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Article ; Online: Comparative Analysis of Water Extracts from Roselle ( Hibiscus sabdariffa L.) Plants and Callus Cells

Won Kyong Cho / Soo-Yun Kim / Sung Joo Jang / Sak Lee / Hye-In Kim / Euihyun Kim / Jeong Hun Lee / Sung Soo Choi / Sang Hyun Moh

International Journal of Molecular Sciences, Vol 24, Iss 10853, p

Constituents, Effects on Human Skin Cells, and Transcriptome Profiles

2023 Volume 10853

Abstract: Roselle ( Hibiscus sabdariffa L.) is a plant that has traditionally been used in various food and beverage products. Here, we investigated the potential of water extracts derived from Roselle leaves and callus cells for cosmetic and pharmaceutical ... ...

Abstract	Roselle ( Hibiscus sabdariffa L.) is a plant that has traditionally been used in various food and beverage products. Here, we investigated the potential of water extracts derived from Roselle leaves and callus cells for cosmetic and pharmaceutical purposes. We generated calluses from Roselle leaves and produced two different water extracts through heat extraction, which we named Hibiscus sabdariffa plant extract (HSPE) and Hibiscus sabdariffa callus extract (HSCE). HPLC analysis showed that the two extracts have different components, with nucleic acids and metabolites such as phenylalanine and tryptophan being the most common components in both extracts. In vitro assays demonstrated that HSCE has strong anti-melanogenic effects and functions for skin barrier and antioxidant activity. Transcriptome profiling of human skin cells treated with HSPE and HSCE showed significant differences, with HSPE having more effects on human skin cells. Up-regulated genes by HSPE function in angiogenesis, the oxidation-reduction process, and glycolysis, while up-regulated genes by HSCE encode ribosome proteins and IFI6, functioning in the healing of radiation-injured skin cells. Therefore, we suggest that the two extracts from Roselle should be applied differently for cosmetics and pharmaceutical purposes. Our findings demonstrate the potential of Roselle extracts as a natural source for skincare products.
Keywords	Roselle ; water extracts ; cosmetics ; skin cells ; transcriptome profiling ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	571
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Lesson from a Measles Outbreak among Healthcare Workers in a Single Hospital in South Korea

Sungim Choi / Jae-Woo Chung / Yun Jung Chang / Eun Jung Lim / Sun Hee Moon / Han Ho Do / Jeong Hun Lee / Sung-Min Cho / Bum Sun Kwon / Yoon-Seok Chung / Seong Yeon Park

Vaccines, Vol 11, Iss 1505, p

The Importance of Knowing the Prevalence of Susceptibility

2023 Volume 1505

Abstract: Background: Despite the high vaccination coverage rate, in-hospital transmission of measles continues to occur in South Korea. We present a measles outbreak in which two healthcare workers (HCWs) with presumptive evidence of measles immunity were ... ...

Abstract	Background: Despite the high vaccination coverage rate, in-hospital transmission of measles continues to occur in South Korea. We present a measles outbreak in which two healthcare workers (HCWs) with presumptive evidence of measles immunity were infected by a patient with typical measles at a single hospital in South Korea. This facilitated the evaluation of measles seroprevalence in all HCWs. Methods: In 2018, suspected patients and contacts exposed during a measles outbreak were investigated based on their medical histories and vaccination status. Cases were confirmed by the detection of measles-specific immunoglobulin M or RNA. After the measles outbreak in 2018, measles IgG testing was conducted on a total of 972 HCWs for point-prevalence, including those exposed to the measles. In addition, we have routinely performed measles IgG tests on newly employed HCWs within one week of their hire date since 2019. The measles vaccine was administered to HCWs who tested negative or equivocally negative for IgG antibodies. Results: An index patient who returned from China with fever and rash was diagnosed with measles at a hospital in Korea. Two additional HCWs were revealed as measles cases: one was vaccinated with the two-dose measles–mumps–rubella (MMR) vaccine, and the other, who was born in 1967, was presumed to have immunity from natural infection in South Korea. All three patients harbored the same D8 genotype. No additional measles cases were identified among the 964 contacts of secondary patients. A total of 2310 HCWs, including those tested during the 2018 outbreak, underwent measles IgG tests. The average age at the time of the test was 32.6 years, and 74.3% were female. The overall seropositivity of measles was 88.9% (95% confidence interval, 87.5–90.1). Although the birth cohorts between 1985 and 1994 were presumed to have received the measles–rubella (MR) catch-up vaccination in 2001, 175 (89.3%) HCWs were born after 1985 among the 195 seronegative cases. Conclusion: Despite high population immunity, ...
Keywords	measles ; outbreak ; HCWs ; vaccination ; immunity ; Medicine ; R
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparative Study of Metagenomics and Metatranscriptomics to Reveal Microbiomes in Overwintering Pepper Fruits

Yeonhwa Jo / Chang-Gi Back / Kook-Hyung Kim / Hyosub Chu / Jeong Hun Lee / Sang Hyun Moh / Won Kyong Cho

International Journal of Molecular Sciences, Vol 22, Iss 6202, p

2021 Volume 6202

Abstract: Red pepper ( Capsicum annuum , L.), is one of the most important spice plants in Korea. Overwintering pepper fruits are a reservoir of various microbial pepper diseases. Here, we conducted metagenomics (DNA sequencing) and metatranscriptomics (RNA ... ...

Abstract	Red pepper ( Capsicum annuum , L.), is one of the most important spice plants in Korea. Overwintering pepper fruits are a reservoir of various microbial pepper diseases. Here, we conducted metagenomics (DNA sequencing) and metatranscriptomics (RNA sequencing) using samples collected from three different fields. We compared two different library types and three different analytical methods for the identification of microbiomes in overwintering pepper fruits. Our results demonstrated that DNA sequencing might be useful for the identification of bacteria and DNA viruses such as bacteriophages, while mRNA sequencing might be beneficial for the identification of fungi and RNA viruses. Among three analytical methods, KRAKEN2 with raw data reads (KRAKEN2_R) might be superior for the identification of microbial species to other analytical methods. However, some microbial species with a low number of reads were wrongly assigned at the species level by KRAKEN2_R. Moreover, we found that the databases for bacteria and viruses were better established as compared to the fungal database with limited genome data. In summary, we carefully suggest that different library types and analytical methods with proper databases should be applied for the purpose of microbiome study.
Keywords	pepper ; fruit ; microbiome ; bacteria ; fungi ; viruses ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Using RNA-Sequencing Data to Examine Tissue-Specific Garlic Microbiomes

Yeonhwa Jo / Chang-Gi Back / Kook-Hyung Kim / Hyosub Chu / Jeong Hun Lee / Sang Hyun Moh / Won Kyong Cho

International Journal of Molecular Sciences, Vol 22, Iss 6791, p

2021 Volume 6791

Abstract: Garlic ( Allium sativum ) is a perennial bulbous plant. Due to its clonal propagation, various diseases threaten the yield and quality of garlic. In this study, we conducted in silico analysis to identify microorganisms, bacteria, fungi, and viruses in ... ...

Abstract	Garlic ( Allium sativum ) is a perennial bulbous plant. Due to its clonal propagation, various diseases threaten the yield and quality of garlic. In this study, we conducted in silico analysis to identify microorganisms, bacteria, fungi, and viruses in six different tissues using garlic RNA-sequencing data. The number of identified microbial species was the highest in inflorescences, followed by flowers and bulb cloves. With the Kraken2 tool, 57% of identified microbial reads were assigned to bacteria and 41% were assigned to viruses. Fungi only made up 1% of microbial reads. At the species level, Streptomyces lividans was the most dominant bacteria while Fusarium pseudograminearum was the most abundant fungi. Several allexiviruses were identified. Of them, the most abundant virus was garlic virus C followed by shallot virus X. We obtained a total of 14 viral genome sequences for four allexiviruses. As we expected, the microbial community varied depending on the tissue types, although there was a dominant microorganism in each tissue. In addition, we found that Kraken2 was a very powerful and efficient tool for the bacteria using RNA-sequencing data with some limitations for virome study.
Keywords	pepper ; fruit ; microbiome ; bacteria ; fungi ; viruses ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Anti-Colitic Effect of an Exopolysaccharide Fraction from Pediococcus pentosaceus KFT-18 on Dextran Sulfate Sodium-Induced Colitis through Suppression of Inflammatory Mediators

Jeong-Hun Lee / Kyung-Sook Chung / Ji-Sun Shin / Seang-Hwan Jung / Sangmin Lee / Myung-Ki Lee / Hee-Do Hong / Young Kyoung Rhee / Kyung-Tae Lee

Polymers, Vol 14, Iss 3594, p

2022 Volume 3594

Abstract: We previously reported the immunostimulatory effect of an exopolysaccharide fraction from Pediococcus pentosaceus KFT18 (PE-EPS), a lactic acid bacterium, in macrophages and primary splenocytes, as well as in cyclophosphamide-induced immunosuppressed ... ...

Abstract	We previously reported the immunostimulatory effect of an exopolysaccharide fraction from Pediococcus pentosaceus KFT18 (PE-EPS), a lactic acid bacterium, in macrophages and primary splenocytes, as well as in cyclophosphamide-induced immunosuppressed mice. In this study, the anti-colitic activity of PE-EPS was investigated in a dextran sulfate sodium (DSS)-induced colitis animal model. PE-EPS relieved DSS-induced colitis symptoms, such as stool blood, decreased colon length, crypt disruption, and mucus layer edema. Regarding the molecular mechanism, PE-EPS reduced the enhanced expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and pro-inflammatory cytokines (TNF-α, IL-6, and IL-1) in the colon tissue of colitis-induced mice. Additionally, PE-EPS protected against DSS-induced phosphorylation of p65 and signal transducer and activator of transcription 1 (STAT1). These findings suggested that the exopolysaccharide fraction from Ped. pentosaceus KFT18 can be used to treat inflammatory bowel disease by alleviating colonic inflammation.
Keywords	exopolysaccharide ; Pediococcus pentosaceus ; DSS-induced colitis ; NF-κB ; STAT1 ; Organic chemistry ; QD241-441
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Concentrations of particulate matter, carbon dioxide, VOCs and risk assessment inside Korean taxis and ships

Kim, Ho-Hyun / Gee-Young Park / Jeong-Hun Lee

Environmental science and pollution research international. 2019 Apr., v. 26, no. 10

2019

Abstract: The objective of this study was to investigate the concentration distribution of indoor air pollutants in taxis and ships (passengers) which are frequently used for public transportation and recreational activities in South Korea. In addition, it aimed ... ...

Abstract	The objective of this study was to investigate the concentration distribution of indoor air pollutants in taxis and ships (passengers) which are frequently used for public transportation and recreational activities in South Korea. In addition, it aimed to assess air quality factors to establish and evaluate the health risks of exposure to polluted indoor air. Particulate matter (PM₁₀) concentrations were not affected by the number of passengers, time of day, and driving characteristics because there were only a few passengers (2 to 4 people) and the space was confined. In the ships, indoor air pollutants responded more sensitively to the operation characteristics depending on the time of sailing (i.e., anchoring and departure, movement of vehicles on the ship, movement of passengers, combustion in the shop, and ventilation) than to the number of people boarding and alighting. The carbon dioxide concentrations in different ship rooms did not vary according to season and degree of congestion; however, there were differences between different ships. These differences may result from the size, type, and operating characteristics of the ships. Volatile organic compounds (VOCs) and aldehydes in new taxis exceeded the standard levels during summer. VOC concentrations in ships were particularly high during summer when the outdoor temperature was high. Similar observations were made for other means of transportation. The risk assessment depended on the means of transportation and demonstrated that mortality risks due to PM₁₀ and excess carcinogenic and non-carcinogenic risks from VOCs and aldehydes were within safety levels.
Keywords	air ; air pollutants ; air pollution ; air quality ; aldehydes ; carbon dioxide ; carcinogenicity ; combustion ; mortality ; particulates ; public transportation ; recreation ; risk ; risk assessment ; ships ; summer ; temperature ; volatile organic compounds ; South Korea
Language	English
Dates of publication	2019-04
Size	p. 9619-9631.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-019-04361-5
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Evaluation of IAQ Management Using an IoT-Based Indoor Garden

Ho-Hyun Kim / Min-Jung Kwak / Kwang-Jin Kim / Yoon-Kyung Gwak / Jeong-Hun Lee / Ho-Hyeong Yang

International Journal of Environmental Research and Public Health, Vol 17, Iss 6, p

2020 Volume 1867

Abstract: This study was designed to verify the effectiveness of smart gardens by improving indoor air quality (IAQ) through the installation of an indoor garden with sensor-based Internet-of-Things (IoT) technology that identifies pollutants such as particulate ... ...

Abstract	This study was designed to verify the effectiveness of smart gardens by improving indoor air quality (IAQ) through the installation of an indoor garden with sensor-based Internet-of-Things (IoT) technology that identifies pollutants such as particulate matter. In addition, the study aims to introduce indoor gardens for customized indoor air cleaning using the data and IoT technology. New apartments completed in 2016 were selected and divided into four households with indoor gardens installed and four households without indoor gardens. Real-time data and data on PM 2.5 , CO 2 , temperature, and humidity were collected through an IoT-based IAQ monitoring system. In addition, in order to examine the effects on the health of occupants, the results were analyzed based on epidemiological data, prevalence data, current maintenance, and recommendation criteria, and were presented and evaluated as indices. The indices were classified into a comfort index, which reflects the temperature and humidity, an IAQ index, which reflects PM 2.5 and CO 2 , and an IAQ composite index. The IAQ index was divided into five grades from “good” to “hazardous”. Using a scale of 1 to 100 points, it was determined as follows: “good (0−20)”, “moderate (21−40)”, “unhealthy for sensitive group (41−60)”, “bad (61−80)”, “hazardous (81−100)”. It showed an increase in the “good” section after installing the indoor garden, and the “bad” section decreased. Additionally, the comfort index was classified into five grades from “very comfortable” to “very uncomfortable”. In the comfort index, the “uncomfortable” section decreased, and the “comfortable” section increased after the indoor garden was installed.
Keywords	internet of things (iot) ; indoor gardens ; indoor air quality ; index ; Medicine ; R
Subject code	100
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bone Regeneration in Peri-Implant Defect Using Autogenous Tooth Biomaterial Enriched with Platelet-Rich Fibrin in Animal Model

Moon Hwan Jung / Jeong Hun Lee / Puneet Wadhwa / Heng Bo Jiang / Hyon Seok Jang / Eui Seok Lee

Applied Sciences, Vol 10, Iss 6, p

2020 Volume 1939

Abstract: Tooth biomaterial may be useful in bone regeneration for restoring peri-implant defects in vivo. The aim of this study was to compare bone regeneration capacity in peri-implant defects augmented with autogenous tooth biomaterial combined with platelet- ... ...

Abstract	Tooth biomaterial may be useful in bone regeneration for restoring peri-implant defects in vivo. The aim of this study was to compare bone regeneration capacity in peri-implant defects augmented with autogenous tooth biomaterial combined with platelet-rich fibrin (PRF), tooth biomaterial alone, or PRF alone. Two monocortical defects were generated on each tibia of 10 New Zealand white rabbits ( n = 10 per group) with a trephine bur, and the dental implant was installed into the defects. In experimental groups 1, 2, and 3, the peri-implant defects were filled with tooth biomaterial and platelet-rich fibrin (PRF), tooth biomaterial only, and PRF only, respectively and the control was left empty. Micro computed tomography (CT), implant stability, and histomorphometric analysis were conducted eight weeks after operation. The mean regenerated bone areas were 53.87 ± 7.60%, 51.56 ± 6.45%, and 18.45 ± 1.34% in experimental groups 1, 2, and 3, respectively, and 11.57 ± 1.12% in the control. Mean bone-to-implant contact values were 43.67 ± 2.50%, 41.07 ± 2.59%, and 21.45 ± 1.25% in experimental groups 1, 2, and 3, respectively, and 16.57 ± 2.83% in the control. Tooth biomaterial enriched with platelet-rich fibrin (PRF) and tooth biomaterial alone showed more enhanced regeneration than PRF alone in our study.
Keywords	tooth biomaterial ; platelet-rich fibrin ; bone regeneration ; graft material ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	670
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Transcriptome Profiling of Human Follicle Dermal Papilla Cells in response to Porphyra-334 Treatment by RNA-Seq

Su Yeon Kim / Won Kyong Cho / Hye-In Kim / Seung Hye Paek / Sung Joo Jang / Yeonhwa Jo / Hoseong Choi / Jeong Hun Lee / Sang Hyun Moh

Evidence-Based Complementary and Alternative Medicine, Vol

2021 Volume 2021

Abstract: Porphyra-334 is a kind of mycosporine-like amino acid absorbing ultraviolet-A. Here, we characterized porphyra-334 as a potential antiaging agent. An in vitro assay revealed that porphyra-334 dramatically promoted collagen synthesis in fibroblast cells. ... ...

Abstract	Porphyra-334 is a kind of mycosporine-like amino acid absorbing ultraviolet-A. Here, we characterized porphyra-334 as a potential antiaging agent. An in vitro assay revealed that porphyra-334 dramatically promoted collagen synthesis in fibroblast cells. The effect of porphyra-334 on cell proliferation was dependent on the cell type, and the increase of cell viability by porphyra-334 was the highest in keratinocyte cells among the three tested cell types. An in vivo clinical test with 22 participants demonstrated the possible role of porphyra-334 in the improvement of periorbital wrinkles. RNA-sequencing using human follicle dermal papilla (HFDP) cells upon porphyra-334 treatment identified the upregulation of metallothionein- (MT-) associated genes, confirming the antioxidant role of porphyra-334 with MT. Moreover, the expression of genes involved in nuclear chromosome segregation and the encoding of components of kinetochores was upregulated by porphyra-334 treatment. Furthermore, we found that several genes associated with the hair follicle cycle, the hair follicle structure, the epidermal structure, and stem cells were upregulated by porphyra-334 treatment, suggesting the potential role of porphyra-334 in hair follicle growth and maintenance. In summary, we provided several new pieces of evidence of porphyra-334 as a potential antiaging cosmetic agent and elucidated the expression network in HFDP cells upon porphyra-334.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: High-Performance Hybrid Photovoltaics with Efficient Interfacial Contacts between Vertically Aligned ZnO Nanowire Arrays and Organic Semiconductors

Yoon Ho Lee / Minjeong Ha / Inho Song / Jeong Hun Lee / Yousang Won / Seongdong Lim / Hyunhyub Ko / Joon Hak Oh

ACS Omega, Vol 4, Iss 6, Pp 9996-

2019 Volume 10002

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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