LIVIVO - Search results -

Search results

Result 1 - 10 of total 17

Search options

Article: Induction of autophagy improves skin and hair conditions in dogs with underlying diseases.

Kim, Yoonji / Lee, Seung-Hwa / Song, Yunji / Jeong, Sekyoo / Kim, Ha-Jung

2023 Volume 10, Page(s) 1078259

Abstract: Background: Autophagy was reported to play a crucial role in maintaining general and skin health.: Methods: The study used a synthesized autophagy inducer (AI) (Aquatide™ cospharm Inc.; Daejeon, Korea), for evaluating the effects of autophagy on skin ...

Abstract	Background: Autophagy was reported to play a crucial role in maintaining general and skin health. Methods: The study used a synthesized autophagy inducer (AI) (Aquatide™ cospharm Inc.; Daejeon, Korea), for evaluating the effects of autophagy on skin and hair in dogs. Twenty-two dogs with poor skin and hair which were diagnosed with canine atopic dermatitis (CAD) or pituitary-dependent hyperadrenocorticism (PDH) were included. Clinical scores using Canine Atopic Dermatitis Extent and Severity Index-04 (CADESI-04), Pruritus Visual Analog Scale (PVAS) and skin barrier function using measurement of transepidermal water loss (TEWL) were evaluated and canine keratinocytes were also used Results: In the AI group, clinical scores and skin barrier function were improved at week 8 significantly compared to in the other groups. In particular, the AI significantly improved the hair surface damage at 8 weeks compared to the baseline. Conclusion: AI improve skin barrier function and hair damage and reduce pro-inflammatory cytokines by inhibiting reactive oxygen species (ROS) production in dogs.
Language	English
Publishing date	2023-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2023.1078259
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Protease-Activated Receptors 2-Antagonist Suppresses Asthma by Inhibiting Reactive Oxygen Species-Thymic Stromal Lymphopoietin Inflammation and Epithelial Tight Junction Degradation.

Kim, Ha Jung / Lee, Seung Hwa / Jeong, Sekyoo / Hong, Soo Jong

Allergy, asthma & immunology research

2019 Volume 11, Issue 4, Page(s) 560–571

Abstract: Purpose: Protease-activated receptor 2 (PAR2) reportedly triggers the immune response in allergic asthma. We aimed to investigate the mechanism on allergic inflammation mediated by PAR2.: Methods: Human lung epithelial cells (A549 cells) were used ... ...

Abstract	Purpose: Protease-activated receptor 2 (PAR2) reportedly triggers the immune response in allergic asthma. We aimed to investigate the mechanism on allergic inflammation mediated by PAR2. Methods: Human lung epithelial cells (A549 cells) were used for Results: In A549 cells, the levels of reactive oxygen species (ROS) and thymic stromal lymphopoietin (TSLP) were significantly increased by GCE treatment, but were suppressed by PAR2-antagonist (PAR2-ant) or N-acetylcysteine (NAC) treatment. Claudin-1 was degraded by GCE, and was restored by PAR2-ant or NAC in the cells. In the mouse model, the clinical appearance including bronchial hyperresponsiveness, bronchoalveolar lavage fluid analysis and total immunoglobulin E were significantly suppressed by PAR2-ant or NAC. Moreover, TSLP levels in the lung were suppressed by the same treatments in the lung. Claudin-1 was also degraded by GCE, and was restored by PAR2-ant or NAC. Conclusions: ROS generation and epidermal tight junction degradation are triggered by protease, followed by the induction of TSLP in allergic asthma. Our findings could suggest that PAR2-ant or anti-oxidants could be considered for allergic diseases as preventive alternatives.
Language	English
Publishing date	2019-05-31
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2545725-1
ISSN	2092-7363 ; 2092-7355
ISSN (online)	2092-7363
ISSN	2092-7355
DOI	10.4168/aair.2019.11.4.560
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Isolation of Bovine Milk Exosome Using Electrophoretic Oscillation Assisted Tangential Flow Filtration with Antifouling of Micro-ultrafiltration Membrane Filters.

Ko, Minji / Kim, Hyeng Jin / Park, Jaeeun / Lee, Hansol / Lee, Keyong Nam / Kim, Kayoung / Lee, Jaehyuk / Yoon, Seok Jeong / Kim, Tony / Jeong, Sekyoo / Heo, Kyun / Lee, Young Kwang / Do, Young Rag

ACS applied materials & interfaces

2023 Volume 15, Issue 21, Page(s) 26069–26080

Abstract: Tangent flow-driven ultrafiltration (TF-UF) is an efficient isolation process of milk exosomes without morphological deformation. However, the TF-UF approach with micro-ultrafiltration ... ...

Abstract	Tangent flow-driven ultrafiltration (TF-UF) is an efficient isolation process of milk exosomes without morphological deformation. However, the TF-UF approach with micro-ultrafiltration SiN
MeSH term(s)	Animals ; Ultrafiltration ; Milk ; Exosomes ; Biofouling/prevention & control ; Filtration ; Membranes, Artificial
Chemical Substances	Membranes, Artificial
Language	English
Publishing date	2023-05-16
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c00446
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Enhanced Large-Scale Production of

Jeong, Yujin / Kim, Hyun Ju / Kim, Suran / Park, Seo-Young / Kim, HyeRan / Jeong, Sekyoo / Lee, Sang Jun / Lee, Moo-Seung

Journal of microbiology and biotechnology

2021 Volume 31, Issue 12, Page(s) 1624–1631

Abstract: Prodigiosin as a high-valued compound, which is a microbial secondary metabolite, has the potential for antioxidant and anticancer effects. However, the large-scale production of functionally ... ...

Abstract	Prodigiosin as a high-valued compound, which is a microbial secondary metabolite, has the potential for antioxidant and anticancer effects. However, the large-scale production of functionally active
MeSH term(s)	Antineoplastic Agents/isolation & purification ; Antineoplastic Agents/metabolism ; Bioreactors ; Carbon/metabolism ; Cell Survival/drug effects ; Culture Media/chemistry ; Fermentation ; Gammaproteobacteria/metabolism ; Humans ; Prodigiosin/isolation & purification ; Prodigiosin/metabolism ; THP-1 Cells
Chemical Substances	Antineoplastic Agents ; Culture Media ; Carbon (7440-44-0) ; Prodigiosin (OL369FU7CJ)
Language	English
Publishing date	2021-11-11
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2412195-2
ISSN	1738-8872 ; 1017-7825
ISSN (online)	1738-8872
ISSN	1017-7825
DOI	10.4014/jmb.2109.09039
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Autophagy Activation by

Yoon, Seok Jeong / Lim, Chae Jin / Chung, Hwa-Jee / Kim, Joo-Hwan / Huh, Yang Hoon / Park, Keedon / Jeong, Sekyoo

International journal of molecular sciences

2019 Volume 20, Issue 3

Abstract: Pollution-induced skin damage results in oxidative stress; cellular toxicity; inflammation; and, ultimately, premature skin aging. Previous studies suggest that the activation of autophagy can protect oxidation-induced cellular damage and aging-like ... ...

Abstract	Pollution-induced skin damage results in oxidative stress; cellular toxicity; inflammation; and, ultimately, premature skin aging. Previous studies suggest that the activation of autophagy can protect oxidation-induced cellular damage and aging-like changes in skin. In order to develop new anti-pollution ingredients, this study screened various kinds of natural extracts to measure their autophagy activation efficacy in cultured dermal fibroblast. The stimulation of autophagy flux by the selected extracts was further confirmed both by the expression of proteins associated with the autophagy signals and by electron microscope.
MeSH term(s)	AMP-Activated Protein Kinases/metabolism ; Asteraceae/chemistry ; Autophagy ; Benzopyrenes/adverse effects ; Cadmium Chloride/adverse effects ; Cells, Cultured ; Cytokines/metabolism ; Environmental Pollutants/adverse effects ; Epidermal Cells/cytology ; Epidermal Cells/drug effects ; Epidermal Cells/metabolism ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Gene Expression Regulation/drug effects ; Humans ; Microscopy, Electron, Transmission ; Oxidative Stress/drug effects ; Phosphorylation ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	Benzopyrenes ; Cytokines ; Environmental Pollutants ; Plant Extracts ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Cadmium Chloride (J6K4F9V3BA)
Language	English
Publishing date	2019-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20030517
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Phenotypic overlap between atopic dermatitis and autism.

Shin, Kyong-Oh / Crumrine, Debra A / Kim, Sungeun / Lee, Yerin / Kim, Bogyeong / Abuabara, Katrina / Park, Chaehyeong / Uchida, Yoshikazu / Wakefield, Joan S / Meyer, Jason M / Jeong, Sekyoo / Park, Byeong Deog / Park, Kyungho / Elias, Peter M

BMC neuroscience

2021 Volume 22, Issue 1, Page(s) 43

Abstract: Background: Autism, a childhood behavioral disorder, belongs to a large suite of diseases, collectively referred to as autism spectrum disorders (ASD). Though multifactorial in etiology, approximately 10% of ASD are associated with atopic dermatitis (AD) ...

Abstract	Background: Autism, a childhood behavioral disorder, belongs to a large suite of diseases, collectively referred to as autism spectrum disorders (ASD). Though multifactorial in etiology, approximately 10% of ASD are associated with atopic dermatitis (AD). Moreover, ASD prevalence increases further as AD severity worsens, though these disorders share no common causative mutations. We assessed here the link between these two disorders in the standard, valproic acid mouse model of ASD. In prior studies, there was no evidence of skin involvement, but we hypothesized that cutaneous involvement could be detected in experiments conducted in BALB/c mice. BALB/c is an albino, laboratory-bred strain of the house mouse and is among the most widely used inbred strains used in animal experimentation. Methods: We performed our studies in valproic acid (VPA)-treated BALB/c hairless mice, a standard mouse model of ASD. Mid-trimester pregnant mice received a single intraperitoneal injection of either valproic acid sodium salt dissolved in saline or saline alone on embryonic day 12.5 and were housed individually until postnatal day 21. Only the brain and epidermis appeared to be affected, while other tissues remain unchanged. At various postnatal time points, brain, skin and blood samples were obtained for histology and for quantitation of tissue sphingolipid content and cytokine levels. Results: AD-like changes in ceramide content occurred by day one postpartum in both VPA-treated mouse skin and brain. The temporal co-emergence of AD and ASD, and the AD phenotype-dependent increase in ASD prevalence correlated with early appearance of cytokine markers (i.e., interleukin [IL]-4, 5, and 13), as well as mast cells in skin and brain. The high levels of interferon (IFN)γ not only in skin, but also in brain likely account for a significant decline in esterified very-long-chain N-acyl fatty acids in brain ceramides, again mimicking known IFNγ-induced changes in AD. Conclusion: Baseline involvement of both AD and ASD could reflect concurrent neuro- and epidermal toxicity, possibly because both epidermis and neural tissues originate from the embryonic neuroectoderm. These studies illuminate the shared susceptibility of the brain and epidermis to a known neurotoxin, suggesting that the atopic diathesis could be extended to include ASD.
MeSH term(s)	Animals ; Anticonvulsants/toxicity ; Autistic Disorder/chemically induced ; Autistic Disorder/genetics ; Autistic Disorder/metabolism ; Dermatitis, Atopic/chemically induced ; Dermatitis, Atopic/genetics ; Dermatitis, Atopic/metabolism ; Female ; Inflammation Mediators/metabolism ; Maze Learning/drug effects ; Maze Learning/physiology ; Mice ; Mice, Inbred BALB C ; Phenotype ; Pregnancy ; Prenatal Exposure Delayed Effects/chemically induced ; Prenatal Exposure Delayed Effects/genetics ; Prenatal Exposure Delayed Effects/metabolism ; Valproic Acid/toxicity
Chemical Substances	Anticonvulsants ; Inflammation Mediators ; Valproic Acid (614OI1Z5WI)
Language	English
Publishing date	2021-06-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2041344-0
ISSN	1471-2202 ; 1471-2202
ISSN (online)	1471-2202
ISSN	1471-2202
DOI	10.1186/s12868-021-00645-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Comparison of the Efficacy of Atopalm(®) Multi-Lamellar Emulsion Cream and Physiogel(®) Intensive Cream in Improving Epidermal Permeability Barrier in Sensitive Skin.

Jeong, Sekyoo / Lee, Sin Hee / Park, Byeong Deog / Wu, Yan / Man, George / Man, Mao-Qiang

Dermatology and therapy

2016 Volume 6, Issue 1, Page(s) 47–56

Abstract: Introduction: The management of sensitive skin, which affects over 60% of the general population, has been a long-standing challenge for both patients and clinicians. Because defective epidermal permeability barrier is one of the clinical features of ... ...

Abstract	Introduction: The management of sensitive skin, which affects over 60% of the general population, has been a long-standing challenge for both patients and clinicians. Because defective epidermal permeability barrier is one of the clinical features of sensitive skin, barrier-enhancing products could be an optimal regimen for sensitive skin. In the present study, we evaluated the efficacy and safety of two barrier-enhancing products, i.e., Atopalm (®) Multi-Lamellar Emulsion (MLE) Cream and Physiogel (®) Intensive Cream for sensitive skin. Methods: 60 patients with sensitive skin, aged 22-40 years old, were randomly assigned to one group treated with Atopalm MLE Cream, and another group treated with Physiogel Intensive Cream twice daily for 4 weeks. Lactic acid stinging test scores (LASTS), stratum hydration (SC) and transepidermal water loss (TEWL) were assessed before, 2 and 4 weeks after the treatment. Results: Atopalm MLE Cream significantly lowered TEWL after 2 and 4 weeks of treatment (p < 0.01). In contrast, Physiogel Intensive Cream significantly increased TEWL after 2 weeks of treatment (p < 0.05) while TEWL significantly decreased after 4-week treatments. Moreover, both Atopalm MLE Cream and Physiogel Intensive Cream significantly increased SC hydration, and improved LASTS after 4 weeks of treatment. Conclusion: Both barrier-enhancing products are effective and safe for improving epidermal functions, including permeability barrier, SC hydration and LASTS, in sensitive skin. These products could be a valuable alternative for management of sensitive skin. Funding: Veterans Affairs Medical Center, San Francisco, California, USA, and NeoPharm Co., Ltd., Daejeon, Korea.
Language	English
Publishing date	2016-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2680284-3
ISSN	2190-9172 ; 2193-8210
ISSN (online)	2190-9172
ISSN	2193-8210
DOI	10.1007/s13555-016-0097-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Erratum to: Comparison of the Efficacy of Atopalm(®) Multi-Lamellar Emulsion Cream and Physiogel(®) Intensive Cream in Improving Epidermal Permeability Barrier in Sensitive Skin.

Jeong, Sekyoo / Lee, Sin Hee / Park, Byeong Deog / Wu, Yan / Man, George / Man, Mao-Qiang

Dermatology and therapy

2016 Volume 6, Issue 1, Page(s) 57

Language	English
Publishing date	2016-02-26
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2680284-3
ISSN	2190-9172 ; 2193-8210
ISSN (online)	2190-9172
ISSN	2193-8210
DOI	10.1007/s13555-016-0103-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Activation of SIRT1 Enhances Epidermal Permeability Barrier Formation through Ceramide Synthase 2- and 3-Dependent Mechanisms.

Shin, Kyong-Oh / Lim, Chae Jin / Park, Hye Yoon / Kim, Sungeun / Kim, Bogyeong / Lee, Yerin / Chung, Hwajee / Jeong, Se-Kyoo / Park, Keedon / Park, Kyungho

The Journal of investigative dermatology

2020 Volume 140, Issue 7, Page(s) 1435–1438.e5

MeSH term(s)	Ceramides/metabolism ; Epidermis/metabolism ; Gene Expression Regulation ; Humans ; Membrane Proteins/metabolism ; Permeability ; RNA, Small Interfering/metabolism ; Sirtuin 1/metabolism ; Skin/metabolism ; Sphingosine N-Acyltransferase/metabolism ; Tumor Suppressor Proteins/metabolism
Chemical Substances	Ceramides ; Membrane Proteins ; RNA, Small Interfering ; Tumor Suppressor Proteins ; CERS2 protein, human (EC 2.3.1.24) ; CERS3 protein, human (EC 2.3.1.24) ; Sphingosine N-Acyltransferase (EC 2.3.1.24) ; SIRT1 protein, human (EC 3.5.1.-) ; Sirtuin 1 (EC 3.5.1.-)
Language	English
Publishing date	2020-01-17
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1016/j.jid.2019.12.021
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui VI Zs.124: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Topical application of autophagy-activating peptide improved skin barrier function and reduced acne symptoms in acne-prone skin.

Lee, Yoonjin / Shin, Kayoung / Shin, Kyong-Oh / Yoon, Seokjeong / Jung, Juyeon / Hwang, Eojin / Chung, Hwa-Jee / Hossini, Amir M / Zouboulis, Christos C / Baek, Min Jeong / Baek, Ji Hwoon / Chi, Young Min / Lee, Sangeun / Jeong, Sekyoo

Journal of cosmetic dermatology

2020 Volume 20, Issue 3, Page(s) 1009–1016

Abstract: Background: Recent studies about the important roles of autophagy signaling in sebaceous lipogenesis and epidermal differentiation suggest potential benefits of autophagy activation in acne.: Aims: To investigate the effects of an autophagy activator ...

Abstract	Background: Recent studies about the important roles of autophagy signaling in sebaceous lipogenesis and epidermal differentiation suggest potential benefits of autophagy activation in acne. Aims: To investigate the effects of an autophagy activator on acne-prone skin. Methods: Autophagy signaling in human immortalized SZ95 sebocytes, normal human epidermal keratinocytes, and 3D reconstituted skin was examined. Effects of an autophagy-activating peptide on sebaceous lipogenesis were measured by fluorescence microscopic analysis. The clinical efficacy in acne-prone skin was evaluated through an eight-week, double-blind, randomized, vehicle-controlled study. Changes in skin surface lipid compositions were further analyzed. Results: In cultured sebocytes and keratinocytes, the investigated autophagy-activating peptide increased LC3-II expression, indicating a stimulation of autophagy signaling. Testosterone and linoleic acid treatment induced lipogenesis in cultured sebocytes and is further inhibited by the autophagy activator peptide treatment. Increased expression of differentiation marker proteins in cultured keratinocytes was also observed by autophagy-activating peptide. In clinical study, reduction of closed comedones and the amount of skin surface lipids as well as of trans-epidermal water loss (TEWL) were observed in acne-prone skin after autophagy-activating peptide application. In addition, reduction of squalene and increase in cholesterol were observed after an 8-week application. Conclusions: Topical application of an autophagy activator downregulated sebaceous lipogenesis and improved the skin barrier function. Considering the important roles of sebum and skin barrier function in acne pathogenesis, autophagy activation might represent a new therapeutic option in early forms of acne.
MeSH term(s)	Acne Vulgaris/drug therapy ; Autophagy ; Humans ; Peptides ; Sebaceous Glands ; Sebum
Chemical Substances	Peptides
Language	English
Publishing date	2020-08-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.13636
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6539: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito