / Funck-Brentano, Christian / Hartemann, Agnès / Bourron, Olivier

    PloS one

    2020  Volume 15, Issue 2, Page(s) e0229145

    Abstract: Aims/hypothesis: Diabetic peripheral neuropathy is a frequent and severe complication of diabetes. As Matrix-gla-protein (MGP) is expressed in several components of the nervous system and is involved in some neurological disease, MGP could play a role ... ...

    Abstract Aims/hypothesis: Diabetic peripheral neuropathy is a frequent and severe complication of diabetes. As Matrix-gla-protein (MGP) is expressed in several components of the nervous system and is involved in some neurological disease, MGP could play a role in peripheral nervous system homeostasis. The aim of this study was to evaluate factors associated with sensitive diabetic neuropathy in Type 2 Diabetes, and, in particular, dephospho-uncarboxylated MGP (dp-ucMGP), the inactive form of MGP.
    Methods: 198 patients with Type 2 Diabetes were included. Presence of sensitive diabetic neuropathy was defined by a neuropathy disability score (NDS) ≥6. Plasma levels of dp-ucMGP were measured by ELISA.
    Results: In this cohort, the mean age was 64+/-8.4 years old, and 80% of patients were men. Peripheral neuropathy was present in 15.7% of the patients and was significantly associated (r = 0.51, p<0.0001) with dp-ucMGP levels (β = -0.26, p = 0.045) after integrating effects of height (β = -0.38, p = 0.01), insulin treatment (β = 0.42, p = 0.002), retinopathy treated by laser (β = 0.26, p = 0.02), and total cholesterol levels (β = 0.3, p = 0.03) by multivariable analysis.
    Conclusions: The association between diabetic neuropathy and the inactive form of MGP suggests the existence of new pathophysiological pathways to explore. Further studies are needed to determine if dp-ucMGP may be used as a biomarker of sensitive neuropathy. Since dp-ucMGP is a marker of poor vitamin K status, clinical studies are warranted to explore the potential protective effect of high vitamin K intake on diabetic peripheral neuropathy.
    MeSH term(s) Aged ; Biomarkers/blood ; Calcium-Binding Proteins/blood ; Cohort Studies ; Diabetes Mellitus, Type 2/complications ; Extracellular Matrix Proteins/blood ; Female ; Humans ; Male ; Middle Aged ; Peripheral Nervous System Diseases/blood ; Peripheral Nervous System Diseases/etiology ; Risk Factors ; Vitamin K/blood ; Matrix Gla Protein
    Chemical Substances Biomarkers ; Calcium-Binding Proteins ; Extracellular Matrix Proteins ; Vitamin K (12001-79-5)
    Language English
    Publishing date 2020-02-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0229145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Prevalence and severity of malnutrition in hospitalized COVID-19 patients.

    Bedock, Dorothée / Bel Lassen, Pierre / Mathian, Alexis / Moreau, Pauline / Couffignal, Julie / Ciangura, Cécile / Poitou-Bernert, Christine / Jeannin, Anne-Caroline / Mosbah, Helena / Fadlallah, Jehane / Amoura, Zahir / Oppert, Jean-Michel / Faucher, Pauline

    Clinical nutrition ESPEN

    2020  Volume 40, Page(s) 214–219

    Abstract: Background & aims: Nutritional knowledge in patients with SARS-Cov2 infection (COVID-19) is limited. Our objectives were: i) to assess malnutrition in hospitalized COVID-19 patients, ii) to investigate the links between malnutrition and disease severity ...

    Abstract Background & aims: Nutritional knowledge in patients with SARS-Cov2 infection (COVID-19) is limited. Our objectives were: i) to assess malnutrition in hospitalized COVID-19 patients, ii) to investigate the links between malnutrition and disease severity at admission, iii) to study the impact of malnutrition on clinical outcomes such as transfer to an intensive care unit (ICU) or death.
    Methods: Consecutive patients hospitalized in a medicine ward at a university hospital were included from March 21st to April 24th 2020 (n = 114, 60.5% males, age: 59.9 ± 15.9 years). Nutritional status was defined using Global Leadership Initiative on Malnutrition (GLIM) criteria. Clinical, radiological and biological characteristics of COVID-19 patients were compared according to the presence of malnutrition. Logistic regression was used to assess associations between nutritional parameters and unfavourable outcomes such as transfer to intensive care unit (ICU) or death.
    Results: The overall prevalence of malnutrition was 42.1% (moderate: 23.7%, severe: 18.4%). The prevalence of malnutrition reached 66.7% in patients admitted from ICU. No significant association was found between nutritional status and clinical signs of COVID-19. Lower albumin levels were associated with a higher risk of transfer to ICU (for 10 g/l of albumin, OR [95%CI]: 0.31 [0.1; 0.7]; p < 0.01) and this association was independent of age and CRP levels.
    Conclusions: COVID-19 in medical units dedicated to non-intensive care is associated with a high prevalence of malnutrition, especially for patients transferred from ICU. These data emphasize the importance of early nutritional screening in these patients to adapt management accordingly.
    MeSH term(s) Adult ; Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Female ; France/epidemiology ; Hospital Mortality ; Hospitalization ; Humans ; Longitudinal Studies ; Male ; Malnutrition/complications ; Malnutrition/epidemiology ; Middle Aged ; Nutrition Assessment ; Pandemics ; Pneumonia, Viral/complications ; Prevalence ; SARS-CoV-2 ; Severity of Illness Index
    Keywords covid19
    Language English
    Publishing date 2020-09-18
    Publishing country England
    Document type Journal Article ; Observational Study
    ISSN 2405-4577
    ISSN (online) 2405-4577
    DOI 10.1016/j.clnesp.2020.09.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Prevalence and severity of malnutrition in hospitalized COVID-19 patients

    Bedock, Dorothée / Bel Lassen, Pierre / Mathian, Alexis / Moreau, Pauline / Couffignal, Julie / Ciangura, Cécile / Poitou-Bernert, Christine / Jeannin, Anne-Caroline / Mosbah, Helena / Fadlallah, Jehane / Amoura, Zahir / Oppert, Jean-Michel / Faucher, Pauline

    Clin Nutr ESPEN

    Abstract: BACKGROUND & AIMS: Nutritional knowledge in patients with SARS-Cov2 infection (COVID-19) is limited. Our objectives were: i) to assess malnutrition in hospitalized COVID-19 patients, ii) to investigate the links between malnutrition and disease severity ... ...

    Abstract BACKGROUND & AIMS: Nutritional knowledge in patients with SARS-Cov2 infection (COVID-19) is limited. Our objectives were: i) to assess malnutrition in hospitalized COVID-19 patients, ii) to investigate the links between malnutrition and disease severity at admission, iii) to study the impact of malnutrition on clinical outcomes such as transfer to an intensive care unit (ICU) or death. METHODS: Consecutive patients hospitalized in a medicine ward at a university hospital were included from March 21st to April 24th 2020 (n = 114, 60.5% males, age: 59.9 ± 15.9 years). Nutritional status was defined using Global Leadership Initiative on Malnutrition (GLIM) criteria. Clinical, radiological and biological characteristics of COVID-19 patients were compared according to the presence of malnutrition. Logistic regression was used to assess associations between nutritional parameters and unfavourable outcomes such as transfer to intensive care unit (ICU) or death. RESULTS: The overall prevalence of malnutrition was 42.1% (moderate: 23.7%, severe: 18.4%). The prevalence of malnutrition reached 66.7% in patients admitted from ICU. No significant association was found between nutritional status and clinical signs of COVID-19. Lower albumin levels were associated with a higher risk of transfer to ICU (for 10 g/l of albumin, OR [95%CI]: 0.31 [0.1; 0.7]; p < 0.01) and this association was independent of age and CRP levels. CONCLUSIONS: COVID-19 in medical units dedicated to non-intensive care is associated with a high prevalence of malnutrition, especially for patients transferred from ICU. These data emphasize the importance of early nutritional screening in these patients to adapt management accordingly.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #778669
    Database COVID19

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  7. Article ; Online: Prevalence and severity of malnutrition in hospitalized COVID-19 patients

    Bedock, Dorothée / Bel Lassen, Pierre / Mathian, Alexis / Moreau, Pauline / Couffignal, Julie / Ciangura, Cécile / Poitou-Bernert, Christine / Jeannin, Anne-Caroline / Mosbah, Helena / Fadlallah, Jehane / Amoura, Zahir / Oppert, Jean-Michel / Faucher, Pauline

    Clinical Nutrition ESPEN

    2020  Volume 40, Page(s) 214–219

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2405-4577
    DOI 10.1016/j.clnesp.2020.09.018
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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