Article ; Online: Rising incidence of Enterococcus species in microbiological specimens from orthopedic patients correlates to increased use of cefuroxime: a study concentrating on tissue samples.
2013 Volume 84, Issue 3, Page(s) 319–322
Abstract: Background and purpose: Enterococci are emerging causes of severe infections, including wound and bone infections in orthopedic patients. The main purpose of this study was to determine whether there was a correlation between the incidence of ... ...
| Abstract | Background and purpose: Enterococci are emerging causes of severe infections, including wound and bone infections in orthopedic patients. The main purpose of this study was to determine whether there was a correlation between the incidence of enterococci in tissue samples (biopsies) from orthopedic patients and consumption of cefuroxime in the orthopedic department. Methods and results: Data were obtained from the department of clinical microbiology and the hospital pharmacy. The consumption of cefuroxime successively increased from 40 defined daily doses (DDD)/10(3) bed days in 2002 to 212 DDD/10(3) bed days in 2009. The incidence of patients with enterococci in tissue samples increased steadily from 1.03/10(3) bed days in 2002 to 5.90/10(3) bed days in 2009. Regression analysis revealed a significant correlation between the consumption of cefuroxime and the incidence of enterococci. Interpretation: Continuous surveillance of species distribution, resistance rates, and antibiotic consumption is of utmost importance for optimal antibiotic strategy in orthopedic patients. |
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| MeSH term(s) | Anti-Bacterial Agents/administration & dosage ; Cefuroxime/administration & dosage ; Cross Infection/epidemiology ; Cross Infection/microbiology ; Denmark/epidemiology ; Drug Utilization/statistics & numerical data ; Drug Utilization/trends ; Enterococcus/classification ; Enterococcus/isolation & purification ; Gram-Positive Bacterial Infections/epidemiology ; Gram-Positive Bacterial Infections/microbiology ; Humans ; Incidence ; Orthopedic Procedures ; Retrospective Studies |
| Chemical Substances | Anti-Bacterial Agents ; Cefuroxime (O1R9FJ93ED) |
| Language | English |
| Publishing date | 2013-04-17 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2180677-9 |
| ISSN | 1745-3682 ; 1745-3674 |
| ISSN (online) | 1745-3682 |
| ISSN | 1745-3674 |
| DOI | 10.3109/17453674.2013.792028 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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