LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 7 of total 7

Search options

  1. Article ; Online: Editorial: Treg potency and the importance of being fit.

    Jeschke, Jonathan C / Williams, Calvin B

    Journal of leukocyte biology

    2016  Volume 100, Issue 1, Page(s) 1–3

    Language English
    Publishing date 2016-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1189/jlb.2CE0116-024R
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 603: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Editorial: Crossing the divide: a novel Cd8 enhancer with activity in CTLs and CD8αα+ dendritic cells.

    Jeschke, Jonathan C / Williams, Calvin B

    Journal of leukocyte biology

    2015  Volume 97, Issue 4, Page(s) 623–625

    MeSH term(s) Animals ; CD8 Antigens/genetics ; CD8-Positive T-Lymphocytes/metabolism ; Conserved Sequence ; Dendritic Cells/metabolism ; Gene Expression Regulation ; Humans ; Regulatory Sequences, Nucleic Acid/genetics
    Chemical Substances CD8 Antigens ; CD8 antigen, alpha chain ; Cd8b1 protein, mouse
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1189/jlb.2CE1214-606R
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 603: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Erratum for Rattenbacher et al., Analysis of CUGBP1 Targets Identifies GU-Repeat Sequences That Mediate Rapid mRNA Decay.

    Rattenbacher, Bernd / Beisang, Daniel / Wiesner, Darin L / Jeschke, Jonathan C / von Hohenberg, Maximilian / Vlasova-St Louis, Irina A / Bohjanen, Paul R

    Molecular and cellular biology

    2016  Volume 36, Issue 4, Page(s) 660

    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/MCB.01084-15
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1666: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: A model of TH17-associated ileal hyperplasia that requires both IL-17A and IFNγ to generate self-tolerance and prevent colitis.

    Jeschke, Jonathan C / Mayne, Christopher G / Ziegelbauer, Jennifer / DeCiantis, Christopher L / Singh, Selina / Kumar, Suresh N / Suchi, Mariko / Iwakura, Yoichiro / Drobyski, William R / Salzman, Nita H / Williams, Calvin B

    Mucosal immunology

    2018  Volume 11, Issue 4, Page(s) 1127–1137

    Abstract: Homeostasis in the ileum, which is commonly disrupted in patients with Crohn's disease, involves ongoing immune responses. To study how homeostatic processes of the ileum impact ... ...

    Abstract Homeostasis in the ileum, which is commonly disrupted in patients with Crohn's disease, involves ongoing immune responses. To study how homeostatic processes of the ileum impact CD4
    MeSH term(s) Animals ; Colitis/immunology ; Crohn Disease/immunology ; Disease Models, Animal ; Humans ; Hyperplasia ; Ileum/pathology ; Interferon-gamma/metabolism ; Interleukin-17/metabolism ; Mice ; Mice, Transgenic ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Self Tolerance ; Th1 Cells/immunology ; Th17 Cells/immunology
    Chemical Substances Interleukin-17 ; Receptors, Antigen, T-Cell, alpha-beta ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2018-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2411370-0
    ISSN 1935-3456 ; 1933-0219
    ISSN (online) 1935-3456
    ISSN 1933-0219
    DOI 10.1038/s41385-018-0023-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6796: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Thymic regulatory T cells arise via two distinct developmental programs.

    Owen, David L / Mahmud, Shawn A / Sjaastad, Louisa E / Williams, Jason B / Spanier, Justin A / Simeonov, Dimitre R / Ruscher, Roland / Huang, Weishan / Proekt, Irina / Miller, Corey N / Hekim, Can / Jeschke, Jonathan C / Aggarwal, Praful / Broeckel, Ulrich / LaRue, Rebecca S / Henzler, Christine M / Alegre, Maria-Luisa / Anderson, Mark S / August, Avery /
    Marson, Alexander / Zheng, Ye / Williams, Calvin B / Farrar, Michael A

    Nature immunology

    2019  Volume 20, Issue 2, Page(s) 195–205

    Abstract: The developmental programs that generate a broad repertoire of regulatory T cells ( ... ...

    Abstract The developmental programs that generate a broad repertoire of regulatory T cells (T
    MeSH term(s) Animals ; Autoantigens/immunology ; Cell Differentiation/immunology ; Colitis/immunology ; Disease Models, Animal ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; Freund's Adjuvant/administration & dosage ; Freund's Adjuvant/immunology ; Humans ; Immune Tolerance/immunology ; Interleukin-2 Receptor alpha Subunit/metabolism ; Lymphoid Progenitor Cells/physiology ; Lymphoid Progenitor Cells/transplantation ; Mice ; Mice, Transgenic ; Mycobacterium tuberculosis/immunology ; Myelin-Oligodendrocyte Glycoprotein/administration & dosage ; Myelin-Oligodendrocyte Glycoprotein/immunology ; Peptide Fragments/administration & dosage ; Peptide Fragments/immunology ; Signal Transduction ; Specific Pathogen-Free Organisms ; T-Lymphocytes, Regulatory/physiology ; Thymus Gland/cytology ; Thymus Gland/growth & development ; Thymus Gland/immunology
    Chemical Substances Autoantigens ; Forkhead Transcription Factors ; Foxp3 protein, mouse ; Il2ra protein, mouse ; Interleukin-2 Receptor alpha Subunit ; Myelin-Oligodendrocyte Glycoprotein ; Peptide Fragments ; myelin oligodendrocyte glycoprotein (35-55) ; Freund's Adjuvant (9007-81-2)
    Language English
    Publishing date 2019-01-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-018-0289-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5294: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Analysis of CUGBP1 targets identifies GU-repeat sequences that mediate rapid mRNA decay.

    Rattenbacher, Bernd / Beisang, Daniel / Wiesner, Darin L / Jeschke, Jonathan C / von Hohenberg, Maximilian / St Louis-Vlasova, Irina A / Bohjanen, Paul R

    Molecular and cellular biology

    2010  Volume 30, Issue 16, Page(s) 3970–3980

    Abstract: CUG-repeat binding protein 1 (CUGBP1) mediates selective mRNA decay by binding to GU-rich elements (GREs) containing the sequence UGUUUGUUUGU found in the 3' untranslated region (UTR) of short-lived transcripts. We used an anti-CUGBP1 antibody to ... ...

    Abstract CUG-repeat binding protein 1 (CUGBP1) mediates selective mRNA decay by binding to GU-rich elements (GREs) containing the sequence UGUUUGUUUGU found in the 3' untranslated region (UTR) of short-lived transcripts. We used an anti-CUGBP1 antibody to immunoprecipitate CUGBP1 from HeLa cytoplasmic extracts and analyzed the associated transcripts using oligonucleotide microarrays. We identified 613 putative mRNA targets of CUGBP1 and found that the UGUUUGUUUGU GRE sequence and a GU-repeat sequence were both highly enriched in the 3' UTRs of these targets. We showed that CUGBP1 bound specifically to the GU-repeat sequence and that insertion of this sequence into the 3' UTR of a beta-globin reporter transcript conferred instability to the transcript. Based on these results, we redefined the GRE to include this GU-repeat sequence. Our results suggest that CUGBP1 coordinately regulates the mRNA decay of a network of transcripts involved in cell growth, cell motility, and apoptosis.
    MeSH term(s) 3' Untranslated Regions ; Apoptosis/genetics ; Base Sequence ; Binding Sites/genetics ; CELF1 Protein ; Consensus Sequence ; Dinucleoside Phosphates/metabolism ; Dinucleotide Repeats ; Gene Knockdown Techniques ; Gene Regulatory Networks ; HeLa Cells ; Humans ; Immunoprecipitation ; Molecular Sequence Data ; Protein Binding ; RNA Processing, Post-Transcriptional ; RNA Stability ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA, Small Interfering/genetics ; RNA-Binding Proteins/antagonists & inhibitors ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
    Chemical Substances 3' Untranslated Regions ; CELF1 Protein ; CELF1 protein, human ; Dinucleoside Phosphates ; RNA, Messenger ; RNA, Small Interfering ; RNA-Binding Proteins ; guanylyl-(3'-5')-uridine (4785-07-3)
    Language English
    Publishing date 2010-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/MCB.00624-10
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1666: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression.

    Schmitt, Erica G / Haribhai, Dipica / Jeschke, Jonathan C / Co, Dominic O / Ziegelbauer, Jennifer / Yan, Ke / Iwakura, Yoichiro / Mishra, Manoj K / Simpson, Pippa / Salzman, Nita H / Williams, Calvin B

    Journal of immunology (Baltimore, Md. : 1950)

    2013  Volume 191, Issue 11, Page(s) 5460–5476

    Abstract: To study regulatory T (Treg) cell control of chronic autoimmunity in a lymphoreplete host, we created and characterized a new model of autoimmune lung inflammation that targets the medium and small airways. We generated transgenic mice that express a ... ...

    Abstract To study regulatory T (Treg) cell control of chronic autoimmunity in a lymphoreplete host, we created and characterized a new model of autoimmune lung inflammation that targets the medium and small airways. We generated transgenic mice that express a chimeric membrane protein consisting of hen egg lysozyme and a hemoglobin epitope tag under the control of the Clara cell secretory protein promoter, which largely limited transgene expression to the respiratory bronchioles. When Clara cell secretory protein-membrane hen egg lysozyme/hemoglobin transgenic mice were crossed to N3.L2 TCR transgenic mice that recognize the hemoglobin epitope, the bigenic progeny developed dense, pseudo-follicular lymphocytic peribronchiolar infiltrates that resembled the histological pattern of follicular bronchiolitis. Aggregates of activated IFN-γ- and IL-17A-secreting CD4(+) T cells as well as B cells surrounded the airways. Lung pathology was similar in Ifng(-/-) and Il17a(-/-) mice, indicating that either cytokine is sufficient to establish chronic disease. A large number of Ag-specific Treg cells accumulated in the lesions, and Treg cell depletion in the affected mice led to an interstitial spread of the disease that ultimately proved fatal. Thus, Treg cells act to restrain autoimmune responses, resulting in an organized and controlled chronic pathological process rather than a progressive disease.
    MeSH term(s) Animals ; B-Lymphocytes/immunology ; Bronchioles/metabolism ; Bronchiolitis/immunology ; Cell Movement ; Cells, Cultured ; Chronic Disease ; Disease Progression ; Hemoglobins/genetics ; Humans ; Interferon-gamma/genetics ; Interferon-gamma/metabolism ; Interleukin-17/genetics ; Interleukin-17/metabolism ; Lymphocyte Depletion ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Muramidase/genetics ; Organ Specificity/genetics ; Promoter Regions, Genetic/genetics ; Receptors, Antigen, T-Cell/genetics ; Recombinant Fusion Proteins/genetics ; T-Lymphocyte Subsets/immunology ; T-Lymphocytes, Regulatory/immunology ; Uteroglobin/genetics
    Chemical Substances Hemoglobins ; Interleukin-17 ; Receptors, Antigen, T-Cell ; Recombinant Fusion Proteins ; Interferon-gamma (82115-62-6) ; Uteroglobin (9060-09-7) ; hen egg lysozyme (EC 3.2.1.-) ; Muramidase (EC 3.2.1.17)
    Language English
    Publishing date 2013-10-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1301576
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 28: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top