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  1. Article ; Online: Iron Overload in an Infant With Rh-Isoimmunization.

    Panda, Santosh Kumar / Jena, Chinmay

    Indian pediatrics

    2023  Volume 60, Issue 1, Page(s) 76

    MeSH term(s) Humans ; Infant ; Rh Isoimmunization ; Iron Overload
    Language English
    Publishing date 2023-05-05
    Publishing country India
    Document type Letter
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
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    Zs.A 859: Show issues Location:
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  2. Article ; Online: Adaptive laboratory evolution of antimicrobial resistance in bacteria for genetic and phenotypic analyses.

    Vinchhi, Rhea / Jena, Chinmaya / Matange, Nishad

    STAR protocols

    2023  Volume 4, Issue 1, Page(s) 102005

    Abstract: Adaptive laboratory evolution (ALE) of bacteria has the potential to provide many insights like revealing novel mechanisms of resistance and elucidating the impact of drug combinations and concentrations on AMR evolution. Here, we describe a step-by-step ...

    Abstract Adaptive laboratory evolution (ALE) of bacteria has the potential to provide many insights like revealing novel mechanisms of resistance and elucidating the impact of drug combinations and concentrations on AMR evolution. Here, we describe a step-by-step ALE protocol for the model bacterium Escherichia coli that can be easily adapted to answer questions related to evolution and genetics of AMR in diverse bacteria. Key issues to consider when designing ALE experiments as well as some downstream mutation mapping analyses are described. For complete details on the use and execution of this protocol, please refer to Patel and Matange (2021)
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Bacterial/genetics ; Escherichia coli/genetics ; Bacteria/genetics
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-01-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.102005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Spectroscopic insights with molecular docking and molecular dynamic simulation studies of anticancer drug 5-Fluorouracil targeting human pyruvate kinase m2.

    Priyadarshinee, Mamali / Dehury, Budheswar / Mishra, Sarbani / Jena, Chitranjali / Patra, Manaswini / Mishra, Neeraj K / Samanta, Luna / Mallick, Bairagi C

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–13

    Abstract: This study was conducted to test the efficacy of 5-fluorouracil (5-FU) as an anticancer drug against the human pyruvate kinase isozyme M2 (PKM2) using spectroscopic, molecular docking and molecular dynamic simulation studies. PKM2 fluorescence quenching ... ...

    Abstract This study was conducted to test the efficacy of 5-fluorouracil (5-FU) as an anticancer drug against the human pyruvate kinase isozyme M2 (PKM2) using spectroscopic, molecular docking and molecular dynamic simulation studies. PKM2 fluorescence quenching studies in the presence of 5-FU performed at three different temperatures indicates dynamic quenching processes with single-set of binding (
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2313158
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    Zs.A 2093: Show issues Location:
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  4. Article ; Online: Shikonin Causes Non-apoptotic Cell Death in B16F10 Melanoma.

    Ahmad, Haleema / Crotts, Megan S / Jacobs, Jena C / Baer, Robert W / Cox, James L

    Anti-cancer agents in medicinal chemistry

    2023  Volume 23, Issue 16, Page(s) 1880–1887

    Abstract: Background: Melanoma treatment is highly resistant to current chemotherapeutic agents. Due to its resistance towards apoptotic cell death, non-apoptotic cell death pathways are sought after.: Objective: We investigated a Chinese herbal medicine, ... ...

    Abstract Background: Melanoma treatment is highly resistant to current chemotherapeutic agents. Due to its resistance towards apoptotic cell death, non-apoptotic cell death pathways are sought after.
    Objective: We investigated a Chinese herbal medicine, shikonin, and its effect on B16F10 melanoma cells in vitro.
    Methods: Cell growth of B16F10 melanoma cells treated with shikonin was analyzed using an MTT assay. Shikonin was combined with necrostatin, an inhibitor of necroptosis; caspase inhibitor; 3-methyladenine, an inhibitor of autophagy; or N-acetyl cysteine, an inhibitor of reactive oxygen species. Flow cytometry was used to assess types of cell death resulting from treatment with shikonin. Cell proliferation was also analyzed utilizing a BrdU labeling assay. Monodansylcadaverine staining was performed on live cells to gauge levels of autophagy. Western blot analysis was conducted to identify specific protein markers of necroptosis including CHOP, RIP1, and pRIP1. MitoTracker staining was utilized to identify differences in mitochondrial density in cells treated with shikonin.
    Results: Analysis of MTT assays revealed a large decrease in cellular growth with increasing shikonin concentrations. The MTT assays with necrostatin, 3-methyladenine, and N-acetyl cysteine involvement, suggested that necroptosis, autophagy, and reactive oxygen species are a part of shikonin's mechanism of action. Cellular proliferation with shikonin treatment was also decreased. Western blotting confirmed that shikonin-treated melanoma cells increase levels of stress-related proteins, e.g., CHOP, RIP, pRIP.
    Conclusion: Our findings suggest that mainly necroptosis is induced by the shikonin treatment of B16F10 melanoma cells. Induction of ROS production and autophagy are also involved.
    MeSH term(s) Humans ; Apoptosis ; Necrosis ; Reactive Oxygen Species/metabolism ; Cysteine/pharmacology ; Cell Line, Tumor ; Naphthoquinones/pharmacology ; Melanoma
    Chemical Substances shikonin (3IK6592UBW) ; Reactive Oxygen Species ; Cysteine (K848JZ4886) ; Naphthoquinones
    Language English
    Publishing date 2023-06-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2217610-X
    ISSN 1875-5992 ; 1871-5206
    ISSN (online) 1875-5992
    ISSN 1871-5206
    DOI 10.2174/1871520623666230701000338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Metastatic Endometrioid Carcinoma Mimicking a Subungual Melanoma

    Jena C. Glavy / Shian L. Peterson / Jonathan Strain / Kevin Byrd / James H. Flint

    International Journal of Environmental Research and Public Health, Vol 19, Iss 14494, p

    2022  Volume 14494

    Abstract: Case: We report a case of a 76-year-old female with a stage IB, grade I endometrioid endometrial carcinoma who presented with right-hip pain and an enlarging black, exophytic, subungual lesion on her right-small-finger distal phalanx. Clinically, the ... ...

    Abstract Case: We report a case of a 76-year-old female with a stage IB, grade I endometrioid endometrial carcinoma who presented with right-hip pain and an enlarging black, exophytic, subungual lesion on her right-small-finger distal phalanx. Clinically, the distal phalanx lesion was suspicious for a subungual melanoma; however, advanced imaging suggested metastatic disease, with lesions in the acetabulum, lungs, brain, vulva, and vagina. Conclusion: Partial amputation of the right, small finger and vulvar biopsies confirmed an endometrial carcinoma. To our knowledge, this is the first described case of endometrial adenocarcinoma metastasis to the phalanx of an upper extremity, mimicking a subungual melanoma.
    Keywords endometrial adenocarcinoma ; bone metastasis ; subungual ; acral metastasis ; exophytic ; Medicine ; R
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Molecular Phylogenetic Relations of Achatina fulica Based on Partial Sequence of COI Gene

    Jena, C / S. Sarkar / N. Jalaja / S. Krupanidhi

    National Academy science letters. 2017 Apr., v. 40, no. 2

    2017  

    Abstract: The Giant African snail (Achatina fulica) is known to be a highly widespread and invasive species. However, none of the studies in India have shown whether there is any phylogenetic structure within the African giant snails of the Indian subcontinent. We ...

    Abstract The Giant African snail (Achatina fulica) is known to be a highly widespread and invasive species. However, none of the studies in India have shown whether there is any phylogenetic structure within the African giant snails of the Indian subcontinent. We have collected a sample of Achatina fulica from Odisha state, India and built a molecular phylogeny of achatinoid and non achatinoid taxa from across its distribution using a mitochondrial gene to infer whether the sample from Odisha is nested within the achatinoid taxa and also to notice whether the A. fulica is more closely related to the conspecifics from the Indian subcontinent or otherwise. Our results indicate a strong support for the monophyly of achatinoid taxa with our focal sample nested deep within the clade and branched with conspecifics from other regions of the Indian subcontinent. In addition, we also show that the family Orthalicidae is paraphyletic with respect to Streptaxida, a pattern that needs to be explored further in future studies.
    Keywords Achatina fulica ; genes ; invasive species ; mitochondria ; monophyly ; nucleotide sequences ; paraphyly ; India
    Language English
    Dates of publication 2017-04
    Size p. 101-103.
    Publishing place Springer India
    Document type Article
    ZDB-ID 2677544-X
    ISSN 2250-1754 ; 0250-541X
    ISSN (online) 2250-1754
    ISSN 0250-541X
    DOI 10.1007/s40009-017-0538-5
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Metastatic Endometrioid Carcinoma Mimicking a Subungual Melanoma.

    Glavy, Jena C / Peterson, Shian L / Strain, Jonathan / Byrd, Kevin / Flint, James H

    International journal of environmental research and public health

    2022  Volume 19, Issue 21

    Abstract: Case: We report a case of a 76-year-old female with a stage IB, grade I endometrioid endometrial carcinoma who presented with right-hip pain and an enlarging black, exophytic, subungual lesion on her right-small-finger distal phalanx. Clinically, the ... ...

    Abstract Case: We report a case of a 76-year-old female with a stage IB, grade I endometrioid endometrial carcinoma who presented with right-hip pain and an enlarging black, exophytic, subungual lesion on her right-small-finger distal phalanx. Clinically, the distal phalanx lesion was suspicious for a subungual melanoma; however, advanced imaging suggested metastatic disease, with lesions in the acetabulum, lungs, brain, vulva, and vagina.
    Conclusion: Partial amputation of the right, small finger and vulvar biopsies confirmed an endometrial carcinoma. To our knowledge, this is the first described case of endometrial adenocarcinoma metastasis to the phalanx of an upper extremity, mimicking a subungual melanoma.
    MeSH term(s) Humans ; Female ; Aged ; Carcinoma, Endometrioid/diagnosis ; Melanoma/diagnosis ; Endometrial Neoplasms/diagnosis ; Endometrial Neoplasms/pathology ; Adenocarcinoma/pathology ; Nail Diseases
    Language English
    Publishing date 2022-11-04
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192114494
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  8. Article ; Online: New Delhi: air-quality warning system cuts peak pollution.

    Ghude, Sachin D / Kumar, Rajesh / Govardhan, Gaurav / Jena, Chinmay / Nanjundiah, Ravi S / Rajeevan, M

    Nature

    2022  Volume 602, Issue 7896, Page(s) 211

    MeSH term(s) Air Pollutants/analysis ; Air Pollution/analysis ; Air Pollution/prevention & control ; India
    Chemical Substances Air Pollutants
    Language English
    Publishing date 2022-02-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-022-00332-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Estimating phenotypic stability for relevant yield and quality traits in French bean (

    Pramanik, Kartik / Sahu, Gouri Shankar / Chandra Acharya, Gobinda / Tripathy, Pradyumna / Dash, Manasi / Koundinya, A V V / Jena, Chinmaya / Kumar, Duvvada Sarath / Mohapatra, Priyadarshani P / Pradhan, Jyostnarani / Karubakee, S / Moharana, Durga Prasad

    Heliyon

    2024  Volume 10, Issue 5, Page(s) e26918

    Abstract: The presence of strong G x E (genotype by environment interaction) is a major hurdle for selecting superior genotypes when genotypes are placed into new and unfamiliar production systems. Genotype or cultivar (s) with high yield potential and having less ...

    Abstract The presence of strong G x E (genotype by environment interaction) is a major hurdle for selecting superior genotypes when genotypes are placed into new and unfamiliar production systems. Genotype or cultivar (s) with high yield potential and having less adaptability and stability to particular environment is never a suitable choice for a breeder and farmer particularly. Purposefully, four successive seasons were chosen to enumerate the phenotypic stability of 27 French bean genotypes for yield and quality traits by involving modern statistical tools like AMMI (Additive Main Effect and Multiplicative Interaction), GGE [G + (G x E)] and cluster analysis. AMMI analysis of variance witnessed magnitude of G, E and G x E was 81.94%, 11.58% and 6.48% of the total variation respectively. The IPCA I (Interaction Principal Component Axes) was contributed with 55.44%, 73.60%, 71.81%, 81.69% and 72.16% G x E variations of days to 50% flowering, pod length, number of pods per plant, average pod weight and pod yield respectively. For qualitative traits
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e26918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Sensitivity of WRF/Chem simulated PM2.5 to initial/boundary conditions and planetary boundary layer parameterization schemes over the Indo-Gangetic Plain.

    Gunwani, Preeti / Govardhan, Gaurav / Jena, Chinmay / Yadav, Prafull / Kulkarni, Santosh / Debnath, Sreyashi / Pawar, Pooja V / Khare, Manoj / Kaginalkar, Akshara / Kumar, Rajesh / Wagh, Sandeep / Chate, Dilip / Ghude, Sachin D

    Environmental monitoring and assessment

    2023  Volume 195, Issue 5, Page(s) 560

    Abstract: The ability of a chemical transport model to simulate accurate meteorological and chemical processes depends upon the physical parametrizations and quality of meteorological input data such as initial/boundary conditions. In this study, weather research ... ...

    Abstract The ability of a chemical transport model to simulate accurate meteorological and chemical processes depends upon the physical parametrizations and quality of meteorological input data such as initial/boundary conditions. In this study, weather research and forecasting model coupled with chemistry (WRF-Chem) is used to test the sensitivity of PM
    MeSH term(s) Air Pollutants/analysis ; Environmental Monitoring/methods ; India ; Weather ; Air Pollution/analysis ; Particulate Matter/analysis
    Chemical Substances Air Pollutants ; Particulate Matter
    Language English
    Publishing date 2023-04-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 782621-7
    ISSN 1573-2959 ; 0167-6369
    ISSN (online) 1573-2959
    ISSN 0167-6369
    DOI 10.1007/s10661-023-10987-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Z 5186: Show issues

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