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Article ; Online: Temporal changes and clinical significance of peridevice leak following left atrial appendage occlusion with Amplatzer devices.

Korsholm, Kasper / Jensen, Jesper M / Nørgaard, Bjarne L / Nielsen-Kudsk, Jens E

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2022 Volume 99, Issue 7, Page(s) 2071–2079

Abstract: Background: The natural history of peridevice leak (PDL) following left atrial appendage occlusion (LAAO) is unknown. This study sought to investigate changes of PDL from 2 until 12 months after LAAO, using cardiac computed tomography (CT), and to ... ...

Abstract	Background: The natural history of peridevice leak (PDL) following left atrial appendage occlusion (LAAO) is unknown. This study sought to investigate changes of PDL from 2 until 12 months after LAAO, using cardiac computed tomography (CT), and to assess the potential association between persistent PDL and clinical outcomes METHODS: Single-center observational study of Amplatzer LAAO implants between 2010 and 2017 (n = 206). Patients with 2 and 12 months cardiac CT were included in the study (n = 153). Images were blindly analyzed. PDL was characterized by frequency and size at the device disc, lobe, and left atrial appendage contrast patency. Patients were followed for the composite outcome of ischemic stroke, transient ischemic attack, systemic embolism, or all-cause death. Median follow up from LAAO was 3.1 (2.3-4.3) years. Results: Contrast patency was present in 101 (66%) and 72 (47%) (p < 0.001) at 2 and 12 months, respectively. PDL was identified at the disc in 103 (67%) patients at 2 months versus 93 (61%) at 12 months (p = 0.08), and at the lobe in 29 (19%) at both time points. PDL area at the disc did not change significantly over time, Conclusion: Persistent PDL was frequently observed following LAAO with Amplatzer devices. The PDL frequency and size appeared unchanged between 2 and 12 months. Persistent PDL was not significantly associated with worse clinical outcomes, yet this needs further delineation in future studies.
MeSH term(s)	Atrial Appendage/diagnostic imaging ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/therapy ; Cardiac Catheterization ; Echocardiography, Transesophageal ; Humans ; Septal Occluder Device/adverse effects ; Stroke/etiology ; Stroke/prevention & control ; Tomography ; Treatment Outcome
Language	English
Publishing date	2022-05-18
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.30178
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Zs.A 1226: Show issues

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Article ; Online: Recent controversy regarding the accuracy of CT-FFR. The truth is out there.

Nørgaard, Bjarne L / Bøtker, Hans Erik / Jensen, Jesper M

Journal of cardiovascular computed tomography

2017 Volume 12, Issue 1, Page(s) e1

MeSH term(s)	Fractional Flow Reserve, Myocardial ; Tomography, X-Ray Computed
Language	English
Publishing date	2017-11-16
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2394360-9
ISSN	1876-861X ; 1934-5925
ISSN (online)	1876-861X
ISSN	1934-5925
DOI	10.1016/j.jcct.2017.11.003
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Article ; Online: Coronary CT angiography derived FFR in patients with left main disease.

Riedl, Katharina A / Jensen, Jesper M / Ko, Brian S / Leipsic, Jonathon / Grove, Erik L / Mathiassen, Ole N / Bøtker, Hans Erik / Nørgaard, Bjarne L

The international journal of cardiovascular imaging

2021 Volume 37, Issue 11, Page(s) 3299–3308

Abstract: The presence of left main coronary artery disease (LMCAD) is associated with an unfavorable clinical outcome. The clinical utility of ... ...

Abstract	The presence of left main coronary artery disease (LMCAD) is associated with an unfavorable clinical outcome. The clinical utility of FFR
MeSH term(s)	Computed Tomography Angiography ; Coronary Angiography ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/therapy ; Coronary Vessels/diagnostic imaging ; Fractional Flow Reserve, Myocardial ; Humans ; Predictive Value of Tests ; Retrospective Studies ; Severity of Illness Index ; Tomography, X-Ray Computed
Language	English
Publishing date	2021-08-12
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	2055311-0
ISSN	1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
ISSN (online)	1875-8312 ; 1573-0743
ISSN	1569-5794 ; 0167-9899
DOI	10.1007/s10554-021-02371-4
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Zs.A 2104: Show issues

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Article ; Online: Impact of Smoking on Coronary Volume-to-Myocardial Mass Ratio: An ADVANCE Registry Substudy.

Radiology. Cardiothoracic imaging

2024 Volume 6, Issue 2, Page(s) e220197

Abstract: Purpose To examine the relationship between smoking status and coronary volume-to-myocardial mass ratio (V/M) among individuals with coronary artery disease (CAD) undergoing CT fractional flow reserve (CT-FFR) analysis. Materials and Methods In this ... ...

Abstract	Purpose To examine the relationship between smoking status and coronary volume-to-myocardial mass ratio (V/M) among individuals with coronary artery disease (CAD) undergoing CT fractional flow reserve (CT-FFR) analysis. Materials and Methods In this secondary analysis, participants from the ADVANCE registry evaluated for suspected CAD from July 15, 2015, to October 20, 2017, who were found to have coronary stenosis of 30% or greater at coronary CT angiography (CCTA) were included if they had known smoking status and underwent CT-FFR and V/M analysis. CCTA images were segmented to calculate coronary volume and myocardial mass. V/M was compared between smoking groups, and predictors of low V/M were determined. Results The sample for analysis included 503 current smokers, 1060 former smokers, and 1311 never-smokers (2874 participants; 1906 male participants). After adjustment for demographic and clinical factors, former smokers had greater coronary volume than never-smokers (former smokers, 3021.7 mm
MeSH term(s)	Male ; Humans ; Fractional Flow Reserve, Myocardial ; Heart ; Myocardium ; Smoking/adverse effects ; Coronary Artery Disease/diagnostic imaging ; Coronary Angiography
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Journal Article
ISSN	2638-6135
ISSN (online)	2638-6135
DOI	10.1148/ryct.220197
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Article ; Online: Prognostic Value of Coronary CT Angiography-derived Fractional Flow Reserve on 3-year Outcomes in Patients with Stable Angina.

Madsen, Kristian T / Nørgaard, Bjarne L / Øvrehus, Kristian A / Jensen, Jesper M / Parner, Erik / Grove, Erik L / Fairbairn, Timothy A / Nieman, Koen / Patel, Manesh R / Rogers, Campbell / Mullen, Sarah / Mickley, Hans / Rohold, Allan / Bøtker, Hans Erik / Leipsic, Jonathon / Sand, Niels Peter R

Radiology

2023 Volume 308, Issue 3, Page(s) e230524

Abstract: Background The prognostic value of coronary CT angiography (CTA)-derived fractional flow reserve (FFR) beyond 1-year outcomes and in patients with high levels of coronary artery calcium (CAC) is uncertain. Purpose To assess the prognostic value of ... ...

Abstract	Background The prognostic value of coronary CT angiography (CTA)-derived fractional flow reserve (FFR) beyond 1-year outcomes and in patients with high levels of coronary artery calcium (CAC) is uncertain. Purpose To assess the prognostic value of coronary CTA-derived FFR test results on 3-year clinical outcomes in patients with coronary stenosis and among a subgroup of patients with high levels of CAC. Materials and Methods This study represents a 3-year follow-up of patients with new-onset stable angina pectoris who were consecutively enrolled in the Assessing Diagnostic Value of Noninvasive CT-FFR in Coronary Care, known as ADVANCE (ClinicalTrials.gov: NCT02499679) registry, between December 2015 and October 2017 at three Danish sites. A high CAC was defined as an Agatston score of at least 400. A lesion-specific coronary CTA-derived FFR value of 2 cm with distal-to-stenosis value at or below 0.80 represented an abnormal test result. The primary end point was a composite of all-cause death and nonfatal spontaneous myocardial infarction. Event rates were estimated using the one-sample binomial model, and relative risk was compared between participants stratified by results of coronary CTA-derived FFR. Results This study included 900 participants: 523 participants with normal results (mean age, 64 years ± 9.6 [SD]; 318 male participants) and 377 with abnormal results from coronary CTA-derived FFR (mean age, 65 years ± 9.6; 264 male participants). The primary end point occurred in 11 of 523 (2.1%) and 25 of 377 (6.6%) participants with normal and abnormal coronary CTA-derived FFR results, respectively (relative risk, 3.1; 95% CI: 1.6, 6.3;
MeSH term(s)	Humans ; Male ; Middle Aged ; Aged ; Angina, Stable/diagnostic imaging ; Computed Tomography Angiography ; Fractional Flow Reserve, Myocardial ; Prognosis ; Coronary Angiography ; Tomography, X-Ray Computed ; Myocardial Infarction ; Calcium
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2023-09-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.230524
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Article ; Online: The Authors Reply.

Nørgaard, Bjarne L / Leipsic, Jonathon / Douglas, Pamela S / Lu, Michael / Bøtker, Hans Erik / Jensen, Jesper M

JACC. Cardiovascular imaging

2018 Volume 11, Issue 2 Pt 1, Page(s) 285–286

MeSH term(s)	Coronary Artery Disease ; Decision Making ; Humans
Language	English
Publishing date	2018-02-07
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2491503-8
ISSN	1876-7591 ; 1936-878X
ISSN (online)	1876-7591
ISSN	1936-878X
DOI	10.1016/j.jcmg.2017.11.022
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Article ; Online: Influence of intensive lipid-lowering on CT derived fractional flow reserve in patients with stable chest pain: Rationale and design of the FLOWPROMOTE study.

Mortensen, Martin B / Sand, Niels-Peter / Busk, Martin / Jensen, Jesper M / Grove, Erik L / Dey, Damini / Iraqi, Nadia / Updegrove, Adam / Fonte, Tim / Mathiassen, Ole N / Hosbond, Susanne / Bøtker, Hans E / Leipsic, Jonathon / Narula, Jagat / Nørgaard, Bjarne L

Clinical cardiology

2022 Volume 45, Issue 10, Page(s) 986–994

Abstract: Introduction: Coronary CT angiography (CTA) derived fractional flow reserve (FFR: Aim: To test whether lipid lowering therapy is associated with significant improvement in FFR: Methods: Investigator driven, prospective, multicenter, randomized ... ...

Abstract	Introduction: Coronary CT angiography (CTA) derived fractional flow reserve (FFR Aim: To test whether lipid lowering therapy is associated with significant improvement in FFR Methods: Investigator driven, prospective, multicenter, randomized study of patients with stable angina, coronary stenosis ≥50% determined by clinically indicated first-line CTA, and FFR Conclusion: The results of this study will provide novel insights into the interplay between lipid lowering, and the pathophysiology in coronary artery disease.
MeSH term(s)	Angina, Stable ; Atorvastatin ; Ezetimibe/therapeutic use ; Fractional Flow Reserve, Myocardial ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Plaque, Atherosclerotic ; Predictive Value of Tests ; Prospective Studies ; Rosuvastatin Calcium ; Severity of Illness Index ; Tomography, X-Ray Computed
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Rosuvastatin Calcium (83MVU38M7Q) ; Atorvastatin (A0JWA85V8F) ; Ezetimibe (EOR26LQQ24)
Language	English
Publishing date	2022-09-03
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	391935-3
ISSN	1932-8737 ; 0160-9289
ISSN (online)	1932-8737
ISSN	0160-9289
DOI	10.1002/clc.23895
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Article ; Online: Cardiac computed tomography-derived coronary artery volume to myocardial mass.

Ihdayhid, Abdul Rahman / Fairbairn, Timothy A / Gulsin, Gaurav S / Tzimas, Georgios / Danehy, Edward / Updegrove, Adam / Jensen, Jesper M / Taylor, Charles A / Bax, Jeroen J / Sellers, Stephanie L / Leipsic, Jonathon A / Nørgaard, Bjarne L

Journal of cardiovascular computed tomography

2021 Volume 16, Issue 3, Page(s) 198–206

Abstract: In the absence of disease impacting the coronary arteries or myocardium, there exists a linear relationship between vessel volume and myocardial mass to ensure balanced distribution of blood supply. This balance may be disturbed in diseases of either the ...

Abstract	In the absence of disease impacting the coronary arteries or myocardium, there exists a linear relationship between vessel volume and myocardial mass to ensure balanced distribution of blood supply. This balance may be disturbed in diseases of either the coronary artery tree, the myocardium, or both. However, in contemporary evaluation the coronary artery anatomy and myocardium are assessed separately. Recently the coronary lumen volume to myocardial mass ratio (V/M), measured noninvasively using coronary computed tomography angiography (CTCA), has emerged as an integrated measure of myocardial blood supply and demand in vivo. This has the potential to yield new insights into diseases where this balance is altered, thus impacting clinical diagnoses and management. In this review, we outline the scientific methodology underpinning CTCA-derived measurement of V/M. We describe recent studies describing alterations in V/M across a range of cardiovascular conditions, including coronary artery disease, cardiomyopathies and coronary microvascular dysfunction. Lastly, we highlight areas of unmet research need and future directions, where V/M may further enhance our understanding of the pathophysiology of cardiovascular disease.
MeSH term(s)	Computed Tomography Angiography/methods ; Coronary Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Coronary Stenosis ; Coronary Vessels/diagnostic imaging ; Fractional Flow Reserve, Myocardial ; Humans ; Predictive Value of Tests
Language	English
Publishing date	2021-10-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2394360-9
ISSN	1876-861X ; 1934-5925
ISSN (online)	1876-861X
ISSN	1934-5925
DOI	10.1016/j.jcct.2021.10.007
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Article: Severe aortic coarctation in an adult patient with normal brachial blood pressure.

Leetmaa, Tina H / Nørgaard, Bjarne L / Mølgaard, Henning / Jensen, Jesper M

Journal of clinical imaging science

2014 Volume 4, Page(s) 41

Abstract: The present case shows that a normal brachial blood pressure (BP) does not exclude severe coarctation and should be considered in normotensive patients presenting with a systolic murmur and/or unexplained severe left ventricular hypertrophy. Congenital ... ...

Abstract	The present case shows that a normal brachial blood pressure (BP) does not exclude severe coarctation and should be considered in normotensive patients presenting with a systolic murmur and/or unexplained severe left ventricular hypertrophy. Congenital coarctation of the aorta is a narrowing of the descending aorta, usually located distal to the origin of the subclavian artery, causing hypertension in the upper part of the body. This condition may be undiagnosed until adult life where the clinical presentation most often is high BP in the upper extremities. A 57-year-old patient with severe aortic coarctation and left ventricular hypertrophy presented with normal brachial BP. However, standard suprasternal view by echocardiography indicated coarctation. Multislice computed tomographic (CT) angiography revealed an uncommon location of the aortic narrowing with the right and left subclavian arteries originating below the area of coarctation, explaining the equally low BP in both upper extremities.
Language	English
Publishing date	2014-07-31
Publishing country	United States
Document type	Case Reports
ZDB-ID	2601233-9
ISSN	2156-5597 ; 2156-7514
ISSN (online)	2156-5597
ISSN	2156-7514
DOI	10.4103/2156-7514.137835
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Article ; Online: Clinical outcomes following real-world computed tomography angiography-derived fractional flow reserve testing in chronic coronary syndrome patients with calcification.

Nørgaard, Bjarne L / Mortensen, Martin B / Parner, Erik / Leipsic, Jonathon / Steffensen, Flemming H / Grove, Erik Lerkevang / Mathiassen, Ole N / Sand, Niels Peter / Pedersen, Kamilla / Riedl, Katharina A / Engholm, Morten / Bøtker, Hans Erik / Jensen, Jesper M

European heart journal. Cardiovascular Imaging

2020 Volume 22, Issue 10, Page(s) 1182–1189

Abstract: Aims: This study sought to investigate outcomes following a normal CT-derived fractional flow reserve (FFRCT) result in patients with moderate stenosis and coronary artery calcification, and to describe the relationship between the extent of ... ...

Abstract	Aims: This study sought to investigate outcomes following a normal CT-derived fractional flow reserve (FFRCT) result in patients with moderate stenosis and coronary artery calcification, and to describe the relationship between the extent of calcification, stenosis, and FFRCT. Methods and results: Data from 975 consecutive patients suspected of chronic coronary syndrome with stenosis (30-70%) determined by computed CT angiography and FFRCT to guide downstream management decisions were reviewed. Median (range) follow-up time was 2.2 (0.5-4.2) years. Coronary artery calcium (CAC) scores were ≥400 in 25%, stenosis ≥50% in 83%, and FFRCT >0.80 in 51% of the patients. There was a lower incidence of the composite endpoint (death, myocardial infarction, hospitalization for unstable angina, and unplanned coronary revascularization) at 4.2 years in patients with any CAC and FFRCT > 0.80 vs. FFRCT ≤ 0.80 (3.9% and 8.7%, P = 0.04), however, in patients with CAC scores ≥400 the risk difference between groups did not reach statistical significance, 4.2% vs. 9.7% (P = 0.24). A negative relationship between CAC scores and FFRCT irrespective of stenosis severity was demonstrated. Conclusion: FFRCT shows promise in identifying patients with stenosis and calcification who can be managed without further downstream testing. Moreover, an inverse relationship between CAC levels and FFRCT was demonstrated. Studies are needed to further assess the clinical utility of FFRCT in patients with extensive coronary calcification.
MeSH term(s)	Computed Tomography Angiography ; Coronary Angiography ; Coronary Artery Disease/diagnostic imaging ; Coronary Stenosis/diagnostic imaging ; Coronary Vessels ; Fractional Flow Reserve, Myocardial ; Humans ; Predictive Value of Tests ; Severity of Illness Index ; Tomography, X-Ray Computed
Language	English
Publishing date	2020-08-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jeaa173
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