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Article ; Online: Concomitant use of Sapien 3 transcatheter valve for severe MAC with Intuity Elite rapid deployment valve for aortic stenosis.

Hooks, Gareth J / Ball, Peter / Spence, Mark S / Jeganathan, Reuben

2022 Volume 17, Issue 1, Page(s) 126

Abstract: Background: Concomitant double valve pathology in the presence of severe MAC poses significant technical challenges when planning surgical intervention. With continued evolution of valve prosthesis, innovative techniques can be considered with the ... ...

Abstract	Background: Concomitant double valve pathology in the presence of severe MAC poses significant technical challenges when planning surgical intervention. With continued evolution of valve prosthesis, innovative techniques can be considered with the potential for additional therapeutic benefit. Case presentation: We present a novel technique of using a rapid deployment surgical aortic valve in combination with open surgical transcatheter mitral valve implantation (TMVI) for severe Mitral Annular Calcification (MAC). The Intuity Elite rapid deployment prosthesis (Edwards Lifesciences, Irvine, CA) was used concomitantly with the Sapien 3 (Edwards Lifesciences, Irvine, CA) transcatheter prosthesis trans-atrially on cardiopulmonary bypass in a patient with critical aortic stenosis and moderate-severe mixed mitral valve disease in the setting of severe MAC (off-label use). Conclusions: We demonstrate how both technologies can, not only be accommodated, but indeed complement each other achieving an excellent outcome in a high-risk patient.
MeSH term(s)	Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Calcinosis/surgery ; Heart Valve Diseases/surgery ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/methods ; Humans ; Mitral Valve/surgery ; Prosthesis Design ; Transcatheter Aortic Valve Replacement ; Treatment Outcome
Language	English
Publishing date	2022-05-23
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-022-01879-7
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Article ; Online: A very rare case of incidental aortic valve fibrolipoma.

Karsan, Rickesh Bharat / Kelly, Ronan / Healy, Estelle / Jeganathan, Reuben

Interactive cardiovascular and thoracic surgery

2021 Volume 34, Issue 3, Page(s) 498–499

Abstract: Cardiac valve fibrolipomas are extremely rare. We report a case of a 38-year-old female initially presenting with palpitations and moderate aortic incompetence who was found to have a lipomatous growth of the aortic valve. She underwent aortic valve ... ...

Abstract	Cardiac valve fibrolipomas are extremely rare. We report a case of a 38-year-old female initially presenting with palpitations and moderate aortic incompetence who was found to have a lipomatous growth of the aortic valve. She underwent aortic valve repair with good postoperative results. Histopathogy verified the lesion as a fibrolipoma. This is the first reported case of fibrolipoma in the aortic valve, whilst aiming to consider repair as a surgical option in young patients with such growths.
MeSH term(s)	Adult ; Aortic Valve/diagnostic imaging ; Aortic Valve/pathology ; Aortic Valve/surgery ; Aortic Valve Insufficiency/diagnostic imaging ; Aortic Valve Insufficiency/etiology ; Aortic Valve Insufficiency/surgery ; Cardiac Surgical Procedures/methods ; Female ; Humans ; Lipoma/diagnostic imaging ; Lipoma/surgery
Language	English
Publishing date	2021-10-12
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2095298-3
ISSN	1569-9285 ; 1569-9293
ISSN (online)	1569-9285
ISSN	1569-9293
DOI	10.1093/icvts/ivab272
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Zs.A 5730: Show issues

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Article ; Online: Considering the optimal procedural Heart Team in TAVI: back to the future?

Brennan, Paul F / Jeganathan, Reuben / Spence, Mark S

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

2019 Volume 14, Issue 18, Page(s) e1802–e1805

MeSH term(s)	Aortic Valve Stenosis ; Humans ; Transcatheter Aortic Valve Replacement
Language	English
Publishing date	2019-04-05
Publishing country	France
Document type	Journal Article
ZDB-ID	2457174-X
ISSN	1969-6213 ; 1774-024X
ISSN (online)	1969-6213
ISSN	1774-024X
DOI	10.4244/EIJV14I18A315
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Zs.A 6680: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 571: Show issues

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Article ; Online: The figure-of-8 aortic valve suturing technique optimizes the effective orifice area of a small aortic annulus-an ex vivo study.

Saisho, Hiroyuki / Kuhlmann, Carina / Scharfschwerdt, Michael / Jeganathan, Reuben / Sadat, Najla / Schaller, Tim / Aboud, Anas / Ensminger, Stephan / Fujita, Buntaro

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2022 Volume 62, Issue 3

Abstract: Objectives: Surgical aortic valve replacement (SAVR) in small annuli carries an elevated risk for the patient-prosthesis mismatch. In this study, we systematically investigated the influence of different implantation techniques including annular ... ...

Abstract	Objectives: Surgical aortic valve replacement (SAVR) in small annuli carries an elevated risk for the patient-prosthesis mismatch. In this study, we systematically investigated the influence of different implantation techniques including annular enlargement (AE) on the functional result after SAVR in small annuli using a standardized ex vivo model. Methods: SAVR using the PERIMOUNT Magna Ease® (PME) 21 mm was performed in small porcine aortic roots using 4 implantation techniques: non-everting pledgeted (NE) suture, single interrupted (SI) suture, continuous suture (CS), figure-of-8 (F8) suture, as well as the PME 23 mm after AE using the Nunez method and the NE suture technique (PME23 AE). The effective orifice area (EOA), mean pressure gradient and leakage volume were evaluated using a mock circulation loop in accordance with ISO regulations. Results: Experiments were conducted on 31 porcine aortic roots. PME21 using F8 and PME23 after AE achieved a significantly larger EOA than using NE. PME23 after AE showed a larger EOA than the PME21 using any suture technique, except the F8 [for stroke volume of 74 ml: PME21 NE: 1.68 (1.63-1.72) cm2, PME21 SI: 1.76 (1.68-1.81) cm2 (P = 0.17), PME21 CS: 1.76 (1.65-1.79) cm2 (P = 0.14), PME21 F8: 1.81 (1.70-1.85) cm2 (P = 0.005); PME23 AE: 1.83 (1.73-1.92) cm2 (P < 0.001)]. SI and CS did not result in larger EOA compared with the NE technique. PME21 using SI had a significantly larger leakage volume than using NE and there was no significant difference between other techniques [for stroke volume of 74 ml: PME21 NE: 3.51 (1.85-4.53) ml/stroke, PME21 SI: 6.00 (4.02-7.06) ml/stroke (P < 0.001), PME21 CS: 4.04 (3.60-4.49) ml/stroke (P = 0.10), PME21 F8: 3.16 (1.99-3.62) ml/stroke (P = 0.74), PME23 NE: 2.89 (2.45-4.72) ml/stroke (P = 0.51)]. Conclusions: The F8 technique with the PME21 achieved a similar EOA as the 1 size larger PME23 using NE after AE. These results suggest that the F8 technique may be an effective surgical modification to improve the haemodynamic result in a small annulus without additional AE.
MeSH term(s)	Animals ; Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Bioprosthesis ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/methods ; Hemodynamics ; Prosthesis Design ; Suture Techniques ; Swine
Language	English
Publishing date	2022-04-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezac195
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Zs.A 2303: Show issues

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Article ; Online: Cardiac sarcoma causing mechanical tamponade: a radiological dilemma!

Burnside, Nathan / Jeganathan, Reuben

European heart journal

2015 Volume 36, Issue 48, Page(s) 3459

MeSH term(s)	Adult ; Cardiac Tamponade/diagnostic imaging ; Cardiac Tamponade/etiology ; Female ; Heart Neoplasms/complications ; Heart Neoplasms/diagnostic imaging ; Humans ; Sarcoma/complications ; Sarcoma/diagnostic imaging ; Tomography, X-Ray Computed
Language	English
Publishing date	2015-12-21
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehv165
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Zs.A 1563: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 640: Show issues

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Article ; Online: Fibroelastoma of the mitral valve apparatus.

Crean, Jonathan / Clinton, Aoibhinn / Afredi, Nasir / Dougherty, Mark / Jeganathan, Reuben

Journal of cardiac surgery

2018 Volume 33, Issue 8, Page(s) 442–443

MeSH term(s)	Cardiac Surgical Procedures/methods ; Echocardiography, Transesophageal ; Fibroma/complications ; Fibroma/diagnostic imaging ; Fibroma/pathology ; Fibroma/surgery ; Heart Neoplasms/complications ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/pathology ; Heart Neoplasms/surgery ; Humans ; Male ; Middle Aged ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Mitral Valve Insufficiency/etiology ; Mitral Valve Insufficiency/surgery ; Treatment Outcome
Language	English
Publishing date	2018-07-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.13748
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Zs.A 2221: Show issues

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Article ; Online: Open transcatheter valve implantation for mitral annular calcification: One-year outcomes.

Hamid, Umar Imran / Gregg, Anne / Ball, Peter / Owens, Colum / Manoharan, Ganesh / Spence, Mark S / Jeganathan, Reuben

JTCVS techniques

2021 Volume 10, Page(s) 254–261

Abstract: Background: Transcatheter mitral valve implantation (TMVI) for native mitral valve pathology with severe mitral annular calcification has emerged as an alternative treatment option to conventional mitral valve surgery. The objective of this study was to ...

Abstract	Background: Transcatheter mitral valve implantation (TMVI) for native mitral valve pathology with severe mitral annular calcification has emerged as an alternative treatment option to conventional mitral valve surgery. The objective of this study was to evaluate patients who were referred for TMVI with severe mitral annular calcification and their procedural outcomes. Methods: Retrospective analysis of patients from 2017 to 2020 referred for TMVI was carried out. Demographic characteristic details; surgical strategy; perioperative complications; and hospital stay, including 30-day and 1-year mortality, were analyzed. Results: Eleven patients were referred for consideration of TMVI. The 8 patients who underwent TMVI had a median age of 74 years (range, 57-80 years), the median Society of Thoracic Surgeons score was 4.6 (range, 2.4-10.9), and European System for Cardiac Operative Risk Evaluation II score was 5.2% (2%-10.1%). The median cardiopulmonary bypass time and crossclamp times were 170 minutes (range, 150-248 minutes) and 152 minutes (range, 118-214 minutes), respectively. The median hospital stay was 29 days (range, 2-40 days). Thirty-day in hospital mortality was 12%, whereas 1-year mortality was 25%. There was symptomatic improvement with downgrade of New York Heart Association functional class from III or IV to I or II. The 3 patients who were turned down had a median age of 73 years, median Society of Thoracic Surgeons score was 13.4, and median European System for Cardiac Operative Risk Evaluation II score was 5.72%. They were alive at 12 months follow-up from the date of surgical assessment; however, all with New York Heart Association functional class III or IV symptoms. Conclusions: We describe a series demonstrating the technical consideration and capability of transatrial TMVI to treat mitral annular calcification and native mitral valve disease. Our results are favorable when compared with TMVI global registry data for transseptal or transapical approach.
Language	English
Publishing date	2021-08-10
Publishing country	United States
Document type	Journal Article
ISSN	2666-2507
ISSN (online)	2666-2507
DOI	10.1016/j.xjtc.2021.08.004
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Article ; Online: Sarcoidosis or acute coronary syndrome: Easily distinguishable?

Marley, William Dominic / Booth, Karen / Jeganathan, Reuben

Asian cardiovascular & thoracic annals

2016 Volume 24, Issue 1, Page(s) 54–56

Abstract: Sinus of Valsalva aneurysm is a rare presenting feature of ST-elevation myocardial infarction. We describe such a case which resolved with thrombolysis, and on further investigation, the patient was found to have a large sinus of Valsalva aneurysm. ... ...

Abstract	Sinus of Valsalva aneurysm is a rare presenting feature of ST-elevation myocardial infarction. We describe such a case which resolved with thrombolysis, and on further investigation, the patient was found to have a large sinus of Valsalva aneurysm. Abnormal gross pathology at the time of surgery was suspected to be aortitis which was only confirmed on postmortem examination 6 months later. We highlight the importance of working closely with a pathologist when aortitis is suspected, because failure to treat it medically results in a poor outcome.
MeSH term(s)	Aneurysm, False/etiology ; Aneurysm, False/surgery ; Aortic Aneurysm/diagnosis ; Aortic Aneurysm/etiology ; Aortic Aneurysm/surgery ; Aortitis/diagnosis ; Aortitis/etiology ; Aortitis/surgery ; Aortography/methods ; Autopsy ; Diagnostic Errors ; Fatal Outcome ; Humans ; Inferior Wall Myocardial Infarction/diagnosis ; Inferior Wall Myocardial Infarction/etiology ; Inferior Wall Myocardial Infarction/therapy ; Male ; Middle Aged ; Predictive Value of Tests ; Sarcoidosis/complications ; Sarcoidosis/diagnosis ; Sinus of Valsalva/diagnostic imaging ; Sinus of Valsalva/pathology ; Sinus of Valsalva/surgery ; Tomography, X-Ray Computed
Language	English
Publishing date	2016-01
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1400468-9
ISSN	1816-5370 ; 0218-4923
ISSN (online)	1816-5370
ISSN	0218-4923
DOI	10.1177/0218492314538036
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Zs.A 5193: Show issues

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Article ; Online: Fibroelastoma of the aortic valve.

McCanny, Andrew / Imran Hamid, Umar / Carroll, Stephen / Jeganathan, Reuben

Journal of cardiac surgery

2017 Volume 32, Issue 11, Page(s) 698–699

MeSH term(s)	Aged ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Bioprosthesis ; Echocardiography, Transesophageal ; Female ; Fibroma/diagnostic imaging ; Fibroma/pathology ; Fibroma/surgery ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/pathology ; Heart Neoplasms/surgery ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/methods ; Humans ; Treatment Outcome
Language	English
Publishing date	2017-11-19
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.13232
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Zs.A 2221: Show issues

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Article ; Online: Reframing Optimal Implantation of the Sapien 3 Transcatheter Heart Valve.

Mailey, Jonathan A / Brennan, Paul F / Kearney, Aileen / Hogg, Meadhbh C / McNeice, Andrew H / Jeganathan, Reuben / Manoharan, Ganesh / Owens, Colum G / Spence, Mark S

The Journal of invasive cardiology

2022 Volume 34, Issue 5, Page(s) E380–E389

Abstract: Objectives: To define the optimal implantation of the Sapien 3 (Edwards Lifesciences) transcatheter heart valve (THV), this study systematically analyzed the predeployment fluoroscopic THV position and correlated this to clinical outcomes.: Methods: ... ...

Abstract	Objectives: To define the optimal implantation of the Sapien 3 (Edwards Lifesciences) transcatheter heart valve (THV), this study systematically analyzed the predeployment fluoroscopic THV position and correlated this to clinical outcomes. Methods: This was an observational study of 279 patients treated with the Sapien 3 THV. Fluoroscopic imaging was used to categorize patients into low (n = 147), intermediate (n = 86), and high (n = 46) implantation zones. These zones were based on the relationship of the balloon marker and radiolucent line of the valve frame (line of lucency) to the annular plane at deployment. The primary outcome was the rate of permanent pacemaker implantation (PPI) at 30 days. The secondary outcomes were the rates of new left bundle-branch block (LBBB) in-hospital and all-cause mortality at 1 year. Results: In the high, intermediate, and low groups, 30-day PPI rates were 4.3%, 8.1%, and 8.8% (P=.62); in-hospital LBBB rates were 10.9%, 26.7%, and 32.0% (P=.02); and all-cause mortality rates at 1 year were 3.1%, 7.3%, and 12.5% (P=.14), respectively. No differences were observed with respect to procedural success/complications or THV performance between the groups. Conclusion: This study demonstrates fewer conduction abnormalities for Sapien 3 valves positioned within a higher zone defined fluoroscopically by the line of lucency and balloon marker.
MeSH term(s)	Aortic Valve/surgery ; Aortic Valve Stenosis/complications ; Aortic Valve Stenosis/diagnosis ; Aortic Valve Stenosis/surgery ; Bundle-Branch Block/etiology ; Heart Valve Prosthesis/adverse effects ; Humans ; Transcatheter Aortic Valve Replacement/adverse effects
Language	English
Publishing date	2022-04-08
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	1154372-3
ISSN	1557-2501 ; 1042-3931
ISSN (online)	1557-2501
ISSN	1042-3931
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Zs.A 3701: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 272: Show issues
Zs.MG 31: Show issues

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