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  1. Article ; Online: Consciousness in Revascularization Decisions for the Cardiac Arrest Survivor.

    Jentzer, Jacob C

    JACC. Cardiovascular interventions

    2022  Volume 15, Issue 13, Page(s) 1349–1351

    MeSH term(s) Consciousness ; Heart Arrest/diagnosis ; Heart Arrest/therapy ; Humans ; Myocardial Revascularization ; Percutaneous Coronary Intervention/adverse effects ; Shock, Cardiogenic ; Survivors ; Treatment Outcome
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2022.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Under pressure: Pulmonary hypertension and right ventricular dysfunction in cardiac arrest.

    Jentzer, Jacob C

    Resuscitation

    2022  Volume 177, Page(s) 38–40

    MeSH term(s) Arterial Pressure ; Blood Pressure ; Heart Arrest/complications ; Heart Arrest/therapy ; Humans ; Hypertension, Pulmonary/complications ; Ventricular Dysfunction, Right/complications
    Language English
    Publishing date 2022-06-29
    Publishing country Ireland
    Document type Editorial ; Comment
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2022.06.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Initial Triage and Management of Patients with Acute Aortic Syndromes.

    Applefeld, Willard N / Jentzer, Jacob C

    Cardiology clinics

    2024  Volume 42, Issue 2, Page(s) 195–213

    Abstract: The acute aortic syndromes (AAS) are life-threatening vascular compromises within the aortic wall. These include aortic dissection (AD), intramural hematoma (IMH), penetrating aortic ulcer (PAU), and blunt traumatic thoracic aortic injury (BTTAI). While ... ...

    Abstract The acute aortic syndromes (AAS) are life-threatening vascular compromises within the aortic wall. These include aortic dissection (AD), intramural hematoma (IMH), penetrating aortic ulcer (PAU), and blunt traumatic thoracic aortic injury (BTTAI). While patients classically present with chest pain, the presentation may be highly variable. Timely diagnosis is critical to initiate definitive treatment and maximize chances of survival. In high-risk patients, treatment should begin immediately, even while diagnostic evaluation proceeds. The mainstay of medical therapy is acute reduction of heart rate and blood pressure. Surgical intervention is often required but is informed by patient anatomy and extent of vascular compromise.
    MeSH term(s) Humans ; Aortic Diseases/diagnosis ; Triage ; Aortic Dissection ; Aorta
    Language English
    Publishing date 2024-03-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1196385-2
    ISSN 1558-2264 ; 0733-8651
    ISSN (online) 1558-2264
    ISSN 0733-8651
    DOI 10.1016/j.ccl.2024.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cardiogenic Shock: Pathogenesis, Classification, and Management.

    Sarma, Dhruv / Jentzer, Jacob C

    Critical care clinics

    2023  Volume 40, Issue 1, Page(s) 37–56

    Abstract: Cardiogenic shock (CS) is a life-threatening circulatory failure syndrome which can progress rapidly to irreversible multiorgan failure through self-perpetuating pathophysiological processes. Recent developments in CS classification have highlighted its ... ...

    Abstract Cardiogenic shock (CS) is a life-threatening circulatory failure syndrome which can progress rapidly to irreversible multiorgan failure through self-perpetuating pathophysiological processes. Recent developments in CS classification have highlighted its etiologic, mechanistic, and hemodynamic heterogeneity. Optimal CS management depends on early recognition, rapid reversal of the underlying cause, and prompt initiation of hemodynamic support.
    MeSH term(s) Humans ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/therapy ; Myocardial Infarction/complications ; Multiple Organ Failure/etiology ; Multiple Organ Failure/therapy ; Hemodynamics ; Treatment Outcome
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1006423-0
    ISSN 1557-8232 ; 0749-0704
    ISSN (online) 1557-8232
    ISSN 0749-0704
    DOI 10.1016/j.ccc.2023.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The changing face of cardiogenic shock: definitions, epidemiology, and severity assessment.

    Jentzer, Jacob C / Baran, David A

    Current opinion in critical care

    2023  Volume 29, Issue 4, Page(s) 363–370

    Abstract: Purpose of review: Cardiogenic shock (CS) has been recognized for >50 years, most commonly in the setting of myocardial infarction. This review covers recent advances in the definitions, epidemiology and severity assessment of cardiogenic shock.: ... ...

    Abstract Purpose of review: Cardiogenic shock (CS) has been recognized for >50 years, most commonly in the setting of myocardial infarction. This review covers recent advances in the definitions, epidemiology and severity assessment of cardiogenic shock.
    Recent findings: In this review, the authors discuss the evolving definitions of cardiogenic shock, detailing the early approaches as well as more contemporary ideas. The epidemiology of CS is reviewed and then granular detail on the assessment of shock severity is provided including the role of lactate measurement and invasive hemodynamic assessment. The development of the Society for Cardiac Angiography and Intervention (SCAI) consensus statement on Classification of Cardiogenic Shock is reviewed by the principal authors. The revised SCAI Shock document is reviewed as well and the future directions for assessment of shock along with clinical applications are reviewed.
    Summary: Cardiogenic shock mortality has not changed in a significant way in many years. Recent advances such as more granular assessment of shock severity have the potential to improve outcomes by allowing research to separate the patient groups which may respond differently to various therapies.
    MeSH term(s) Humans ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/epidemiology ; Shock, Cardiogenic/therapy ; Myocardial Infarction/therapy ; Hospital Mortality
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Indications for Cardiac Catheterization and Percutaneous Coronary Intervention in Patients with Resuscitated Out-of-Hospital Cardiac Arrest.

    Sarma, Dhruv / Jentzer, Jacob C

    Current cardiology reports

    2023  Volume 25, Issue 11, Page(s) 1523–1533

    Abstract: Purpose of review: The role of emergent cardiac catheterization after resuscitated out-of-hospital cardiac arrest (OHCA) has evolved based on recent randomized evidence. This review aims to discuss the latest evidence and current indications for ... ...

    Abstract Purpose of review: The role of emergent cardiac catheterization after resuscitated out-of-hospital cardiac arrest (OHCA) has evolved based on recent randomized evidence. This review aims to discuss the latest evidence and current indications for emergent coronary angiography (CAG) and mechanical circulatory support (MCS) use following OHCA.
    Recent findings: In contrast to previous observational data, recent RCTs evaluating early CAG in resuscitated OHCA patients without ST elevation have uniformly demonstrated a lack of benefit in terms of survival or neurological outcome. There is currently no randomized evidence supporting MCS use specifically in patients with resuscitated OHCA and cardiogenic shock. Urgent CAG should be considered in all patients with ST elevation, recurrent electrical or hemodynamic instability, those who are awake following resuscitated OHCA, and those receiving extracorporeal cardiopulmonary resuscitation (ECPR). Recent evidence suggests that CAG may be safely delayed in hemodynamically stable patients without ST-segment elevation following resuscitated OHCA.
    MeSH term(s) Humans ; Out-of-Hospital Cardiac Arrest/therapy ; Out-of-Hospital Cardiac Arrest/etiology ; ST Elevation Myocardial Infarction/diagnostic imaging ; ST Elevation Myocardial Infarction/surgery ; Cardiopulmonary Resuscitation/adverse effects ; Percutaneous Coronary Intervention/adverse effects ; Coronary Angiography ; Cardiac Catheterization
    Language English
    Publishing date 2023-10-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055373-0
    ISSN 1534-3170 ; 1523-3782
    ISSN (online) 1534-3170
    ISSN 1523-3782
    DOI 10.1007/s11886-023-01980-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: 60-Year-Old Man With Acute-Onset Exertional Dyspnea.

    Abraham, Helayna / Fredrick, Thomas / Jentzer, Jacob C

    Mayo Clinic proceedings

    2024  Volume 99, Issue 2, Page(s) 306–311

    MeSH term(s) Humans ; Male ; Dyspnea/diagnosis ; Dyspnea/etiology ; Middle Aged
    Language English
    Publishing date 2024-01-06
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2023.06.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Understanding Cardiogenic Shock Severity and Mortality Risk Assessment.

    Jentzer, Jacob C

    Circulation. Heart failure

    2020  Volume 13, Issue 9, Page(s) e007568

    MeSH term(s) Heart Failure ; Hemodynamics ; Hospital Mortality ; Humans ; Risk Assessment ; Shock, Cardiogenic/diagnosis
    Language English
    Publishing date 2020-09-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2429459-7
    ISSN 1941-3297 ; 1941-3289
    ISSN (online) 1941-3297
    ISSN 1941-3289
    DOI 10.1161/CIRCHEARTFAILURE.120.007568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Acute Myocardial Infarction Cardiogenic Shock in Younger Adults: A Patient's Experience.

    Jentzer, Jacob C / Monroe, Rhonda E

    Journal of cardiac failure

    2022  Volume 29, Issue 1, Page(s) 30–32

    MeSH term(s) Adult ; Humans ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/therapy ; Heart Failure ; Myocardial Infarction/complications ; Myocardial Infarction/diagnosis ; Hospital Mortality
    Language English
    Publishing date 2022-12-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2022.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cardiogenic shock: a major challenge for the clinical trialist.

    Sarma, Dhruv / Jentzer, Jacob C / Soussi, Sabri

    Current opinion in critical care

    2023  Volume 29, Issue 4, Page(s) 371–380

    Abstract: Purpose of review: Cardiogenic shock (CS) results in persistently high short-term mortality and a lack of evidence-based therapies. Several trials of novel interventions have failed to show an improvement in clinical outcomes despite promising ... ...

    Abstract Purpose of review: Cardiogenic shock (CS) results in persistently high short-term mortality and a lack of evidence-based therapies. Several trials of novel interventions have failed to show an improvement in clinical outcomes despite promising preclinical and physiologic principles. In this review, we highlight the challenges of CS trials and provide suggestions for the optimization and harmonization of their design.
    Recent findings: CS clinical trials have been plagued by slow or incomplete enrolment, heterogeneous or nonrepresentative patient cohorts, and neutral results. To achieve meaningful, practice-changing results in CS clinical trials, an accurate CS definition, a pragmatic staging of its severity for appropriate patient selection, an improvement in informed consent process, and the use of patient-centered outcomes are required. Future optimizations include the use of predictive enrichment using host response biomarkers to unravel the biological heterogeneity of the CS syndrome and identify subphenotypes most likely to benefit from individualized treatment to allow a personalized medicine approach.
    Summary: Accurate characterization of CS severity and its pathophysiology are crucial to unravel heterogeneity and identify the patients most likely to benefit from a tested treatment. Implementation of biomarker-stratified adaptive clinical trial designs (i.e., biomarker or subphenotype-based therapy) might provide important insights into treatment effects.
    MeSH term(s) Humans ; Shock, Cardiogenic/drug therapy ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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