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Article ; Online: Intracardiac bone cement embolism.

Lee, J-S / Jeong, Y-S / Ahn, S-G

2010 Volume 96, Issue 5, Page(s) 387

MeSH term(s)	Aged ; Bone Cements/adverse effects ; Female ; Heart Atria ; Heart Ventricles ; Humans ; Polymethyl Methacrylate/adverse effects ; Pulmonary Embolism/etiology ; Vertebroplasty/adverse effects
Chemical Substances	Bone Cements ; Polymethyl Methacrylate (9011-14-7)
Language	English
Publishing date	2010-03
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/hrt.2009.182162
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Article: Rapid detection of Bacillus spore aerosol particles by direct in situ analysis using MALDI‐TOF mass spectrometry

Jeong, Y.‐S / Choi, S / Chong, E / Kim, J.H / Kim, S.‐J

Letters in applied microbiology. 2014 Aug., v. 59, no. 2

2014

Abstract: Accurate and rapid analytical methods are essential for the detection and identification of biological warfare agents (BWA). Although various studies have investigated the use of MALDI‐TOF MS for bacterial classification, only a few studies have examined ...

Abstract	Accurate and rapid analytical methods are essential for the detection and identification of biological warfare agents (BWA). Although various studies have investigated the use of MALDI‐TOF MS for bacterial classification, only a few studies have examined the applicability of method for the identification of BWAs. This study aimed to generate, collect and analyse Bacillus spore aerosol particles of 2–10� μm, the optimal size of a BWA. Bacillus spore aerosol particles of 2–10� μm were rapidly analysed using direct in situ MALDI‐TOF MS without pretreatment processes. A mass spectrum of Bacillus spore aerosol particles was successfully detected. For real‐time detection and identification, a mass spectral database of Bacillus spores was constructed, and an algorithm was developed and applied. Bacillus spore particles were rapidly detected and identified by MS, which can be used for the detection and inspection of BWAs. SIGNIFICANCE AND IMPACT OF THE STUDY: Methods that permit accurate and fast detection and identification are essential in the case of pathogens such as Bacillus anthracis, which can be used as biological warfare agents or bioterrorism materials. Here, direct in situ MALDI‐TOF MS allowed the high‐throughput detection and identification of aerosolized Bacillus spore particles, and this method could be effectively applied for the detection and inspection of BWAs. In this context, we believe that this method may contribute to the realization of real‐time and on‐site identification of BWAs.
Keywords	Bacillus anthracis ; aerosols ; algorithms ; bioterrorism ; databases ; mass spectrometry ; pathogens ; spores
Language	English
Dates of publication	2014-08
Size	p. 177-183.
Publishing place	Society for Applied Bacteriology by Blackwell Scientific Publications
Document type	Article
ZDB-ID	632584-1
ISSN	1472-765X ; 0266-8254
ISSN (online)	1472-765X
ISSN	0266-8254
DOI	10.1111/lam.12261
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Article ; Online: Rapid detection of Bacillus spore aerosol particles by direct in situ analysis using MALDI-TOF mass spectrometry.

Jeong, Y-S / Choi, S / Chong, E / Kim, J H / Kim, S-J

Letters in applied microbiology

2014 Volume 59, Issue 2, Page(s) 177–183

Abstract: Unlabelled: Accurate and rapid analytical methods are essential for the detection and identification of biological warfare agents (BWA). Although various studies have investigated the use of MALDI-TOF MS for bacterial classification, only a few studies ... ...

Abstract	Unlabelled: Accurate and rapid analytical methods are essential for the detection and identification of biological warfare agents (BWA). Although various studies have investigated the use of MALDI-TOF MS for bacterial classification, only a few studies have examined the applicability of method for the identification of BWAs. This study aimed to generate, collect and analyse Bacillus spore aerosol particles of 2-10 μm, the optimal size of a BWA. Bacillus spore aerosol particles of 2-10 μm were rapidly analysed using direct in situ MALDI-TOF MS without pretreatment processes. A mass spectrum of Bacillus spore aerosol particles was successfully detected. For real-time detection and identification, a mass spectral database of Bacillus spores was constructed, and an algorithm was developed and applied. Bacillus spore particles were rapidly detected and identified by MS, which can be used for the detection and inspection of BWAs. Significance and impact of the study: Methods that permit accurate and fast detection and identification are essential in the case of pathogens such as Bacillus anthracis, which can be used as biological warfare agents or bioterrorism materials. Here, direct in situ MALDI-TOF MS allowed the high-throughput detection and identification of aerosolized Bacillus spore particles, and this method could be effectively applied for the detection and inspection of BWAs. In this context, we believe that this method may contribute to the realization of real-time and on-site identification of BWAs.
MeSH term(s)	Aerosols ; Air Microbiology ; Bacillus anthracis/chemistry ; Biological Warfare Agents ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Spores, Bacterial/chemistry
Chemical Substances	Aerosols ; Biological Warfare Agents
Language	English
Publishing date	2014-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632584-1
ISSN	1472-765X ; 0266-8254
ISSN (online)	1472-765X
ISSN	0266-8254
DOI	10.1111/lam.12261
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Article: A new guaiane type sesquiterpene from Torilis japonica.

Ryu, J H / Jeong, Y S

Archives of pharmacal research

2002 Volume 24, Issue 6, Page(s) 532–535

Abstract: A new guaiane type sesquiterpene was isolated from the fruit of Torilis japonica (Umbelliferae). Based on NMR, IR and mass spectroscopy its structure was confirmed as deangeloyloxy torilin, 1beta, 7alpha, 10alphaH-11-acetoxy-guaia-4-en-3-one (1). This is ...

Abstract	A new guaiane type sesquiterpene was isolated from the fruit of Torilis japonica (Umbelliferae). Based on NMR, IR and mass spectroscopy its structure was confirmed as deangeloyloxy torilin, 1beta, 7alpha, 10alphaH-11-acetoxy-guaia-4-en-3-one (1). This is the first report showing that this compound can be isolated from Torilis japonica.
MeSH term(s)	Cycloheptanes/chemistry ; Cycloheptanes/isolation & purification ; Magnetic Resonance Spectroscopy ; Plants, Medicinal/chemistry ; Sesquiterpenes/isolation & purification ; Sesquiterpenes, Guaiane
Chemical Substances	11-acetoxyguaia-4-en-3-one ; Cycloheptanes ; Sesquiterpenes ; Sesquiterpenes, Guaiane ; guaiane
Language	English
Publishing date	2002-01-28
Publishing country	Korea (South)
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	447623-2
ISSN	1976-3786 ; 0253-6269
ISSN (online)	1976-3786
ISSN	0253-6269
DOI	10.1007/bf02975160
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Article: Suitability of Setting Summer Indoor Temperature for Thermal Comfort

Shim, H.S., Korea National University of Education, Cheongwon, Republic of Korea / Jeong, Y.S., Andong National University, Andong, Republic of Korea

The Korean Journal of Community Living Science

(Dec 2013) Volume v. 24, Issue (4), Page(s) p. 583–589

Abstract: This study was to provide the information for optimum utilization of the air-conditioning system in the human health and energy saving perspective. Subjects were 17 male and female college students(7 males and 10 females) with normal weight. They wore a ... ...

Abstract	This study was to provide the information for optimum utilization of the air-conditioning system in the human health and energy saving perspective. Subjects were 17 male and female college students(7 males and 10 females) with normal weight. They wore a short sleeved shirt, knee length trousers, socks, and underwear(0.4clo). They were asked to choose the preferred temperature from different environmental temperatures(28℃, 25℃). The physiological responses were measured and the subjective sensation was voted during the step changes of environmental temperature, starting at 28℃ to 25℃ with 1℃ decrease every 20 minutes. The preferred temperature was 25.9±0.4℃ for males and 26.9±0.2℃ for females at 28℃ and 24.8±0.6℃ for males and 25.6±0.1℃ for females at 25℃. The preferred temperature decreased about 1.3℃ while the environmental temperature changed 3℃. During the environmental step changes, mean skin temperature decreased more in females while the oxygen uptake and rectal temperature were kept constant for both males and females. We found the preferred temperature was affected by the exposed temperature and the thermal sensation in the condition. Subjects preferred a lower environmental temperature when they were exposed to a lower temperature with cooler sensation. Therefore, in the perspective of human health and energy saving, it is recommended to start setting the air-conditioning temperature higher than the preferred temperature.
Keywords	ETE ; VERANO ; SUMMER
Language	Korean
Document type	Article
ISSN	1229-8565
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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Article ; Online: Characterization of DDRI-18 (3,3'-(1H,3'H-5,5'-bibenzo[d]imidazole-2,2'-diyl)dianiline), a novel small molecule inhibitor modulating the DNA damage response.

Jun, D W / Jeong, Y S / Kim, H J / Jeong, K-C / Kim, S / Lee, C-H

British journal of pharmacology

2012 Volume 167, Issue 1, Page(s) 141–150

Abstract: Background and purpose: Recently, the DNA damage response (DDR) has emerged as a promising target for anticancer drug development. In our previous study, we identified several DDR-inhibiting compounds via high-content screening of a small molecule ... ...

Abstract	Background and purpose: Recently, the DNA damage response (DDR) has emerged as a promising target for anticancer drug development. In our previous study, we identified several DDR-inhibiting compounds via high-content screening of a small molecule library using γH2AX foci as a biomarker. Here, we studied the effects of the DNA damage response inhibitor DDRI-18 (3,3'-(1H,3'H-5,5'-bibenzo[d]imidazole-2,2'-diyl)dianiline) on DDR. Experimental approach: Osteosarcoma U2OS cells were treated with etoposide to induce DDR. The nuclear foci of γH2AX and other signalling molecules in DDR were visualized by immunofluorescence and quantified using an IN Cell Analyzer. The DNA repair capacity of cells was analysed using the comet assay and in vivo DNA end-joining assay. Cell survival after drug treatment was quantified using the MTT assay, and apoptotic cell death was analysed by Annexin V staining and flow cytometry. Key results: DDRI-18 inhibited the non-homologous end-joining (NHEJ) DNA repair process and delayed the resolution of DNA damage-related proteins (γH2AX, ATM and BRCA1) from DNA lesions at a later phase of DDR. Furthermore, DDRI-18 enhanced the cytotoxic effects of anticancer DNA-damaging drugs, including etoposide, camptothecin, doxorubicin and bleomycin. This synergistic effect on cell death was shown to be due to caspase-dependent apoptosis. Conclusions and implications: We identified a chemical compound, DDRI-18, that has chemosensitization activity. Although the target molecule and mechanism of action of DDRI-18 remain unknown, DDRI-18 is an effective chemosensitizing agent and may improve the therapy with classical anticancer drugs.
MeSH term(s)	Aniline Compounds/pharmacology ; Antineoplastic Agents/pharmacology ; Benzimidazoles/pharmacology ; Bleomycin/pharmacology ; Camptothecin/pharmacology ; Cell Line, Tumor ; DNA Damage ; DNA Repair/drug effects ; Drug Synergism ; Etoposide/pharmacology ; Humans
Chemical Substances	3,3'-(1H,3'H-5,5'-bibenzo(d)imidazole-2,2'-diyl)dianiline ; Aniline Compounds ; Antineoplastic Agents ; Benzimidazoles ; Bleomycin (11056-06-7) ; Etoposide (6PLQ3CP4P3) ; Camptothecin (XT3Z54Z28A)
Language	English
Publishing date	2012-05-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/j.1476-5381.2012.01977.x
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Article: Evidence for coronavirus discontinuous transcription.

Jeong, Y S / Makino, S

Journal of virology

1994 Volume 68, Issue 4, Page(s) 2615–2623

Abstract: Coronavirus subgenomic mRNA possesses a 5'-end leader sequence which is derived from the 5' end of genomic RNA and is linked to the mRNA body sequence. This study examined whether coronavirus transcription involves a discontinuous transcription step; the ...

Abstract	Coronavirus subgenomic mRNA possesses a 5'-end leader sequence which is derived from the 5' end of genomic RNA and is linked to the mRNA body sequence. This study examined whether coronavirus transcription involves a discontinuous transcription step; the possibility that a leader sequence from mouse hepatitis virus (MHV) genomic RNA could be used for MHV subgenomic defective interfering (DI) RNA transcription was examined. This was tested by using helper viruses and DI RNAs that were easily distinguishable. MHV JHM variant JHM(2), which synthesizes a subgenomic mRNA encoding the HE gene, and variant JHM(3-9), which does not synthesize this mRNA, were used. An MHV DI RNA, DI(J3-9), was constructed to contain a JHM(3-9)-derived leader sequence and an inserted intergenic region derived from the region preceding the MHV JHM HE gene. DI(J3-9) replicated efficiently in JHM(2)- or JHM(3-9)-infected cells, whereas synthesis of subgenomic DI RNAs was observed only in JHM(2)-infected cells. Sequence analyses demonstrated that the 5' regions of both helper virus genomic RNAs and genomic DI RNAs maintained their original sequences in DI RNA-replicating cells, indicating that the genomic leader sequences derived from JHM(2) functioned for subgenomic DI RNA transcription. Replication and transcription of DI(J3-9) were observed in cells infected with an MHV A59 strain whose leader sequence was similar to that of JHM(2), except for one nucleotide substitution within the leader sequence. The 5' region of the helper virus genomic RNA and that of the DI RNA were the same as their original structures in virus-infected cells, and the leader sequence of DI(J3-9) subgenomic DI RNA contained the MHV A59-derived leader sequence. The leader sequence of subgenomic DI RNA was derived from that of helper virus; therefore, the genomic leader sequence had a trans-acting property indicative of a discontinuous step in coronavirus transcription.
MeSH term(s)	Animals ; Base Sequence ; Blotting, Northern ; Defective Viruses/genetics ; Helper Viruses/genetics ; Mice ; Molecular Sequence Data ; Murine hepatitis virus/genetics ; Plasmids ; Polymerase Chain Reaction ; Regulatory Sequences, Nucleic Acid/genetics ; Sequence Analysis, RNA ; Transcription, Genetic ; Transfection
Keywords	covid19
Language	English
Publishing date	1994-04
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.68.4.2615-2623.1994
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Article: Mechanism of coronavirus transcription: duration of primary transcription initiation activity and effects of subgenomic RNA transcription on RNA replication.

Jeong, Y S / Makino, S

Journal of virology

1992 Volume 66, Issue 6, Page(s) 3339–3346

Abstract: Previously, we established a system whereby an intergenic region from mouse hepatitis virus (MHV) inserted into an MHV defective interfering (DI) RNA led to transcription of a subgenomic DI RNA in helper virus-infected cells. By using this system, the ... ...

Abstract	Previously, we established a system whereby an intergenic region from mouse hepatitis virus (MHV) inserted into an MHV defective interfering (DI) RNA led to transcription of a subgenomic DI RNA in helper virus-infected cells. By using this system, the duration of a primary transcription initiation activity which transcribes subgenomic-size RNAs from the genomic-size RNA template in MHV-infected cells was examined. Efficient DI genomic and subgenomic RNA synthesis was observed when the DI RNA was transfected at 1, 3, 3.5, 5, and 6 h postinfection, indicating that all activities which are necessary for MHV RNA synthesis are present continuously during the first 6 h of infection. The effect of subgenomic DI RNA synthesis on DI genomic RNA replication was then examined. Replication efficiency of the DI genomic RNA which synthesized the subgenomic RNA was approximately 70% lower than that of DI genomic RNA which did not synthesize the subgenomic DI RNA in MHV-infected cells. Cotransfection of two different-size DI RNAs demonstrated that replication of the larger DI RNA was strongly inhibited by replication of the smaller genomic DI RNA. Cotransfection of two DI RNA species of the same length into MHV-infected cells demonstrated that reduced replication of the genomic DI RNA which synthesizes the subgenomic RNA did not affect the replication of cotransfected DI RNA, demonstrating that the reduction in DI genomic RNA replication works only in cis, not in trans. Therefore, the previously proposed hypothesis that coronavirus, subgenomic RNA synthesis may inhibit the replication of genomic RNA by competing for a limited amount of virus-derived factors seems unlikely. Possible mechanisms of coronavirus transcription are discussed.
MeSH term(s)	Animals ; Cells, Cultured ; Coronaviridae/metabolism ; Gene Expression Regulation, Viral ; Genome, Viral ; Helper Viruses/metabolism ; Hepatitis Viruses/metabolism ; Mice ; Models, Genetic ; Mutagenesis ; RNA, Viral/biosynthesis ; Time Factors ; Transcription, Genetic ; Transfection ; Virus Replication
Chemical Substances	RNA, Viral
Keywords	covid19
Language	English
Publishing date	1992-06
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.66.6.3339-3346.1992
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Article: A new bisabolene epoxide from Tussilago farfara, and inhibition of nitric oxide synthesis in LPS-activated macrophages.

Ryu, J H / Jeong, Y S / Sohn, D H

Journal of natural products

1999 Volume 62, Issue 10, Page(s) 1437–1438

Abstract: A new bisabolene epoxide was isolated from the flower buds of Tussilago farfara, and the structure was determined by spectroscopic methods to be 1alpha,5alpha-bisacetoxy-8-angeloyloxy-3beta, 4beta-epoxy-bisabola-7(14),10-dien-2-one (1). Compound 1 showed ...

Abstract	A new bisabolene epoxide was isolated from the flower buds of Tussilago farfara, and the structure was determined by spectroscopic methods to be 1alpha,5alpha-bisacetoxy-8-angeloyloxy-3beta, 4beta-epoxy-bisabola-7(14),10-dien-2-one (1). Compound 1 showed inhibition of nitric oxide synthesis in lipopolysaccharide-activated macrophages.
MeSH term(s)	Animals ; Asteraceae/chemistry ; Cell Line ; Lipopolysaccharides/pharmacology ; Macrophage Activation/drug effects ; Macrophages/drug effects ; Macrophages/metabolism ; Medicine, Chinese Traditional ; Mice ; Nitric Oxide/antagonists & inhibitors ; Nitric Oxide/biosynthesis ; Phytotherapy ; Sesquiterpenes/chemistry ; Sesquiterpenes/isolation & purification ; Sesquiterpenes/pharmacology ; Spectrum Analysis
Chemical Substances	1,5-bisacetoxy-8-angeloyloxy-3,4-epoxy-bisabola-7(14),10-dien-2-one ; Lipopolysaccharides ; Sesquiterpenes ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	1999-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/np990116c
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Article ; Audio / Video: A simple method for evaluation of sprout characters in soybean

Lee, J.D / Shannon, J.G / Jeong, Y.S / Lee, J.M / Hwang, Y.H

Euphytica. 2007 Jan., v. 153, no. 1-2

2007

Keywords	bean sprouts ; Glycine max ; vegetables ; seed germination ; sprouting ; genotype ; bioassays ; agar ; germplasm evaluation
Language	English
Dates of publication	2007-01
Size	p. 171-180.
Document type	Article ; Audio / Video
ZDB-ID	216568-5
ISSN	0014-2336
ISSN	0014-2336
DOI	10.1007/s10681-006-9252-y
Database	NAL-Catalogue (AGRICOLA)

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