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Book ; Thesis: Lebensqualität bei Kopfschmerzen - welchen Effekt hat Akupunktur?

Jena, Susanne

2008

Author's details	von Susanne Jena
Language	German
Size	89 Bl. : graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Berlin, Charité, Univ.-Med., Diss., 2008
HBZ-ID	HT015812634
Database	Catalogue ZB MED Medicine, Health

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2009 E 231	order for loan	Magazin

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Article ; Online: Copper Catalyzed Synthesis of Heterocyclic Molecules via C-N and C-O Bond Formation under Microwaves: A Mini-Review.

Jena, Sushovan / Chanda, Kaushik

ACS omega

2023 Volume 8, Issue 26, Page(s) 23240–23256

Abstract: Heterocyclic moieties play a significant role in the field of drug discovery. C-N and C-O bond formation reactions are the primary synthetic sequence for the generation of heterocyclic molecules. The generation of C-N and C-O bonds involves the use of ... ...

Abstract	Heterocyclic moieties play a significant role in the field of drug discovery. C-N and C-O bond formation reactions are the primary synthetic sequence for the generation of heterocyclic molecules. The generation of C-N and C-O bonds involves the use of mostly Pd or Cu catalysts although other transition metal catalyst's are also involved. However, in C-N and C-O bond formation reactions, several problems were faced such as catalytic systems containing costly ligands, lack of substrate scope, lots of waste generation, and high temperature conditions. So it is imperative to uncover new eco-friendly synthetic strategies. In view of enormous drawbacks, it is important to develop an alternate microwave-assisted synthesis of heterocycles via C-N and C-O bond formation, which provides a short reaction time, tolerance for functional groups, and less waste production. Numerous chemical reactions have been accelerated using microwave irradiation which provides a cleaner reaction profile, lower energy consumption, and higher yields. This review article highlights a comprehensive overview on the potential application of microwave assisted synthetic routes for the synthesis of diverse heterocycles via mechanistic pathways covering the year ranges from 2014 to 2023, along with possible biological interests.
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c02041
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Performance monitoring and error detection: The role of mid frontal theta and error-related negativity (ERN) among Indian adolescents from different socioeconomic background.

Raturi, Aman Kumar / Narayanan, Sreelatha S / Jena, S P K

Applied neuropsychology. Child

2024 , Page(s) 1–13

Abstract: The aim of the study was to investigate the relationship between socioeconomic status (SES) and executive functioning, focusing specifically on performance monitoring, error detection, and their association with mid-frontal theta and error-related ... ...

Abstract	The aim of the study was to investigate the relationship between socioeconomic status (SES) and executive functioning, focusing specifically on performance monitoring, error detection, and their association with mid-frontal theta and error-related negativity (ERN). Employing the widely used flanker task, the research involved two phases with participants aged 10-16 years (15 individuals in the pilot phase and 35 in the second phase). Electroencephalogram (EEG) recordings from distinct brain regions were analyzed during various conditions. The study revealed a notable increase in both absolute and relative theta power at Fcz during the flanker task, with a stronger effect observed during incorrect trials. Furthermore, it underscored the influence of socioeconomic status (SES) on mid-frontal theta, highlighting interactions between SES, gender, and experimental conditions impacting both absolute and relative theta. Intriguingly, the research disclosed a positive correlation between parental occupation and error-related negativity (ERN), as well as between age and ERN. These findings underscore the significance of SES, gender, and age in shaping the neural mechanisms associated with performance monitoring and executive functions. The study contributes valuable insights into the intricate interplay between socio-demographic factors and cognitive processes, shedding light on their impact on goal-directed behaviors and brain activity.
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2673759-0
ISSN	2162-2973 ; 2162-2965
ISSN (online)	2162-2973
ISSN	2162-2965
DOI	10.1080/21622965.2024.2333809
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Article ; Online: Spherical Cap Studs: A novel speed bump alternative to reduce discomfort with effective speed reduction.

Advani, Nainesh / Danak, Het / Dutta, Manish / Jena, Suprava

Traffic injury prevention

2024 Volume 25, Issue 2, Page(s) 228–236

Abstract: Objective: The aim of this study is to assess the potential of Spherical Cap Studs (SCS) as a substitute for conventional speed bumps, with a focus on limiting two wheeler speed while minimizing discomfort to riders by comparing the speed reduction ... ...

Abstract	Objective: The aim of this study is to assess the potential of Spherical Cap Studs (SCS) as a substitute for conventional speed bumps, with a focus on limiting two wheeler speed while minimizing discomfort to riders by comparing the speed reduction capabilities and discomfort levels associated with SCS and speed bumps. Methods: The study uses experimental approach to compare the speed limiting ability and discomfort caused to rider by the proposed SCS and a standard speed bump. Speed profiles were developed for two wheelers passing over both SCS and speed bump. The parameter employed to compare speed profiles is the Mean Absolute Percentage Difference (MAPD), offering valuable insights into how effectively the two traffic calming measures reduce two wheeler speeds. To compare discomfort, the study calculates the 'Vibration Dose Value' (VDV) experienced by riders when traversing both speed bump and SCS. Additionally, 'Static Compressive Stress' (S Results: The analysis of speed profiles reveals an MAPD value of 13.70% indicating that SCS exhibits speed reduction capabilities comparable to traditional speed bump. In terms of discomfort, the VDV for two wheelers passing over a speed bump is measured at 5.92 m/s Conclusion: The study's findings support the potential adoption of SCS as an effective alternative to conventional speed bumps for controlling two wheeler speeds. SCS demonstrate a speed reduction capability similar to that of traditional speed bumps while significantly alleviating discomfort for riders. SCS is expected to be a promising solution for traffic calming purposes in various settings, such as markets, residential areas, institutional campuses, and parking lots.
MeSH term(s)	Humans ; Accidents, Traffic ; Anxiety
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2089818-6
ISSN	1538-957X ; 1538-9588
ISSN (online)	1538-957X
ISSN	1538-9588
DOI	10.1080/15389588.2023.2278415
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Article ; Online: Disability in Patients With Bipolar Disorder in Full or Partial Remission: A Cross-Sectional Study.

Sengupta, Gunja / Jena, Shivananda

The primary care companion for CNS disorders

2022 Volume 24, Issue 5

Abstract: Objective:: Methods:: Results:: Conclusions: ...

Abstract	Objective: Methods: Results: Conclusions:
MeSH term(s)	Bipolar Disorder/drug therapy ; Cross-Sectional Studies ; Diagnostic and Statistical Manual of Mental Disorders ; Humans ; Mania ; Psychiatric Status Rating Scales
Language	English
Publishing date	2022-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2675414-9
ISSN	2155-7780 ; 2155-7780
ISSN (online)	2155-7780
ISSN	2155-7780
DOI	10.4088/PCC.21m03183
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Article ; Online: Fluorescence Lifetime Imaging Probes for Cell-Based Measurements of Enzyme Activity.

Jena, Sampreeti / Parker, Laurie L

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2394, Page(s) 133–162

Abstract: Posttranslational modification (PTM) enzymes are important modulators of protein structure and function. They typically act by chemically modifying amino acids, often on side chain functional groups, to change the physiochemical landscape of the protein ... ...

Abstract	Posttranslational modification (PTM) enzymes are important modulators of protein structure and function. They typically act by chemically modifying amino acids, often on side chain functional groups, to change the physiochemical landscape of the protein and thus its biophysical behavior. In particular, protein kinases are enzymes that transfer phosphate from ATP to serine, threonine, or tyrosine in protein substrates. They are key regulators of vital cellular pathways such as survival, proliferation, and apoptosis, and their dysregulation in the context of cancer has been widely investigated for the purpose of development of anticancer drugs. However, several critical questions pertaining to their physiology, such as heterogeneity of kinase signaling within and between cells, and other factors that may play into the mechanisms of drug resistance, remain unanswered. Many of the current strategies to measure kinase activity lack the scope, subcellular resolution, and real-time monitoring ability needed to obtain the type of information needed about their dynamics and localization in cells. While FRET-based biosensors are capable of dynamic single cell imaging, their applications can be limited by difficulties in multiplexing and the inherent inadequacies of steady state measurements. In this chapter, we describe our fluorescence lifetime imaging microscopy (FLIM) probe technology in which peptide kinase substrates, linked to cell-penetrating peptides and labeled with small molecule fluorophores, are used to report kinase activity through time-resolved fluorescence imaging to visualize and quantify changes to the probe's fluorescence lifetime. These can be multiplexed for more than one kinase at a time, and interpretation is not affected by differences in local intensity due to probe uptake and distribution or photobleaching. With careful choice of peptide substrate(s), fluorophore label, and imaging set-up, high specificity and spatiotemporal resolution can be achieved. Due to the mechanism by which the lifetime change occurs, this approach is compatible with other PTMs (such as acetylation, methylation), and so the considerations for kinase FLIM probe design described in this chapter should be broadly applicable for other PTMs as well.
MeSH term(s)	Fluorescence Resonance Energy Transfer ; Fluorescent Dyes/chemistry ; Microscopy, Fluorescence/methods ; Optical Imaging ; Photobleaching
Chemical Substances	Fluorescent Dyes
Language	English
Publishing date	2022-01-29
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1811-0_9
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Article: Psychiatric comorbidity and quality of life in patients with bipolar disorder.

Sengupta, Gunja / Jena, Shivananda

Industrial psychiatry journal

2022 Volume 31, Issue 2, Page(s) 318–324

Abstract: Background: Psychiatric comorbidity in patients with bipolar disorder (BD) has been associated with an earlier onset, rapid cycling, worsening severity and outcome, and increased suicidality. Patients with BD have been reported to have poor quality of ... ...

Abstract	Background: Psychiatric comorbidity in patients with bipolar disorder (BD) has been associated with an earlier onset, rapid cycling, worsening severity and outcome, and increased suicidality. Patients with BD have been reported to have poor quality of life (QOL) even during remission. Aims and objectives: Estimate the prevalence of psychiatric comorbidity and assess the QOL in patients with BD, and find the associated sociodemographic and clinical variables. Materials and methods: This cross-sectional study was done in a general hospital psychiatric unit on 100 patients (both inpatients and outpatients) with DSM-IV-TR BD in partial or complete remission. Patients were assessed using a semi-structured pro forma, Mini International Neuropsychiatric Interview 6.0 - Hindi version, Hamilton Rating Scale for Depression or Young Mania Rating Scale and World Health Organization QOL instrument, short-form (WHOQOL-BREF), Hindi Version. Results: Sixty-one percent of the sample had at least one psychiatric comorbidity, and the commonest comorbid disorders were substance use disorders (SUD) (30%) and anxiety disorders (AD) (28%). Male gender was identified as a predictor for comorbidity in BD. The mean QOL-BREF score was 85.96 ± 14.35. Poor QOL was associated with older age at onset of comorbidity, multiple comorbidities, mixed episodes, rapid cycling, partial remission, and increased severity of depression while patients with current hypomanic symptoms were found to have better QOL. BD with comorbidity had worse QOL than those without comorbidity. Conclusion: The majority of patients with BD had at least one comorbidity. SUD were the most common comorbid disorders. QOL, already poor in BD patients, was poorer in cases with comorbidity.
Language	English
Publishing date	2022-06-27
Publishing country	India
Document type	Journal Article
ZDB-ID	2580355-4
ISSN	0976-2795 ; 0972-6748
ISSN (online)	0976-2795
ISSN	0972-6748
DOI	10.4103/ipj.ipj_24_21
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Article: An Audit of Breast Conservation Surgery for Breast Cancer - a 7-Year Experience from Southern India.

Ranganath, R / Hui, Monalisa / Uppin, Shantveer / Jena, S / Shantappa, Rajshekar

Indian journal of surgical oncology

2022 Volume 14, Issue 2, Page(s) 492–496

Abstract: To audit the use of breast conservation surgery for breast cancer treatment in a tertiary care centre over a 7-year period, and also to chart the clinical, demographic and pathological characteristics of breast cancer patients treated in the setting of a ...

Abstract	To audit the use of breast conservation surgery for breast cancer treatment in a tertiary care centre over a 7-year period, and also to chart the clinical, demographic and pathological characteristics of breast cancer patients treated in the setting of a referral centre in a middle income (MDI) group country. A retrospective analysis of the case records of all patients of invasive breast cancer treated at our institute between January 2014 and December 2020 was done after obtaining approval from the Institute Ethics Committee (IEC). The number of patients seen, age, parity, menopausal status, family history of cancer, laterality, site of tumour in the breast, the symptomatology, clinical stage and presence or absence of metastases was the clinical parameters examined. The pathological stage and grade of the tumour, receptor status, treatment offered according to stage and the patterns of failure with respect to the surgery performed were recorded. Statistical analysis was a direct head to head comparison of the percentage proportions of the different variables. A total of 685 patients of breast cancer were treated between January 2014 and December 2020. A total of 53% of the cohort was more than 45 years old and 56.7% were post menopausal. A total of 58.8% of the patients presented with a cancer in the left breast and in the upper outer quadrant. Nearly 41% of the tumours were more than 4 cm in size. The most common receptor profile in our patient population was ER positive, PR positive and HER 2 negative. A total of 27.7% of the patients were offered neo-adjuvant chemotherapy and 63.06% underwent upfront surgery. A total of 19.7% of all surgeries performed (overall) were breast conservation surgeries (BCS). The use of BCS showed an increasing trend over the 7 years studied rising from 16.79 to 25% (annually). The local failure rate for BCS was 11.8% but the incidence of distant metastases was not significantly different compared to the patients who underwent a mastectomy. Breast conservation is safe and feasible in a referral setting even in a middle income nation with multi-disciplinary treatment planning and needs to be adopted widely to preserve the body image and self esteem of patients with breast cancer.
Language	English
Publishing date	2022-04-18
Publishing country	India
Document type	Journal Article
ZDB-ID	2568289-1
ISSN	0976-6952 ; 0975-7651
ISSN (online)	0976-6952
ISSN	0975-7651
DOI	10.1007/s13193-022-01532-8
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Article ; Online: Concurrent replacement of four major joints in a woman with advanced rheumatoid arthritis.

Tripathy, Sujit K / Jain, Mantu / Varghese, Paulson / Jena, Sritam

BMJ case reports

2024 Volume 17, Issue 2

Abstract: We report a case of a woman in her mid-40s with advanced rheumatoid arthritis (RA), with bilateral hip and knee joint involvement, who underwent a one-stage quadruple joint arthroplasty during a single session of anaesthesia. Chronic RA had severely ... ...

Abstract	We report a case of a woman in her mid-40s with advanced rheumatoid arthritis (RA), with bilateral hip and knee joint involvement, who underwent a one-stage quadruple joint arthroplasty during a single session of anaesthesia. Chronic RA had severely incapacitated her, necessitating this uncommon surgical intervention. The surgical approach involved sequential bilateral total hip and knee replacements, which were completed within 180 min with a cumulative blood loss of 950 mL. The patient showed significant improvement with rapid mobilisation and regained joint function postoperatively. At 8 months post-surgery, the patient resumed her daily activities, showcasing the potential benefits and positive outcomes of quadruple joint arthroplasty in selected RA patients. This case, only the second documented globally, highlights the complexities and possibilities surrounding a single-stage quadruple joint arthroplasty in advanced RA.
MeSH term(s)	Female ; Humans ; Arthritis, Rheumatoid/complications ; Arthroplasty, Replacement, Hip ; Arthroplasty, Replacement, Knee ; Knee Joint/diagnostic imaging ; Knee Joint/surgery ; Movement ; Middle Aged
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2023-258214
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Book: Behaviour therapy

Jena, S. P. K.

techniques, research and applications

2008

Author's details	S. P. K. Jena
Keywords	Behavior Therapy ; Behavior therapy
Subject code	616.89142
Language	English
Size	XVII, 261 S. : ill., graph. Darst., 25cm
Publisher	SAGE
Publishing place	Los Angeles u.a.
Publishing country	United States
Document type	Book
Note	The philosophical and historical foundations -- Conceptual issues -- Psychobiological basis of behaviour therapy behavioural markers -- Developmental perspective -- Behavioural assessment and diagnosis -- Reinforcing desirable responding -- Developing new behaviour -- Modelling and observational learning rationale -- Aversive procedures -- Non-aversive procedures -- Exposure procedures -- Relaxation and systematic desensitisation -- Restricted environmental stimulation techniques -- Eye movement desensitisation reprocessing: EMDR -- Covert conditioning procedures -- Cognitive-behaviour therapy -- Research designs -- The evidence-based approach -- Ethical issues in behaviour therapy. - Includes bibliographical references (p. 185-227) and index
HBZ-ID	HT016018378
ISBN	978-0-7619-3624-4 ; 0-7619-3624-6 ; 978-81-7829-788-0 ; 81-7829-788-4
Database	Catalogue ZB MED Medicine, Health

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