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  1. Article ; Online: An Overview of Environmental Risk Factors for Food Allergy

    Rachel L. Peters / Suzanne Mavoa / Jennifer J. Koplin

    International Journal of Environmental Research and Public Health, Vol 19, Iss 722, p

    2022  Volume 722

    Abstract: IgE-mediated food allergy is an increasing public health concern in many regions around the world. Although genetics play a role in the development of food allergy, the reported increase has occurred largely within a single generation and therefore it is ...

    Abstract IgE-mediated food allergy is an increasing public health concern in many regions around the world. Although genetics play a role in the development of food allergy, the reported increase has occurred largely within a single generation and therefore it is unlikely that this can be accounted for by changes in the human genome. Environmental factors must play a key role. While there is strong evidence to support the early introduction of allergenic solids to prevent food allergy, this is unlikely to be sufficient to prevent all food allergy. The purpose of this review is to summarize the evidence on risk factors for food allergy with a focus the outdoor physical environment. We discuss emerging evidence of mechanisms that could explain a role for vitamin D, air pollution, environmental greenness, and pollen exposure in the development of food allergy. We also describe the recent extension of the dual allergen exposure hypothesis to potentially include the respiratory epithelial barrier in addition to the skin. Few existing studies have examined the relationship between these environmental factors with objective measures of IgE-mediated food allergy and further research in this area is needed. Future research also needs to consider the complex interplay between multiple environmental factors.
    Keywords food allergy ; vitamin D ; environmental greenness ; air pollution ; pollen ; biodiversity ; Medicine ; R
    Subject code 333
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Mass cytometry analysis of blood from peanut-sensitized tolerant and clinically allergic infants

    Amanda R. Tursi / Nicholas K. Saba / Diane Dunham / Monali Manohar / Rachel L. Peters / Richard Saffery / Jennifer J. Koplin / Kari C. Nadeau / Melanie R. Neeland / Sandra Andorf

    Scientific Data, Vol 9, Iss 1, Pp 1-

    2022  Volume 8

    Abstract: Measurement(s) expression profiling Technology Type(s) cytometry time of flight assay Sample Characteristic - Organism Homo sapiens Sample Characteristic - Location ... ...

    Abstract Measurement(s) expression profiling Technology Type(s) cytometry time of flight assay Sample Characteristic - Organism Homo sapiens Sample Characteristic - Location Australia
    Keywords Science ; Q
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: PrEggNut Study

    Kirsten P Perrett / Jennifer J Koplin / Dianne E Campbell / Michael O'Sullivan / Maria Makrides / Michael S Gold / Patrick Quinn / Thomas R Sullivan / Rosalie Grivell / Susan L Prescott / Merryn J Netting / Ralph Nanan / Debra J Palmer / Peter S Hsu / Vicki McWilliam

    BMJ Open, Vol 12, Iss

    protocol for a randomised controlled trial investigating the effect of a maternal diet rich in eggs and peanuts from

    2022  Volume 6

    Keywords Medicine ; R
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Backyard benefits? A cross-sectional study of yard size and greenness and children’s physical activity and outdoor play

    Jessica Oakley / Rachel L. Peters / Melissa Wake / Anneke C. Grobler / Jessica A. Kerr / Kate Lycett / Raisa Cassim / Melissa Russell / Cong Sun / Mimi L. K. Tang / Jennifer J. Koplin / Suzanne Mavoa

    BMC Public Health, Vol 21, Iss 1, Pp 1-

    2021  Volume 10

    Abstract: Abstract Background The home environment is the most important location in young children’s lives, yet few studies have examined the relationship between the outdoor home environment and child physical activity levels, and even fewer have used ... ...

    Abstract Abstract Background The home environment is the most important location in young children’s lives, yet few studies have examined the relationship between the outdoor home environment and child physical activity levels, and even fewer have used objectively measured exposures and outcomes. This study examined relationships between objectively assessed home yard size and greenness, and child physical activity and outdoor play. Methods Data were drawn from the HealthNuts study, a longitudinal study of 5276 children in Melbourne, Australia. We used cross-sectional data from a sample at Wave 3 (2013–2016) when participants were aged 6 years (n = 1648). A sub-sample of 391 children had valid accelerometer data collected from Tri-axial GENEActive accelerometers worn on their non-dominant wrist for 8 consecutive days. Yard area and greenness were calculated using geographic information systems. Objective outcome measures were minutes/day in sedentary, light, and moderate-vigorous physical activity (weekday and weekend separately). Parent-reported outcome measures were minutes/day playing outdoors (weekend and weekday combined). Multi-level regression models (adjusted for child’s sex, mother’s age at the birth of child, neighbourhood socioeconomic index, maternal education, and maternal ethnicity) estimated effects of yard size and greenness on physical activity. Results Data were available on outdoor play for 1648 children and usable accelerometer data for 391. Associations between yard size/greenness and components of physical activity were minimal. For example, during weekdays, yard size was not associated with daily minutes in sedentary behaviour (β: 2.4, 95% CI: − 6.2, 11.0), light physical activity (β: 1.4, 95% CI: − 5.7, 8.5) or MVPA (β: -2.4, 95% CI: − 6.5, 1.7), with similar patterns at weekends. There was no relationship between median annual yard greenness and physical activity or play. Conclusion In our study of young children residing in higher socio-economic areas of Melbourne yard characteristics did not ...
    Keywords Children ; Physical activity ; outdoor play ; Yard ; Greenness ; Built environment ; Public aspects of medicine ; RA1-1270
    Subject code 796
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Mass cytometry reveals cellular fingerprint associated with IgE+ peanut tolerance and allergy in early life

    Melanie R. Neeland / Sandra Andorf / Monali Manohar / Diane Dunham / Shu-Chen Lyu / Thanh D. Dang / Rachel L. Peters / Kirsten P. Perrett / Mimi L. K. Tang / Richard Saffery / Jennifer J. Koplin / Kari C. Nadeau

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 10

    Abstract: Food allergy is triggered by IgE, but some individuals are not allergic to peanuts despite making peanut-specific IgE, and are considered peanut-tolerant. Here, the authors identify differences in blood immune cell composition of peanut-allergic and ... ...

    Abstract Food allergy is triggered by IgE, but some individuals are not allergic to peanuts despite making peanut-specific IgE, and are considered peanut-tolerant. Here, the authors identify differences in blood immune cell composition of peanut-allergic and tolerant infants using mass cytometry, which may help uncover the mechanism of allergic tolerance.
    Keywords Science ; Q
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The Natural History of IgE-Mediated Food Allergy

    Jennifer J. Koplin / Rachel L. Peters / Lyle C. Gurrin / Shyamali C. Dharmage / Katrina J. Allen

    International Journal of Environmental Research and Public Health, Vol 10, Iss 10, Pp 5039-

    Can Skin Prick Tests and Serum-Specific IgE Predict the Resolution of Food Allergy?

    2013  Volume 5061

    Abstract: IgE-mediated food allergy is a transient condition for some children, however there are few indices to predict when and in whom food allergy will resolve. Skin prick test (SPT) and serum-specific IgE levels (sIgE) are usually monitored in the management ... ...

    Abstract IgE-mediated food allergy is a transient condition for some children, however there are few indices to predict when and in whom food allergy will resolve. Skin prick test (SPT) and serum-specific IgE levels (sIgE) are usually monitored in the management of food allergy and are used to predict the development of tolerance or persistence of food allergy. The aim of this article is to review the published literature that investigated the predictive value of SPT and sIgE in development of tolerance in children with a previous diagnosis of peanut, egg and milk allergy. A systematic search identified twenty-six studies, of which most reported SPT or sIgE thresholds which predicted persistent or resolved allergy. However, results were inconsistent between studies. Previous research was hampered by several limitations including the absence of gold standard test to diagnose food allergy or tolerance, biased samples in retrospective audits and lack of systematic protocols for triggering re-challenges. There is a need for population-based, prospective studies that use the gold standard oral food challenge (OFC) to diagnose food allergy at baseline and follow-up to develop SPT and sIgE thresholds that predict the course of food allergy.
    Keywords food allergy ; natural history ; tolerance ; skin prick test ; serum-specific immunoglobulin E ; hen’s egg ; peanut ; cow’s milk ; Medicine ; R
    Subject code 590 ; 360
    Language English
    Publishing date 2013-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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