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  1. Article ; Online: High amplitude pulses on the same charge condition efficiently elicit bipolar cell-mediated retinal ganglion cell responses in the degenerate retina.

    Ahn, Jungryul / Jeong, Yurim / Cha, Seongkwang / Lee, Joo Yong / Yoo, Yongseok / Goo, Yong Sook

    Biomedical engineering letters

    2023  Volume 13, Issue 2, Page(s) 129–140

    Abstract: Retinal pigmentosa (RP) patients lose vision due to the loss of photoreceptors. Retinal prostheses bypass the dead photoreceptors by electrically stimulating surviving retinal neurons, such as bipolar cells or retinal ganglion cells (RGCs). In previous ... ...

    Abstract Retinal pigmentosa (RP) patients lose vision due to the loss of photoreceptors. Retinal prostheses bypass the dead photoreceptors by electrically stimulating surviving retinal neurons, such as bipolar cells or retinal ganglion cells (RGCs). In previous studies, stimulus charge has been mainly optimized to maximize the RGC response to electrical stimulation. This study aimed to investigate the effect of amplitude and duration even under the same charge condition on eliciting RGC spikes in the wild-type and degenerate retinas. Wild-type (WT) Sprague-Dawley rats were used as the normal retinal model, and
    Language English
    Publishing date 2023-01-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2602422-6
    ISSN 2093-985X ; 2093-9868
    ISSN (online) 2093-985X
    ISSN 2093-9868
    DOI 10.1007/s13534-023-00260-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Overcoming the therapeutic limitations of EZH2 inhibitors in Burkitt's lymphoma: a comprehensive study on the combined effects of MS1943 and Ibrutinib.

    Jeong, Yurim / Kim, Se Been / Yang, Chae-Eun / Yu, Min Seo / Choi, Wan-Su / Jeon, Youngwoo / Lim, Jung-Yeon

    Frontiers in oncology

    2023  Volume 13, Page(s) 1252658

    Abstract: Enhancer of zeste homolog 2 (EZH2) and Bruton's tyrosine kinase (BTK) are both key factors involved in the development and progression of hematological malignancies. Clinical studies have demonstrated the potential of various EZH2 inhibitors, which ... ...

    Abstract Enhancer of zeste homolog 2 (EZH2) and Bruton's tyrosine kinase (BTK) are both key factors involved in the development and progression of hematological malignancies. Clinical studies have demonstrated the potential of various EZH2 inhibitors, which target the methyltransferase activity of EZH2, for the treatment of lymphomas. However, despite their ability to effectively reduce the H3K27me3 levels, these inhibitors have shown limited efficacy in blocking the proliferation of lymphoma cells. To overcome this challenge, we employed a hydrophobic tagging approach utilizing MS1943, a selective EZH2 degrader. In this study, we investigated the inhibitory effects of two drugs, the FDA-approved EZH2 inhibitor Tazemetostat, currently undergoing clinical trials, and the novel drug MS1943, on Burkitt's lymphoma. Furthermore, we assessed the potential synergistic effect of combining these drugs with the BTK inhibitor Ibrutinib. In this study, we evaluated the effects of combination therapy with MS1943 and Ibrutinib on the proliferation of three Burkitt's lymphoma cell lines, namely RPMI1788, Ramos, and Daudi cells. Our results demonstrated that the combination of MS1943 and Ibrutinib significantly suppressed cell proliferation to a greater extent compared to the combination of Tazemetostat and Ibrutinib. Additionally, we investigated the underlying mechanisms of action and found that the combination therapy of MS1943 and Ibrutinib led to the upregulation of miR29B-mediated p53-upregulated modulator of apoptosis PUMA, BAX, cleaved PARP, and cleaved caspase-3 in Burkitt's lymphoma cells. These findings highlight the potential of this innovative therapeutic strategy as an alternative to traditional EZH2 inhibitors, offering promising prospects for improving treatment outcomes in Burkitt's lymphoma.
    Language English
    Publishing date 2023-09-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1252658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Dual Targeting of EZH2 Degradation and EGFR/HER2 Inhibition for Enhanced Efficacy against Burkitt's Lymphoma.

    Kim, Se Been / Yang, Chae-Eun / Jeong, Yurim / Yu, Minseo / Choi, Wan-Su / Lim, Jung-Yeon / Jeon, Youngwoo

    Cancers

    2023  Volume 15, Issue 18

    Abstract: EZH2, a histone methyltransferase, contributes significantly to cancer cell survival and proliferation. Although various EZH2 inhibitors have demonstrated promise in treating lymphoma, they have not fully managed to curb lymphoma cell proliferation ... ...

    Abstract EZH2, a histone methyltransferase, contributes significantly to cancer cell survival and proliferation. Although various EZH2 inhibitors have demonstrated promise in treating lymphoma, they have not fully managed to curb lymphoma cell proliferation despite effective reduction of the H3K27me3 mark. We used MS1943, an EZH2 selective degrader, which successfully diminishes EZH2 levels in lymphoma cells. Additionally, lapatinib, a dual inhibitor of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) tyrosine kinases, targets a receptor protein that regulates cell growth and division. The overexpression of this protein is often observed in lymphoma cells. Our study aims to combine these two therapeutic targets to stimulate apoptosis pathways and potentially suppress Burkitt's lymphoma cell survival and proliferation in a complementary and synergistic manner. We observed that a combination of MS1943 and lapatinib induced apoptosis in Daudi cells and caused cell cycle arrest at the S and G2/M phases in both Ramos and Daudi cells. This strategy, using a combination of MS1943 and lapatinib, presents a promising therapeutic approach for treating lymphoma and potentially Burkitt's lymphoma.
    Language English
    Publishing date 2023-09-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15184472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Focal stimulation of retinal ganglion cells using subretinal 3D microelectrodes with peripheral electrodes of opposite current.

    Seo, Hee Won / Cha, Seongkwang / Jeong, Yurim / Ahn, Jungryul / Lee, Kyeong Jae / Kim, Sohee / Goo, Yong Sook

    Biomedical engineering letters

    2023  Volume 14, Issue 2, Page(s) 355–365

    Abstract: Subretinal prostheses have been developed to stimulate survived retinal ganglion cells (RGCs), indirectly following the physiological visual pathways. However, current spreading from the prosthesis electrode causes the activation of unintended RGCs, ... ...

    Abstract Subretinal prostheses have been developed to stimulate survived retinal ganglion cells (RGCs), indirectly following the physiological visual pathways. However, current spreading from the prosthesis electrode causes the activation of unintended RGCs, thereby limiting the spatial resolution of artificial vision. This study proposes a strategy for focal stimulation of RGCs using a subretinal electrode array, in which six hexagonally arranged peripheral electrodes surround a stimulating electrode. RGCs in an in-vitro condition were subretinally stimulated using a fabricated electrode array coated with iridium oxide, following the three different stimulation configurations (with no peripheral, six electrodes of opposite current, and six ground). In-vitro experiments showed that the stimulation with six electrodes of opposite current was most effective in controlling RGC responses with a high spatial resolution. The results suggest that the effective utilization of return electrodes, such as by applying an opposite current to them, could help reduce current spreading beyond the local area targeted for stimulation and elicit RGC responses only in the vicinity of the stimulating electrode.
    Supplementary information: The online version contains supplementary material available at 10.1007/s13534-023-00342-3.
    Language English
    Publishing date 2023-12-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2602422-6
    ISSN 2093-985X ; 2093-9868
    ISSN (online) 2093-985X
    ISSN 2093-9868
    DOI 10.1007/s13534-023-00342-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  5. Article: Stage-Dependent Changes of Visual Function and Electrical Response of the Retina in the

    Cha, Seongkwang / Ahn, Jungryul / Jeong, Yurim / Lee, Yong Hee / Kim, Hyong Kyu / Lee, Daekee / Yoo, Yongseok / Goo, Yong Sook

    Frontiers in cellular neuroscience

    2022  Volume 16, Page(s) 926096

    Abstract: One of the critical prerequisites for the successful development of retinal prostheses is understanding the physiological features of retinal ganglion cells (RGCs) in the different stages of retinal degeneration (RD). This study used our custom- ... ...

    Abstract One of the critical prerequisites for the successful development of retinal prostheses is understanding the physiological features of retinal ganglion cells (RGCs) in the different stages of retinal degeneration (RD). This study used our custom-made
    Language English
    Publishing date 2022-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2022.926096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Electrical response of retinal ganglion cells in an N-methyl-N-nitrosourea-induced retinal degeneration porcine model.

    Cha, Seongkwang / Choi, Kwang-Eon / Ahn, Jungryul / Yoo, Minsu / Jeong, Yurim / Kim, Seong-Woo / Goo, Yong Sook

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 24135

    Abstract: Retinal prosthesis is regarded as the treatment for vision restoration in the blind with retinal degeneration (RD) due to the loss of photoreceptors. A strategy for retinal prosthesis is to electrically activate surviving neurons. The retina's response ... ...

    Abstract Retinal prosthesis is regarded as the treatment for vision restoration in the blind with retinal degeneration (RD) due to the loss of photoreceptors. A strategy for retinal prosthesis is to electrically activate surviving neurons. The retina's response to electrical stimulation in a larger RD model has not been studied yet. Therefore, in this study, we investigated electrically evoked retinal responses in a previously validated N-methyl-N-nitrosourea (MNU)-induced porcine RD model. Electrically evoked responses were evaluated based on the number of retinal ganglion cell (RGC) spikes via multichannel recordings. Stimulation pulses were applied to degenerative and wild-type retinas with pulse modulation. Compared to wild-type retinas, degenerative retinas showed higher threshold values of pulse amplitude and pulse duration. The rate of increase in the number of RGC spikes relative to stimulus intensity was lower in degenerative retinas than in normal retinas. In severely degenerated retinas, few RGCs showed electrically evoked spikes. Our results suggest that the degenerative porcine retina requires a higher charge than the normal porcine retina. In the early stage of RD, it is easier to induce RGC spikes through electrical stimulation using retinal prosthesis; however, when the degeneration is severe, there may be difficulty recovering patient vision.
    MeSH term(s) Animals ; Disease Models, Animal ; Electric Stimulation ; Evoked Potentials, Visual/drug effects ; Female ; Methylnitrosourea/toxicity ; Retinal Degeneration/chemically induced ; Retinal Degeneration/metabolism ; Retinal Degeneration/physiopathology ; Retinal Ganglion Cells/metabolism ; Swine ; Swine, Miniature
    Chemical Substances Methylnitrosourea (684-93-5)
    Language English
    Publishing date 2021-12-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-03439-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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