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Article: Elevated water lead levels in schools using water from on-site wells.

Latham, Scott / Jennings, Jennifer L

2022 Volume 20, Issue 9, Page(s) 1425–1435

Abstract: Only 8% of US public schools operate their own community water systems, and thus are subject to the federal Lead and Copper Rule's regulation of water lead levels (WLLs). To date, the absence of parallel water testing data for all other schools has ... ...

Abstract	Only 8% of US public schools operate their own community water systems, and thus are subject to the federal Lead and Copper Rule's regulation of water lead levels (WLLs). To date, the absence of parallel water testing data for all other schools has prevented the comparison of WLLs with schools that do not face federal regulation. This study compiled and analyzed newly available school-level WLL data that included water source (on-site well water or public utility) and pipe material data for public schools in New York State located outside of New York City. Despite direct federal regulation, schools that used water from on-site wells had a substantially higher percentage of water fixtures with elevated WLLs. Schools that used both on-site well water and iron pipes in their water distribution system had the highest percentage of elevated fixtures. Variation in water treatment practices was identified as a potential contributing mechanism, as schools that used on-site well water were less likely to implement corrosion control. The study concluded that information about water source and premise plumbing material may be useful to policymakers targeting schools for testing and remediation.
MeSH term(s)	Copper ; Drinking Water ; Iron ; Lead/analysis ; Schools ; Water Supply
Chemical Substances	Drinking Water ; Lead (2P299V784P) ; Copper (789U1901C5) ; Iron (E1UOL152H7)
Language	English
Publishing date	2022-09-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2123845-5
ISSN	1996-7829 ; 1477-8920
ISSN (online)	1996-7829
ISSN	1477-8920
DOI	10.2166/wh.2022.141
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Article: Reducing lead exposure in school water: Evidence from remediation efforts in New York City public schools

Latham, Scott / Jennings, Jennifer L.

Environmental research. 2022 Jan., v. 203

2022

Abstract: Following the Flint Water Crisis, many states passed legislation requiring schools to measure and remediate lead in school drinking water. In this study, we present new evidence on the level and distribution of lead in school drinking water by examining ... ...

Abstract	Following the Flint Water Crisis, many states passed legislation requiring schools to measure and remediate lead in school drinking water. In this study, we present new evidence on the level and distribution of lead in school drinking water by examining the case of New York City, which tested water from every public school fixture in the 2016-17 school year, remediated fixtures that showed elevated levels of lead above 15 ppb, and retested a sample of fixtures in 2018–19. Prior to remediation, 8 % of fixtures showed elevated levels of lead; after remediation, 5 % of fixtures did. In both pre- and post-remediation periods, Black children attended schools with a higher proportion of elevated fixtures than White, Asian, and Hispanic children. We observe post-remediation lead exposure reductions that were largest for Black children, though racial disparities in exposure remained. Together, our results show that New York City's remediation efforts significantly reduced lead in its schools' drinking water in a short period of time, providing evidence of the promise of such efforts. However, the continued presence of lead in school drinking water and persistent racial disparities in exposure demonstrate the ongoing challenges to eradicating lead exposure in schools.
Keywords	laws and regulations ; lead ; public schools ; remediation ; research ; New York
Language	English
Dates of publication	2022-01
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2021.111735
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Article ; Online: Reducing lead exposure in school water: Evidence from remediation efforts in New York City public schools.

Latham, Scott / Jennings, Jennifer L

Environmental research

2021 Volume 203, Page(s) 111735

Abstract	Following the Flint Water Crisis, many states passed legislation requiring schools to measure and remediate lead in school drinking water. In this study, we present new evidence on the level and distribution of lead in school drinking water by examining the case of New York City, which tested water from every public school fixture in the 2016-17 school year, remediated fixtures that showed elevated levels of lead above 15 ppb, and retested a sample of fixtures in 2018-19. Prior to remediation, 8 % of fixtures showed elevated levels of lead; after remediation, 5 % of fixtures did. In both pre- and post-remediation periods, Black children attended schools with a higher proportion of elevated fixtures than White, Asian, and Hispanic children. We observe post-remediation lead exposure reductions that were largest for Black children, though racial disparities in exposure remained. Together, our results show that New York City's remediation efforts significantly reduced lead in its schools' drinking water in a short period of time, providing evidence of the promise of such efforts. However, the continued presence of lead in school drinking water and persistent racial disparities in exposure demonstrate the ongoing challenges to eradicating lead exposure in schools.
MeSH term(s)	Child ; Drinking Water/analysis ; Hispanic or Latino ; Humans ; Lead ; New York City ; Schools
Chemical Substances	Drinking Water ; Lead (2P299V784P)
Language	English
Publishing date	2021-07-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2021.111735
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Article ; Online: Social and behavioral skills and the gender gap in early educational achievement.

Diprete, Thomas A / Jennings, Jennifer L

Social science research

2012 Volume 41, Issue 1, Page(s) 1–15

Abstract: Though many studies have suggested that social and behavioral skills play a central role in gender stratification processes, we know little about the extent to which these skills affect gender gaps in academic achievement. Analyzing data from the Early ... ...

Abstract	Though many studies have suggested that social and behavioral skills play a central role in gender stratification processes, we know little about the extent to which these skills affect gender gaps in academic achievement. Analyzing data from the Early Child Longitudinal Study-Kindergarten Cohort, we demonstrate that social and behavioral skills have substantively important effects on academic outcomes from kindergarten through fifth grade. Gender differences in the acquisition of these skills, moreover, explain a considerable fraction of the gender gap in academic outcomes during early elementary school. Boys get roughly the same academic return to social and behavioral skills as their female peers, but girls begin school with more advanced social and behavioral skills and their skill advantage grows over time. While part of the effect may reflect an evaluation process that rewards students who better conform to school norms, our results imply that the acquisition of social and behavioral skills enhances learning as well. Our results call for a reconsideration of the family and school-level processes that produce gender gaps in social and behavioral skills and the advantages they confer for academic and later success.
Language	English
Publishing date	2012-01
Publishing country	United States
Document type	Journal Article
ISSN	1096-0317
ISSN (online)	1096-0317
DOI	10.1016/j.ssresearch.2011.09.001
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Article ; Online: Targeted Identification of Protein Interactions in Eukaryotic mRNA Translation.

Link, Andrew J / Niu, Xinnan / Weaver, Connie M / Jennings, Jennifer L / Duncan, Dexter T / McAfee, K Jill / Sammons, Morgan / Gerbasi, Vince R / Farley, Adam R / Fleischer, Tracey C / Browne, Christopher M / Samir, Parimal / Galassie, Allison / Boone, Braden

Proteomics

2020 Volume 20, Issue 7, Page(s) e1900177

Abstract: To identify protein-protein interactions and phosphorylated amino acid sites in eukaryotic mRNA translation, replicate TAP-MudPIT and control experiments are performed targeting Saccharomyces cerevisiae genes previously implicated in eukaryotic mRNA ... ...

Abstract	To identify protein-protein interactions and phosphorylated amino acid sites in eukaryotic mRNA translation, replicate TAP-MudPIT and control experiments are performed targeting Saccharomyces cerevisiae genes previously implicated in eukaryotic mRNA translation by their genetic and/or functional roles in translation initiation, elongation, termination, or interactions with ribosomal complexes. Replicate tandem affinity purifications of each targeted yeast TAP-tagged mRNA translation protein coupled with multidimensional liquid chromatography and tandem mass spectrometry analysis are used to identify and quantify copurifying proteins. To improve sensitivity and minimize spurious, nonspecific interactions, a novel cross-validation approach is employed to identify the most statistically significant protein-protein interactions. Using experimental and computational strategies discussed herein, the previously described protein composition of the canonical eukaryotic mRNA translation initiation, elongation, and termination complexes is calculated. In addition, statistically significant unpublished protein interactions and phosphorylation sites for S. cerevisiae's mRNA translation proteins and complexes are identified.
MeSH term(s)	Chromatography, Liquid ; Protein Biosynthesis ; Protein Interaction Mapping ; Proteomics ; Ribosomes/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/analysis ; Saccharomyces cerevisiae Proteins/isolation & purification ; Saccharomyces cerevisiae Proteins/metabolism ; Tandem Mass Spectrometry
Chemical Substances	Saccharomyces cerevisiae Proteins
Language	English
Publishing date	2020-03-03
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2032093-0
ISSN	1615-9861 ; 1615-9853
ISSN (online)	1615-9861
ISSN	1615-9853
DOI	10.1002/pmic.201900177
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Article ; Online: Assessing the components of the eIF3 complex and their phosphorylation status.

Farley, Adam R / Powell, David W / Weaver, Connie M / Jennings, Jennifer L / Link, Andrew J

Journal of proteome research

2011 Volume 10, Issue 4, Page(s) 1481–1494

Abstract: The eukaryotic initiation factor 3 (eIF3) is an essential, highly conserved multiprotein complex that is a key component in the recruitment and assembly of the translation initiation machinery. To better understand the molecular function of eIF3, we ... ...

Abstract	The eukaryotic initiation factor 3 (eIF3) is an essential, highly conserved multiprotein complex that is a key component in the recruitment and assembly of the translation initiation machinery. To better understand the molecular function of eIF3, we examined its composition and phosphorylation status in Saccharomyces cerevisiae. The yeast eIF3 complex contains five core components: Rpg1, Nip1, Prt1, Tif34, and Tif35. 2-D LC-MS/MS analysis of affinity purified eIF3 complexes showed that several other initiation factors (Fun12, Tif5, Sui3, Pab1, Hcr1, and Sui1) and the casein kinase 2 complex (CK2) copurify. In Vivo metabolic labeling of proteins with (32)P revealed that Nip1 is phosphorylated. Using 2-D LC-MS/MS analysis of eIF3 complexes, we identified Prt1 phosphopeptides indicating phosphorylation at S22 and T707 and a Tif5 phosphopeptide with phosphorylation at T191. Additionally, we used immobilized metal affinity chromatography (IMAC) to enrich for eIF3 phosphopeptides and tandem mass spectrometry to identify phosphorylated residues. We found that three CK2 consensus sequences in Nip1 are phosphorylated: S98, S99, and S103. Using in vitro kinase assays, we showed that CK2 phophorylates Nip1 and that a synthetic Nip1 peptide containing S98, S99, and S103 competitively inhibits the reaction. Replacement of these three Nip1 serines with alanines causes a slow growth phenotype.
MeSH term(s)	Amino Acid Sequence ; Animals ; Chromatography, Liquid/methods ; Eukaryotic Initiation Factor-3/chemistry ; Eukaryotic Initiation Factor-3/genetics ; Eukaryotic Initiation Factor-3/metabolism ; Molecular Sequence Data ; Multiprotein Complexes/chemistry ; Multiprotein Complexes/genetics ; Multiprotein Complexes/metabolism ; Phosphopeptides/genetics ; Phosphopeptides/metabolism ; Phosphorylation ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Tandem Mass Spectrometry/methods
Chemical Substances	Eukaryotic Initiation Factor-3 ; Multiprotein Complexes ; NIP1 protein, S cerevisiae ; Phosphopeptides ; Saccharomyces cerevisiae Proteins
Language	English
Publishing date	2011-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/pr100877m
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Article ; Online: Analysis of protein composition using multidimensional chromatography and mass spectrometry.

Link, Andrew J / Jennings, Jennifer L / Washburn, Michael P

Current protocols in protein science

2004 Volume Chapter 23, Page(s) Unit 23.1

Abstract: Multidimensional liquid chromatography of peptides produced by protease digestion of complex protein mixtures followed by tandem mass spectrometry can be coupled with automated database searching to identify large numbers of proteins in complex samples. ... ...

Abstract	Multidimensional liquid chromatography of peptides produced by protease digestion of complex protein mixtures followed by tandem mass spectrometry can be coupled with automated database searching to identify large numbers of proteins in complex samples. These methods avoid the limitations of gel electrophoresis and in-gel digestions by directly identifying protein mixtures in solution.
MeSH term(s)	Angiotensins/chemistry ; Buffers ; Chromatography/instrumentation ; Chromatography/methods ; Mass Spectrometry/instrumentation ; Mass Spectrometry/methods ; Proteins/analysis ; Software
Chemical Substances	Angiotensins ; Buffers ; Proteins
Language	English
Publishing date	2004-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2179077-2
ISSN	1934-3663 ; 1934-3655
ISSN (online)	1934-3663
ISSN	1934-3655
DOI	10.1002/0471140864.ps2301s34
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Article: Dyggve-Melchior-Clausen syndrome: Chondrodysplasia resulting from defects in intracellular vesicle traffic

Osipovich, Anna B / Jennings, Jennifer L / Lin, Qing / Link, Andrew J / Ruley, H. Earl

Proceedings of the National Academy of Sciences of the United States of America. 2008 Oct. 21, v. 105, no. 42

2008

Abstract: Dyggve-Melchior-Clausen syndrome and Smith-McCort dysplasia are recessive spondyloepimetaphyseal dysplasias caused by loss-of-function mutations in dymeclin (Dym), a gene with previously unknown function. Here we report that Dym-deficient mice display ... ...

Abstract	Dyggve-Melchior-Clausen syndrome and Smith-McCort dysplasia are recessive spondyloepimetaphyseal dysplasias caused by loss-of-function mutations in dymeclin (Dym), a gene with previously unknown function. Here we report that Dym-deficient mice display defects in endochondral bone formation similar to that of Dyggve-Melchior-Clausen syndrome and Smith-McCort dysplasia, demonstrating functional conservation between the two species. Dym-mutant cells display multiple defects in vesicle traffic, as evidenced by enhanced dispersal of Golgi markers in interphase cells, delayed Golgi reassembly after brefeldin A treatment, delayed retrograde traffic of an endoplasmic reticulum-targeted Shiga toxin B subunit, and altered furin trafficking; and the Dym protein associates with multiple cellular proteins involved in vesicular traffic. These results establish dymeclin as a novel protein involved in Golgi organization and intracellular vesicle traffic and clarify the molecular basis for chondrodysplasia in mice and men.
Keywords	Shiga toxin ; bone formation ; genes ; interphase ; loss-of-function mutation ; men ; mice ; physiological transport ; proteins
Language	English
Dates of publication	2008-1021
Size	p. 16171-16176.
Publishing place	National Academy of Sciences
Document type	Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.0804259105
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Article: Mto2p, a novel fission yeast protein required for cytoplasmic microtubule organization and anchoring of the cytokinetic actin ring.

Venkatram, Srinivas / Jennings, Jennifer L / Link, Andrew / Gould, Kathleen L

Molecular biology of the cell

2005 Volume 16, Issue 6, Page(s) 3052–3063

Abstract: Microtubules regulate diverse cellular processes, including chromosome segregation, nuclear positioning, and cytokinesis. In many organisms, microtubule nucleation requires gamma-tubulin and associated proteins present at specific microtubule organizing ... ...

Abstract	Microtubules regulate diverse cellular processes, including chromosome segregation, nuclear positioning, and cytokinesis. In many organisms, microtubule nucleation requires gamma-tubulin and associated proteins present at specific microtubule organizing centers (MTOCs). In fission yeast, interphase cytoplasmic microtubules originate from poorly characterized interphase MTOCs and spindle pole body (SPB), and during late anaphase from the equatorial MTOC (EMTOC). It has been previously shown that Mto1p (Mbo1p/Mod20p) function is important for the organization/nucleation of all cytoplasmic microtubules. Here, we show that Mto2p, a novel protein, interacts with Mto1p and is important for establishing a normal interphase cytoplasmic microtubule array. In addition, mto2Delta cells fail to establish a stable EMTOC and localize gamma-tubulin complex members to this medial structure. As predicted from these functions, Mto2p localizes to microtubules, the SPB, and the EMTOC in an Mto1p-dependent manner. mto2Delta cells fail to anchor the cytokinetic actin ring in the medial region of the cell and under conditions that mildly perturb actin structures, these rings unravel in mto2Delta cells. Our results suggest that the Mto2p and the EMTOC are critical for anchoring the cytokinetic actin ring to the medial region of the cell and for proper coordination of mitosis with cytokinesis.
MeSH term(s)	Actins/metabolism ; Anaphase ; Antibodies, Monoclonal/metabolism ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Cell Cycle Proteins/metabolism ; Fluorescent Antibody Technique, Indirect ; Fluorescent Dyes ; Fungal Proteins/genetics ; Fungal Proteins/isolation & purification ; Fungal Proteins/metabolism ; GTP-Binding Proteins/metabolism ; Gene Deletion ; Green Fluorescent Proteins/metabolism ; Indoles ; Microscopy, Fluorescence ; Microscopy, Video ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Microtubule-Organizing Center/metabolism ; Microtubules/metabolism ; Recombinant Fusion Proteins/isolation & purification ; Recombinant Fusion Proteins/metabolism ; Schizosaccharomyces/genetics ; Schizosaccharomyces/growth & development ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; Schizosaccharomyces pombe Proteins/metabolism ; Spindle Apparatus/metabolism ; Thiazoles/pharmacology ; Thiazolidines ; Tubulin/metabolism
Chemical Substances	Actins ; Antibodies, Monoclonal ; Bridged Bicyclo Compounds, Heterocyclic ; CDC15 protein ; Cell Cycle Proteins ; Fluorescent Dyes ; Fungal Proteins ; Indoles ; Microtubule-Associated Proteins ; Recombinant Fusion Proteins ; Schizosaccharomyces pombe Proteins ; Thiazoles ; Thiazolidines ; Tubulin ; mto2p protein, S pombe ; Green Fluorescent Proteins (147336-22-9) ; DAPI (47165-04-8) ; GTP-Binding Proteins (EC 3.6.1.-) ; latrunculin A (SRQ9WWM084)
Language	English
Publishing date	2005-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1098979-1
ISSN	1939-4586 ; 1059-1524
ISSN (online)	1939-4586
ISSN	1059-1524
DOI	10.1091/mbc.E04-12-1043
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Article: Proteomic analysis of human norepinephrine transporter complexes reveals associations with protein phosphatase 2A anchoring subunit and 14-3-3 proteins.

Sung, Uhna / Jennings, Jennifer L / Link, Andrew J / Blakely, Randy D

Biochemical and biophysical research communications

2005 Volume 333, Issue 3, Page(s) 671–678

Abstract: The norepinephrine transporter (NET) terminates noradrenergic signals by clearing released NE at synapses. NET regulation by receptors and intracellular signaling pathways is supported by a growing list of associated proteins including syntaxin1A, ... ...

Abstract	The norepinephrine transporter (NET) terminates noradrenergic signals by clearing released NE at synapses. NET regulation by receptors and intracellular signaling pathways is supported by a growing list of associated proteins including syntaxin1A, protein phosphatase 2A (PP2A) catalytic subunit (PP2A-C), PICK1, and Hic-5. In the present study, we sought evidence for additional partnerships by mass spectrometry-based analysis of proteins co-immunoprecipitated with human NET (hNET) stably expressed in a mouse noradrenergic neuroblastoma cell line. Our initial proteomic analyses reveal multiple peptides derived from hNET, peptides arising from the mouse PP2A anchoring subunit (PP2A-Ar) and peptides derived from 14-3-3 proteins. We verified physical association of NET with PP2A-Ar via co-immunoprecipitation studies using mouse vas deferens extracts and with 14-3-3 via a fusion pull-down approach, implicating specifically the hNET NH2-terminus for interactions. The transporter complexes described likely support mechanisms regulating transporter activity, localization, and trafficking.
MeSH term(s)	14-3-3 Proteins/metabolism ; Amino Acid Sequence ; Animals ; Catalytic Domain ; Cell Line, Tumor ; Humans ; Immunoprecipitation ; Mass Spectrometry ; Mice ; Molecular Sequence Data ; Norepinephrine Plasma Membrane Transport Proteins ; Phosphoprotein Phosphatases/metabolism ; Protein Binding ; Protein Phosphatase 2 ; Proteome ; Symporters/chemistry ; Symporters/metabolism
Chemical Substances	14-3-3 Proteins ; Norepinephrine Plasma Membrane Transport Proteins ; Proteome ; SLC6A2 protein, human ; Slc6a2 protein, mouse ; Symporters ; Phosphoprotein Phosphatases (EC 3.1.3.16) ; Protein Phosphatase 2 (EC 3.1.3.16)
Language	English
Publishing date	2005-08-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2005.05.165
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