Article ; Online: Kaposi sarcoma in the setting of cushing disease.
2008 Volume 17, Issue 4, Page(s) e87–91
Abstract: Objective: To report a case of a human immunodeficiency virus (HIV)-negative Kaposi sarcoma (KS) associated with Cushing disease (CD).: Methods: The details of case presentation, evaluation, diagnosis, and treatment are presented and cases of KS and ... ...
Abstract | Objective: To report a case of a human immunodeficiency virus (HIV)-negative Kaposi sarcoma (KS) associated with Cushing disease (CD). Methods: The details of case presentation, evaluation, diagnosis, and treatment are presented and cases of KS and CD published before November 1, 2010 on PubMed and Scopus are reviewed. Results: A 54-year-old Hispanic HIV-negative man presented with typical signs and symptoms of CD (easy bruisability, proximal muscle wasting, and abdominal fat pads). Numerous raised, purplish, nonblanching plaques 0.5 to 2 cm in diameter extended throughout his lower extremities. Biochemical tests and pituitary magnetic resonance imaging confirmed CD. A lesion biopsy showed atypical vascular proliferation positive by immunohistochemistry for human herpesvirus 8 (HHV-8), consistent with KS. He underwent 2 transsphenoidal surgeries followed by a bilateral adrenalectomy. After recovery, his KS was treated with a systemic combination of liposomal doxorubicin and paclitaxel. Conclusion: The occurrence of CD and KS is rare. Specific therapy for CD and chemotherapy for KS are effective in the treatment of KS associated with CD. |
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MeSH term(s) | Antineoplastic Agents/therapeutic use ; Doxorubicin/therapeutic use ; Herpesvirus 8, Human/pathogenicity ; Humans ; Male ; Middle Aged ; Paclitaxel/therapeutic use ; Pituitary ACTH Hypersecretion/diagnosis ; Pituitary ACTH Hypersecretion/virology ; Sarcoma, Kaposi/diagnosis ; Sarcoma, Kaposi/virology |
Chemical Substances | Antineoplastic Agents ; Doxorubicin (80168379AG) ; Paclitaxel (P88XT4IS4D) |
Language | English |
Publishing date | 2008-09-13 |
Publishing country | United States |
Document type | Case Reports ; Journal Article |
ZDB-ID | 1473503-9 |
ISSN | 1934-2403 ; 1530-891X |
ISSN (online) | 1934-2403 |
ISSN | 1530-891X |
DOI | 10.4158/EP10355.CR |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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