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Article ; Online: Pharmacogenomic Biomarkers and Their Applications in Psychiatry.

Kam, Heejin / Jeong, Hotcherl

2020 Volume 11, Issue 12

Abstract: Realizing the promise of precision medicine in psychiatry is a laudable and beneficial endeavor, since it should markedly reduce morbidity and mortality and, in effect, alleviate the economic and social burden of psychiatric disorders. This review aims ... ...

Abstract	Realizing the promise of precision medicine in psychiatry is a laudable and beneficial endeavor, since it should markedly reduce morbidity and mortality and, in effect, alleviate the economic and social burden of psychiatric disorders. This review aims to summarize important issues on pharmacogenomics in psychiatry that have laid the foundation towards personalized pharmacotherapy and, in a broader sense, precision medicine. We present major pharmacogenomic biomarkers and their applications in a variety of psychiatric disorders, such as depression, attention-deficit/hyperactivity disorder (ADHD), narcolepsy, schizophrenia, and bipolar disorder. In addition, we extend the scope into epilepsy, since antiepileptic drugs are widely used to treat psychiatric disorders, although epilepsy is conventionally considered to be a neurological disorder.
MeSH term(s)	Anticonvulsants/therapeutic use ; Biomarkers/metabolism ; Epilepsy/drug therapy ; Humans ; Mental Disorders/drug therapy ; Mental Disorders/metabolism ; Pharmacogenetics/methods ; Precision Medicine/methods ; Psychiatry/methods
Chemical Substances	Anticonvulsants ; Biomarkers
Language	English
Publishing date	2020-11-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes11121445
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Pharmacogenomic Biomarkers and Their Applications in Psychiatry

Kam, Heejin / Jeong, Hotcherl

Genes. 2020 Nov. 30, v. 11, no. 12

2020

Abstract	Realizing the promise of precision medicine in psychiatry is a laudable and beneficial endeavor, since it should markedly reduce morbidity and mortality and, in effect, alleviate the economic and social burden of psychiatric disorders. This review aims to summarize important issues on pharmacogenomics in psychiatry that have laid the foundation towards personalized pharmacotherapy and, in a broader sense, precision medicine. We present major pharmacogenomic biomarkers and their applications in a variety of psychiatric disorders, such as depression, attention-deficit/hyperactivity disorder (ADHD), narcolepsy, schizophrenia, and bipolar disorder. In addition, we extend the scope into epilepsy, since antiepileptic drugs are widely used to treat psychiatric disorders, although epilepsy is conventionally considered to be a neurological disorder.
Keywords	biomarkers ; bipolar disorder ; drug therapy ; epilepsy ; morbidity ; mortality ; narcolepsy ; pharmacogenomics ; precision medicine ; schizophrenia
Language	English
Dates of publication	2020-1130
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes11121445
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Exploiting virus-like particles as innovative vaccines against emerging viral infections.

Jeong, Hotcherl / Seong, Baik Lin

Journal of microbiology (Seoul, Korea)

2017 Volume 55, Issue 3, Page(s) 220–230

Abstract: Emerging viruses pose a major threat to humans and livestock with global public health and economic burdens. Vaccination remains an effective tool to reduce this threat, and yet, the conventional cell culture often fails to produce sufficient vaccine ... ...

Abstract	Emerging viruses pose a major threat to humans and livestock with global public health and economic burdens. Vaccination remains an effective tool to reduce this threat, and yet, the conventional cell culture often fails to produce sufficient vaccine dose. As an alternative to cell-culture based vaccine, virus-like particles (VLPs) are considered as a highpriority vaccine strategy against emerging viruses. VLPs represent highly ordered repetitive structures via macromolecular assemblies of viral proteins. The particulate nature allows efficient uptake into antigen presenting cells stimulating both innate and adaptive immune responses towards enhanced vaccine efficacy. Increasing research activity and translation opportunity necessitate the advances in the design of VLPs and new bioprocessing modalities for efficient and cost-effective production. Herein, we describe major achievements and challenges in this endeavor, with respect to designing strategies to harnessing the immunogenic potential, production platforms, downstream processes, and some exemplary cases in developing VLP-based vaccines.
MeSH term(s)	Antibodies, Viral/immunology ; Communicable Diseases, Emerging/immunology ; Communicable Diseases, Emerging/prevention & control ; Communicable Diseases, Emerging/virology ; Drug Discovery ; History, 20th Century ; Vaccination ; Vaccines, Virus-Like Particle/chemistry ; Vaccines, Virus-Like Particle/history ; Vaccines, Virus-Like Particle/immunology ; Viral Proteins/chemistry ; Viral Proteins/immunology ; Virus Diseases/prevention & control ; Virus Diseases/virology
Chemical Substances	Antibodies, Viral ; Vaccines, Virus-Like Particle ; Viral Proteins
Keywords	covid19
Language	English
Publishing date	2017-02-28
Publishing country	Korea (South)
Document type	Historical Article ; Journal Article ; Review
ZDB-ID	2012399-1
ISSN	1976-3794 ; 1225-8873
ISSN (online)	1976-3794
ISSN	1225-8873
DOI	10.1007/s12275-017-7058-3
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Article: Exploiting virus-like particles as innovative vaccines against emerging viral infections

Jeong, Hotcherl / Seong, Baik Lin

journal of microbiology. 2017 Mar., v. 55, no. 3

2017

Abstract	Emerging viruses pose a major threat to humans and livestock with global public health and economic burdens. Vaccination remains an effective tool to reduce this threat, and yet, the conventional cell culture often fails to produce sufficient vaccine dose. As an alternative to cell-culture based vaccine, virus-like particles (VLPs) are considered as a highpriority vaccine strategy against emerging viruses. VLPs represent highly ordered repetitive structures via macromolecular assemblies of viral proteins. The particulate nature allows efficient uptake into antigen presenting cells stimulating both innate and adaptive immune responses towards enhanced vaccine efficacy. Increasing research activity and translation opportunity necessitate the advances in the design of VLPs and new bioprocessing modalities for efficient and cost-effective production. Herein, we describe major achievements and challenges in this endeavor, with respect to designing strategies to harnessing the immunogenic potential, production platforms, downstream processes, and some exemplary cases in developing VLP-based vaccines.
Keywords	adaptive immunity ; antigen-presenting cells ; bioprocessing ; cell culture ; cost effectiveness ; humans ; livestock ; public health ; vaccination ; vaccines ; viral proteins ; virus-like particles ; viruses ; covid19
Language	English
Dates of publication	2017-03
Size	p. 220-230.
Publishing place	The Microbiological Society of Korea
Document type	Article
Note	Review
ZDB-ID	2012399-1
ISSN	1225-8873
ISSN	1225-8873
DOI	10.1007/s12275-017-7058-3
Database	NAL-Catalogue (AGRICOLA)

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Article: RNA-binding as chaperones of DNA binding proteins from starved cells

Park, Chan / Jin, Yoontae / Kim, Young Jun / Jeong, Hotcherl / Seong, Baik L

Biochemical and biophysical research communications. 2020 Apr. 02, v. 524, no. 2

2020

Abstract: DNA-binding proteins from starved cells (Dps) in Escherichia coli protects DNA from multiple stresses during the stationary phase by forming a stable Dps-DNA complex. In contrast, Dps cannot bind to DNA during the exponential phase and it has not been ... ...

Abstract	DNA-binding proteins from starved cells (Dps) in Escherichia coli protects DNA from multiple stresses during the stationary phase by forming a stable Dps-DNA complex. In contrast, Dps cannot bind to DNA during the exponential phase and it has not been clear why Dps conditionally binds to DNA depending on the growth phase. In this study, we show that DNA-free Dps in the exponential phase can also bind to RNA and the preemptive binding of RNA precludes DNA from interacting with Dps. The critical role of RNA in modulating the stability and functional competence of Dps and their morphology, leads us to propose a two-state model of Dps in executing stress responses. In the exponential phase, Dps is present predominantly as ribonucleoprotein complex. Under starvation, RNAs are degraded by up-regulated RNases, activating Dps to bind with chromosomal DNAs protecting them from diverse stresses. A dual role of RNA as an inhibitor of DNA binding and chaperone to keep dynamic functional status of Dps would be crucial for operating an immediate protection of chromosomal DNAs on starvation. The holdase-type chaperoning role of RNA in Dps-mediated stress responses would shed light on the role of RNAs as chaperone (Chaperna).
Keywords	DNA ; Escherichia coli ; RNA ; functional status ; models ; research ; ribonucleases ; ribonucleoproteins ; starvation
Language	English
Dates of publication	2020-0402
Size	p. 484-489.
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2020.01.121
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Article ; Online: RNA-binding as chaperones of DNA binding proteins from starved cells.

Park, Chan / Jin, Yoontae / Kim, Young Jun / Jeong, Hotcherl / Seong, Baik L

Biochemical and biophysical research communications

2020 Volume 524, Issue 2, Page(s) 484–489

Abstract	DNA-binding proteins from starved cells (Dps) in Escherichia coli protects DNA from multiple stresses during the stationary phase by forming a stable Dps-DNA complex. In contrast, Dps cannot bind to DNA during the exponential phase and it has not been clear why Dps conditionally binds to DNA depending on the growth phase. In this study, we show that DNA-free Dps in the exponential phase can also bind to RNA and the preemptive binding of RNA precludes DNA from interacting with Dps. The critical role of RNA in modulating the stability and functional competence of Dps and their morphology, leads us to propose a two-state model of Dps in executing stress responses. In the exponential phase, Dps is present predominantly as ribonucleoprotein complex. Under starvation, RNAs are degraded by up-regulated RNases, activating Dps to bind with chromosomal DNAs protecting them from diverse stresses. A dual role of RNA as an inhibitor of DNA binding and chaperone to keep dynamic functional status of Dps would be crucial for operating an immediate protection of chromosomal DNAs on starvation. The holdase-type chaperoning role of RNA in Dps-mediated stress responses would shed light on the role of RNAs as chaperone (Chaperna).
MeSH term(s)	DNA, Bacterial/metabolism ; DNA-Binding Proteins/metabolism ; Escherichia coli/cytology ; Escherichia coli/metabolism ; Escherichia coli Infections/microbiology ; Escherichia coli Proteins/metabolism ; Humans ; RNA, Bacterial/metabolism ; Stress, Physiological
Chemical Substances	DNA, Bacterial ; DNA-Binding Proteins ; Escherichia coli Proteins ; RNA, Bacterial
Language	English
Publishing date	2020-01-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2020.01.121
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Article ; Online: Correction: Awareness and attitude of the public toward personalized medicine in Korea.

Lee, Iyn-Hyang / Kang, Hye-Young / Suh, Hae Sun / Lee, Sukhyang / Oh, Eun Sil / Jeong, Hotcherl

PloS one

2018 Volume 13, Issue 4, Page(s) e0195847

Abstract: This corrects the article DOI: 10.1371/journal.pone.0192856.]. ...

Abstract	[This corrects the article DOI: 10.1371/journal.pone.0192856.].
Language	English
Publishing date	2018
Publishing country	United States
Document type	Journal Article ; Published Erratum
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0195847
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Awareness and attitude of the public toward personalized medicine in Korea.

Lee, Iyn-Hyang / Kang, Hye-Young / Suh, Hae Sun / Lee, Sukhyang / Oh, Eun Sil / Jeong, Hotcherl

PloS one

2018 Volume 13, Issue 2, Page(s) e0192856

Abstract: Objectives: As personalized medicine (PM) is expected to greatly improve health outcomes, efforts have recently been made for its clinical implementation in Korea. We aimed to evaluate public awareness and attitude regarding PM.: Methods: We ... ...

Abstract	Objectives: As personalized medicine (PM) is expected to greatly improve health outcomes, efforts have recently been made for its clinical implementation in Korea. We aimed to evaluate public awareness and attitude regarding PM. Methods: We performed a self-administered questionnaire survey to 703 adults, who participated in the survey on a voluntary basis. The primary outcome measures included public knowledge, attitude, and acceptance of PM. We conducted multinomial multivariate logistic analysis for outcome variables with three response categories and performed multivariate logistic regression analyses for dichotomous outcome variables. Results: Only 28% of participants had knowledge that genetic factors can contribute to inter-individual variations in drug response and the definition of PM (199 out of 702). Higher family income was correlated with greater knowledge concerning PM (OR = 3.76, p = 0.034). A majority of respondents preferred integrated pharmacogenomic testing over drug-specific testing and agreed to inclusion of pharmacogenomic testing in the national health examination (64% and 77%, respectively), but only 51% were willing to pay for it. Discussion: Our results identify the urgent need for public education as well as the potential health disparities in access to PM. This study helps to frame policies for implementing PM in clinical practice.
MeSH term(s)	Adult ; Attitude to Health ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Middle Aged ; Patient Education as Topic ; Pharmacogenomic Testing ; Precision Medicine ; Public Health ; Republic of Korea ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2018
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0192856
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Conversion of a soluble protein into a potent chaperone in vivo.

Kwon, Soon Bin / Ryu, Kisun / Son, Ahyun / Jeong, Hotcherl / Lim, Keo-Heun / Kim, Kyun-Hwan / Seong, Baik L / Choi, Seong Il

Scientific reports

2019 Volume 9, Issue 1, Page(s) 2735

Abstract: Molecular chaperones play an important role in cellular protein-folding assistance and aggregation inhibition. As a different but complementary model, we previously proposed that, in general, soluble cellular macromolecules with large excluded volume and ...

Abstract	Molecular chaperones play an important role in cellular protein-folding assistance and aggregation inhibition. As a different but complementary model, we previously proposed that, in general, soluble cellular macromolecules with large excluded volume and surface charges exhibit intrinsic chaperone activity to prevent aggregation of their connected polypeptides irrespective of the connection type, thereby contributing to efficient protein folding. As a proof of concept, we here demonstrated that a model recombinant protein with a specific sequence-binding domain robustly exerted chaperone activity toward various proteins harbouring a short recognition tag of 7 residues in Escherichia coli. The chaperone activity of this protein was comparable to that of representative E. coli chaperones in vivo. Furthermore, in vitro refolding experiments confirmed the in vivo results. Our findings reveal that a soluble protein exhibits the intrinsic chaperone activity to prevent off-pathway aggregation of its interacting proteins, leading to more productive folding while allowing them to fold according to their intrinsic folding pathways. This study gives new insights into the plausible chaperoning role of soluble cellular macromolecules in terms of aggregation inhibition and indirect folding assistance.
MeSH term(s)	Binding Sites ; Escherichia coli/chemistry ; Escherichia coli/metabolism ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/metabolism ; Molecular Chaperones/chemistry ; Molecular Chaperones/metabolism ; Protein Aggregates ; Protein Binding ; Protein Folding ; Protein Refolding ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Solubility
Chemical Substances	Escherichia coli Proteins ; Molecular Chaperones ; Protein Aggregates ; Recombinant Proteins
Language	English
Publishing date	2019-02-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-39158-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Publisher Correction: Conversion of a soluble protein into a potent chaperone in vivo.

Kwon, Soon Bin / Ryu, Kisun / Son, Ahyun / Jeong, Hotcherl / Lim, Keo-Heun / Kim, Kyun-Hwan / Seong, Baik L / Choi, Seong Il

Scientific reports

2019 Volume 9, Issue 1, Page(s) 12812

Abstract: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

Abstract	A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Language	English
Publishing date	2019-09-02
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-46941-y
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