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Article ; Online: Assigning Function to Phylogeny: MAR-FISH.

Nielsen, Jeppe L

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2246, Page(s) 225–236

Abstract: Microautoradiography (MAR) is a technique by which assimilated radioactive tracers incorporated into the biomass can be detected by a film emulsion. This allows for the testing of cellular preferences in electron donors and acceptors of individual cells ... ...

Abstract	Microautoradiography (MAR) is a technique by which assimilated radioactive tracers incorporated into the biomass can be detected by a film emulsion. This allows for the testing of cellular preferences in electron donors and acceptors of individual cells in complex microbial assemblages, as well as the ability to take up substrates under diverse environmental exposures.Combination with staining techniques such as fluorescence in situ hybridization (FISH) can be used to identify the involved cells. Here, the practical aspects of a combined microautoradiography and fluorescence in situ hybridization (MAR-FISH) approach are described.
MeSH term(s)	Autoradiography/methods ; Biomass ; Electrons ; In Situ Hybridization, Fluorescence/methods ; Microbiota/genetics ; Phylogeny
Language	English
Publishing date	2021-03-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1115-9_14
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Article ; Online: The Selenoproteome as a Dynamic Response Mechanism to Oxidative Stress in Hydrogenotrophic Methanogenic Communities.

Kleikamp, Hugo B C / Palacios, Paola A / Kofoed, Michael V W / Papacharalampos, Georgios / Bentien, Anders / Nielsen, Jeppe L

Environmental science & technology

2024 Volume 58, Issue 15, Page(s) 6637–6646

Abstract: Methanogenesis is a critical process in the carbon cycle that is applied industrially in anaerobic digestion and biogas production. While naturally occurring in diverse environments, methanogenesis requires anaerobic and reduced conditions, although ... ...

Abstract	Methanogenesis is a critical process in the carbon cycle that is applied industrially in anaerobic digestion and biogas production. While naturally occurring in diverse environments, methanogenesis requires anaerobic and reduced conditions, although varying degrees of oxygen tolerance have been described. Microaeration is suggested as the next step to increase methane production and improve hydrolysis in digestion processes; therefore, a deeper understanding of the methanogenic response to oxygen stress is needed. To explore the drivers of oxygen tolerance in methanogenesis, two parallel enrichments were performed under the addition of H
MeSH term(s)	Methane ; Proteomics ; Selenium ; Selenocysteine/metabolism ; Euryarchaeota/metabolism ; Oxidative Stress ; Oxygen ; Anaerobiosis ; Bioreactors
Chemical Substances	Methane (OP0UW79H66) ; Selenium (H6241UJ22B) ; Selenocysteine (0CH9049VIS) ; Oxygen (S88TT14065)
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c07725
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Article ; Online: The Hierarchy of Controls as an Approach to Visualize the Impact of Occupational Safety and Health Coordination

Jeppe Z. N. Ajslev / Jeppe L. Møller / Malene F. Andersen / Payam Pirzadeh / Helen Lingard

International Journal of Environmental Research and Public Health, Vol 19, Iss 2731, p

2022 Volume 2731

Abstract: Occupational safety and health (OSH) in construction work continues to be a problematic issue, and OSH coordinators are a pivotal initiative for improving this in the EU. However, no studies on the impact of (OSH) coordinators in construction exists. ... ...

Abstract	Occupational safety and health (OSH) in construction work continues to be a problematic issue, and OSH coordinators are a pivotal initiative for improving this in the EU. However, no studies on the impact of (OSH) coordinators in construction exists. This study conceptualizes the hierarchy of controls (HOC) as a means for visualizing and evaluating the impact of OSH coordinators’ work. The study engages with a large observational material based on fieldwork notes from 107 days of observations with 12 successful OSH coordinators. The analysis shows that during the 107 observation days, the coordinators implemented 280 OSH measures and were prevented 71 times from implementing measures. Most of the implemented measures were in the administrative (53.6%) and engineering (35%) controls. This may provide part of the explanation of why an increasing focus on OSH coordination has not translated into improved OSH outcomes in construction. The study contributes with insights for OSH coordinators and professionals seeking to improve the visibility and legitimacy of their work. In addition, it may be beneficial to organizations interested in ensuring the effectiveness of their organizational OSH practices. The study also creates foundations for more research-based practices, education, and professionalization of OSH coordinators as a profession.
Keywords	OSH coordinator ; OSH professional ; construction industry ; observation study ; occupational safety and health ; Medicine ; R
Subject code	690
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: The Hierarchy of Controls as an Approach to Visualize the Impact of Occupational Safety and Health Coordination.

Ajslev, Jeppe Z N / Møller, Jeppe L / Andersen, Malene F / Pirzadeh, Payam / Lingard, Helen

International journal of environmental research and public health

2022 Volume 19, Issue 5

Abstract	Occupational safety and health (OSH) in construction work continues to be a problematic issue, and OSH coordinators are a pivotal initiative for improving this in the EU. However, no studies on the impact of (OSH) coordinators in construction exists. This study conceptualizes the
MeSH term(s)	Occupational Health
Language	English
Publishing date	2022-02-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19052731
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Article: Effects of levothyroxine substitution therapy on hunger and food intake in individuals with hypothyroidism.

Medici, Bjarke R / Nygaard, Birte / la Cour, Jeppe L / Krakauer, Martin / Brønden, Andreas / Sonne, Mette P / Holst, Jens J / Rehfeld, Jens F / Vilsbøll, Tina / Faber, Jens / Knop, Filip K

Endocrine connections

2023 Volume 12, Issue 10

Abstract: Context: In individuals with hypothyroidism and overweight, levothyroxine substitution therapy is often expected to cause weight loss due to its effect on resting energy expenditure. However, despite levothyroxine-induced enhancement of resting energy ... ...

Abstract	Context: In individuals with hypothyroidism and overweight, levothyroxine substitution therapy is often expected to cause weight loss due to its effect on resting energy expenditure. However, despite levothyroxine-induced enhancement of resting energy expenditure, fat mass loss is rarely seen after levothyroxine substitution therapy. The mechanism behind this conundrum is unknown. Aim: The aim of the study was to assess the effect of levothyroxine therapy on hunger sensations and ad libitum food intake in individuals with hypothyroidism. Design and setting: Prospective cohort study of 18 newly diagnosed hypothyroid women (thyroid-stimulating hormone (TSH) >10 mU/L). Participants were investigated at diagnosis, after normalization of TSH (<4.0 mU/L), and after 6 months of successful treatment. Eighteen age and body mass index-matched healthy controls were also included. Intervention: Hypothyroid individuals were treated with levothyroxine according to European Thyroid Association guidelines. Main outcomes: Changes in hunger sensation were assessed using visual analog scales (cm) before and during a standardized mixed meal test, and food intake was measured during a subsequent ad libitum meal (g). Results: After 6 months of levothyroxine therapy, mean resting energy expenditure was increased by 144 kcal/day (10%) (P < 0.001). Weight loss was comprised of 0.8 kg fat-free mass while fat mass remained unchanged. Fasting hunger sensation increased from a mean of 4.5 (s.d. 2.2) cm to 5.5 (s.d. 2.2) cm (P = 0.047). The numerical increase in ad libitum meal intake did not reach statistical significance. Conclusion: Our data suggest that levothyroxine-induced hunger may be a culprit in the lack of fat mass loss from levothyroxine therapy.
Language	English
Publishing date	2023-09-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2668428-7
ISSN	2049-3614
ISSN	2049-3614
DOI	10.1530/EC-23-0314
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Article ; Online: Functional connectivity of spoken language processing in early-stage Parkinson's disease: An MEG study.

Hyder, Rasha / Jensen, Mads / Højlund, Andreas / Kimppa, Lilli / Bailey, Christopher J / Schaldemose, Jeppe L / Kinnerup, Martin B / Østergaard, Karen / Shtyrov, Yury

NeuroImage. Clinical

2021 Volume 32, Page(s) 102718

Abstract: Parkinson's disease (PD) is a neurodegenerative disorder, well-known for its motor symptoms; however, it also adversely affects cognitive functions, including language, a highly important human ability. PD pathology is associated, even in the early stage ...

Abstract	Parkinson's disease (PD) is a neurodegenerative disorder, well-known for its motor symptoms; however, it also adversely affects cognitive functions, including language, a highly important human ability. PD pathology is associated, even in the early stage of the disease, with alterations in the functional connectivity within cortico-subcortical circuitry of the basal ganglia as well as within cortical networks. Here, we investigated functional cortical connectivity related to spoken language processing in early-stage PD patients. We employed a patient-friendly passive attention-free paradigm to probe neurophysiological correlates of language processing in PD patients without confounds related to active attention and overt motor responses. MEG data were recorded from a group of newly diagnosed PD patients and age-matched healthy controls who were passively presented with spoken word stimuli (action and abstract verbs, as well as grammatically correct and incorrect inflectional forms) while focussing on watching a silent movie. For each of the examined linguistic aspects, a logistic regression classifier was used to classify participants as either PD patients or healthy controls based on functional connectivity within the temporo-fronto-parietal cortical language networks. Classification was successful for action verbs (accuracy = 0.781, p-value = 0.003) and, with lower accuracy, for abstract verbs (accuracy = 0.688, p-value = 0.041) and incorrectly inflected forms (accuracy = 0.648, p-value = 0.021), but not for correctly inflected forms (accuracy = 0.523, p-value = 0.384). Our findings point to quantifiable differences in functional connectivity within the cortical systems underpinning language processing in newly diagnosed PD patients compared to healthy controls, which arise early, in the absence of clinical evidence of deficits in cognitive or general language functions. The techniques presented here may aid future work on establishing neurolinguistic markers to objectively and noninvasively identify functional changes in the brain's language networks even before clinical symptoms emerge.
MeSH term(s)	Attention ; Basal Ganglia ; Cognition ; Humans ; Language ; Magnetic Resonance Imaging ; Parkinson Disease/complications
Language	English
Publishing date	2021-06-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701571-3
ISSN	2213-1582 ; 2213-1582
ISSN (online)	2213-1582
ISSN	2213-1582
DOI	10.1016/j.nicl.2021.102718
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Article ; Online: Hypothyroid women have persistently higher oxidative stress compared to healthy controls.

Riis, Kamilla R / Larsen, Camilla B / Medici, Bjarke R / Jensen, Christian Z / Winther, Kristian H / Larsen, Emil L / Ellervik, Christina / la Cour, Jeppe L / Hegedüs, Laszlo / Brix, Thomas H / Poulsen, Henrik E / Knop, Filip K / Nygaard, Birte / Bonnema, Steen J

European thyroid journal

2023 Volume 12, Issue 6

Abstract: Objective: Some studies suggest that hypothyroidism is associated with increased oxidative stress. Urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) represents whole-body RNA and DNA oxidation, ... ...

Abstract	Objective: Some studies suggest that hypothyroidism is associated with increased oxidative stress. Urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) represents whole-body RNA and DNA oxidation, respectively. These biomarkers have only been explored sparsely in patients with thyroid disorders. Methods: In 45 Danish women with newly diagnosed hypothyroidism, we compared 8-oxoGuo and 8-oxodG before or shortly after initiating levothyroxine with the excretion rates at euthyroidism. We also compared the excretion of 8-oxoGuo and 8-oxodG in the patients after restored euthyroidism with 18 healthy control subjects. Results: Compared with baseline, none of the biomarkers changed significantly in the patients after becoming euthyroid. The geometric mean of 8-oxoGuo was 1.63 (95% CI: 1.49-1.78) nmol/mmol creatinine at baseline and 1.67 nmol/mmol at euthyroidism (95% CI: 1.53-1.83) (P = 0.39), while that of 8-oxodG was 1.28 nmol/mmol creatinine at baseline (95% CI: 1.14-1.44) and 1.32 nmol/mmol at euthyroidism (95% CI: 1.18-1.48), respectively (P = 0.47). The relative mean differences were 0.97 (95% CI: 0.91-1.04) for 8-oxoGuo and 0.97 (95% CI: 0.88-1.06) for 8-oxodG. At baseline, multiple linear regression revealed a positive association between free thyroxine and both biomarkers (8-oxoGuo, P < 0.001; 8-oxodG, P = 0.04). Furthermore, 8-oxoGuo was positively associated with age (P = 0.04) and negatively associated with thyrotropin (P = 0.02). In the control group, the geometric mean of 8-oxoGuo was 1.23 nmol/mmol creatinine (95% CI: 1.07-1.42), while that of 8-oxodG was 1.04 nmol/mmol creatinine (95% CI: 0.88-1.23). Thus, compared with control subjects, euthyroid patients showed a significantly higher level of both 8-oxoGuo (P < 0.001) and 8-oxodG (P = 0.03). Conclusion: In hypothyroid women, no significant effect of levothyroxine treatment on the oxidative stress biomarkers 8-oxoGuo and 8-oxodG could be demonstrated. However, the excretion of these biomarkers was significantly higher than in healthy controls.
MeSH term(s)	Humans ; Female ; 8-Hydroxy-2'-Deoxyguanosine/urine ; Thyroxine ; Creatinine/urine ; Oxidative Stress/genetics ; Biomarkers/urine ; Hypothyroidism/drug therapy
Chemical Substances	8-Hydroxy-2'-Deoxyguanosine (88847-89-6) ; Thyroxine (Q51BO43MG4) ; Creatinine (AYI8EX34EU) ; Biomarkers
Language	English
Publishing date	2023-11-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659767-6
ISSN	2235-0802 ; 2235-0640
ISSN (online)	2235-0802
ISSN	2235-0640
DOI	10.1530/ETJ-23-0167
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Book ; Online: Design of a prototype laser-plasma injector for the DESY-II synchrotron

Antipov, S. A. / Pousa, A. Ferran / Agapov, I. / Brinkmann, R. / Maier, A. R. / Jalas, S. / Jeppe, L. / Kirchen, M. / de la Ossa, A. Martinez / Thévenet, M. / Winkler, P.

2021

Abstract: The present state of progress in laser wakefield acceleration encourages considering it as a practical alternative to conventional particle accelerators. A promising application would be to use a laser plasma accelerator as an injector for a synchrotron ... ...

Abstract	The present state of progress in laser wakefield acceleration encourages considering it as a practical alternative to conventional particle accelerators. A promising application would be to use a laser plasma accelerator as an injector for a synchrotron light source. The injector could deliver low charge ($\sim 100$~pC) beams to top up the storage ring and reduce the load on the chain of conventional injectors. Yet, the energy spread and jitter of the laser plasma beam pose a significant difficulty for an efficient injection. In this paper we propose a design of a prototype injector to deliver 500 MeV low-intensity electron bunches to the DESY-II electron synchrotron. The design utilizes presently available conventional accelerator technology, such as a chicane and an X-band radio frequency cavity, to reduce the energy spread and jitter of the electron beam down to a sub-per-mille level.
Keywords	Physics - Accelerator Physics
Subject code	621
Publishing date	2021-06-14
Publishing country	us
Document type	Book ; Online
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Article ; Online: Functional connectivity of spoken language processing in early-stage Parkinson’s disease

Rasha Hyder / Mads Jensen / Andreas Højlund / Lilli Kimppa / Christopher J. Bailey / Jeppe L. Schaldemose / Martin B. Kinnerup / Karen Østergaard / Yury Shtyrov

NeuroImage: Clinical, Vol 32, Iss , Pp 102718- (2021)

An MEG study

2021

Abstract: Parkinson’s disease (PD) is a neurodegenerative disorder, well-known for its motor symptoms; however, it also adversely affects cognitive functions, including language, a highly important human ability. PD pathology is associated, even in the early stage ...

Abstract	Parkinson’s disease (PD) is a neurodegenerative disorder, well-known for its motor symptoms; however, it also adversely affects cognitive functions, including language, a highly important human ability. PD pathology is associated, even in the early stage of the disease, with alterations in the functional connectivity within cortico-subcortical circuitry of the basal ganglia as well as within cortical networks. Here, we investigated functional cortical connectivity related to spoken language processing in early-stage PD patients. We employed a patient-friendly passive attention-free paradigm to probe neurophysiological correlates of language processing in PD patients without confounds related to active attention and overt motor responses. MEG data were recorded from a group of newly diagnosed PD patients and age-matched healthy controls who were passively presented with spoken word stimuli (action and abstract verbs, as well as grammatically correct and incorrect inflectional forms) while focussing on watching a silent movie. For each of the examined linguistic aspects, a logistic regression classifier was used to classify participants as either PD patients or healthy controls based on functional connectivity within the temporo-fronto-parietal cortical language networks. Classification was successful for action verbs (accuracy = 0.781, p-value = 0.003) and, with lower accuracy, for abstract verbs (accuracy = 0.688, p-value = 0.041) and incorrectly inflected forms (accuracy = 0.648, p-value = 0.021), but not for correctly inflected forms (accuracy = 0.523, p-value = 0.384). Our findings point to quantifiable differences in functional connectivity within the cortical systems underpinning language processing in newly diagnosed PD patients compared to healthy controls, which arise early, in the absence of clinical evidence of deficits in cognitive or general language functions. The techniques presented here may aid future work on establishing neurolinguistic markers to objectively and noninvasively identify ...
Keywords	Parkinson’s disease (PD) ; Magnetoencephalography (MEG) ; Functional connectivity ; Classification ; Action verb ; Morphosyntax ; Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurology. Diseases of the nervous system ; RC346-429
Subject code	150
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Optimal Beam Loading in a Laser-Plasma Accelerator.

Kirchen, Manuel / Jalas, Sören / Messner, Philipp / Winkler, Paul / Eichner, Timo / Hübner, Lars / Hülsenbusch, Thomas / Jeppe, Laurids / Parikh, Trupen / Schnepp, Matthias / Maier, Andreas R

Physical review letters

2021 Volume 126, Issue 17, Page(s) 174801

Abstract: Applications of laser-plasma accelerators demand low energy spread beams and high-efficiency operation. Achieving both requires flattening the accelerating fields by controlled beam loading of the plasma wave. Here, we optimize the generation of an ... ...

Abstract	Applications of laser-plasma accelerators demand low energy spread beams and high-efficiency operation. Achieving both requires flattening the accelerating fields by controlled beam loading of the plasma wave. Here, we optimize the generation of an electron bunch via localized ionization injection, such that the combination of injected current profile and averaged acceleration dynamics results in optimal beam loading conditions. This enables the reproducible production of 1.2% rms energy spread bunches with 282 MeV and 44 pC at an estimated energy-transfer efficiency of ∼19%. We correlate shot-to-shot variations to reveal the phase space dynamics and train a neural network that predicts the beam quality as a function of the drive laser.
Language	English
Publishing date	2021-05-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.126.174801
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