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Article ; Online: SPECIJALIZACIJA DRŽAVNIH ORGANA U SUZBIJANjU FINANSIJSKOG KRIMINALITETA I KORUPCIJE

Marina Matić Bošković / Jelena Kostić

Srpska Politička Misao, Vol 65, Iss 3/2019, Pp 255-

2019 Volume 279

Abstract: Tokom 2016. godine, izmenjen je i dopunjen Krivični zakonik. Najviše izmena izvršeno je u pogledu krivičnih dela protiv privrede. S obzirom na to da se ona mogu svrstati u ekonomski (finansijski) kriminalitet, za njihovo otkrivanje i dokazivanje ... ...

Abstract	Tokom 2016. godine, izmenjen je i dopunjen Krivični zakonik. Najviše izmena izvršeno je u pogledu krivičnih dela protiv privrede. S obzirom na to da se ona mogu svrstati u ekonomski (finansijski) kriminalitet, za njihovo otkrivanje i dokazivanje neophodno je posedovanje i nekih dodatnih vankrivičnih znanja. U otkrivanju dela ekonomskog karaktera osim organa formalne socijalne kontrole učestvuju i neke druge institucije. Tako npr. u otkrivanju krivičnih dela na štetu javnih sredstava učestvuje i vrhovna revizorska institucija, a u otkrivanju krivičnog dela pranje novca, nadležne banke ili društva za osiguranje. Dokazi koje ti organi pribave u svom radu od ključnog su značaja za blagovremeno dokazivanje postojanja krivičnog dela i izricanje adekvatne sankcije njihovim izvršiocima. Zbog toga je tokom 2016. godine donet novi Zakon o organizaciji i nadležnosti državnih organa u suzbijanju organizovanog kriminala, terorizma i korupcije. Tim Zakonom su uvedeni novi instituti krivičnog prava: finansijski forenzičari, službenici za vezu i udarne grupe. S obzirom na činjenicu da takve kategorije nisu prepoznate kao subjekti krivičnog postupka u postojećem Zakoniku o krivičnom postupku i da predstavljaju novinu u našem krivičnom zakonodavstvu, primenom dogmatskog i normativno pravnog metoda autorke ukazuju na potrebu unapređenja, zakonske i podzakonske regulative u cilju omogućavanja efikasne primene tih instituta u praksi.
Keywords	Political science ; J
Language	German
Publishing date	2019-11-01T00:00:00Z
Publisher	Institute for Political Studies, Belgrade
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pilomyxoid astrocytoma of the thoracic spinal cord

Mohamed A. Almzeogi / Zeyad A. Abousabie / Jelena Kostic / Aleksandar M. Janicijevic / Goran Tasic

Clinical Case Reports, Vol 9, Iss 7, Pp n/a-n/a (2021)

Extremely rare case report of over 70‐year‐old patient

2021

Abstract: Abstract The Pilomyxoid is rare tumor in elderly population, in addition to the occurrence of an isolated lesion in spinal cord is extremely rare in non‐pediatric population. Taking biopsy and subtotal resection is the starting point in essential ... ...

Abstract	Abstract The Pilomyxoid is rare tumor in elderly population, in addition to the occurrence of an isolated lesion in spinal cord is extremely rare in non‐pediatric population. Taking biopsy and subtotal resection is the starting point in essential approach for the treatment. After defining the histopathological nature of the tumor and specified that is Pilomyxoid, the next step is the combination of reoperation and adjuvant therapy.
Keywords	case report ; elderly ; pilomyxoid astrocytoma ; thoracic spinal cord ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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Article ; Online: The Significance of MGMT Promoter Methylation Status in Diffuse Glioma

Nikola Jovanović / Milica Lazarević / Vladimir J. Cvetković / Vesna Nikolov / Jelena Kostić Perić / Milena Ugrin / Sonja Pavlović / Tatjana Mitrović

International Journal of Molecular Sciences, Vol 23, Iss 13034, p

2022 Volume 13034

Abstract: A single-institution observational study with 43 newly diagnosed diffuse gliomas defined the isocitrate dehydrogenase 1 and 2 ( IDH1/2 ) gene mutation status and evaluated the prognostic relevance of the methylation status of the epigenetic marker O 6 - ... ...

Abstract	A single-institution observational study with 43 newly diagnosed diffuse gliomas defined the isocitrate dehydrogenase 1 and 2 ( IDH1/2 ) gene mutation status and evaluated the prognostic relevance of the methylation status of the epigenetic marker O 6 -methylguanine-DNA methyltransferase ( MGMT ). Younger patients (<50 years) with surgically resected glioma and temozolomide (TMZ) adjuvant chemotherapy were associated with better prognosis, consistent with other studies. The methylation status depends on the chosen method and the cut-off value determination. Methylation-specific PCR (MSP) established the methylation status for 36 glioma patients (19 (52.8%) positively methylated and 17 (47.2%) unmethylated) without relevancy for the overall survival (OS) ( p = 0.33). On the other side, real-time methylation-specific PCR (qMSP) revealed 23 tumor samples (54%) that were positively methylated without association with OS ( p = 0.15). A combined MSP analysis, which included the homogenous cohort of 24 patients (>50 years with surgical resection and IDH1/2 -wildtype diffuse glioma), distinguished 10 (41.6%) methylated samples from 14 (58.4%) unmethylated samples. Finally, significant correlation between OS and methylation status was noticed ( p ≈ 0.05). The OS of the hypermethylated group was 9.6 ± 1.77 months, whereas the OS of the unmethylated group was 5.43 ± 1.04 months. Our study recognized the MGMT promoter methylation status as a positive prognostic factor within the described homogenous cohort, although further verification in a larger population of diffuse gliomas is required.
Keywords	diffuse glioma ; glioblastoma ; MGMT ; IDH1 ; IDH2 ; MSP ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	570
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Risk Factors and Predictive Value of Depression and Anxiety in Cervical Cancer Patients

Suzana Tosic Golubovic / Iva Binic / Dane Krtinic / Vladimir Djordjevic / Irena Conic / Uros Gugleta / Marija Andjelkovic Apostolovic / Marko Stanojevic / Jelena Kostic

Medicina, Vol 58, Iss 4, p

2022 Volume 507

Abstract: Background and Objectives : Women with cervical cancer may experience depression or anxiety, influencing their quality of life and even their adherence to cancer treatments. This study aimed to explore and measure the levels of anxiety and depression in ... ...

Abstract	Background and Objectives : Women with cervical cancer may experience depression or anxiety, influencing their quality of life and even their adherence to cancer treatments. This study aimed to explore and measure the levels of anxiety and depression in patients suffering from cervical cancer and to identify the possible predictors among known risk factors such as age, cancer stage, smoking status, number of partners, use of contraceptives, and annual gynecological visits. Materials and Methods : In total, 59 patients with cervical cancer were included. A consecutive sampling method was used to select participants in this research. Depression and anxiety were assessed using the Zung Anxiety Scale (SAS) and Zung Depression Scale (SDS). The subjects were divided into three groups, according to the stage of cancer. Results : Scores of depression and anxiety were increased in all recruited cervical cancer patients. A significant correlation was found between disease stage and the scores of depression ( p = 0.002) and anxiety ( p = 0.016). More severe depressive symptoms correlated to a more advanced stage of the disease. A multiple linear regression showed that disease stage and annual visits to the gynecologist are the risk factors associated with higher depression scores. Conclusions : Patients diagnosed with cervical cancer are a vulnerable group for the development of the psychiatric disorders and they require screening programs, which could potentially detect candidates for co-psychiatric and/or psychotherapeutic treatment. They demand particular attention because anxiety and depression are associated with the significant burden of the underlying disease and unfavorable survival rates.
Keywords	anxiety ; depression ; cervical cancer ; Medicine (General) ; R5-920
Subject code	610 ; 150
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Comparison of MGMT Testing by MSP and qMSP in Paired Snap-Frozen and Formalin-Fixed Paraffin-Embedded Gliomas

Milica Lazarević / Nikola Jovanović / Vladimir J. Cvetković / Svetlana Tošić / Jelena Vitorović / Slaviša Stamenković / Vesna Nikolov / Nataša Vidović / Jelena Kostić Perić / Marija Jovanović / Tatjana Mitrović

Diagnostics, Vol 13, Iss 360, p

2023 Volume 360

Abstract: Comparative analysis of the conventional methylation-specific PCR (MSP) vs. the quantitative MSP (qMSP) assessment of the O 6 -methylguanine-DNA methyltransferase ( MGMT ) promoter methylation status in 34 snap-frozen (SF) glioma samples was performed. ... ...

Abstract	Comparative analysis of the conventional methylation-specific PCR (MSP) vs. the quantitative MSP (qMSP) assessment of the O 6 -methylguanine-DNA methyltransferase ( MGMT ) promoter methylation status in 34 snap-frozen (SF) glioma samples was performed. The accuracy of the semi-quantitative MSP was compared with the corresponding qMSP semi-quantitative values using two semi-quantitative cut-off values (0—unmethylated and 1—weakly methylated) to discriminate methylated from unmethylated samples. In the case of the cut-off value 0, MSP test showed 80.0% sensitivity and 78.9% specificity compared to the reference qMSP analysis. However, when using the cut-off value 1, the diagnostic accuracy of the MSP test was significantly higher (85.7% sensitivity, 85.2% specificity). Fleiss’ Kappa statistical analyses indicated moderate agreement (Fleiss’ Kappa Coefficient = 0.509; 70.59% agreement) between MSP and qMSP semi-quantitative measurements of MGMT promoter methylation in glioma patients, justifying the conventional MSP use in diagnostics and confirming its high reliability. Further, we aimed to compare the validity of SF and formalin-fixed paraffin-embedded (FFPE) glioma samples for MGMT testing. Statistical analyses indicated moderate overall agreement of FFPE glioma samples and SF MSP semi-quantitative measurements (Fleiss’ Kappa Coefficient = 0.516/0.509; 70.0% agreement) and emphasized their low reliability in the assessment of highly methylated MGMT promoter samples.
Keywords	MSP ; qMSP ; glioma ; MGMT ; FFPE ; prognostic factor ; Medicine (General) ; R5-920
Subject code	570
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: DEVELOPMENTAL TAXONOMY OF CONDUCT DISORDER

Jelena Kostić / Milkica Nešić / Jasminka Marković / Miodrag Stanković

Acta Medica Medianae, Vol 54, Iss 4, Pp 79-

2015 Volume 83

Abstract: Conduct disorder is a heterogeneous disorder in terms of etiology, course and prognosis, and currently, there is no singular model that would describe the development of the disorder. The results of empirical research on males confirm this heterogeneity, ...

Abstract	Conduct disorder is a heterogeneous disorder in terms of etiology, course and prognosis, and currently, there is no singular model that would describe the development of the disorder. The results of empirical research on males confirm this heterogeneity, as they point out to two possible developmental pathways: childhood-onset and adolescentonset type. This paper presents the basic elements of developmental taxonomic theory which argues that there are two different developmental pathways to conduct disorder which have different causes and serve as the basis for the current typology of conduct disorders in the classification systems. Such a typology of conduct disorders in the diagnostic classification allows better understanding, prognosis and choice of treatment.
Keywords	course and prognosis ; and currently ; there is no singular model that would describe the development of the disorder. The results of empirical research on males confirm this heterogeneity ; as they point out to two possible developmental pathways: childhood-onset and adolescentonset type. This paper presents the basic elements of developmental taxonomic theory which argues that there are two different developmental pathways to conduct disorder which have different causes and serve as the basis for the current typology of conduct disorders in the classification systems. Such a typology of conduct disorders in the diagnostic classification allows better understanding ; conduct disorder ; children ; adolescents ; Medicine ; R
Language	English
Publishing date	2015-12-01T00:00:00Z
Publisher	University in Nis, Faculty of Medicine
Document type	Article ; Online
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Article ; Online: PRODROMAL PHASE IN THE DEVELOPMENT OF EARLY ONSET SCHIZOPHRENIC PSYCHOSIS - CASE REPORT

Jelena Kostić / Miodrag Stanković / Milkica Nešić / Dragana Krasić

Acta Medica Medianae, Vol 51, Iss 2, Pp 19-

2012 Volume 24

Abstract: Schizophrenia and other mental disorders are often preceded by prodromal changes in behavior that can last from several days to several years, indicating the beginning of psychosis. If the disease starts at an earlier age, especially in adolescence, the ... ...

Abstract	Schizophrenia and other mental disorders are often preceded by prodromal changes in behavior that can last from several days to several years, indicating the beginning of psychosis. If the disease starts at an earlier age, especially in adolescence, the prodromal phase is more non-specific and difficult to detect. There is a large number of operational instruments used for clinical assessment and quantification of prodromal symptoms and "at risk mental state", as well as the predictive potential for psychosis. This paper describes the prodromal phase in the development of early onset schizophrenic psychosis, with the emphasis on gradual, several-month psychopathological accumulation and evolution of nonspecific and subclinical, prodromal symptoms to florid schizophrenic symptoms.
Keywords	prodrome ; schizophrenia ; adolescence ; Medicine ; R
Language	English
Publishing date	2012-06-01T00:00:00Z
Publisher	University in Nis, Faculty of Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Folic acid affects cardiometabolic, oxidative stress, and immunohistochemical parameters in monocrotaline-induced rat heart failure.

Jakovljevic Uzelac, Jovana / Djukic, Tatjana / Radic, Tanja / Mutavdzin, Slavica / Stankovic, Sanja / Rakocevic, Jelena Kostic / Labudovic Borovic, Milica / Milic, Natasa / Simic, Tatjana / Savic-Radojevic, Ana / Djuric, Dragan

Canadian journal of physiology and pharmacology

2020 Volume 98, Issue 10, Page(s) 708–716

Abstract: Heart failure (HF) is one of the major cardiovascular causes of death worldwide. In this study, we explored the effects of folic acid (FA) on cardiometabolic, oxidative stress biomarker changes, and the activity of proliferation marker Ki67 in ... ...

Abstract	Heart failure (HF) is one of the major cardiovascular causes of death worldwide. In this study, we explored the effects of folic acid (FA) on cardiometabolic, oxidative stress biomarker changes, and the activity of proliferation marker Ki67 in monocrotaline-induced HF. The research was conducted during a 4 week period using five experimental groups (eight animals per group): blank solution exposed controls (C1: 1 mL/kg physiological saline, 1 day; C2: 1 mL/kg physiological saline, 28 days), monocrotaline (MCT) induced HF (50 mg/kg MCT), FA (5 mg·kg
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Biomarkers/metabolism ; Cell Proliferation/drug effects ; Disease Models, Animal ; Energy Metabolism/drug effects ; Folic Acid/pharmacology ; Glutathione/metabolism ; Heart Failure/chemically induced ; Heart Failure/drug therapy ; Heart Failure/metabolism ; Heart Failure/pathology ; Immunohistochemistry ; Ki-67 Antigen/metabolism ; Male ; Monocrotaline ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Oxidative Stress/drug effects ; Rats, Wistar ; Ventricular Remodeling/drug effects
Chemical Substances	Antioxidants ; Biomarkers ; Ki-67 Antigen ; Monocrotaline (73077K8HYV) ; Folic Acid (935E97BOY8) ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2020-04-30
Publishing country	Canada
Document type	Journal Article
ZDB-ID	127527-6
ISSN	1205-7541 ; 0008-4212
ISSN (online)	1205-7541
ISSN	0008-4212
DOI	10.1139/cjpp-2020-0030
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: PERCUTANEOUS NEPHROSTOMY AND DOUBLE PIGTAIL (JJ) URETERAL STENTS AS TEMPORARY METHODS IN SOLVING SUPRAVESICAL OBSTRUCTION CAUSED BY STONE

Ljubomir Dinić / Jablan Stanković / Milan Potić / Aleksandar Skakić / Marija Mihajlović-Tošić / Vladimir Milić / Natalija Vuković / Jelena Kostić / Nataša Đinđić

Acta Medica Medianae, Vol 54, Iss 3, Pp 39-

2015 Volume 44

Abstract: Percutaneous nephrostomy and ureteral stenting are temporary treatments for the upper urinary tract obstruction. The aim of this study was to evaluate the efficacy of these two methods by comparing complications, placement success, urinary symptoms, ... ...

Abstract	Percutaneous nephrostomy and ureteral stenting are temporary treatments for the upper urinary tract obstruction. The aim of this study was to evaluate the efficacy of these two methods by comparing complications, placement success, urinary symptoms, urine culture analyses prior to derivation placement and derivation removal and success of stone elimination after extracorporeal shock wave lithotripsy (ESWL). This prospective study included 157 patients with supravesical obstruction caused by ureteral stones. Eighty-one patients underwent percutaneus nephrostomy, and JJ stent was inserted in seventy-six (76) patients. After resolving the obstruction, ESWL was performed in all patients. There were no statistically significant differences in success of the urinary derivation placement, the urine culture results before and after placement and success of ESWL treatment between the two studied groups (p>0.05). Urinary symptoms (dysuria, hematuria, urinary urgency, frequent urination during the day) were significantly more present in patients with a JJ stent and this difference was statistically significant for each symptom (p<0.001). Major complications were verified in 2 (2.46%) patients with PCN catheter, and in 7 (9.2%) patients in the group with the JJ stent. Minor complications were significantly more frequent in the group with the JJ stent compared to the group with PCN catheter (28.39% vs 60.52%, p<0.001). Percutaneous nephrostomy and JJ stenting are optimal methods for temporary treatment of supravesical obstruction caused by ureteral stones, with similar incidence of the following complications, except for the pain, which dominates in patients with the JJ stent. Urinary symptoms and asymptomatic bacteriuria are more common in patients with the JJ stent. If the ESWL treatment of ureteral stone is performed after urinary derivation placement, we can expect greater success in patients with the JJ stent.
Keywords	placement success ; urinary symptoms ; urine culture analyses prior to derivation placement and derivation removal and success of stone elimination after extracorporeal shock wave lithotripsy (ESWL). This prospective study included 157 patients with supravesical obstruction caused by ureteral stones. Eighty-one patients underwent percutaneus nephrostomy ; and JJ stent was inserted in seventy-six (76) patients. After resolving the obstruction ; ESWL was performed in all patients. There were no statistically significant differences in success of the urinary derivation placement ; the urine culture results before and after placement and success of ESWL treatment between the two studied groups (p>0.05). Urinary symptoms (dysuria ; hematuria ; urinary urgency ; frequent urination during the day) were significantly more present in patients with a JJ stent and this difference was statistically significant for each symptom (p<0.001). Major complications were verified in 2 (2.46%) patients with PCN catheter ; and in 7 (9.2%) patients in the group with the JJ stent. Minor complications were significantly more frequent in the group with the JJ stent compared to the group with PCN catheter (28.39% vs 60.52% ; p<0.001). Percutaneous nephrostomy and JJ stenting are optimal methods for temporary treatment of supravesical obstruction caused by ureteral stones ; with similar incidence of the following complications ; except for the pain ; which dominates in patients with the JJ stent. Urinary symptoms and asymptomatic bacteriuria are more common in patients with the JJ stent. If the ESWL treatment of ureteral stone is performed after urinary derivation placement ; percutaneous nephrostomy ; double pigtail (JJ) ureteral stent ; ESWL ; Medicine ; R
Subject code	616
Language	English
Publishing date	2015-08-01T00:00:00Z
Publisher	University in Nis, Faculty of Medicine
Document type	Article ; Online
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Article ; Online: DISORDERS OF PHOSPHORUS-CALCIUM BALANCE IN PATIENTS ON CHRONIC HEMODIALYSIS - TIME-BASED DURATION RELATIONSHIP –

Ivan Kostić / Jelena Kostić / Branka Mitić / Svetislav Kostić / Vidojko Đorđević / Petar Babović

Acta Medica Medianae, Vol 50, Iss 1, Pp 32-

2011 Volume 37

Abstract: Chronic renal failure (CRF) is a progressive, irreversible deterioration of kidney function that leads to complete loss of kidney function and the need for dialysis treatment. Bone disease is a chronic complication in the CRF and poses a significant ... ...

Abstract	Chronic renal failure (CRF) is a progressive, irreversible deterioration of kidney function that leads to complete loss of kidney function and the need for dialysis treatment. Bone disease is a chronic complication in the CRF and poses a significant problem in hemodialysis patients. The aim of our study was to assess the influence of peritoneal dialysis treatment on biochemical parameters of mineral and bone metabolism in hemodialysis patients, and identify the most important parameters for the monitoring of this disorder. The research involved 172 patients, mean age 58.69±12:54, divided into groups in respect to the length of dialysis treatment (group I - 5 years, group II - 5-10 years and group III - over 10 years). Serum phosphorus in all the patients was increased, but the values increased with duration of dialysis (I: 1.77±0.58, II: 1.97±0.66, III: 1.92±0.82), with no statistical differences (p>0.05). Calcemia values were significantly increased (I vs. II. and I vs. III, p<0.0001), as well as the values of Ca x P (I vs. II., p<0.001, II vs. III., p<0.01), primarily on the account of the increased calcium value. The values of alkaline phosphatase (I: 105.12±65.60; II: 125.27±96.79, III: 172.43±163.99) were significantly higher in group III compared to other groups (p <0.05). Also, the values of PTH (I: 234.21±18.74; II: 273.09±247.98; III: 489.46±468.49) were significantly higher in group III compared to other groups (p<0.001). In the group of patients with duration of dialysis up to 5 years, the values of phosphorus were increased, the values of calcemiawere decreased, with mild elevation of AF and PTH values, which best corresponds to the bone disease with rapid turnover. In the P group, there is a significant increase in calcemia in respect to phosphorus, alkaline phosphatase, and PTH. The most reliable marker for clinical monitoring of bone disease in dialysis patients is PTH, which correlates well with the values of alkaline phosphatase and calcium. The values of calcium and phosphorus are highly variable and not the most reliable markers for bone disease monitoring.
Keywords	hemodialysis ; duration ; mineral and bone metabolism ; PTH ; calcium ; phosphorus ; Medicine ; R
Subject code	610
Language	English
Publishing date	2011-03-01T00:00:00Z
Publisher	University in Nis, Faculty of Medicine
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