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  1. Article ; Online: Off-site facilities: Friend or foe of outpatient parenteral antimicrobial therapy (OPAT)?

    Jensen, Kelsey L / Van Abel, Amy / Frykman, Paul / Rivera, Christina G

    Infection control and hospital epidemiology

    2024  , Page(s) 1–2

    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2024.20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Multiple Simultaneous Infections With Nontuberculous Mycobacteria in the Setting of

    Tabaja, Hussam / Jensen, Kelsey L / Rivera, Christina G / Misra, Anisha / Pruthi, Rajiv K / Vergidis, Paschalis

    Open forum infectious diseases

    2022  Volume 9, Issue 7, Page(s) ofac309

    Abstract: ... ...

    Abstract GATA2
    Language English
    Publishing date 2022-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofac309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Comparative renal risk of long-term use of beta-lactams in combination with vancomycin across the continuum of care.

    Dolly, Lauren M / Rivera, Christina G / Jensen, Kelsey L / Mara, Kristin C / Schreier, Diana J / Virk, Abinash / Arensman Hannan, Kellie N

    Therapeutic advances in infectious disease

    2023  Volume 10, Page(s) 20499361231189589

    Abstract: Background: Data are controversial regarding nephrotoxicity risk with vancomycin plus piperacillin-tazobactam (VPT) compared to vancomycin alone or in combination with other beta-lactams (BLs) in acute care use. Furthermore, data are lacking on the ... ...

    Abstract Background: Data are controversial regarding nephrotoxicity risk with vancomycin plus piperacillin-tazobactam (VPT) compared to vancomycin alone or in combination with other beta-lactams (BLs) in acute care use. Furthermore, data are lacking on the incidence of acute kidney injury (AKI) with long-term use of VPT including outpatient parenteral antimicrobial therapy (OPAT).
    Methods: This retrospective study included 826 adult patients on an intravenous vancomycin plus BL for ⩾2 weeks, including cefepime, piperacillin/tazobactam, ertapenem, or meropenem, from August 2017 to January 2022. The primary outcome was incidence of AKI. Univariate and multivariable Cox proportional hazard regression analyses were conducted to adjust for confounding variables. A secondary analysis based on the propensity score (PS)-matched cohort was performed.
    Results: AKI occurred in 14.4% of patients in the VPT group (
    Conclusion: Clinicians should exercise caution when using VPT for >2 weeks, including in the OPAT setting, even when no renal dysfunction is observed during the initial week of combination therapy.
    Language English
    Publishing date 2023-08-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2728410-4
    ISSN 2049-937X ; 2049-9361
    ISSN (online) 2049-937X
    ISSN 2049-9361
    DOI 10.1177/20499361231189589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A review of evidence, antimicrobial stability, and feasibility considerations for OPAT continuous infusion.

    Van Abel, Amy L / Childs-Kean, Lindsey M / Jensen, Kelsey L / Mynatt, Ryan P / Ryan, Keenan L / Rivera, Christina G

    Therapeutic advances in infectious disease

    2023  Volume 10, Page(s) 20499361231191877

    Abstract: Outpatient parenteral antimicrobial therapy (OPAT) has been widely used in clinical practice for many decades because of its associated cost savings, reductions in inpatient hospital days, and decreases in hospital-associated infections. Despite this ... ...

    Abstract Outpatient parenteral antimicrobial therapy (OPAT) has been widely used in clinical practice for many decades because of its associated cost savings, reductions in inpatient hospital days, and decreases in hospital-associated infections. Despite this long history, evolving practice patterns and new drug delivery devices continue to present challenges as well as opportunities for clinicians when designing appropriate outpatient antimicrobial regimens. One such change is the increasing use of extended and continuous infusion (CI) of antimicrobials to optimize the achievement of pharmacokinetic and pharmacodynamic targets. Elastomeric devices are also becoming increasingly popular in OPAT, including for the delivery of CI. In this article, we review the clinical evidence for CI in OPAT, as well as practical considerations of patient preferences, cost, and antimicrobial stability.
    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2728410-4
    ISSN 2049-937X ; 2049-9361
    ISSN (online) 2049-937X
    ISSN 2049-9361
    DOI 10.1177/20499361231191877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Identification of priority targets for intervention in outpatient antimicrobial stewardship.

    Arensman Hannan, Kellie N / Draper, Evan W / Uecker-Bezdicek, Karen A / Gomez-Urena, Eric O / Jensen, Kelsey L

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2022  Volume 2, Issue 1, Page(s) e133

    Abstract: A multimodal antimicrobial stewardship intervention was associated with a decrease in antibiotic prescribing for targeted non-coronavirus disease 2019 (COVID-19) upper respiratory infections from 27.6% in 2019 to 7.6% in 2021. We describe our approach to ...

    Abstract A multimodal antimicrobial stewardship intervention was associated with a decrease in antibiotic prescribing for targeted non-coronavirus disease 2019 (COVID-19) upper respiratory infections from 27.6% in 2019 to 7.6% in 2021. We describe our approach to prioritizing departments for 3 levels of interventions in the setting of limited stewardship personnel.
    Language English
    Publishing date 2022-08-05
    Publishing country England
    Document type Journal Article
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2022.277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Association of hyperlipidaemia with 5-year survival after hospitalisation for acute myocardial infarction: a propensity score matched analysis.

    Yousufuddin, Mohammed / Zhu, Ye / Al Ward, Ruaa / Peters, Jessica / Doyle, Taylor / Jensen, Kelsey L / Wang, Zhen / Murad, Mohammad Hassan

    Open heart

    2020  Volume 7, Issue 1, Page(s) e001163

    Abstract: Objectives: The primary objective was to examine the association between hyperlipidaemia (HLP) and 5-year survival after incident acute myocardial infarction (AMI). The secondary objectives were to assess the effect of HLP on survival to discharge ... ...

    Abstract Objectives: The primary objective was to examine the association between hyperlipidaemia (HLP) and 5-year survival after incident acute myocardial infarction (AMI). The secondary objectives were to assess the effect of HLP on survival to discharge across patient subgroups, and the impact of statin prescription, intensity and long-term statin adherence on 5-year survival.
    Methods: Retrospective cohort study of 7071 patients hospitalised for AMI at Mayo Clinic from 2001 through 2011. Of these, 2091 patients with HLP (age (mean±SD) 69.7±13.5) were propensity score matched to 2091 patients without HLP (age 70.6±14.2).
    Results: In matched patients, HLP was associated with higher rate of survival to discharge than no HLP (95% vs 91%; log-rank <0.0001). At year 5, the adjusted HR for all-cause mortality in patients with HLP versus no HLP was 0.66 (95% CI 0.58-0.74), and patients with prescription statin versus no statin was 0.24 (95% CI 0.21 to 0.28). The mean survival was 0.35 year greater in patients with HLP than in those with no HLP (95% CI 0.25 to 0.46). Patients with HLP gained on an average 0.17 life year and those treated with statin 0.67 life year at 5 years after AMI. The benefit of concurrent HLP was consistent across study subgroups.
    Conclusions: In patients with AMI, concomitant HLP was associated with increased survival and a net gain in life years, independent of survival benefit from statin therapy. The results also reaffirm the role of statin prescription, intensity and adherence in reducing the mortality after incident AMI.
    MeSH term(s) Aged ; Aged, 80 and over ; Biomarkers/blood ; Female ; Hospitalization ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hyperlipidemias/blood ; Hyperlipidemias/diagnosis ; Hyperlipidemias/drug therapy ; Hyperlipidemias/mortality ; Lipids/blood ; Male ; Middle Aged ; Minnesota/epidemiology ; Non-ST Elevated Myocardial Infarction/diagnosis ; Non-ST Elevated Myocardial Infarction/mortality ; Non-ST Elevated Myocardial Infarction/therapy ; Prognosis ; Propensity Score ; Retrospective Studies ; Risk Assessment ; Risk Factors ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/mortality ; ST Elevation Myocardial Infarction/therapy ; Time Factors
    Chemical Substances Biomarkers ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Lipids
    Language English
    Publishing date 2020-03-17
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2747269-3
    ISSN 2053-3624 ; 2044-6055
    ISSN 2053-3624 ; 2044-6055
    DOI 10.1136/openhrt-2019-001163
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Initial and subsequent 3-year cost after hospitalization for first acute ischemic stroke and intracerebral hemorrhage.

    Yousufuddin, Mohammed / Moriarty, James P / Lackore, Kandace A / Zhu, Ye / Peters, Jessica L / Doyle, Taylor / Jensen, Kelsey L / Ahmmad, Eimad M / Al Ward, Ruaa Y / Al-Zu'bi, Hossam M / Sharma, Umesh M / Seshadri, Ashok / Arumaithurai, Kogulavadanan / Keenan, Lawrence R / Bhagra, Sumit / Murad, Mohammad Hassan / Borah, Bijan J

    Journal of the neurological sciences

    2020  Volume 419, Page(s) 117181

    Abstract: Aims: To examine 1) the major drivers of index hospitalization and 3-year post-acute follow-up care, 2) cost for rehabilitation and homecare, and 3) indirect cost from lost productivity after acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH) ...

    Abstract Aims: To examine 1) the major drivers of index hospitalization and 3-year post-acute follow-up care, 2) cost for rehabilitation and homecare, and 3) indirect cost from lost productivity after acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH).
    Methods: Retrospective study of adults hospitalized with AIS (n = 811) and ICH (N = 145) between 2003 and 2014. Direct costs standardized to Medicare reimbursement rates were captured for hospitalization and 3-year follow-up or death. Adjusted cost estimates were assessed using generalized linear modeling with gamma distribution. Costs for rehabilitation, home healthcare, and lost productivity were assessed using sets of cost captured through literature review.
    Results: Calculated as mean cost per person: hospitalization $18,154 for AIS and $24,077 for ICH; monthly 3-year aggregate $5138 for AIS and $8172 for ICH; 3-year inpatient rehabilitation $4185 for AIS and $4196 for ICH; homecare $19,728 for AIS and $14,487 for ICH; indirect cost from lost productivity $77,078 for AIS and $56,601 for ICH. Age < 55 years, being non-white, and stroke severity were strongly associated with greater hospitalization cost for AIS and ICH. Hyperlipidemia incurred lower while cancer, coronary artery disease, asthma/chronic obstructive pulmonary disease, heart failure, and anemia incurred higher 3-year aggregate cost for AIS. Cancer and diabetes mellitus incurred higher 3-year aggregate cost for ICH.
    Conclusions: We provide estimates of direct and indirect costs incurred for acute and continuing post-acute care through a 3-year follow-up period after first-ever AIS and ICH with important comparisons for predictors between index hospitalization and 3-year post-stroke costs.
    MeSH term(s) Adult ; Aged ; Brain Ischemia/complications ; Brain Ischemia/therapy ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/therapy ; Hospitalization ; Humans ; Ischemic Stroke ; Medicare ; Middle Aged ; Retrospective Studies ; Stroke/complications ; Stroke/therapy ; United States
    Language English
    Publishing date 2020-10-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2020.117181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 308: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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