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Article ; Online: 'Meningiomics'-an integration of data on the patient, tumour, extent of resection and molecular pathology to optimise the management and follow-up for meningiomas.

Jenkinson, Michael D

2019 Volume 161, Issue 12, Page(s) 2551–2552

MeSH term(s)	Follow-Up Studies ; Humans ; Meningeal Neoplasms ; Meningioma ; Pathology, Molecular
Language	English
Publishing date	2019-10-28
Publishing country	Austria
Document type	Editorial ; Comment
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-019-04102-0
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Article ; Online: Incidence and Risk Factors of Surgical Site Infection After Cranial Surgery for Patients with Brain Tumors: A Systematic Review and Meta-analysis.

Lee, Keng Siang / Borbas, Balint / Plaha, Puneet / Ashkan, Keyoumars / Jenkinson, Michael D / Price, Stephen J

World neurosurgery

2024

Abstract: Background: Surgical site infections after craniotomy (SSI-CRANs) are a serious adverse event given the proximity of the wound to the central nervous system. SSI-CRANs are associated with substantial patient morbidity and mortality. Despite the ... ...

Abstract	Background: Surgical site infections after craniotomy (SSI-CRANs) are a serious adverse event given the proximity of the wound to the central nervous system. SSI-CRANs are associated with substantial patient morbidity and mortality. Despite the importance and recognition of this event in other surgical fields, there is a paucity of evidence in the neurosurgical literature devoted to SSI-CRAN specifically in patients after brain tumor surgery. Methods: Systematic searches of Medline, Embase, and Cochrane Central were undertaken. The primary outcome was the incidence of SSI-CRAN at 30 and 90 days. Secondary outcomes were risk factors for SSI-CRAN. Results: Thirty-seven studies reporting 91,907 patients with brain tumors who underwent cranial surgery were included in the meta-analysis. Pooled incidence of SSI-CRAN at 30 and 90 days was 4.03% (95% CI: 2.94%-5.28%, I Conclusions: SSI-CRAN affects up to 1 in 14 patients with brain tumors. High-risk groups include those with reintervention, previous radiotherapy, longer duration of operation, and CSF leaks. Further prospective studies should focus on bundles of care that will reduce SSI-CRAN.
Language	English
Publishing date	2024-03-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2024.02.133
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Article ; Online: Letter: Estimating the baseline local recurrence rate for a brain metastasis after neurosurgical resection.

Suppree, Joshua S / Kannan, Siddarth / Hughes, David M / Jenkinson, Michael D / Zakaria, Rasheed

Clinical & experimental metastasis

2024 Volume 41, Issue 2, Page(s) 155–157

Abstract: Brain metastases represent a growing healthcare challenge with a rising incidence attributed to earlier detection and improved systemic cancer treatments. We conducted a systematic review and meta-analysis to investigate the local recurrence rate ... ...

Abstract	Brain metastases represent a growing healthcare challenge with a rising incidence attributed to earlier detection and improved systemic cancer treatments. We conducted a systematic review and meta-analysis to investigate the local recurrence rate following surgical resection of a brain metastasis without adjuvant therapy. The analysis included four studies with a total of 235 cases. It was found that the rate of local recurrence by 12-months was 48.1% (95% CI 41.2-58.9). These findings underscore the high rate of patients who will experience local recurrence within 12-months of surgery, emphasising the need for vigilant surveillance when omitting adjuvant radiotherapy in favour of systemic treatments with potential but unproven CNS penetrance. The analysis highlights unmet needs in this patient population.
MeSH term(s)	Humans ; Brain Neoplasms/secondary ; Radiotherapy, Adjuvant ; Combined Modality Therapy ; Radiosurgery ; Neoplasm Recurrence, Local/surgery ; Retrospective Studies
Language	English
Publishing date	2024-02-14
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Letter
ZDB-ID	604952-7
ISSN	1573-7276 ; 0262-0898
ISSN (online)	1573-7276
ISSN	0262-0898
DOI	10.1007/s10585-024-10274-6
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Article ; Online: LAT1, a novel pharmacological target for the treatment of glioblastoma.

Cappoli, Natalia / Jenkinson, Michael D / Dello Russo, Cinzia / Dickens, David

Biochemical pharmacology

2022 Volume 201, Page(s) 115103

Abstract: The L-Type Amino Acid transporter, LAT1 (SLC7A5), has a crucial role in mediating amino acid uptake into the cells, thus modulating cell growth and proliferation as well as other intracellular functions. Different studies have reported a central role of ... ...

Abstract	The L-Type Amino Acid transporter, LAT1 (SLC7A5), has a crucial role in mediating amino acid uptake into the cells, thus modulating cell growth and proliferation as well as other intracellular functions. Different studies have reported a central role of LAT1 in glioblastoma development and progression, suggesting that the modulation of its activity could be a novel therapeutic strategy. LAT1 also has an important role in the peripheral immune system, by regulating the activation status of several immune cells through modulation of the mechanistic target of rapamycin kinase. In glioblastoma (GBM), the blood-brain barrier is disrupted, which allows the recruitment of peripheral immune cells to the tumour site. These cells, together with resident microglia, contribute to cancer growth and progression. Currently, little is known about the function of LAT1 in the reprogramming of the immune component of the tumour microenvironment in the context of GBM. In this article, we review the available data on the role of LAT1 in the regulation of GBM biology, including its potential role in the tumour microenvironment, particularly in infiltrating-peripheral immune cells and resident microglial cells. In addition, we review the available data on the main pharmacological inhibitors of LAT1, aiming to evaluate their possible role as novel therapeutics for GBM.
MeSH term(s)	Blood-Brain Barrier/metabolism ; Cell Proliferation ; Glioblastoma/drug therapy ; Glioblastoma/pathology ; Humans ; Large Neutral Amino Acid-Transporter 1/metabolism ; Tumor Microenvironment
Chemical Substances	Large Neutral Amino Acid-Transporter 1
Language	English
Publishing date	2022-05-23
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2022.115103
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Article ; Online: Evaluation of systemic inflammation in seizure phenotypes following meningioma resection.

Bakhsh, Ali / Gillespie, Conor S / Richardson, George E / Mustafa, Mohammed A / Millward, Christopher P / Mirza, Nasir / Jenkinson, Michael D

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2024 Volume 120, Page(s) 82–86

Abstract: Purpose: To investigate the association between perioperative peripheral blood inflammatory markers and seizures in patients who have undergone meningioma resection.: Materials and methods: A single neurosurgery tertiary centre blood bank database ... ...

Abstract	Purpose: To investigate the association between perioperative peripheral blood inflammatory markers and seizures in patients who have undergone meningioma resection. Materials and methods: A single neurosurgery tertiary centre blood bank database was screened to extract pre-operative and post-operative white cell count (WCC), neutrophils, lymphocytes, monocytes, platelets and neutrophil-lymphocyte ratio (NLR) and derived NLR (dNLR). All patients who underwent resection of meningioma from 2012 to 2020 were eligible. Patients were excluded if they had an inflammatory condition, peri-operative infection, medical illness or operative complication. Results: 30 patients suffered pre-operative seizures only, 16 experienced de novo post-operative seizures within 1 year and 42 patients did not experience seizures throughout their treatment timeline. Patients with post-operative de novo seizures had a significantly higher WCC when compared those who never had a seizure (7.1 vs. 4.8x10 Conclusions: There is a significantly higher post-operative systemic white cell count response in patients who suffered de novo seizures after meningioma resection. Peripheral blood markers have the potential to predict seizures in patients with meningioma.
MeSH term(s)	Humans ; Meningioma/surgery ; Meningioma/complications ; Inflammation/complications ; Seizures/diagnosis ; Seizures/etiology ; Lymphocytes ; Neutrophils ; Meningeal Neoplasms/surgery ; Meningeal Neoplasms/complications ; Phenotype ; Retrospective Studies ; Prognosis
Language	English
Publishing date	2024-01-13
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2024.01.003
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Article ; Online: Investigating centrifugal filtration of serum-based FTIR spectroscopy for the stratification of brain tumours.

Theakstone, Ashton G / Brennan, Paul M / Jenkinson, Michael D / Goodacre, Royston / Baker, Matthew J

PloS one

2023 Volume 18, Issue 2, Page(s) e0279669

Abstract: Discrimination of brain cancer versus non-cancer patients using serum-based attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy diagnostics was first developed by Hands et al with a reported sensitivity of 92.8% and specificity ...

Abstract	Discrimination of brain cancer versus non-cancer patients using serum-based attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy diagnostics was first developed by Hands et al with a reported sensitivity of 92.8% and specificity of 91.5%. Cameron et al. then went on to stratifying between specific brain tumour types: glioblastoma multiforme (GBM) vs. primary cerebral lymphoma with a sensitivity of 90.1% and specificity of 86.3%. Expanding on these studies, 30 GBM, 30 lymphoma and 30 non-cancer patients were selected to investigate the influence on test performance by focusing on specific molecular weight regions of the patient serum. Membrane filters with molecular weight cut offs of 100 kDa, 50 kDa, 30 kDa, 10 kDa and 3 kDa were purchased in order to remove the most abundant high molecular weight components. Three groups were classified using both partial least squares-discriminate analysis (PLS-DA) and random forest (RF) machine learning algorithms; GBM versus non-cancer, lymphoma versus non-cancer and GBM versus lymphoma. For all groups, once the serum was filtered the sensitivity, specificity and overall balanced accuracies decreased. This illustrates that the high molecular weight components are required for discrimination between cancer and non-cancer as well as between tumour types. From a clinical application point of view, this is preferable as less sample preparation is required.
MeSH term(s)	Humans ; Spectroscopy, Fourier Transform Infrared/methods ; Brain Neoplasms/diagnosis ; Lymphoma/diagnosis ; Glioblastoma/diagnosis ; Least-Squares Analysis
Language	English
Publishing date	2023-02-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0279669
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Article: Clinical Presentation and Prognosis.

Millward, Christopher P / Keshwara, Sumirat / Islim, Abdurrahman I / Zakaria, Rasheed / Jenkinson, Michael D

Advances in experimental medicine and biology

2023 Volume 1416, Page(s) 5–20

Abstract: Over the past three decades, the care for patients with meningioma has steadily improved as a result of a better understanding of the natural history, molecular biology, and classification of these tumors. Surgical frameworks for management have been ... ...

Abstract	Over the past three decades, the care for patients with meningioma has steadily improved as a result of a better understanding of the natural history, molecular biology, and classification of these tumors. Surgical frameworks for management have been established and validated with more options for adjuvant and salvage treatment available for patients with residual or recurrent disease. Overall these advances have improved clinical outcomes and prognosis.Alongside the improved clinical management has come an increase in biological understanding of these tumors. The number of publications within the field of meningioma research continues to expand and biological studies identifying molecular factors at the cytogenic and genomic level offer exciting potential for more personalized management strategies. As survival and understanding have increased, treatment outcomes are moving from traditional metrics, which describe the morbidity and mortality to more patient-centered measures. The subjective experiences of patients with meningioma are gaining interest among clinical researchers and it is recognized that even supposedly mild symptoms arising from meningioma can have a significant effect on a patient's quality of life.This chapter reviews the varied clinical presentations of meningioma, which in the modern era of widespread brain imaging must include a discussion of incidental meningioma. The second part examines prognosis and the clinical, pathological, and molecular factors that can be used to predict outcomes.
MeSH term(s)	Humans ; Meningioma/diagnosis ; Meningioma/genetics ; Meningioma/therapy ; Quality of Life ; Adjuvants, Immunologic ; Benchmarking ; Meningeal Neoplasms
Chemical Substances	Adjuvants, Immunologic
Language	English
Publishing date	2023-07-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	410187-X
ISSN	0065-2598
ISSN	0065-2598
DOI	10.1007/978-3-031-29750-2_2
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Zs.A 3192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: A semi-automatic segmentation method for meningioma developed using a variational approach model.

Burrows, Liam / Patel, Jay / Islim, Abdurrahman I / Jenkinson, Michael D / Mills, Samantha J / Chen, Ke

The neuroradiology journal

2023 Volume 37, Issue 2, Page(s) 199–205

Abstract: Background: Meningioma is the commonest primary brain tumour. Volumetric post-contrast magnetic resonance imaging (MRI) is recognised as gold standard for delineation of meningioma volume but is hindered by manual processing times. We aimed to ... ...

Abstract	Background: Meningioma is the commonest primary brain tumour. Volumetric post-contrast magnetic resonance imaging (MRI) is recognised as gold standard for delineation of meningioma volume but is hindered by manual processing times. We aimed to investigate the utility of a model-based variational approach in segmenting meningioma. Methods: A database of patients with a meningioma (2007-2015) was queried for patients with a contrast-enhanced volumetric MRI, who had consented to a research tissue biobank. Manual segmentation by a neuroradiologist was performed and results were compared to the mathematical model, using a battery of tests including the Sørensen-Dice coefficient (DICE) and JACCARD index. A publicly available meningioma dataset (708 segmented T1 contrast-enhanced slices) was also used to test the reliability of the model. Results: 49 meningioma cases were included. The most common meningioma location was convexity ( Conclusions: Segmentation of meningioma volume using the proposed mathematical model was possible with accurate results. Application of this model on contrast-enhanced volumetric imaging may help reduce work burden on neuroradiologists with the increasing number in meningioma diagnoses.
MeSH term(s)	Humans ; Meningioma/diagnostic imaging ; Reproducibility of Results ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods ; Meningeal Neoplasms/diagnostic imaging
Language	English
Publishing date	2023-12-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2257770-1
ISSN	2385-1996 ; 1971-4009 ; 1120-9976
ISSN (online)	2385-1996
ISSN	1971-4009 ; 1120-9976
DOI	10.1177/19714009231224442
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Article ; Online: COVID-legal study: neurosurgeon experience in Britain during the first phase of the COVID-19 pandemic - medico-legal considerations.

Finn, Roisin / Ganau, Mario / Jenkinson, Michael D / Plaha, Puneet

British journal of neurosurgery

2021 Volume 35, Issue 5, Page(s) 547–550

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	COVID-19 ; Humans ; Neurosurgeons ; Neurosurgical Procedures ; Pandemics ; SARS-CoV-2 ; Surveys and Questionnaires ; United Kingdom/epidemiology
Language	English
Publishing date	2021-03-24
Publishing country	England
Document type	Journal Article
ZDB-ID	639029-8
ISSN	1360-046X ; 0268-8697
ISSN (online)	1360-046X
ISSN	0268-8697
DOI	10.1080/02688697.2021.1902475
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Article ; Online: Management of pineal and colloid cysts.

Jenkinson, Michael D / Mills, Samantha / Mallucci, Conor L / Santarius, Thomas

Practical neurology

2021

Abstract: The widespread use of MRI has led to the increasingly frequent diagnosis of pineal and colloid cysts. While most are small and incidental, do not require long-term monitoring and will never need treatment, they are a cause of patient anxiety and ... ...

Abstract	The widespread use of MRI has led to the increasingly frequent diagnosis of pineal and colloid cysts. While most are small and incidental, do not require long-term monitoring and will never need treatment, they are a cause of patient anxiety and clinician uncertainty regarding the optimal management-particularly for larger cysts or those with an atypical appearance. Occasionally pineal cysts, and more commonly colloid cysts, cause hydrocephalus that requires urgent neurosurgical treatment. More recently the non-hydrocephalic symptomatic pineal cyst has been described in the neurosurgical literature but there is controversy over this entity and its management. This review addresses the difficulties in managing pineal and colloid cysts and provides a pragmatic framework for the practising clinician.
Language	English
Publishing date	2021-05-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2170881-2
ISSN	1474-7766 ; 1474-7758
ISSN (online)	1474-7766
ISSN	1474-7758
DOI	10.1136/practneurol-2020-002838
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