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  1. Article: Free online genome analyses reveal multiple strains in the beginning of a hospital outbreak of

    Kemp, Michael / Jespersen, Magnus G / Toft, Annette / Holm, Anette

    Journal of infection prevention

    2022  Volume 23, Issue 5, Page(s) 243–247

    Abstract: Free online tools for bacterial genome analyses are available for local infection surveillance at hospitals. The tools do not require bioinformatic expertise and provide rapid actionable results. Within half a year carbapenemase ... ...

    Abstract Free online tools for bacterial genome analyses are available for local infection surveillance at hospitals. The tools do not require bioinformatic expertise and provide rapid actionable results. Within half a year carbapenemase producing
    Language English
    Publishing date 2022-06-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2595000-9
    ISSN 1757-1782 ; 1757-1774
    ISSN (online) 1757-1782
    ISSN 1757-1774
    DOI 10.1177/17571774221107293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Global genomic epidemiology of Streptococcus pyogenes

    Jespersen, Magnus G / Lacey, Jake A / Tong, Steven Y.C / Davies, Mark R

    Infection, genetics, and evolution. 2020 Dec., v. 86

    2020  

    Abstract: Streptococcus pyogenes is one of the Top 10 human infectious disease killers worldwide causing a range of clinical manifestations in humans. Colonizing a range of ecological niches within its sole host, the human, is key to the ability of this ... ...

    Abstract Streptococcus pyogenes is one of the Top 10 human infectious disease killers worldwide causing a range of clinical manifestations in humans. Colonizing a range of ecological niches within its sole host, the human, is key to the ability of this opportunistic pathogen to cause direct and post-infectious manifestations. The expansion of genome sequencing capabilities and data availability over the last decade has led to an improved understanding of the evolutionary dynamics of this pathogen within a global framework where epidemiological relationships and evolutionary mechanisms may not be universal. This review uses the recent publication by Davies et al., 2019 as an updated global framework to address S. pyogenes population genomics, highlighting how genomics is being used to gain new insights into evolutionary processes, transmission pathways, and vaccine design.
    Keywords Streptococcus pyogenes ; epidemiology ; evolution ; genome ; humans ; infectious diseases ; metagenomics ; opportunistic pathogens ; vaccine development
    Language English
    Dates of publication 2020-12
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2037068-4
    ISSN 1567-1348
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2020.104609
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5645: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Global genomic epidemiology of Streptococcus pyogenes.

    Jespersen, Magnus G / Lacey, Jake A / Tong, Steven Y C / Davies, Mark R

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2020  Volume 86, Page(s) 104609

    Abstract: Streptococcus pyogenes is one of the Top 10 human infectious disease killers worldwide causing a range of clinical manifestations in humans. Colonizing a range of ecological niches within its sole host, the human, is key to the ability of this ... ...

    Abstract Streptococcus pyogenes is one of the Top 10 human infectious disease killers worldwide causing a range of clinical manifestations in humans. Colonizing a range of ecological niches within its sole host, the human, is key to the ability of this opportunistic pathogen to cause direct and post-infectious manifestations. The expansion of genome sequencing capabilities and data availability over the last decade has led to an improved understanding of the evolutionary dynamics of this pathogen within a global framework where epidemiological relationships and evolutionary mechanisms may not be universal. This review uses the recent publication by Davies et al., 2019 as an updated global framework to address S. pyogenes population genomics, highlighting how genomics is being used to gain new insights into evolutionary processes, transmission pathways, and vaccine design.
    MeSH term(s) Genome, Bacterial ; Genomics/methods ; Global Health ; Humans ; Molecular Epidemiology ; Population Surveillance ; Streptococcal Infections/epidemiology ; Streptococcal Infections/microbiology ; Streptococcus pyogenes/classification ; Streptococcus pyogenes/genetics
    Language English
    Publishing date 2020-11-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2020.104609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5645: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Author Correction: Pathogenesis, epidemiology and control of Group A Streptococcus infection.

    Brouwer, Stephan / Rivera-Hernandez, Tania / Curren, Bodie F / Harbison-Price, Nichaela / De Oliveira, David M P / Jespersen, Magnus G / Davies, Mark R / Walker, Mark J

    Nature reviews. Microbiology

    2023  Volume 21, Issue 9, Page(s) 619

    Language English
    Publishing date 2023-07-03
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2139054-X
    ISSN 1740-1534 ; 1740-1526
    ISSN (online) 1740-1534
    ISSN 1740-1526
    DOI 10.1038/s41579-023-00939-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5865: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 74: Show issues

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  5. Article ; Online: Pathogenesis, epidemiology and control of Group A Streptococcus infection.

    Brouwer, Stephan / Rivera-Hernandez, Tania / Curren, Bodie F / Harbison-Price, Nichaela / De Oliveira, David M P / Jespersen, Magnus G / Davies, Mark R / Walker, Mark J

    Nature reviews. Microbiology

    2023  Volume 21, Issue 7, Page(s) 431–447

    Abstract: Streptococcus pyogenes (Group A Streptococcus; GAS) is exquisitely adapted to the human host, resulting in asymptomatic infection, pharyngitis, pyoderma, scarlet fever or invasive diseases, with potential for triggering post-infection immune sequelae. ... ...

    Abstract Streptococcus pyogenes (Group A Streptococcus; GAS) is exquisitely adapted to the human host, resulting in asymptomatic infection, pharyngitis, pyoderma, scarlet fever or invasive diseases, with potential for triggering post-infection immune sequelae. GAS deploys a range of virulence determinants to allow colonization, dissemination within the host and transmission, disrupting both innate and adaptive immune responses to infection. Fluctuating global GAS epidemiology is characterized by the emergence of new GAS clones, often associated with the acquisition of new virulence or antimicrobial determinants that are better adapted to the infection niche or averting host immunity. The recent identification of clinical GAS isolates with reduced penicillin sensitivity and increasing macrolide resistance threatens both frontline and penicillin-adjunctive antibiotic treatment. The World Health Organization (WHO) has developed a GAS research and technology road map and has outlined preferred vaccine characteristics, stimulating renewed interest in the development of safe and effective GAS vaccines.
    MeSH term(s) Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Macrolides/pharmacology ; Macrolides/therapeutic use ; Drug Resistance, Bacterial ; Streptococcal Infections/drug therapy ; Streptococcal Infections/epidemiology ; Streptococcal Infections/prevention & control ; Streptococcus pyogenes/genetics ; Penicillins/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Macrolides ; Penicillins
    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2139054-X
    ISSN 1740-1534 ; 1740-1526
    ISSN (online) 1740-1534
    ISSN 1740-1526
    DOI 10.1038/s41579-023-00865-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5865: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 74: Show issues

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  6. Article ; Online: Streptococcus pyogenes Hijacks Host Glutathione for Growth and Innate Immune Evasion.

    Brouwer, Stephan / Jespersen, Magnus G / Ong, Cheryl-Lynn Y / De Oliveira, David M P / Keller, Bernhard / Cork, Amanda J / Djoko, Karrera Y / Davies, Mark R / Walker, Mark J

    mBio

    2022  Volume 13, Issue 3, Page(s) e0067622

    Abstract: The nasopharynx and the skin are the major oxygen-rich anatomical sites for colonization by the human pathogen Streptococcus pyogenes (group A Streptococcus [GAS]). To establish infection, GAS must survive oxidative stress generated during aerobic ... ...

    Abstract The nasopharynx and the skin are the major oxygen-rich anatomical sites for colonization by the human pathogen Streptococcus pyogenes (group A Streptococcus [GAS]). To establish infection, GAS must survive oxidative stress generated during aerobic metabolism and the release of reactive oxygen species (ROS) by host innate immune cells. Glutathione is the major host antioxidant molecule, while GAS is glutathione auxotrophic. Here, we report the molecular characterization of the ABC transporter substrate binding protein GshT in the GAS glutathione salvage pathway. We demonstrate that glutathione uptake is critical for aerobic growth of GAS and that impaired import of glutathione induces oxidative stress that triggers enhanced production of the reducing equivalent NADPH. Our results highlight the interrelationship between glutathione assimilation, carbohydrate metabolism, virulence factor production, and innate immune evasion. Together, these findings suggest an adaptive strategy employed by extracellular bacterial pathogens to exploit host glutathione stores for their own benefit.
    MeSH term(s) ATP-Binding Cassette Transporters/metabolism ; Antioxidants/metabolism ; Bacterial Proteins/metabolism ; Glutathione/metabolism ; Humans ; Immune Evasion ; Reactive Oxygen Species/metabolism ; Streptococcal Infections/microbiology ; Streptococcus pyogenes/metabolism ; Virulence Factors/metabolism
    Chemical Substances ATP-Binding Cassette Transporters ; Antioxidants ; Bacterial Proteins ; Reactive Oxygen Species ; Virulence Factors ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00676-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis.

    Xie, Ouli / Morris, Jacqueline M / Hayes, Andrew J / Towers, Rebecca J / Jespersen, Magnus G / Lees, John A / Ben Zakour, Nouri L / Berking, Olga / Baines, Sarah L / Carter, Glen P / Tonkin-Hill, Gerry / Schrieber, Layla / McIntyre, Liam / Lacey, Jake A / James, Taylah B / Sriprakash, Kadaba S / Beatson, Scott A / Hasegawa, Tadao / Giffard, Phil /
    Steer, Andrew C / Batzloff, Michael R / Beall, Bernard W / Pinho, Marcos D / Ramirez, Mario / Bessen, Debra E / Dougan, Gordon / Bentley, Stephen D / Walker, Mark J / Currie, Bart J / Tong, Steven Y C / McMillan, David J / Davies, Mark R

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2286

    Abstract: Streptococcus dysgalactiae subsp. equisimilis (SDSE) is an emerging cause of human infection with invasive disease incidence and clinical manifestations comparable to the closely related species, Streptococcus pyogenes. Through systematic genomic ... ...

    Abstract Streptococcus dysgalactiae subsp. equisimilis (SDSE) is an emerging cause of human infection with invasive disease incidence and clinical manifestations comparable to the closely related species, Streptococcus pyogenes. Through systematic genomic analyses of 501 disseminated SDSE strains, we demonstrate extensive overlap between the genomes of SDSE and S. pyogenes. More than 75% of core genes are shared between the two species with one third demonstrating evidence of cross-species recombination. Twenty-five percent of mobile genetic element (MGE) clusters and 16 of 55 SDSE MGE insertion regions were shared across species. Assessing potential cross-protection from leading S. pyogenes vaccine candidates on SDSE, 12/34 preclinical vaccine antigen genes were shown to be present in >99% of isolates of both species. Relevant to possible vaccine evasion, six vaccine candidate genes demonstrated evidence of inter-species recombination. These findings demonstrate previously unappreciated levels of genomic overlap between these closely related pathogens with implications for streptococcal pathobiology, disease surveillance and prevention.
    MeSH term(s) Humans ; Streptococcus pyogenes/genetics ; Gene Flow ; Streptococcal Infections ; Vaccines ; Streptococcus
    Chemical Substances Vaccines
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46530-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Detection of Streptococcus pyogenes M1

    Davies, Mark R / Keller, Nadia / Brouwer, Stephan / Jespersen, Magnus G / Cork, Amanda J / Hayes, Andrew J / Pitt, Miranda E / De Oliveira, David M P / Harbison-Price, Nichaela / Bertolla, Olivia M / Mediati, Daniel G / Curren, Bodie F / Taiaroa, George / Lacey, Jake A / Smith, Helen V / Fang, Ning-Xia / Coin, Lachlan J M / Stevens, Kerrie / Tong, Steven Y C /
    Sanderson-Smith, Martina / Tree, Jai J / Irwin, Adam D / Grimwood, Keith / Howden, Benjamin P / Jennison, Amy V / Walker, Mark J

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 1051

    Abstract: A new variant of Streptococcus pyogenes serotype M1 (designated ' ... ...

    Abstract A new variant of Streptococcus pyogenes serotype M1 (designated 'M1
    MeSH term(s) Humans ; Streptococcus pyogenes/genetics ; Scarlet Fever/epidemiology ; Superantigens ; Bacterial Proteins/genetics ; United Kingdom ; Exotoxins/genetics ; Mutation ; Australia ; Streptococcal Infections
    Chemical Substances Superantigens ; Bacterial Proteins ; Exotoxins
    Language English
    Publishing date 2023-02-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-36717-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes.

    Brouwer, Stephan / Barnett, Timothy C / Ly, Diane / Kasper, Katherine J / De Oliveira, David M P / Rivera-Hernandez, Tania / Cork, Amanda J / McIntyre, Liam / Jespersen, Magnus G / Richter, Johanna / Schulz, Benjamin L / Dougan, Gordon / Nizet, Victor / Yuen, Kwok-Yung / You, Yuanhai / McCormick, John K / Sanderson-Smith, Martina L / Davies, Mark R / Walker, Mark J

    Nature communications

    2020  Volume 11, Issue 1, Page(s) 5018

    Abstract: The re-emergence of scarlet fever poses a new global public health threat. The capacity of North-East Asian serotype M12 (emm12) Streptococcus pyogenes (group A Streptococcus, GAS) to cause scarlet fever has been linked epidemiologically to the presence ... ...

    Abstract The re-emergence of scarlet fever poses a new global public health threat. The capacity of North-East Asian serotype M12 (emm12) Streptococcus pyogenes (group A Streptococcus, GAS) to cause scarlet fever has been linked epidemiologically to the presence of novel prophages, including prophage ΦHKU.vir encoding the secreted superantigens SSA and SpeC and the DNase Spd1. Here, we report the molecular characterization of ΦHKU.vir-encoded exotoxins. We demonstrate that streptolysin O (SLO)-induced glutathione efflux from host cellular stores is a previously unappreciated GAS virulence mechanism that promotes SSA release and activity, representing the first description of a thiol-activated bacterial superantigen. Spd1 is required for resistance to neutrophil killing. Investigating single, double and triple isogenic knockout mutants of the ΦHKU.vir-encoded exotoxins, we find that SpeC and Spd1 act synergistically to facilitate nasopharyngeal colonization in a mouse model. These results offer insight into the pathogenesis of scarlet fever-causing GAS mediated by prophage ΦHKU.vir exotoxins.
    MeSH term(s) Animals ; Bacterial Proteins/pharmacology ; Cell Line ; Erythrocytes/drug effects ; Exotoxins/genetics ; Exotoxins/metabolism ; Female ; Glutathione/metabolism ; Humans ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Mutation ; Pharynx/cytology ; Prophages/genetics ; Scarlet Fever/epidemiology ; Scarlet Fever/microbiology ; Streptococcus pyogenes/genetics ; Streptococcus pyogenes/pathogenicity ; Streptococcus pyogenes/virology ; Streptolysins/pharmacology ; Superantigens/genetics ; Superantigens/metabolism
    Chemical Substances Bacterial Proteins ; Exotoxins ; Streptolysins ; Superantigens ; streptolysin O ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2020-10-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-18700-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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