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  1. Article ; Online: Effects of Water Extract of Cynanchum paniculatum (Bge.) Kitag. on Different Breast Cancer Cell Lines

    Shu-Yu Yang / Jen Ying Li / Guan-Jhong Huang / Badrinathan Sridharan / Jen-Shu Wang / Kai-Ming Chang / Meng-Jen Lee

    Evidence-Based Complementary and Alternative Medicine, Vol

    2021  Volume 2021

    Abstract: Cynanchum paniculatum (Bge.) Kitag. (CP) is an important medicinal herb used in Chinese herbal medicine, with a variety of biological activities including anticancer property. In this study, we explored the water extract of CP, for its anticancer effects ...

    Abstract Cynanchum paniculatum (Bge.) Kitag. (CP) is an important medicinal herb used in Chinese herbal medicine, with a variety of biological activities including anticancer property. In this study, we explored the water extract of CP, for its anticancer effects against breast cancer cells with different mutation types. Cells were grouped as untreated (Control); CP direct treatment (dir-CP); Conditioned medium from CP treated (sup-CP), and untreated cells (sup-Control). Effects of dir-CP and sup-CP were compared to corresponding untreated cells on cytotoxicity, cell migration, and protein expression (cleaved caspase-3, caspase-9, and MMP-2 and 9). CP treatment showed time-dependent decrease in cell number of MDA-MB-231 and SK-Br-3 (both ER(−) PR(−)), while the decrease in cell number was not as significant in MCF-7 and ZR-75-1 cells (both ER(+) PR(+)). sup-CP treatment inhibited the cell migration of MDA-MB-231 and MCF-7 (Her2(−)) in a 24 h scratch assay. Our data suggested that ER(−) PR(−) cells are more sensitive to the CP in terms of direct cytotoxicity, which is not regulated by caspase-3. CP inhibited the migration of the two Her2(−) cells, and this correlated with MMP-2 regulation. The migration of ER(−) PR(−) cells was more sensitive to conditioned medium with CP treatment than to direct CP, and this is not regulated by MMP-2. Our data suggested that CP has anticancer potential on various breast cancer cells through different mechanisms and is specifically effective in inhibiting the migration of the triple negative MDA-MB-231. Our data provide insight into the mechanism of CP against breast cancer progression and would benefit the medical practitioners in better management with CP usage.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 616
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The effects of Cordyceps militaris fruiting bodies in micturition and prostate size in benign prostatic hyperplasia patients

    Shao-An Hsieh / Tien-Huang Lin / Jen-Shu Wang / Jian-Jung Chen / Wen-Kuang Hsu / Li-Chih Ying / Zeng-Chin Liang

    Pharmacological Research - Modern Chinese Medicine, Vol 4, Iss , Pp 100143- (2022)

    A pilot study

    2022  

    Abstract: ABSTRACT: Ethnopharmacological relevance: Cordyceps militaris have proven to be effective in treating inflammation, prostate cancer and oxidative in cell line models. Experimental treatments on animal subjects have demonstrated evidence of increased sex ... ...

    Abstract ABSTRACT: Ethnopharmacological relevance: Cordyceps militaris have proven to be effective in treating inflammation, prostate cancer and oxidative in cell line models. Experimental treatments on animal subjects have demonstrated evidence of increased sex hormones and gonadal volumes, and phytosterols, especially β-sitosterol, in terms of decreasing hypertrophied prostate glands. Aim of the study: Evaluating the effects of how ingesting Cordyceps militaris fruiting bodies can alleviate BPH disease as well as improve sexual function in elderly male volunteers who were the main subjects of this study. Materials and Methods: We conducted an open clinical trial, consisting of 62 patients in conjunction with administering the standard medical treatment. The maximum flow (Q-max), post void residual volume (PVR), the prostate volume, International Prostate Symptom Score questionnaire (IPSS), International Index of Erectile Function questionnaire (IIEF) and blood test for prostate specific antigen (PSA), blood urea nitrogen (BUN), creatinine (Cr), testosterone (T), estradiol (E2) and luteinizing hormone (LH) were recorded before and after administering the treatment. We used a Pair-t-test for the analysis. Results: The study showed an increase in the maximum flow (p = 0.025*), and a decrease in prostate volume (p = 0.016*). The IPSS and IIEF Questionnaire results were (p = 0.0001***) and (p = 0.005**) respectively, and was therefore duly significant in terms of demonstrating visible clinical results. Conclusions: Cordyceps militaris fruiting bodies had the tendency in increasing the urinary flow, decreasing the size of the prostatic gland and alleviating micturition symptoms as well as having positive effect on sexual functions.
    Keywords Cordyceps militaris ; Benign prostatic hyperplasia ; Urinary-tract disorder ; Clinical trial ; Erectile dysfunction ; Other systems of medicine ; RZ201-999 ; Therapeutics. Pharmacology ; RM1-950
    Subject code 630 ; 610
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Immunomodulatory Effect of Chinese Herbal Medicine Formula Sheng-Fei-Yu-Chuan-Tang in Lipopolysaccharide-Induced Acute Lung Injury Mice

    Chia-Hung Lin / Ching-Hua Yeh / Li-Jen Lin / Shulhn-Der Wang / Jen-Shu Wang / Shung-Te Kao

    Evidence-Based Complementary and Alternative Medicine, Vol

    2013  Volume 2013

    Abstract: Traditional Chinese medicine formula Sheng-Fei-Yu-Chuan-Tang (SFYCT), consisting of 13 medicinal plants, was used to treat patients with lung diseases. This study investigated the immunoregulatory effect of SFYCT on intratracheal lipopolysaccharides- ( ... ...

    Abstract Traditional Chinese medicine formula Sheng-Fei-Yu-Chuan-Tang (SFYCT), consisting of 13 medicinal plants, was used to treat patients with lung diseases. This study investigated the immunoregulatory effect of SFYCT on intratracheal lipopolysaccharides- (LPS-) challenged acute lung injury (ALI) mice. SFYCT attenuated pulmonary edema, macrophages, and neutrophils infiltration in the airways. SFYCT decreased inflammatory cytokines, including tumor necrosis factor-α (TNFα), interleukin-1β, and interleukin-6 and inhibited nitric oxide (NO) production but increased anti-inflammatory cytokines, interleukin-4, and interleukin-10, in the bronchoalveolar lavage fluid of LPS-challenged mice. TNFα and monocyte chemotactic protein-1 mRNA expression in the lung of LPS-challenged mice as well as LPS-stimulated lung epithelial cell and macrophage were decreased by SFYCT treatment. SFYCT treatment also decreased the inducible nitric oxide synthase expression and phosphorylation of nuclear factor-κB (NF-κB) in the lung of mice and macrophage with LPS stimulation. SFYCT treatment dose dependently decreased the LPS-induced NO and reactive oxygen species generation in LPS-stimulated macrophage. In conclusion, SFYCT attenuated lung inflammation during LPS-induced ALI through decreasing inflammatory cytokines production while increasing anti-inflammatory cytokines production. The immunoregulatory effect of SFYCT is related to inhibiting NF-κB phosphorylation.
    Keywords Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  4. Article ; Online: The Chinese Herbal Medicine Formula Sheng-Fei-Yu-Chuan-Tang Suppresses Th2 Responses and Increases IFNγ in Dermatophagoides pteronyssinus Induced Chronic Asthmatic Mice

    Chia-Hung Lin / Ching-Hua Yeh / Li-Jen Lin / Jen-Shu Wang / Shulhn-Der Wang / Shung-Te Kao

    Evidence-Based Complementary and Alternative Medicine, Vol

    2013  Volume 2013

    Abstract: Sheng-Fei-Yu-Chuan-Tang (SFYCT), a traditional Chinese medicine formula consisting of 13 medicinal plants, has been used in the treatment of asthma. This study demonstrated the immunoregulatory effect of SFYCT on chronic allergic asthma using the ... ...

    Abstract Sheng-Fei-Yu-Chuan-Tang (SFYCT), a traditional Chinese medicine formula consisting of 13 medicinal plants, has been used in the treatment of asthma. This study demonstrated the immunoregulatory effect of SFYCT on chronic allergic asthma using the Dermatophagoides-pteronyssinus- (Der p-) challenged chronic asthmatic murine model. SFYCT decreased the airway hyperresponseness (AHR), pulmonary inflammatory cell infiltration, and airway remodeling in Der p mice. SFYCT treatment decreased Der p-induced total IgE and Der-p-specific IgG1 but not IgG2a/2b Ab titer in serum of Der p mice. SFYCT also decreased Th2 cytokines, IL-4, IL-5, and IL-13, but increased IFN-γ and IL-12 in the BALF of Der p mice. TGF-β1 and collagen production in the lung of mice were decreased by SFYCT. The mRNA expression of chemokine including Eotaxin, RANTES, and MCP-1 in the lung of Der p mice was decreased by SFYCT. In conclusion, the suppressed Der-p-induced airway inflammation, remodeling, and hyperresponseness in chronic asthma murine model are related to SFYCT inhibits Th2 responses, decreases chemokine expression and promotes IFN-γ and IL-12 production. SFYCT could show Der-p-induced Th2 responses to Th1 responses by increasing IFN-γ which is merit for clinical application on asthma patients.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 610
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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