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Article ; Conference proceedings: Endoscopic submucosal dissection is useful for the diagnosis of indefinite pathology

Moon, J. S. / Jeong, J. H.

2023 Volume 55, Issue S 02

Event/congress	ESGE Days 2023, Dublin, Ireland, 2023-04-20
Language	English
Publishing date	2023-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0043-1765838
Database	Thieme publisher's database

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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Intramedullary pneumorrhachis following a cervical epidural steroid injection.

Han, H J / Kim, J W / Jeong, J H

Neuro-Chirurgie

2020 Volume 67, Issue 2, Page(s) 189–192

Abstract: Pneumorrhachis (PR) is a rare radiological condition characterized by the presence of intraspinal air. PR is commonly classified as spontaneous (nontraumatic), traumatic, or iatrogenic, and iatrogenic PR is the most common and often occurs secondary to ... ...

Abstract	Pneumorrhachis (PR) is a rare radiological condition characterized by the presence of intraspinal air. PR is commonly classified as spontaneous (nontraumatic), traumatic, or iatrogenic, and iatrogenic PR is the most common and often occurs secondary to invasive procedures such as epidural anesthesia, lumbar puncture, or spinal surgery. PR is usually asymptomatic, but it can produce symptoms associated with its underlying pathology. Here, we report a rare case of intramedullary cervical PR following a cervical epidural steroid injection (ESI) and include pertinent discussion.
MeSH term(s)	Analgesics/therapeutic use ; Cervical Vertebrae/diagnostic imaging ; Epidural Space/diagnostic imaging ; Female ; Humans ; Injections, Epidural/adverse effects ; Middle Aged ; Pneumorrhachis/diagnostic imaging ; Pneumorrhachis/drug therapy ; Pregabalin/therapeutic use ; Steroids/administration & dosage
Chemical Substances	Analgesics ; Steroids ; Pregabalin (55JG375S6M)
Language	English
Publishing date	2020-10-10
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	207146-0
ISSN	1773-0619 ; 0028-3770 ; 0150-9586
ISSN (online)	1773-0619
ISSN	0028-3770 ; 0150-9586
DOI	10.1016/j.neuchi.2020.08.002
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Article ; Online: Safety and effectiveness of lumbar cerebrospinal fluid drainage to prevent delayed cerebral ischemia after Fisher grade 3 subarachnoid hemorrhage with minimal intraventricular hemorrhage.

Jeong, J H / Kim, J W / Choi, D H

Neuro-Chirurgie

2020 Volume 66, Issue 4, Page(s) 225–231

Abstract: Objective: Lumbar drainage (LD) of cerebrospinal fluid (CSF) is a simple way of clearing subarachnoid hemorrhage (SAH) and reducing the risk of delayed cerebral ischemia (DCI). We focused on Fisher grade 3 SAH with or without minimal intraventricular ... ...

Abstract	Objective: Lumbar drainage (LD) of cerebrospinal fluid (CSF) is a simple way of clearing subarachnoid hemorrhage (SAH) and reducing the risk of delayed cerebral ischemia (DCI). We focused on Fisher grade 3 SAH with or without minimal intraventricular hemorrhage (IVH; Graeb score ≤5), which has a lower risk of cerebellar tonsillar herniation during LD. The aim of this study was to test the efficacy of LD with respect to reducing the risk of DCI in this patient group. Methods: The authors retrospectively reviewed the medical records of 107 patients with Fisher grade 3 SAH with or without minimal IVH, admitted to two hospitals from 2013 to 2019. Patients were retrospectively divided into two groups: study group receiving standard therapy plus LD, or control group receiving standard therapy alone. Primary outcome measures were efficient in preventing DCI. Results: One hundred and seven subjects were allocated to the control (n=79) or study (n=28) groups. Incidence of DCI was 28% (n=22) and 18% (n=5), respectively (P=0.448). Subgroup analysis for HH grade 3+4 (n=68) showed incidence of DCI of 24% (n=19) in the control group (n=50) and 7% (n=2) in the study group (n=18) (P=0.040). There were no LD-related complications. Conclusions: This study could not draw a meaningful conclusion about the overall efficacy of LD on DCI reduction due to small sample size. However, there was a significant reduction of DCI by LD in the HH 3+4 subpopulation. Larger-scale studies are required to confirm our results.
MeSH term(s)	Adult ; Aged ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/etiology ; Brain Ischemia/prevention & control ; Cerebral Ventricles/diagnostic imaging ; Cerebrospinal Fluid ; Cerebrospinal Fluid Leak ; Drainage/adverse effects ; Drainage/methods ; Female ; Humans ; Incidence ; Intracranial Hemorrhages/complications ; Intracranial Hemorrhages/diagnostic imaging ; Lumbosacral Region ; Male ; Middle Aged ; Retrospective Studies ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/diagnostic imaging ; Tomography, X-Ray Computed ; Treatment Outcome
Language	English
Publishing date	2020-06-20
Publishing country	France
Document type	Journal Article
ZDB-ID	207146-0
ISSN	1773-0619 ; 0028-3770 ; 0150-9586
ISSN (online)	1773-0619
ISSN	0028-3770 ; 0150-9586
DOI	10.1016/j.neuchi.2020.03.003
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Article ; Online: Management of Discolored Anterior Teeth with Pulp Canal Obliteration.

Park, T Y / Jung, S R / Jeong, J H / Min, J B / Jo, H H

Operative dentistry

2022

Abstract: The purpose of this article is to present the effect and follow-up results of combined single-tooth vital bleaching when discoloration is due to pulp canal obliteration. In these cases, discoloration was managed successfully via home bleaching with a ... ...

Abstract	The purpose of this article is to present the effect and follow-up results of combined single-tooth vital bleaching when discoloration is due to pulp canal obliteration. In these cases, discoloration was managed successfully via home bleaching with a customized single-tooth tray and in-office bleaching without root canal treatment.
Language	English
Publishing date	2022-11-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	752995-8
ISSN	1559-2863 ; 0361-7734
ISSN (online)	1559-2863
ISSN	0361-7734
DOI	10.2341/22-015-T
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Book ; Online: Classification of Upper Limb Movements \newline Using Convolutional Neural Network \newline with 3D Inception Block

Lee, D. -Y. / Jeong, J. -H. / Shim, K. -H. / Kim, D. -J.

2020

Abstract: A brain-machine interface (BMI) based on electroencephalography (EEG) can overcome the movement deficits for patients and real-world applications for healthy people. Ideally, the BMI system detects user movement intentions transforms them into a control ... ...

Abstract	A brain-machine interface (BMI) based on electroencephalography (EEG) can overcome the movement deficits for patients and real-world applications for healthy people. Ideally, the BMI system detects user movement intentions transforms them into a control signal for a robotic arm movement. In this study, we made progress toward user intention decoding and successfully classified six different reaching movements of the right arm in the movement execution (ME). Notably, we designed an experimental environment using robotic arm movement and proposed a convolutional neural network architecture (CNN) with inception block for robust classify executed movements of the same limb. As a result, we confirmed the classification accuracies of six different directions show 0.45 for the executed session. The results proved that the proposed architecture has approximately 6~13% performance increase compared to its conventional classification models. Hence, we demonstrate the 3D inception CNN architecture to contribute to the continuous decoding of ME. Comment: 5 pages, accepted by BCI2020
Keywords	Computer Science - Human-Computer Interaction ; Electrical Engineering and Systems Science - Signal Processing
Subject code	629
Publishing date	2020-02-03
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Safety and efficacy of trastuzumab biosimilar plus irinotecan or gemcitabine in patients with previously treated HER2 (ERBB2)-positive non-breast/non-gastric solid tumors: a phase II basket trial with circulating tumor DNA analysis.

Hyung, J / Lee, J Y / Kim, J E / Yoon, S / Yoo, C / Hong, Y S / Jeong, J H / Kim, T W / Jeon, S / Jun, H R / Jung, C K / Jang, J P / Kim, J / Chun, S M / Ahn, J H

ESMO open

2023 Volume 8, Issue 3, Page(s) 101583

Abstract: Background: Human epidermal growth factor receptor 2 (HER2) (ERBB2)-directed agents are standard treatments for patients with HER2-positive breast and gastric cancer. Herein, we report the results of an open-label, single-center, phase II basket trial ... ...

Abstract	Background: Human epidermal growth factor receptor 2 (HER2) (ERBB2)-directed agents are standard treatments for patients with HER2-positive breast and gastric cancer. Herein, we report the results of an open-label, single-center, phase II basket trial to investigate the efficacy and safety of trastuzumab biosimilar (Samfenet®) plus treatment of physician's choice for patients with previously treated HER2-positive advanced solid tumors, along with biomarker analysis employing circulating tumor DNA (ctDNA) sequencing. Methods: Patients with HER2-positive unresectable or metastatic non-breast, non-gastric solid tumors who failed at least one prior treatment were included in this study conducted at Asan Medical Center, Seoul, Korea. Patients received trastuzumab combined with irinotecan or gemcitabine at the treating physicians' discretion. The primary endpoint was the objective response rate as per RECIST version 1.1. Plasma samples were collected at baseline and at the time of disease progression for ctDNA analysis. Results: Twenty-three patients were screened from 31 December 2019 to 17 September 2021, and 20 were enrolled in this study. Their median age was 64 years (30-84 years), and 13 patients (65.0%) were male. The most common primary tumor was hepatobiliary cancer (seven patients, 35.0%), followed by colorectal cancer (six patients, 30.0%). Among 18 patients with an available response evaluation, the objective response rate was 11.1% (95% confidence interval 3.1% to 32.8%). ERBB2 amplification was detected from ctDNA analysis of baseline plasma samples in 85% of patients (n = 17), and the ERBB2 copy number from ctDNA analysis showed a significant correlation with the results from tissue sequencing. Among 16 patients with post-progression ctDNA analysis, 7 (43.8%) developed new alterations. None of the patients discontinued the study due to adverse events. Conclusions: Trastuzumab plus irinotecan or gemcitabine was safe and feasible for patients with previously treated HER2-positive advanced solid tumors with modest efficacy outcomes, and ctDNA analysis was useful for detecting HER2 amplification.
MeSH term(s)	Female ; Humans ; Male ; Middle Aged ; Biosimilar Pharmaceuticals/adverse effects ; Circulating Tumor DNA/genetics ; Gemcitabine ; Irinotecan ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/genetics ; Trastuzumab/adverse effects ; Adult ; Aged ; Aged, 80 and over
Chemical Substances	Biosimilar Pharmaceuticals ; Circulating Tumor DNA ; ERBB2 protein, human (EC 2.7.10.1) ; Gemcitabine ; Irinotecan (7673326042) ; Trastuzumab (P188ANX8CK)
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Clinical Trial, Phase II ; Journal Article
ISSN	2059-7029
ISSN (online)	2059-7029
DOI	10.1016/j.esmoop.2023.101583
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Article ; Online: Tumor immune-gene expression profiles and peripheral immune phenotypes associated with clinical outcomes of locally advanced pancreatic cancer following FOLFIRINOX.

Hyung, J / Lee, H / Jin, H / Lee, S / Lee, H J / Gong, G / Song, T J / Lee, S S / Hwang, D W / Kim, S C / Jeong, J H / Ryoo, B-Y / Kim, K / Yoo, C

ESMO open

2022 Volume 7, Issue 3, Page(s) 100484

Abstract: Background: A comprehensive analysis of peripheral immune cell phenotypes and tumor immune-gene expression profiles in locally advanced pancreatic cancer patients treated with neoadjuvant chemotherapy in a phase II clinical trial was carried out.: ... ...

Abstract	Background: A comprehensive analysis of peripheral immune cell phenotypes and tumor immune-gene expression profiles in locally advanced pancreatic cancer patients treated with neoadjuvant chemotherapy in a phase II clinical trial was carried out. Methods: Patients were treated with neoadjuvant modified folinic acid, fluorouracil, irinotecan hydrochloride, oxaliplatin (mFOLFIRINOX) followed by surgery and adjuvant gemcitabine at the Asan Medical Center. Correlations between survival outcomes and baseline peripheral immune cells and their changes during preoperative chemotherapy were analyzed. Patients who had surgery were divided into two groups according to achievement of disease-free survival >10 months (achieved versus failed). Differential expression and pathway analysis of immune-related genes were carried out using the Nanostring platform, and immune cells within the tumor microenvironment were compared by immunohistochemistry. Results: Forty-four patients were treated in the phase II clinical trial. Higher baseline CD14+CD11c+HLA-DR+ monocytes (P = 0.044) and lower Foxp3+CD4+ T cells (P = 0.02) were associated with poor progression-free survival of neoadjuvant mFOLFIRINOX. During the preoperative chemotherapy, PD-1 T cells significantly decreased (P = 0.0110). Differential expression and pathway analysis of immune-genes from the resected tumor after neoadjuvant treatment revealed transforming growth factor-β pathway enrichment and higher expression of MARCO (adjusted P < 0.05) associated with early recurrence. Enrichment of the Th1 pathway and higher peritumoral CD8+ T cells (P = 0.0103) were associated with durable disease-free survival from surgery (>10 months) following neoadjuvant mFOLFIRINOX. Conclusions: Our results identify potential immune biomarkers for locally advanced pancreatic cancer and provide insights into pancreatic cancer immunity.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Fluorouracil/pharmacology ; Fluorouracil/therapeutic use ; Humans ; Irinotecan/pharmacology ; Irinotecan/therapeutic use ; Leucovorin/pharmacology ; Leucovorin/therapeutic use ; Oxaliplatin/pharmacology ; Oxaliplatin/therapeutic use ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Phenotype ; Transcriptome ; Tumor Microenvironment
Chemical Substances	folfirinox ; Oxaliplatin (04ZR38536J) ; Irinotecan (7673326042) ; Leucovorin (Q573I9DVLP) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2022-05-13
Publishing country	England
Document type	Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2059-7029
ISSN (online)	2059-7029
DOI	10.1016/j.esmoop.2022.100484
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Article ; Online: Stachydrine alleviates lipid-induced skeletal muscle insulin resistance via AMPK/HO-1-mediated suppression of inflammation and endoplasmic reticulum stress.

Jung, T W / Kim, H / Park, S Y / Cho, W / Oh, H / Lee, H J / Abd El-Aty, A M / Hacimuftuoglu, A / Jeong, J H

Journal of endocrinological investigation

2022 Volume 45, Issue 11, Page(s) 2181–2191

Abstract: Objective: Insulin resistance develops due to skeletal muscle inflammation and endoplasmic reticulum (ER) stress. Stachydrine (STA), extracted from Leonurus heterophyllus, has been shown to suppress proliferation and induce apoptosis in breast cancer ... ...

Abstract	Objective: Insulin resistance develops due to skeletal muscle inflammation and endoplasmic reticulum (ER) stress. Stachydrine (STA), extracted from Leonurus heterophyllus, has been shown to suppress proliferation and induce apoptosis in breast cancer cells and exert anti-inflammatory properties in the brain, heart, and liver. However, the roles of STA in insulin signaling in skeletal muscle remain unclear. Herein, we examined the impacts of STA on insulin signaling in skeletal muscle under hyperlipidemic conditions and its related molecular mechanisms. Methods: Various protein expression levels were determined by Western blotting. Levels of mouse serum cytokines were measured by ELISA. Results: We found that STA-ameliorated inflammation and ER stress, leading to attenuation of insulin resistance in palmitate-treated C2C12 myocytes. STA dose-dependently enhanced AMPK phosphorylation and HO-1 expression. Administration of STA attenuated not only insulin resistance but also inflammation and ER stress in the skeletal muscle of high-fat diet (HFD)-fed mice. Additionally, STA-ameliorated glucose tolerance and insulin sensitivity, as well as serum TNFα and MCP-1, in mice fed a HFD. Small interfering (si) RNA-associated suppression of AMPK or HO-1 expression abolished the effects of STA in C2C12 myocytes. Conclusions: These results suggest that STA activates AMPK/HO-1 signaling, resulting in reduced inflammation and ER stress, thereby improving skeletal muscle insulin resistance. Using STA as a natural ingredient, this research successfully treated insulin resistance and type 2 diabetes.
MeSH term(s)	AMP-Activated Protein Kinases/metabolism ; AMP-Activated Protein Kinases/pharmacology ; Animals ; Diabetes Mellitus, Type 2/metabolism ; Diet, High-Fat/adverse effects ; Endoplasmic Reticulum Stress ; Glucose/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Insulin/metabolism ; Insulin Resistance ; Mice ; Mice, Inbred C57BL ; Muscle, Skeletal/metabolism ; Palmitates ; Proline/analogs & derivatives ; RNA/metabolism ; Tumor Necrosis Factor-alpha/pharmacology
Chemical Substances	Insulin ; Palmitates ; Tumor Necrosis Factor-alpha ; RNA (63231-63-0) ; Proline (9DLQ4CIU6V) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Glucose (IY9XDZ35W2) ; stachydrine (S1L688345C)
Language	English
Publishing date	2022-07-14
Publishing country	Italy
Document type	Journal Article
ZDB-ID	432272-1
ISSN	1720-8386 ; 0391-4097 ; 1121-1369
ISSN (online)	1720-8386
ISSN	0391-4097 ; 1121-1369
DOI	10.1007/s40618-022-01866-8
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Article ; Online: A systematic review of metformin to limit weight-gain with atypical antipsychotics.

Lee, Y J / Jeong, J H

Journal of clinical pharmacy and therapeutics

2011 Volume 36, Issue 5, Page(s) 537–545

Abstract: What is known and objective: Weight-gain is commonly reported in patients taking atypical antipsychotic agents. A systematic review was performed to evaluate the effectiveness of metformin for attenuation of weight-gain induced by atypical antipsychotic ...

Abstract	What is known and objective: Weight-gain is commonly reported in patients taking atypical antipsychotic agents. A systematic review was performed to evaluate the effectiveness of metformin for attenuation of weight-gain induced by atypical antipsychotic agents. Methods: A PubMed database (1966-May 2010) search was conducted, using metformin, atypical antipsychotic and weight-gain as search terms. Review articles, letters and commentaries were excluded. Results and discussion: Thirteen trials were identified (eight randomized, double-blind, placebo-controlled trials, one crossover adult trial, one open-label uncontrolled adult trial, two open-label uncontrolled paediatric trials and one case report). Of the eight randomized, double-blind, placebo-controlled trials, three studied adult subjects and one studied children. Metformin was well tolerated. The heterogeneity of the trials did not justify meta-analytic pooling of outcomes, and we provide a best evidence synthesis. What is new and conclusion: There is limited evidence for the efficacy of metformin in limiting weight-gain induced by atypical antipsychotic agents. However, the evidence is weak and further well-powered randomized, double-blind, placebo-controlled studies of longer duration should be conducted to confirm the preliminary evidence and provide better estimates of effect.
MeSH term(s)	Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Humans ; Hypoglycemic Agents/therapeutic use ; Metformin/adverse effects ; Metformin/therapeutic use ; Randomized Controlled Trials as Topic ; Weight Gain/drug effects ; Weight Gain/physiology
Chemical Substances	Antipsychotic Agents ; Hypoglycemic Agents ; Metformin (9100L32L2N)
Language	English
Publishing date	2011-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639006-7
ISSN	1365-2710 ; 0269-4727
ISSN (online)	1365-2710
ISSN	0269-4727
DOI	10.1111/j.1365-2710.2011.01255.x
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Article ; Online: The effects of biodegradable poly(lactic-co-glycolic acid)-based microspheres loaded with quercetin on stemness, viability and osteogenic differentiation potential of stem cell spheroids.

Lee, H / Nguyen, T T / Kim, M / Jeong, J-H / Park, J-B

Journal of periodontal research

2018 Volume 53, Issue 5, Page(s) 801–815

Abstract: Objective: Quercetin has been reported to exert many beneficial effects on the protection against various diseases, such as diabetes, cancer, and inflammation. The aim of this study is to evaluate the potential osteogenic differentiation ability of ... ...

Abstract	Objective: Quercetin has been reported to exert many beneficial effects on the protection against various diseases, such as diabetes, cancer, and inflammation. The aim of this study is to evaluate the potential osteogenic differentiation ability of mesenchymal stem cells in the presence of quercetin. Material and methods: Quercetin-loaded poly(lactic-co-glycolic acid) microspheres were prepared using an electrospraying technique. Characterization of the microspheres was evaluated with a scanning electron microscope and release profile. Three-dimensional cell spheroids were fabricated using silicon elastomer-based concave microwells. Qualitative results of cellular viability were seen under a confocal microscope, and quantitative cellular viability was evaluated using the Cell Counting Kit-8 assay. The alkaline phosphatase activity and Alizarin Red S staining were performed. A quantitative real-time polymerase chain reaction and a western blot analysis were performed. Results: Spheroids were well formed irrespective of quercetin concentration. Most of the cells in spheroids emitted green fluorescence, and the morphology was round without significant changes. The application of quercetin-loaded microspheres produced a significant increase in the alkaline phosphatase activity. The real-time polymerase chain reaction results showed a significant increase in Runx2, and western blot results showed higher expression of Runx2 protein expression. Conclusion: Biodegradable microspheres loaded with quercetin produced prolonged release profiles with increased mineralization. Microspheres loaded with quercetin can be used for the enhancement of osteoblastic differentiation in cell therapy.
MeSH term(s)	Biocompatible Materials/pharmacology ; Blotting, Western ; Cell Differentiation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Gingiva/cytology ; Humans ; In Vitro Techniques ; Mesenchymal Stem Cells/drug effects ; Microscopy, Electron, Scanning ; Microspheres ; Osteogenesis/drug effects ; Polylactic Acid-Polyglycolic Acid Copolymer/pharmacology ; Quercetin/pharmacology ; RNA, Messenger/metabolism ; Real-Time Polymerase Chain Reaction
Chemical Substances	Biocompatible Materials ; RNA, Messenger ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Quercetin (9IKM0I5T1E)
Language	English
Publishing date	2018-05-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	390953-0
ISSN	1600-0765 ; 0022-3484
ISSN (online)	1600-0765
ISSN	0022-3484
DOI	10.1111/jre.12569
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