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  1. AU="Jeff Lewis"
  2. AU=Carbone Antonino
  3. AU="Walker, Naomi"
  4. AU="Alaskar, Turki M"
  5. AU=Hofstra Julia M
  6. AU="Françoise Baldi"
  7. AU="Chen, Zipeng"
  8. AU=Bilinski Alyssa
  9. AU="Honboh, Takuya"
  10. AU=Dobie David Robertson
  11. AU=Gagnon R F
  12. AU="Suthaharan, Praveen"
  13. AU=Freeman Alexandra F
  14. AU="Szabo, Gergo"

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  1. Artikel ; Online: Rock art and mining violence on the Australian Burrup Peninsula

    Jeff Lewis / Belinda Lewis

    Perspectives in Ecology and Conservation, Vol 15, Iss 3, Pp 179-

    language wars, economy and culture

    2017  Band 186

    Abstract: Humans have lived on the Australian continent for around 50,000 years. During that time, the indigenous people developed complex cultural, economic and social systems. These systems were sustained and expressed through the myths and songlines which ... ...

    Abstract Humans have lived on the Australian continent for around 50,000 years. During that time, the indigenous people developed complex cultural, economic and social systems. These systems were sustained and expressed through the myths and songlines which comprise the indigenous people's Dreaming. It was through the Dreaming that the natural, symbolic and material worlds converge, enabling humans to orient themselves spiritually, cosmologically and geographically. This cultural and natural contingency was shattered by the British invasion and settlement of Australia from 1788. In one particular region of the country, the Burrup Peninsula, this violation has been perpetuated through the destructive practices of mining. The Burrup Peninsula is located in the remote Western Australia Pilbara region on the Dampier Archipelago. This area hosts one of the world's most extensive and significant indigenous Palaeolithic art galleries—petroglyphs that may be as old as 30,000 years Before Present. The Pilbara also contains one of the world's most extensive and richest iron ore deposits, as well as a vast array of other minerals and fuels. This paper examines the ways in which the cultural and natural heritage of the Burrup has been excoriated by the mining industries. The paper examines recent attempts to protect the heritage of the area from further destruction. It focuses on the World Heritage nomination of the Burrup, indigenous activism and the complex politics of conservation in the area.
    Schlagwörter Cultural heritage ; Petroglyph ; Rock art ; Indigenous Australia ; Burrup ; Mining ; Ecology ; QH540-549.5 ; General. Including nature conservation ; geographical distribution ; QH1-199.5
    Thema/Rubrik (Code) 950
    Sprache Englisch
    Erscheinungsdatum 2017-07-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: An interdisciplinary framework for derivation of occupational exposure limits

    Laura L. Maurer / Melannie S. Alexander / Ammie N. Bachman / Fabian A. Grimm / R. Jeff Lewis / Colin M. North / Nancy C. Wojcik / Katy O. Goyak

    Frontiers in Public Health, Vol

    2022  Band 10

    Abstract: Protecting the health and safety of workers in industrial operations is a top priority. One of the resources used in industry to ensure worker safety is the occupational exposure limit (OEL). OELs are derived from the assessment and interpretation of ... ...

    Abstract Protecting the health and safety of workers in industrial operations is a top priority. One of the resources used in industry to ensure worker safety is the occupational exposure limit (OEL). OELs are derived from the assessment and interpretation of empirical data from animal and/or human studies. There are various guidelines for the derivation and implementation of OELs globally, with a range of stakeholders (including regulatory bodies, governmental agencies, expert groups and others). The purpose of this manuscript is to supplement existing guidance with learnings from a multidisciplinary team approach within an industry setting. The framework we present is similar in construct to other risk assessment frameworks and includes: (1) problem formulation, (2) literature review, (3) weight of evidence considerations, (4) point of departure selection/derivation, (5) application of assessment factors, and the final step, (6) derivation of the OEL. Within each step are descriptions and examples to consider when incorporating data from various disciplines such as toxicology, epidemiology, and exposure science. This manuscript describes a technical framework by which available data relevant for occupational exposures is compiled, analyzed, and utilized to inform safety threshold derivation applicable to OELs.
    Schlagwörter risk assessment ; problem formulation ; literature review ; weight of evidence (WOE) ; point of departure (POD) ; assessment factors (AFs) ; Public aspects of medicine ; RA1-1270
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Groundwater surveys in Developing Regions

    Jeff Lewis / Birgitta Liljedahl

    Air, Soil and Water Research, Vol

    2010  Band 3

    Abstract: This paper discusses the interpretation of surface features that can assist in the evaluation of groundwater resources in semi-arid and arid developing regions. The lack of infrastructure in these areas places serious constraints on borehole drilling, ... ...

    Abstract This paper discusses the interpretation of surface features that can assist in the evaluation of groundwater resources in semi-arid and arid developing regions. The lack of infrastructure in these areas places serious constraints on borehole drilling, which in turn limits the data which can be obtained directly from the subsurface. Under these conditions, surface indicators may be used to infer useful information about the subsurface, which includes shallow aquifers. This article summarizes those surface indicators which provide useful data in arid and semi-arid regions and provides a review of the literature to assist in their interpretation. Patterns of surface indicators covering a large area may be more effective and less costly for interpreting basic regional hydrogeological conditions than detailed data obtained from a limited number of boreholes. The hydrogeological information which can be obtained by using the methods discussed in this article include the regional flow patterns, an estimate of the depth to groundwater, aquifer geology and estimates of the regional recharge and discharge zones. This data may in turn provide support for subsequent well drilling campaigns, limited environmental assessments, and potable water assessments for humanitarian base camps in developing regions.
    Schlagwörter Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 550
    Sprache Englisch
    Erscheinungsdatum 2010-01-01T00:00:00Z
    Verlag SAGE Publishing
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Groundwater Surveys in Developing Regions

    Birgitta Liljedahl / Jeff Lewis

    Air, Soil and Water Research, Vol 2010, Iss 3, Pp 95-

    2010  Band 104

    Schlagwörter Environmental sciences ; GE1-350
    Sprache Englisch
    Erscheinungsdatum 2010-11-01T00:00:00Z
    Verlag SAGE Publishing
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Efficacy and clinicogenomic correlates of response to immune checkpoint inhibitors alone or with chemotherapy in non-small cell lung cancer

    Lingzhi Hong / Muhammad Aminu / Shenduo Li / Xuetao Lu / Milena Petranovic / Maliazurina B. Saad / Pingjun Chen / Kang Qin / Susan Varghese / Waree Rinsurongkawong / Vadeerat Rinsurongkawong / Amy Spelman / Yasir Y. Elamin / Marcelo V. Negrao / Ferdinandos Skoulidis / Carl M. Gay / Tina Cascone / Saumil J. Gandhi / Steven H. Lin /
    Percy P. Lee / Brett W. Carter / Carol C. Wu / Mara B. Antonoff / Boris Sepesi / Jeff Lewis / Don L. Gibbons / Ara A. Vaporciyan / Xiuning Le / J. Jack Lee / Sinchita Roy-Chowdhuri / Mark J. Routbort / Justin F. Gainor / John V. Heymach / Yanyan Lou / Jia Wu / Jianjun Zhang / Natalie I. Vokes

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Band 15

    Abstract: Immune checkpoint inhibitors with or without chemotherapy are now standard of care for non-small cell lung cancer. However, the benefits of combination vs sequential therapy have not been fully explored. Here, the authors analysed 1,133 patient records ... ...

    Abstract Immune checkpoint inhibitors with or without chemotherapy are now standard of care for non-small cell lung cancer. However, the benefits of combination vs sequential therapy have not been fully explored. Here, the authors analysed 1,133 patient records and show combination therapy showed increased protection against early progression, but similar overall survival.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2023-02-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers

    Omar Alhalabi / Jianfeng Chen / Yuxue Zhang / Yang Lu / Qi Wang / Sumankalai Ramachandran / Rebecca Slack Tidwell / Guangchun Han / Xinmiao Yan / Jieru Meng / Ruiping Wang / Anh G. Hoang / Wei-Lien Wang / Jian Song / Lidia Lopez / Alex Andreev-Drakhlin / Arlene Siefker-Radtke / Xinqiao Zhang / William F. Benedict /
    Amishi Y. Shah / Jennifer Wang / Pavlos Msaouel / Miao Zhang / Charles C. Guo / Bogdan Czerniak / Carmen Behrens / Luisa Soto / Vassiliki Papadimitrakopoulou / Jeff Lewis / Waree Rinsurongkawong / Vadeerat Rinsurongkawong / Jack Lee / Jack Roth / Stephen Swisher / Ignacio Wistuba / John Heymach / Jing Wang / Matthew T. Campbell / Eleni Efstathiou / Mark Titus / Christopher J. Logothetis / Thai H. Ho / Jianjun Zhang / Linghua Wang / Jianjun Gao

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Band 12

    Abstract: The deficiency of MTAP, an enzyme of the adenine salvage pathway, occurs in some cancers. Here the authors perform a small cohort phase II clinical trial with metastatic MTAP-deficient urothelial cancer (UC) and show an increased overall response when ... ...

    Abstract The deficiency of MTAP, an enzyme of the adenine salvage pathway, occurs in some cancers. Here the authors perform a small cohort phase II clinical trial with metastatic MTAP-deficient urothelial cancer (UC) and show an increased overall response when comparing to MTAP-proficient UC patients.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-04-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Predicting benefit from immune checkpoint inhibitors in patients with non-small-cell lung cancer by CT-based ensemble deep learning

    Maliazurina B Saad, PhD / Lingzhi Hong, MD / Muhammad Aminu, MD / Natalie I Vokes, MD / Pingjun Chen, PhD / Morteza Salehjahromi, PhD / Kang Qin, MD / Sheeba J Sujit, PhD / Xuetao Lu, PhD / Elliana Young, MS / Qasem Al-Tashi, PhD / Rizwan Qureshi, PhD / Carol C Wu, ProfMD / Brett W Carter, ProfMD / Steven H Lin, ProfMD / Percy P Lee, ProfMD / Saumil Gandhi, MD / Joe Y Chang, ProfMD / Ruijiang Li, PhD /
    Michael F Gensheimer, MD / Heather A Wakelee, ProfMD / Joel W Neal, MD / Hyun-Sung Lee, MD / Chao Cheng, PhD / Vamsidhar Velcheti, ProfMD / Yanyan Lou, MD / Milena Petranovic, MD / Waree Rinsurongkawong, PhD / Xiuning Le, MD / Vadeerat Rinsurongkawong, PhD / Amy Spelman, PhD / Yasir Y Elamin, MD / Marcelo V Negrao, MD / Ferdinandos Skoulidis, MD / Carl M Gay, MD / Tina Cascone, MD / Mara B Antonoff, MD / Boris Sepesi, MD / Jeff Lewis, BS / Ignacio I Wistuba, ProfMD / John D Hazle, ProfPhD / Caroline Chung, MD / David Jaffray, ProfPhD / Don L Gibbons, ProfMD / Ara Vaporciyan, ProfMD / J Jack Lee, ProfPhD / John V Heymach, ProfMD / Jianjun Zhang, MD / Jia Wu, PhD

    The Lancet: Digital Health, Vol 5, Iss 7, Pp e404-e

    a retrospective study

    2023  Band 420

    Abstract: Summary: Background: Only around 20–30% of patients with non-small-cell lung cancer (NCSLC) have durable benefit from immune-checkpoint inhibitors. Although tissue-based biomarkers (eg, PD-L1) are limited by suboptimal performance, tissue availability, ... ...

    Abstract Summary: Background: Only around 20–30% of patients with non-small-cell lung cancer (NCSLC) have durable benefit from immune-checkpoint inhibitors. Although tissue-based biomarkers (eg, PD-L1) are limited by suboptimal performance, tissue availability, and tumour heterogeneity, radiographic images might holistically capture the underlying cancer biology. We aimed to investigate the application of deep learning on chest CT scans to derive an imaging signature of response to immune checkpoint inhibitors and evaluate its added value in the clinical context. Methods: In this retrospective modelling study, 976 patients with metastatic, EGFR/ALK negative NSCLC treated with immune checkpoint inhibitors at MD Anderson and Stanford were enrolled from Jan 1, 2014, to Feb 29, 2020. We built and tested an ensemble deep learning model on pretreatment CTs (Deep-CT) to predict overall survival and progression-free survival after treatment with immune checkpoint inhibitors. We also evaluated the added predictive value of the Deep-CT model in the context of existing clinicopathological and radiological metrics. Findings: Our Deep-CT model demonstrated robust stratification of patient survival of the MD Anderson testing set, which was validated in the external Stanford set. The performance of the Deep-CT model remained significant on subgroup analyses stratified by PD-L1, histology, age, sex, and race. In univariate analysis, Deep-CT outperformed the conventional risk factors, including histology, smoking status, and PD-L1 expression, and remained an independent predictor after multivariate adjustment. Integrating the Deep-CT model with conventional risk factors demonstrated significantly improved prediction performance, with overall survival C-index increases from 0·70 (clinical model) to 0·75 (composite model) during testing. On the other hand, the deep learning risk scores correlated with some radiomics features, but radiomics alone could not reach the performance level of deep learning, indicating that the deep learning model ...
    Schlagwörter Computer applications to medicine. Medical informatics ; R858-859.7
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2023-07-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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