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Article ; Online: The alarmin IL33 orchestrates type 2 immune-mediated control of thymus regeneration.

Cosway, Emilie J / James, Kieran D / White, Andrea J / Parnell, Sonia M / Bacon, Andrea / McKenzie, Andrew N J / Jenkinson, W E / Anderson, Graham

Nature communications

2023  Volume 14, Issue 1, Page(s) 7201

Abstract: As the primary site of T-cell development, the thymus dictates immune competency of the host. The rates of thymus function are not constant, and thymus regeneration is essential to restore new T-cell production following tissue damage from environmental ... ...

Abstract As the primary site of T-cell development, the thymus dictates immune competency of the host. The rates of thymus function are not constant, and thymus regeneration is essential to restore new T-cell production following tissue damage from environmental factors and therapeutic interventions. Here, we show the alarmin interleukin (IL) 33 is a product of Sca1
MeSH term(s) Interleukin-33 ; Alarmins ; Immunity, Innate ; Interleukin-4 ; Lymphocytes
Chemical Substances Interleukin-33 ; Alarmins ; Interleukin-4 (207137-56-2)
Language English
Publishing date 2023-11-08
Publishing country England
Document type Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID 2553671-0
ISSN 2041-1723 ; 2041-1723
ISSN (online) 2041-1723
ISSN 2041-1723
DOI 10.1038/s41467-023-43072-x
Database MEDical Literature Analysis and Retrieval System OnLINE

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