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  1. Article ; Online: MicroRNA-194 reciprocally stimulates osteogenesis and inhibits adipogenesis via regulating COUP-TFII expression.

    Jeong, B-C / Kang, I-H / Hwang, Y-C / Kim, S-H / Koh, J-T

    Cell death & disease

    2014  Volume 5, Page(s) e1532

    Abstract: Osteoblasts and adipocytes are differentiated from common mesenchymal stem cells (MSCs) in processes which are tightly controlled by various growth factors, signaling molecules, transcriptional factors and microRNAs. Recently, chicken ovalbumin upstream ... ...

    Abstract Osteoblasts and adipocytes are differentiated from common mesenchymal stem cells (MSCs) in processes which are tightly controlled by various growth factors, signaling molecules, transcriptional factors and microRNAs. Recently, chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) was identified as a critical regulator of MSC fate. In the present study, we aimed to identify some microRNAs (miR), which target COUP-TFII, and to determine the effects on MSCs fate. During osteoblastic or adipocytic differentiation from MSCs lineage cells, miR-194 expression was found to be reversal. In the cultures of mesenchymal C3H10T1/2 and primary bone marrow stromal cells, osteogenic stimuli increased miR-194 expression with accompanying decreases in COUP-TFII expression, whereas adipogenic stimuli reduced miR-194 expression with accompanying increases in COUP-TFII expression. A luciferase assay with COUP-TFII 3'-untranslated region (UTR) reporter plasmid, including the miR-194 binding sequences, showed that the introduction of miR-194 reduced the luciferase activity. However, it did not affect the activity of mutated COUP-TFII 3'-UTR reporter. Enforced expression of miR-194 significantly enhanced osteoblast differentiation, but inhibited adipocyte differentiation by decreasing COUP-TFII mRNA and protein levels. In contrast, inhibition of the endogenous miR-194 reduced matrix mineralization in the MSCs cultures, promoting the formation of lipid droplets by rescuing COUP-TFII expression. Furthermore, overexpression of COUP-TFII reversed the effects of miR-194 on the cell fates. Taken together, our results showed that miR-194 acts as a critical regulator of COUP-TFII, and can determinate the fate of MSCs to differentiate into osteoblasts and adipocytes. This suggests that miR-194 and COUP-TFII may be good target molecules for controlling bone and metabolic diseases.
    MeSH term(s) 3' Untranslated Regions ; Adipocytes/cytology ; Adipocytes/drug effects ; Adipocytes/metabolism ; Adipogenesis/genetics ; Animals ; Bone Marrow Cells/cytology ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/metabolism ; Bone Morphogenetic Protein 2/pharmacology ; COUP Transcription Factor II/genetics ; COUP Transcription Factor II/metabolism ; Cell Differentiation ; Cell Proliferation ; Culture Media/pharmacology ; Femur/cytology ; Gene Expression Regulation ; Genes, Reporter ; Humans ; Luciferases/genetics ; Luciferases/metabolism ; Mesenchymal Stromal Cells/cytology ; Mesenchymal Stromal Cells/drug effects ; Mesenchymal Stromal Cells/metabolism ; Mice ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Osteoblasts/cytology ; Osteoblasts/drug effects ; Osteoblasts/metabolism ; Osteogenesis/genetics ; Primary Cell Culture ; Signal Transduction ; Tibia/cytology
    Chemical Substances 3' Untranslated Regions ; BMP2 protein, human ; Bone Morphogenetic Protein 2 ; COUP Transcription Factor II ; Culture Media ; MIRN194 microRNA, mouse ; MicroRNAs ; Nr2f2 protein, mouse ; Luciferases (EC 1.13.12.-)
    Language English
    Publishing date 2014-11-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/cddis.2014.485
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  2. Article ; Online: Clinical applications of platelet-rich plasma in patellar tendinopathy.

    Jeong, D U / Lee, C-R / Lee, J H / Pak, J / Kang, L-W / Jeong, B C / Lee, S H

    BioMed research international

    2014  Volume 2014, Page(s) 249498

    Abstract: Platelet-rich plasma (PRP), a blood derivative with high concentrations of platelets, has been found to have high levels of autologous growth factors (GFs), such as transforming growth factor-β (TGF-β), platelet-derived growth factor (PDGF), fibroblastic ...

    Abstract Platelet-rich plasma (PRP), a blood derivative with high concentrations of platelets, has been found to have high levels of autologous growth factors (GFs), such as transforming growth factor-β (TGF-β), platelet-derived growth factor (PDGF), fibroblastic growth factor (FGF), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF). These GFs and other biological active proteins of PRP can promote tissue healing through the regulation of fibrosis and angiogenesis. Moreover, PRP is considered to be safe due to its autologous nature and long-term usage without any reported major complications. Therefore, PRP therapy could be an option in treating overused tendon damage such as chronic tendinopathy. Here, we present a systematic review highlighting the clinical effectiveness of PRP injection therapy in patellar tendinopathy, which is a major cause of athletes to retire from their respective careers.
    MeSH term(s) Blood Platelets ; Chronic Disease ; Fibrosis/drug therapy ; Fibrosis/metabolism ; Fibrosis/pathology ; Fibrosis/physiopathology ; Humans ; Intercellular Signaling Peptides and Proteins/pharmacology ; Neovascularization, Physiologic/drug effects ; Plasma ; Tendinopathy/drug therapy ; Tendinopathy/metabolism ; Tendinopathy/pathology ; Tendinopathy/physiopathology
    Chemical Substances Intercellular Signaling Peptides and Proteins
    Language English
    Publishing date 2014-07-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2014/249498
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  3. Article ; Online: Compensatory structural and functional adaptation after radical nephrectomy for renal cell carcinoma according to preoperative stage of chronic kidney disease. Choi DK, Jung SB, Park BH, Jeong BC, Seo SI, Jeon SS, Lee HM, Choi HY, Jeon HG.J Urol. 2015 Oct;194(4):910-5. [Epub 2015 Apr 28]. doi: 10.1016/j.juro.2015.04.093.

    Jay, Raman / Jung, S B / Park, B H / Jeong, B C / Seo, S I / Jeon, S S / Lee, H M / Choi, H Y / Jeon, H G

    Urologic oncology

    2017  Volume 35, Issue 3, Page(s) 118–119

    Abstract: Purpose: We investigated structural hypertrophy and functional hyperfiltration as compensatory adaptations after radical nephrectomy in patients with renal cell carcinoma according to the preoperative chronic kidney disease stage.: Materials and ... ...

    Abstract Purpose: We investigated structural hypertrophy and functional hyperfiltration as compensatory adaptations after radical nephrectomy in patients with renal cell carcinoma according to the preoperative chronic kidney disease stage.
    Materials and methods: We retrospectively identified 543 patients who underwent radical nephrectomy for renal cell carcinoma between 1997 and 2012. Patients were classified according to preoperative glomerular filtration rate as no chronic kidney disease-glomerular filtration rate 90ml/min/1.73m
    Results: Among all patients (mean age = 56.0y) mean preoperative glomerular filtration rate, functional renal volume, and glomerular filtration rate/functional renal volume were 83.2ml/min/1.73m
    Conclusions: Patients with a lower preoperative glomerular filtration rate had a smaller reduction in postoperative renal function than those with a higher preoperative glomerular filtration rate due to greater degrees of functional hyperfiltration.
    Language English
    Publishing date 2017-02-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1336505-8
    ISSN 1873-2496 ; 1078-1439
    ISSN (online) 1873-2496
    ISSN 1078-1439
    DOI 10.1016/j.urolonc.2016.12.024
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  4. Article ; Online: Radiotolerance of phosphatases of a Serratia sp.: potential for the use of this organism in the biomineralization of wastes containing radionuclides.

    Paterson-Beedle, M / Jeong, B C / Lee, C H / Jee, K Y / Kim, W H / Renshaw, J C / Macaskie, L E

    Biotechnology and bioengineering

    2012  Volume 109, Issue 8, Page(s) 1937–1946

    Abstract: Aqueous wastes from nuclear fuel reprocessing present special problems of radiotoxicity of the active species. Cells of Serratia sp. were found previously to accumulate high levels of hydrogen uranyl phosphate (HUP) via the activity of a phosphatase ... ...

    Abstract Aqueous wastes from nuclear fuel reprocessing present special problems of radiotoxicity of the active species. Cells of Serratia sp. were found previously to accumulate high levels of hydrogen uranyl phosphate (HUP) via the activity of a phosphatase enzyme. Uranium is of relatively low radiotoxicity whereas radionuclide fission products such as (90)Sr and (137)Cs are highly radiotoxic. These radionuclides can be co-crystallized, held within the bio-HUP "host" lattice on the bacterial cells and thereby removed from contaminated solution, depending on continued phosphatase activity. Radiostability tests using a commercial (60)Co γ-source showed that while cell viability and activity of purified phosphatase were lost within a few hours on irradiation, whole-cell phosphatase retained 80% of the initial activity, even after loss of cell culturability, which was increased to 100% by the incorporation of mercaptoethanol as an example radioprotectant, beyond an accumulated dose of >1.3 MGy. Using this co-crystallization approach (without mercaptoethanol) (137)Cs(+) and (85)Sr(2+) were removed from a simulated waste selectively against a 33-fold excess of Na(+).
    MeSH term(s) Crystallization ; Mercaptoethanol/metabolism ; Microbial Viability/radiation effects ; Phosphoric Monoester Hydrolases/metabolism ; Radiation-Protective Agents/metabolism ; Radioactive Waste ; Radioisotopes/metabolism ; Serratia/enzymology ; Serratia/radiation effects ; Time Factors ; Waste Disposal, Fluid/methods ; Waste Management/methods
    Chemical Substances Radiation-Protective Agents ; Radioactive Waste ; Radioisotopes ; Mercaptoethanol (60-24-2) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2)
    Language English
    Publishing date 2012-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 280318-5
    ISSN 1097-0290 ; 0006-3592
    ISSN (online) 1097-0290
    ISSN 0006-3592
    DOI 10.1002/bit.24467
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  5. Article ; Online: COUP-TFII Stimulates Dentin Sialophosphoprotein Expression and Mineralization in Odontoblasts.

    Hur, S-W / Oh, S-H / Jeong, B-C / Choi, H / Kim, J-W / Lee, K-N / Hwang, Y-C / Ryu, J-H / Kim, S-H / Koh, J-T

    Journal of dental research

    2015  Volume 94, Issue 8, Page(s) 1135–1142

    Abstract: Chicken ovalbumin upstream promoter transcription factor 2 (COUP-TFII), an orphan nuclear receptor belonging to the steroid-thyroid hormone receptor superfamily, plays an important role in cell fate determination of various tissues. However, the specific ...

    Abstract Chicken ovalbumin upstream promoter transcription factor 2 (COUP-TFII), an orphan nuclear receptor belonging to the steroid-thyroid hormone receptor superfamily, plays an important role in cell fate determination of various tissues. However, the specific role of COUP-TFII in tooth development has not yet been elucidated. In the present study, we aimed to explore the role of COUP-TFII in dentin sialophosphoprotein (DSPP) expression and matrix mineralization in odontoblast-lineage cells. In primary human dental pulp cells (HDPCs) and murine dental papilla-derived cells (MDPC-23) cultured in a mineralizing medium, the expression of COUP-TFII was induced along with the increased odontoblast-specific dentin matrix protein-1 (DMP-1) and DSPP expression. Endogenous expression of COUP-TFII in maxillary second molar germs of rats showed an increasing tendency as development of the tooth progressed. Also, COUP-TFII protein was detected in greater quantity in the odontoblastic layer of second molar germs than in that of third molar germs of rats. Overexpression of COUP-TFII using an adenoviral system upregulated the expression of odontoblast-specific genes with increased alkaline phosphatase activity and matrix mineralization in odontoblast-lineage cells. In contrast, knockdown of COUP-TFII using small interfering RNA decreased the expression of odontoblast-specific genes, which reduced matrix mineralization. Mechanistic studies revealed that COUP-TFII increased DSPP transcription by direct binding on the DSPP promoter. In addition, COUP-TFII physically interacted with the homeodomain transcription factor Msx2 and antagonistically regulated the Msx2 effect on DSPP promoter activity. Taken together, these results suggest that COUP-TFII has a stimulatory role in DSPP expression and matrix mineralization in odontoblast-lineage cells.
    MeSH term(s) Animals ; Blotting, Western ; COUP Transcription Factor II/metabolism ; Cell Differentiation ; Cells, Cultured ; Dentinogenesis ; Extracellular Matrix Proteins/metabolism ; Homeodomain Proteins/metabolism ; Humans ; Immunoprecipitation ; Mice ; Odontoblasts/metabolism ; Phosphoproteins/metabolism ; Rats ; Rats, Sprague-Dawley ; Real-Time Polymerase Chain Reaction ; Sialoglycoproteins/metabolism ; Staining and Labeling ; Transfection
    Chemical Substances COUP Transcription Factor II ; Extracellular Matrix Proteins ; Homeodomain Proteins ; MSX2 protein ; Phosphoproteins ; Sialoglycoproteins ; dentin sialophosphoprotein
    Language English
    Publishing date 2015-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/0022034515585125
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  6. Article ; Online: Lactone form 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) stimulate the osteoblastic differentiation of mouse periodontal ligament cells via the ERK pathway.

    Kim, I S / Jeong, B C / Kim, O S / Kim, Y J / Lee, S E / Lee, K N / Koh, J T / Chung, H J

    Journal of periodontal research

    2011  Volume 46, Issue 2, Page(s) 204–213

    Abstract: Background and objective: Recent studies reported that the lactone forms of 3-hydroxy- 3-methylglutaryl-coenzyme A reductase inhibitors, which are also known as statins, have a bone stimulatory effect. However, there are few reports on the effect of ... ...

    Abstract Background and objective: Recent studies reported that the lactone forms of 3-hydroxy- 3-methylglutaryl-coenzyme A reductase inhibitors, which are also known as statins, have a bone stimulatory effect. However, there are few reports on the effect of statins on periodontal ligament cells. This study examined the statin-induced osteoblastic differentiation of mouse periodontal ligament cells as well as its mechanism.
    Material and methods: Mouse periodontal ligament cells were cultured with lovastatin or simvastatin, and their viability was measured. The levels of alkaline phosphatase (ALP), osteocalcin, bone sialoprotein and bone morphogenetic protein-2 mRNA expression were evaluated by RT-PCR. The osteoblastic differentiation was characterized by the ALP activity and Alizarin Red-S staining for calcium deposition. The activity of the osteocalcin gene (OG2) and synthetic osteoblast-specific elements (6× OSE) promoter with statins was also measured using a luciferase assay. For the signal mechanism of statins, the ERK1/2 MAPK activity was determined by western blot analysis.
    Results: A statin treatment at concentrations < 1 μM did not affect the cell viability. Lovastatin or simvastatin at 0.1 μM increased the levels of ALP, osteocalcin, bone sialoprotein and bone morphogenetic protein-2 mRNA in mouse periodontal ligament cells. In addition, the ALP activity, mineralized nodule formation and OG2 and OSE promoter activity were higher in the lovastatin- or simvastatin-treated cells than the control cells. Western blot analysis confirmed that the statins stimulated the phosphorylation of ERK1/2.
    Conclusion: Lovastatin and simvastatin may stimulate the osteoblastic differentiation of periodontal ligament cells via the ERK1/2 pathway. This suggests that the statins may be useful for regenerating periodontal hard tissue.
    MeSH term(s) Alkaline Phosphatase/analysis ; Animals ; Anthraquinones ; Blotting, Western ; Bone Morphogenetic Protein 2/analysis ; Butadienes/pharmacology ; Calcification, Physiologic/drug effects ; Cell Culture Techniques ; Cell Differentiation/drug effects ; Cell Line ; Cell Survival/drug effects ; Coloring Agents ; Enzyme Inhibitors/pharmacology ; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors ; Extracellular Signal-Regulated MAP Kinases/drug effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Integrin-Binding Sialoprotein/analysis ; Lovastatin/pharmacology ; Mice ; Mitogen-Activated Protein Kinase 1/drug effects ; Nitriles/pharmacology ; Osteoblasts/drug effects ; Osteocalcin/analysis ; Periodontal Ligament/cytology ; Periodontal Ligament/drug effects ; Promoter Regions, Genetic/drug effects ; Simvastatin/pharmacology ; Transcriptional Activation/drug effects
    Chemical Substances Anthraquinones ; Bmp2 protein, mouse ; Bone Morphogenetic Protein 2 ; Butadienes ; Coloring Agents ; Enzyme Inhibitors ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Integrin-Binding Sialoprotein ; Nitriles ; U 0126 ; Osteocalcin (104982-03-8) ; Alizarin Red S (3F3AT0Q12H) ; Lovastatin (9LHU78OQFD) ; Simvastatin (AGG2FN16EV) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24) ; Alkaline Phosphatase (EC 3.1.3.1)
    Language English
    Publishing date 2011-04
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390953-0
    ISSN 1600-0765 ; 0022-3484
    ISSN (online) 1600-0765
    ISSN 0022-3484
    DOI 10.1111/j.1600-0765.2010.01329.x
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  7. Article ; Online: Transcriptional factor ATF6 is involved in odontoblastic differentiation.

    Kim, J W / Choi, H / Jeong, B C / Oh, S H / Hur, S W / Lee, B N / Kim, S H / Nör, J E / Koh, J T / Hwang, Y C

    Journal of dental research

    2014  Volume 93, Issue 5, Page(s) 483–489

    Abstract: ATF6 is an endoplasmic reticulum (ER) membrane-bound transcription factor that regulates various cellular functions. The purpose of this study was to investigate the role of ATF6 in odontoblast differentiation. Rat tooth germs were isolated, changes in ... ...

    Abstract ATF6 is an endoplasmic reticulum (ER) membrane-bound transcription factor that regulates various cellular functions. The purpose of this study was to investigate the role of ATF6 in odontoblast differentiation. Rat tooth germs were isolated, changes in gene expression were evaluated over time, and localization of ATF6 was determined by immunohistochemistry. Human dental pulp cells (HDPCs) were cultured with 50 µg/mL ascorbic acid and 5 mmol/L β-glycerophosphate or 100 ng/mL bone morphogenetic protein 2 to induce differentiation. Translocation of ATF6 was observed by immunofluorescence and confocal microscopy. Overexpression of ATF6 was performed with an adenoviral vector. Matrix mineralization was evaluated by alizarin red staining. Immunoreactivity to anti-ATF6 was observed in the odontoblastic layer of the molar tooth germ, and expressions of ATF6, dentin sialophosphoprotein (DSPP) and dentin matrix protein 1 (DMP1) increased gradually during tooth germ development. When HDPCs were cultured in differentiation media, ATF6, DSPP, and DMP1 expression increased with the expression of unfolded protein response (UPR) markers, BiP and CHOP. Immunofluorescence results showed that ATF6 protein moved from cytoplasm to nucleus when cells were exposed to differentiation media. Notably, overexpression of ATF6 increased DSPP and DMP1 expression, alkaline phosphatase (ALP) activity, and matrix mineralization in HDPC cultures. Inhibition of ATF6 decreased ALP activity and mineralization. These results suggest that ER membrane-bound transcriptional factor ATF6 may be involved in odontoblastic differentiation.
    MeSH term(s) Activating Transcription Factor 6/analysis ; Activating Transcription Factor 6/physiology ; Adenoviridae/genetics ; Alkaline Phosphatase/analysis ; Animals ; Bone Morphogenetic Protein 2/pharmacology ; Calcification, Physiologic/physiology ; Cell Culture Techniques ; Cell Differentiation/drug effects ; Cell Differentiation/physiology ; Cell Line ; Cell Nucleus/ultrastructure ; Cytoplasm/ultrastructure ; Dental Pulp/cytology ; Extracellular Matrix Proteins/analysis ; Gene Expression Regulation/genetics ; Genetic Vectors/genetics ; Humans ; Odontoblasts/drug effects ; Odontoblasts/physiology ; Phosphoproteins/analysis ; Rats ; Rats, Sprague-Dawley ; Sialoglycoproteins/analysis ; Tooth Germ/cytology ; Tooth Germ/growth & development ; Transcription Factor CHOP/analysis ; Unfolded Protein Response/physiology
    Chemical Substances ATF6 protein, human ; Activating Transcription Factor 6 ; Atf6 protein, rat ; BMP2 protein, human ; Bone Morphogenetic Protein 2 ; DDIT3 protein, human ; DMP1 protein, human ; Dmp1 protein, rat ; Extracellular Matrix Proteins ; Phosphoproteins ; Sialoglycoproteins ; dentin sialophosphoprotein ; Transcription Factor CHOP (147336-12-7) ; Alkaline Phosphatase (EC 3.1.3.1)
    Language English
    Publishing date 2014-02-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/0022034514525199
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  8. Article ; Online: Erythrocyte sedimentation rate and anaemia are independent predictors of survival in patients with clear cell renal cell carcinoma.

    Choi, Y / Park, B / Kim, K / Jeong, B C / Seo, S I / Jeon, S S / Choi, H Y / Lee, J E / Lee, H M

    British journal of cancer

    2013  Volume 108, Issue 2, Page(s) 387–394

    Abstract: Background: The 1997 international consensus conference on renal cell cancer (RCC) prognosis suggested erythrocyte sedimentation rate (ESR), alkaline phosphatase (ALP), and anaemia as prognostic biomarkers, but most studies reviewed were limited by ... ...

    Abstract Background: The 1997 international consensus conference on renal cell cancer (RCC) prognosis suggested erythrocyte sedimentation rate (ESR), alkaline phosphatase (ALP), and anaemia as prognostic biomarkers, but most studies reviewed were limited by small sample sizes.
    Methods: The Cox proportional hazards model was used to evaluate whether ESR, ALP, haemoglobin (Hb), and haematocrit (Hct) could predict survival outcomes in 1307 patients with clear cell RCC (ccRCC) who underwent nephrectomy during 1994-2008.
    Results: During a median follow-up of 43 months, we found that the patients with preoperative high levels of ESR, had a 2.10-fold (95% confidence interval (CI): 1.21-3.67) greater risk of dying from RCC compared with patients with low levels (normal range). Patients with preoperative anaemia, assessed by Hb and Hct, had a 3.11-fold (95% CI: 1.17-8.25) and 6.20-fold (95% CI: 2.30-16.72) greater risk of dying from other illnesses, respectively, compared with patients without anaemia. ALP levels were not associated with ccRCC patients' survival. These associations for ESR and anaemia were more pronounced in patients with body mass index (BMI) <25 compared with patients with BMI ≥ 25 kg m(-2).
    Conclusion: Preoperative high ESR, but not ALP, was a significant predictor for cancer-specific survival among ccRCC patients. Anaemia increases the risk of death from other illness.
    MeSH term(s) Aged ; Alkaline Phosphatase/blood ; Anemia/etiology ; Biomarkers, Tumor/blood ; Blood Sedimentation ; Body Mass Index ; Carcinoma, Renal Cell/blood ; Carcinoma, Renal Cell/mortality ; Carcinoma, Renal Cell/surgery ; Female ; Humans ; Kidney Neoplasms/blood ; Kidney Neoplasms/mortality ; Kidney Neoplasms/surgery ; Male ; Middle Aged ; Prognosis ; Survival Rate
    Chemical Substances Biomarkers, Tumor ; Alkaline Phosphatase (EC 3.1.3.1)
    Language English
    Publishing date 2013-01-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/bjc.2012.565
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  9. Article: Various forms of utilization and breeding of sweetpotato in Korea

    Lee, J.S / Kim, H.S / Chung, M.N / Ahn, Y.S / Jeong, B.C / Bang, J.K

    Acta horticulturae. 2006 Feb., no. 703

    2006  

    Keywords Ipomoea batatas ; sweet potatoes ; food crops ; product utilization ; plant breeding ; South Korea
    Language English
    Dates of publication 2006-02
    Size p. 125-131.
    Document type Article
    Note Paper presented at the Second International Symposium on Sweetpotato and Cassava: "Innovative Technologies for Commercialization", held June 14-17, 2005, Kuala Lumpur, Malaysia.
    ISSN 0567-7572
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Enzymically accelerated biomineralization of heavy metals: application to the removal of americium and plutonium from aqueous flows.

    Macaskie, L E / Jeong, B C / Tolley, M R

    FEMS microbiology reviews

    1994  Volume 14, Issue 4, Page(s) 351–367

    Abstract: A biological process for the removal of heavy metals from the aqueous flows is described. Metals are precipitated on the surface of immobilized cells of a Citrobacter sp. as cell-bound metal phosphates. This uses phosphate liberated by the activity of a ... ...

    Abstract A biological process for the removal of heavy metals from the aqueous flows is described. Metals are precipitated on the surface of immobilized cells of a Citrobacter sp. as cell-bound metal phosphates. This uses phosphate liberated by the activity of a cell-bound phosphatase. Some radionuclides (e.g. 241americium) form metal phosphates readily; efficient removal of 241Am on a continuous basis is demonstrated. At low phosphatase activities, the efficiency of uranium removal correlates with enzyme activity. High phosphatase activities are not realised as an increase in metal removal, suggesting that chemical events become rate-limiting. Studies have suggested that maximal metal uptake occurs only after nucleation and the formation of precipitation foci. A model is presented to illustrate how nucleation and crystallization processes could enhance the removal of plutonium and neptunium from dilute solutions.
    MeSH term(s) Acrylic Resins ; Americium/isolation & purification ; Citrobacter/enzymology ; Europium/isolation & purification ; Lanthanum/isolation & purification ; Phosphoric Monoester Hydrolases/metabolism ; Plutonium/isolation & purification ; Radioactive Waste ; Water Pollutants, Radioactive/isolation & purification
    Chemical Substances Acrylic Resins ; Radioactive Waste ; Water Pollutants, Radioactive ; polyacrylamide gels ; Europium (444W947O8O) ; Plutonium (53023GN24M) ; Lanthanum (6I3K30563S) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2) ; Americium (VW92PHU2UY)
    Language English
    Publishing date 1994-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 283740-7
    ISSN 1574-6976 ; 0168-6445
    ISSN (online) 1574-6976
    ISSN 0168-6445
    DOI 10.1111/j.1574-6976.1994.tb00109.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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