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  1. Article ; Online: Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6

    Jacqueline Howie / Lindsay B. Tulloch / Elaine Brown / Louise Reilly / Fiona B. Ashford / Jennifer Kennedy / Krzysztof J. Wypijewski / Karen L. Aughton / Jason K.C. Mak / Michael J. Shattock / Niall J. Fraser / William Fuller

    Cell Reports, Vol 43, Iss 2, Pp 113679- (2024)

    2024  

    Abstract: Summary: Phospholemman (PLM) regulates the cardiac sodium pump: PLM phosphorylation activates the pump whereas PLM palmitoylation inhibits its activity. Here, we show that the anti-oxidant protein peroxiredoxin 6 (Prdx6) interacts with and ... ...

    Abstract Summary: Phospholemman (PLM) regulates the cardiac sodium pump: PLM phosphorylation activates the pump whereas PLM palmitoylation inhibits its activity. Here, we show that the anti-oxidant protein peroxiredoxin 6 (Prdx6) interacts with and depalmitoylates PLM in a glutathione-dependent manner. Glutathione loading cells acutely reduce PLM palmitoylation; glutathione depletion significantly increases PLM palmitoylation. Prdx6 silencing abolishes these effects, suggesting that PLM can be depalmitoylated by reduced Prdx6. In vitro, only recombinant Prdx6, among several peroxiredoxin isoforms tested, removes palmitic acid from recombinant palmitoylated PLM. The broad-spectrum depalmitoylase inhibitor palmostatin B prevents Prdx6-dependent PLM depalmitoylation in cells and in vitro. Our data suggest that Prdx6 is a thioesterase that can depalmitoylate proteins by nucleophilic attack via its reactive thiol, linking PLM palmitoylation and hence sodium pump activity to cellular glutathione status. We show that protein depalmitoylation can occur via a catalytic cysteine in which substrate specificity is determined by a protein-protein interaction.
    Keywords CP: Cell biology ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2024-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  2. Article ; Online: Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase

    Fiona Plain / Jacqueline Howie / Jennifer Kennedy / Elaine Brown / Michael J. Shattock / Niall J. Fraser / William Fuller

    Communications Biology, Vol 3, Iss 1, Pp 1-

    2020  Volume 10

    Abstract: The Na-pump accessory sub-unit phospholemman (PLM) is palmitoylated by the acyltransferase zDHHC5. Plain & Howie et al identify a binding site on zDHHC5 for the Na-pump, discover that the interaction is regulated by post-translational modifications near ... ...

    Abstract The Na-pump accessory sub-unit phospholemman (PLM) is palmitoylated by the acyltransferase zDHHC5. Plain & Howie et al identify a binding site on zDHHC5 for the Na-pump, discover that the interaction is regulated by post-translational modifications near this binding site, and find that disrupting the zDHHC5-Na-pump interaction reduces PLM palmitoylation.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: CFTC’s demanding new cooperation guidelines for companies and individuals

    Peace, Breon S / Bamberger, Nowell D / Bergen, Robin M / Park, Jennifer Kennedy

    The journal of investment compliance Vol. 18, No. 3 , p. 52-58

    2017  Volume 18, Issue 3, Page(s) 52–58

    Author's details Breon S. Peace, Jennifer Kennedy Park, Robin M. Bergen and Nowell D. Bamberger
    Keywords US Commodity Futures Trading Commission (CFTC) ; Investigation ; Cooperation standards ; Enforcement Advisory ; Enforcement proceeding
    Language English
    Publisher Emerald
    Publishing place Bingley
    Document type Article
    ZDB-ID 2278191-2 ; 2048718-6
    ISSN 1528-5812
    ISSN 1528-5812
    Database ECONomics Information System

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  4. Book ; Online: He Restores My Soul

    Dean, Jennifer Kennedy

    1999  

    Abstract: Forty-day program for spiritual renewal assists readers in discovering potential for an inner transformation that will make them sensitive and malleable to God's shaping ... ...

    Abstract Forty-day program for spiritual renewal assists readers in discovering potential for an inner transformation that will make them sensitive and malleable to God's shaping hand
    Language English
    Size Online-Ressource (203 p.)
    Publisher B&H Publishing Group
    Publishing place Nashville
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780805420272 ; 0805420274
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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