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  1. Article: Initial use of subcutaneous plasma-derived C1 inhibitor in prophylaxis of acute attacks of hereditary angioedema in pregnant patients in Slovakia.

    Hrubišková, Katarína / Jeseňák, Miloš / Payer, Juraj

    Vnitrni lekarstvi

    2023  Volume 69, Issue 4, Page(s) 265–268

    Abstract: Hereditary angioedema (HAE) is a rare, inborn disease manifested with recurrent attacks of angioedema. They can affect the skin and subcutaneous tissue, mucous membranes (gastrointestinal, respiratory, and uropoietic tracts), and submucous tissue. Women ... ...

    Title translation Prvé použitie podkožného C1 inhibítora v profylaxii atakov hereditárneho angioedému u tehotných pacientok na Slovensku.
    Abstract Hereditary angioedema (HAE) is a rare, inborn disease manifested with recurrent attacks of angioedema. They can affect the skin and subcutaneous tissue, mucous membranes (gastrointestinal, respiratory, and uropoietic tracts), and submucous tissue. Women in reproductive age require specific management of the disease regarding both the course of the disease and treatment options. It is not only the treatment in female patients that is specific, but also the situations (pregnancy, breastfeeding). We present a case report of the initial use of a subcutaneous C1 inhibitor in the long-term prophylaxis of HAE attacks in two pregnant patients.
    MeSH term(s) Pregnancy ; Humans ; Female ; Angioedemas, Hereditary/drug therapy ; Angioedemas, Hereditary/prevention & control ; Subcutaneous Tissue ; Slovakia ; Angioedema
    Language English
    Publishing date 2023-06-09
    Publishing country Czech Republic
    Document type Case Reports ; Journal Article
    ZDB-ID 138213-5
    ISSN 1801-7592 ; 0042-773X
    ISSN (online) 1801-7592
    ISSN 0042-773X
    DOI 10.36290/vnl.2023.050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Managing T2-high severe asthma in HIV-infected patients.

    Terl, Milan / Jesenak, Milos

    The journal of allergy and clinical immunology. In practice

    2021  Volume 9, Issue 2, Page(s) 1041–1043

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Asthma/epidemiology ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans
    Chemical Substances Antibodies, Monoclonal, Humanized ; mepolizumab (90Z2UF0E52)
    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2020.11.015
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  3. Article: Identification of a novel

    Kolkova, Zuzana / Durdik, Peter / Holubekova, Veronika / Durdikova, Anna / Jesenak, Milos / Banovcin, Peter

    Frontiers in pediatrics

    2024  Volume 12, Page(s) 1339664

    Abstract: Background: The mutations in the : Methods: Two young brothers from a non-consanguineous Slovak family with diagnosed retinal dystrophy and recurrent respiratory infections were examined. Suspected PCD was diagnosed based on a PICADAR questionnaire, ... ...

    Abstract Background: The mutations in the
    Methods: Two young brothers from a non-consanguineous Slovak family with diagnosed retinal dystrophy and recurrent respiratory infections were examined. Suspected PCD was diagnosed based on a PICADAR questionnaire, nasal nitric oxide analysis, transmission electron microscopy, high-speed video microscopy analysis, and genetic testing.
    Results: We identified a novel frameshift
    Conclusion: The identified novel pathogenic mutation in the
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2024.1339664
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  4. Article ; Online: Editorial: Definition of the immune parameters related to COVID-19 severity.

    Tincati, Camilla / de Vries, Rory / Jesenak, Milos / Marchetti, Giulia

    Frontiers in immunology

    2023  Volume 14, Page(s) 1204125

    MeSH term(s) Humans ; COVID-19/immunology
    Language English
    Publishing date 2023-04-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1204125
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  5. Article ; Online: Mild Hyperglycaemia in Hospitalised Children with Moderate COVID-19 Infection.

    Vojtková, Jarmila / Bánovčin, Peter / Ďurdíková, Anna / Nováková, Elena / Jeseňák, Miloš

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 5

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Child ; Humans ; Hyperglycemia/complications ; COVID-19/complications ; Child, Hospitalized ; Prognosis ; Hospitalization
    Language English
    Publishing date 2023-05-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59050944
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  6. Article ; Online: Blood eosinophils: In quest of a Holy Grail for personalized asthma treatment with biologicals.

    Jesenak, Milos / Diamant, Zuzana

    Allergy

    2020  Volume 75, Issue 6, Page(s) 1294–1297

    MeSH term(s) Asthma/drug therapy ; Biological Products/therapeutic use ; Eosinophils ; Humans
    Chemical Substances Biological Products
    Language English
    Publishing date 2020-03-31
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.14253
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  7. Article ; Online: Real-world outcomes of mepolizumab treatment in severe eosinophilic asthma patients - retrospective cohort study in Slovakia.

    Jesenak, Milos / Vanecek, Vaclav / Ondrusova, Martina / Urdova, Veronika / Dostalova, Katarina / Hochmuth, Ludek

    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia

    2023  Volume 167, Issue 3, Page(s) 272–280

    Abstract: Aims: Mepolizumab, a fully-humanized recombinant IgG1 kappa monoclonal antibody directed against IL-5, has shown improved asthma control and lung function in randomised controlled trials. The aim of this study was to evaluate real-world clinical ... ...

    Abstract Aims: Mepolizumab, a fully-humanized recombinant IgG1 kappa monoclonal antibody directed against IL-5, has shown improved asthma control and lung function in randomised controlled trials. The aim of this study was to evaluate real-world clinical experience in patients with severe eosinophilic asthma treated with mepolizumab in Slovakia.
    Methods: A retrospective, non-interventional study based on medical records of all adult asthma patients initiating mepolizumab between November 1, 2017 and January 31, 2019, completing 12 months of treatment. At baseline, general and clinical profile data were recorded 12 months prior to treatment. Primary and secondary endpoints described the results of mepolizumab use at 2, 6, and 12 months after the initiation and compared to baseline. Statistical testing of individual change (in each patient) in selected parameters was performed.
    Results: The cohort included 17 patients with particularly severe asthma at baseline, with frequent severe exacerbations (SE, median 5 [IQR 4-6]/patient/year), high blood eosinophil counts (median 0.6x10
    Conclusions: The results provide clinical evidence of mepolizumab efficacy in a real sample of patients with severe asthma when administered in routine care settings in Slovakia.
    MeSH term(s) Adult ; Humans ; Anti-Asthmatic Agents/therapeutic use ; Retrospective Studies ; Slovakia ; Asthma/drug therapy ; Asthma/complications ; Eosinophilia/complications ; Eosinophilia/drug therapy ; Adrenal Cortex Hormones/therapeutic use
    Chemical Substances mepolizumab (90Z2UF0E52) ; Anti-Asthmatic Agents ; Adrenal Cortex Hormones
    Language English
    Publishing date 2023-07-10
    Publishing country Czech Republic
    Document type Journal Article
    ZDB-ID 17196-7
    ISSN 1804-7521 ; 1213-8118 ; 0231-5599 ; 0862-481X
    ISSN (online) 1804-7521
    ISSN 1213-8118 ; 0231-5599 ; 0862-481X
    DOI 10.5507/bp.2023.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Asthma in the era of COVID-19.

    Assaf, Sara / Stenberg, Henning / Jesenak, Milos / Tarasevych, Svitlana P / Hanania, Nicola A / Diamant, Zuzana

    Respiratory medicine

    2023  Volume 218, Page(s) 107373

    Abstract: Since its global invasion in 2019, COVID-19 has affected several aspects of patients' lives and posed a significant impact on the health care system. Several patient populations were identified to be at high risk of contracting SARS-CoV-2 infection and/ ... ...

    Abstract Since its global invasion in 2019, COVID-19 has affected several aspects of patients' lives and posed a significant impact on the health care system. Several patient populations were identified to be at high risk of contracting SARS-CoV-2 infection and/or developing severe COVID-19-related sequelae. Conversely, anyone who has contracted SARS-CoV-2 is at risk to experience symptoms and signs consistent with post-COVID manifestations. Patients with asthma were initially thought to be at increased risk and severity for SARS-CoV-2 infection. However, accumulating evidence demonstrates that asthma endotypes/phenotypes and comorbidities influence the risk stratification in this population. Furthermore, initial concerns about the potentially increased risk of poor outcomes with asthma treatments such as inhaled corticosteroids and biologics have not been substantiated. In this review, we provide an update on COVID-19 and asthma, including risk of susceptibility, clinical manifestations and course in this population as well as discuss recommendations for management.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/complications ; SARS-CoV-2 ; Asthma/diagnosis ; Comorbidity ; Adrenal Cortex Hormones/therapeutic use
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2023-08-10
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2023.107373
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  9. Article ; Online: Allergen immunotherapy for allergic asthma: The future seems bright.

    Diamant, Zuzana / van Maaren, Maurits / Muraro, Antonella / Jesenak, Milos / Striz, Ilja

    Respiratory medicine

    2023  Volume 210, Page(s) 107125

    Abstract: Allergen specific immunotherapy (AIT) is the only causal therapeutic option for allergic airway diseases including asthma and allergic rhinitis. AIT has been shown to restore the allergen immune tolerance, can modify both the early and late-onset ... ...

    Abstract Allergen specific immunotherapy (AIT) is the only causal therapeutic option for allergic airway diseases including asthma and allergic rhinitis. AIT has been shown to restore the allergen immune tolerance, can modify both the early and late-onset allergen-specific airway hyperreactivity, helps to achieve disease control/remission and prevents new sensitisations. Recent real life data on long-term effectiveness of house dust mite (HDM) AIT in a large group of patients with HDM-driven asthma further underscored its unique therapeutic potential as well as confirmed previous data with pollen AIT. More widespread use of this causal treatment in select patient populations should further move this promising therapeutic field. In this mini-review, we discuss updates on new insights based on real world patient data.
    MeSH term(s) Animals ; Humans ; Asthma/etiology ; Desensitization, Immunologic ; Rhinitis, Allergic/drug therapy ; Allergens ; Pollen ; Antigens, Dermatophagoides/therapeutic use ; Pyroglyphidae ; Sublingual Immunotherapy
    Chemical Substances Allergens ; Antigens, Dermatophagoides
    Language English
    Publishing date 2023-01-24
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2023.107125
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  10. Article ; Online: Biologics in severe asthma: A pragmatic approach for choosing the right treatment for the right patient.

    Rogers, Linda / Jesenak, Milos / Bjermer, Leif / Hanania, Nicola A / Seys, Sven F / Diamant, Zuzana

    Respiratory medicine

    2023  Volume 218, Page(s) 107414

    Abstract: The development of monoclonal antibody therapies targeting specific components of the pathways relevant to asthma pathophysiology has revolutionized treatment of severe asthma both in adults and children and helped to further unravel the heterogeneity of ...

    Abstract The development of monoclonal antibody therapies targeting specific components of the pathways relevant to asthma pathophysiology has revolutionized treatment of severe asthma both in adults and children and helped to further unravel the heterogeneity of this disease. However, the availability of multiple agents, often with overlapping eligibility criteria, creates a need for pragmatic guidance for specialists undertaking care of patients with severe asthma. In this review, we provide an overview of the data supporting the clinical efficacy of biologics in distinct asthma phenotypes/endotypes. We also focus on the role of biomarkers and treatable traits, including comorbidities, in the choice of asthma biologics, highlight which treatments have been demonstrated to be steroid sparing in corticosteroid dependent asthma, and provide practical guidance that can drive shared decision making on treatment choice with patients. In addition, we summarize what is known to date regarding long-term safety of these drugs, and lastly, discuss future directions in biologics research.
    MeSH term(s) Adult ; Child ; Humans ; Biological Products/therapeutic use ; Asthma ; Biomarkers ; Phenotype ; Precision Medicine ; Anti-Asthmatic Agents/therapeutic use
    Chemical Substances Biological Products ; Biomarkers ; Anti-Asthmatic Agents
    Language English
    Publishing date 2023-09-29
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2023.107414
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