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Article: Persisterende subjectieve geheugen-klachten op middelbare leeftijd: diagnostiek en behandeling.

Verfaillie, S C J / Korten, N / van der Sluijs, M G J M / Jeuring, H W / van Oppen, P / van de Flier, W M / Overbeek, J M / Slot, R E R / Bouwman, F / Dols, A

Tijdschrift voor psychiatrie

2023 Volume 65, Issue 4, Page(s) 272–277

Abstract: A 47-year-old highly educated man without psychiatric history was referred for psychiatric evaluation because of persistent subjective cognitive decline after repeated and extensive diagnostic evaluation in an outpatient memory clinic. The patient ... ...

Title translation	Persistent subjective cognitive decline in middle age: diagnosis and treatment.
Abstract	A 47-year-old highly educated man without psychiatric history was referred for psychiatric evaluation because of persistent subjective cognitive decline after repeated and extensive diagnostic evaluation in an outpatient memory clinic. The patient developed increasing preoccupation and anxiety with memory complaints and concerns, despite repetitive negative findings from clinical investigations. This clinical case is coined as ‘neurocognitive hypochondria’, a syndrome interfacing with cogniform and illness anxiety disorders, in which obsessions and concerns about progression of unexplained memory deficits are indicated for specialized treatment. This case study provides more insight into differential diagnosis, classification according to the current DSM-5 criteria and discussion on potential treatment approaches.
MeSH term(s)	Male ; Humans ; Middle Aged ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/therapy ; Diagnosis, Differential ; Anxiety ; Anxiety Disorders ; Memory Disorders ; Neuropsychological Tests
Language	Dutch
Publishing date	2023-05-08
Publishing country	Netherlands
Document type	English Abstract ; Journal Article
ZDB-ID	604662-9
ISSN	0303-7339
ISSN	0303-7339
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Zs.B 2520: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 29: Show issues

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Article ; Online: The impact of a history of child abuse on cognitive performance: a cross-sectional study in older patients with a depressive, anxiety, or somatic symptom disorder.

Tjoelker, F M / Jeuring, H W / Aprahamian, I / Naarding, P / Marijnissen, R M / Hendriks, G J / Rhebergen, D / Lugtenburg, A / Lammers, M W / van den Brink, R H S / Oude Voshaar, R C

BMC geriatrics

2022 Volume 22, Issue 1, Page(s) 377

Abstract: Background: Child abuse is a major global burden with an enduring negative impact on mental and physical health. A history of child abuse is consistently associated with worse cognitive performance among adults; data in older age groups are inconclusive. ...

Abstract	Background: Child abuse is a major global burden with an enduring negative impact on mental and physical health. A history of child abuse is consistently associated with worse cognitive performance among adults; data in older age groups are inconclusive. Since affective symptoms and cognitive functioning are interrelated among older persons, a synergistic effect can be assumed in patients with affective symptoms who also have suffered from child abuse. This study examines the association between a history of child abuse and cognitive performance in such patients. Methods: Cross-sectional data were collected from the 'Routine Outcome Monitoring for Geriatric Psychiatry & Science' project, including 179 older adults (age 60-88 years) with either a unipolar depressive, any anxiety, or somatic symptom disorder referred to specialized geriatric mental health care. A history of physical, sexual, and psychological abuse, and emotional neglect was assessed with a structured interview. Cognitive functioning was measured with three paper and pencils tests (10-words verbal memory test, Stroop Colour-Word test, Digit Span) and four tests from the computerized Cogstate Test Battery (Detection Test, Identification Test, One Card Learning Test, One Back Test). The association between a history of child abuse and cognitive performance was examined by multiple linear regression analyses adjusted for covariates. Results: Principal component analyses of nine cognitive parameters revealed four cognitive domains, i.e., visual-verbal memory, psychomotor speed, working memory and interference control. A history of child abuse was not associated with any of these cognitive domains. However, when looking at the specific types of child abuse separately, a history of physical abuse and emotional neglect were associated with poorer interference control. A history of physical abuse was additionally associated with better visual-verbal memory. Conclusions: The association between a history of child abuse and cognitive performance differs between the different types of abuse. A history of physical abuse might particularly be a key determinant of cognitive performance in older adults with a depressive, anxiety, or somatic symptom disorder. Future studies on the impact of these disorders on the onset of dementia should take child abuse into account. Trial registration: ROM-GPS is registered at the Dutch Trial Register ( NL6704 at www.trialregister.nl ).
MeSH term(s)	Aged ; Aged, 80 and over ; Anxiety ; Child ; Child Abuse/psychology ; Cognition ; Cross-Sectional Studies ; Humans ; Medically Unexplained Symptoms
Language	English
Publishing date	2022-04-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-022-03068-6
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Article ; Online: Course of frailty stratified by physical and mental multimorbidity patterns: a 5-year follow-up of 92,640 participants of the LifeLines cohort study.

Oude Voshaar, R C / Jeuring, H W / Borges, M K / van den Brink, R H S / Marijnissen, R M / Hoogendijk, E O / van Munster, B / Aprahamian, I

BMC medicine

2021 Volume 19, Issue 1, Page(s) 29

Abstract: Background: The frailty index (FI) is a well-recognized measurement for risk stratification in older people. Among middle-aged and older people, we examined the prospective association between the FI and mortality as well as its course over time in ... ...

Abstract	Background: The frailty index (FI) is a well-recognized measurement for risk stratification in older people. Among middle-aged and older people, we examined the prospective association between the FI and mortality as well as its course over time in relation to multimorbidity and specific disease clusters. Methods: A frailty index (FI) was constructed based on either 64 (baseline only) or 35 health deficits (baseline and follow-up) among people aged ≥ 40 years who participated in LifeLines, a prospective population-based cohort living in the Northern Netherlands. Among 92,640 participants, multivariable Cox proportional hazard models were fitted to study the hazard ratio (HR) of the FI at baseline, as well as for 10 chronic disease clusters for all-cause mortality over a 10-year follow-up. Among 55,426 participants, linear regression analyses were applied to study the impact of multimorbidity and of specific chronic disease clusters (independent variables) on the change of frailty over a 5-year follow-up, adjusted for demographic and lifestyle characteristics. Results: The FI predicted mortality independent of multimorbidity and specific disease clusters, with the highest impact in people with either endocrine, lung, or heart diseases. Adjusted for demographic and lifestyle characteristics, all chronic disease clusters remained independently associated with an accelerated increase of frailty over time. Conclusions: Frailty may be seen as a final common pathway for premature death due to chronic diseases. Our results suggest that initiating frailty prevention at middle age, when the first chronic diseases emerge, might be relevant from a public health perspective.
MeSH term(s)	Aged ; Aged, 80 and over ; Cohort Studies ; Follow-Up Studies ; Frail Elderly/statistics & numerical data ; Frailty/epidemiology ; Geriatric Assessment/methods ; Humans ; Life Style ; Longitudinal Studies ; Male ; Middle Aged ; Multimorbidity/trends ; Netherlands ; Proportional Hazards Models ; Prospective Studies
Language	English
Publishing date	2021-02-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1741-7015
ISSN (online)	1741-7015
DOI	10.1186/s12916-021-01904-x
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Article ; Online: Excess mortality in depressive and anxiety disorders: The Lifelines Cohort Study.

Oude Voshaar, R C / Aprahamian, I / Borges, M K / van den Brink, R H S / Marijnissen, R M / Hoogendijk, E O / van Munster, B / Jeuring, H W

European psychiatry : the journal of the Association of European Psychiatrists

2021 Volume 64, Issue 1, Page(s) e54

Abstract: Background: To examine the mortality risk of current and life-time depressive as well as anxiety disorders, whether this risk is moderated by sex or age, and whether this risk can be explained by lifestyle and/or somatic health status.: Methods: A ... ...

Abstract	Background: To examine the mortality risk of current and life-time depressive as well as anxiety disorders, whether this risk is moderated by sex or age, and whether this risk can be explained by lifestyle and/or somatic health status. Methods: A cohort study (Lifelines) including 141,377 participants (18-93 years) which were followed-up regarding mortality for 8.6 years (range 3.0-13.7). Baseline depressive and anxiety disorders according to Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria were assessed with the Mini International Neuropsychiatric Interview and lifetime diagnoses by self-report. All-cause mortality was retrieved from Statistics Netherlands. Cox-regression was applied to calculate proportional hazard ratios, adjusted for lifestyle (physical activity, alcohol use, smoking, and body mass index) and somatic health status (multimorbidity and frailty) in different models. Results: The mortality rate of depressive and anxiety disorders was conditional upon age but not on sex. Only in people below 60 years, current depressive and anxiety disorders were associated with mortality. Only depressive disorder and panic disorder independently predicted mortality when all mental disorders were included simultaneously in one overall model (hazard ratio [HR] = 2.18 [95% confidence intervals (CI): 1.56-3.05], p < 0.001 and HR = 2.39 [95% CI: 1.15-4.98], p = 0.020). Life-time depressive and anxiety disorders, however, were independent of each other associated with mortality. Associations hardly changed when adjusted for lifestyle characteristics but decreased substantially when adjusted for somatic health status (in particular physical frailty). Conclusions: In particular, depressive disorder is associated with excess mortality in people below 60 years, independent of their lifestyle. This effect seems partly explained by multimorbidity and frailty, which suggest that chronic disease management of depression-associated somatic morbidity needs to be (further) improved.
MeSH term(s)	Anxiety Disorders/epidemiology ; Cohort Studies ; Diagnostic and Statistical Manual of Mental Disorders ; Humans ; Life Style ; Psychiatric Status Rating Scales
Language	English
Publishing date	2021-08-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1074337-6
ISSN	1778-3585 ; 0767-399X ; 0924-9338
ISSN (online)	1778-3585
ISSN	0767-399X ; 0924-9338
DOI	10.1192/j.eurpsy.2021.2229
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Zs.A 2369: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 558: Show issues

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Article ; Online: The tide has turned: incidence of depression declined in community living young-old adults over one decade.

Jeuring, H W / Hoogendijk, E O / Comijs, H C / Deeg, D J H / Beekman, A T F / Huisman, M / Stek, M L

Epidemiology and psychiatric sciences

2019 Volume 29, Page(s) e16

Abstract: Aims: Studying birth-cohort differences in depression incidence and their explanatory factors may provide insight into the aetiology of depression and could help to optimise prevention strategies to reduce the worldwide burden of depression.: Methods!# ...

Abstract	Aims: Studying birth-cohort differences in depression incidence and their explanatory factors may provide insight into the aetiology of depression and could help to optimise prevention strategies to reduce the worldwide burden of depression. Methods: Data were used from the Longitudinal Aging Study Amsterdam, a nationally representative study among community dwelling older adults in the Netherlands. Cohort differences in depression incidence over a 10-year-period (score ⩾16 on the Center for Epidemiologic Studies Depression scale) were tested using a cohort-sequential-longitudinal-design, comparing two identically measured cohorts of non-depressed 55-64-year-olds, born 10-years apart. Baseline measurements took place in 1992/93 (early cohort, n = 794), and 2002/03 (recent cohort, n = 771). As indicated by the dynamic equilibrium model of depression, potential explanatory factors were distinguished in risk and protective factors. Results: The incidence rates for depression in the early and recent cohort were 1.91 (95% confidence interval (CI) 1.59-2.27) and 1.60 (95% CI 1.31-1.94) per 100 person-years, respectively. A 29% risk reduction in depression incidence was observed in the recent cohort (HRcohort: 0.71, 95% CI 0.54-0.92, p = 0.011), as compared with the early cohort, even though average levels of risk factors such as chronic disease and functional limitations had increased. This reduction was primarily explained by increased levels of education, mastery and labour market participation. Conclusions: These findings suggest that favourable developments of protective factors have counterbalanced unfavourable effects of risk factors on the incidence of depression, resulting in a net reduction of depression incidence among young-old adults. However, maintaining a good physical health must be a priority to further decrease depression rates.
MeSH term(s)	Age Distribution ; Aged ; Aged, 80 and over ; Cohort Studies ; Depressive Disorder/epidemiology ; Female ; Humans ; Incidence ; Independent Living ; Longitudinal Studies ; Male ; Middle Aged ; Netherlands/epidemiology
Language	English
Publishing date	2019-01-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2607964-1
ISSN	2045-7979 ; 2045-7960
ISSN (online)	2045-7979
ISSN	2045-7960
DOI	10.1017/S2045796018000811
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Zs.A 5143: Show issues

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Article ; Online: Impact of childhood trauma on multidimensional frailty in older patients with a unipolar depressive-, anxiety- or somatic symptom disorder.

Schmahl, O C / Jeuring, H W / Aprahamian, I / Naarding, P / Marijnissen, R M / Hendriks, G J / Fluiter, M / Rhebergen, D / Lugtenburg, A / Lammers, M W / van den Brink, R H S / Oude Voshaar, R C

Archives of gerontology and geriatrics

2021 Volume 96, Page(s) 104452

Abstract: Objectives: Frailty marks an increased risk for adverse health outcomes. Since childhood trauma is associated with the onset of physical and mental health diseases during the lifespan, we examined the link between childhood trauma and multidimensional ... ...

Abstract	Objectives: Frailty marks an increased risk for adverse health outcomes. Since childhood trauma is associated with the onset of physical and mental health diseases during the lifespan, we examined the link between childhood trauma and multidimensional frailty. Method: A cross-sectional study embedded in a clinical cohort study (ROM-GPS) of older (≥60 years) patients (n=182) with a unipolar depressive-, anxiety- and/or somatic symptom disorder according to DSM-criteria referred to specialized geriatric mental health care. Frailty was assessed with the Tilburg Frailty Indicator (TFI), comprising a physical, psychological, and social dimension. Physical, sexual and psychological abuse and emotional neglect before the age of 16 years was measured with a structured interview. Results: Of 182 patients, 103 (56.6%) had experienced any childhood trauma and 154 (84.6%) were frail (TFI sum score ≥5). Linear regression analyses, adjusted for lifestyle, psychological and physical-health factors, showed that the presence of any type of childhood trauma was not associated with the TFI sum score, however when considered separately, physical abuse was (ß=0.16, p=.037). Regarding the specific frailty dimensions, any childhood trauma was associated with social frailty (ß=0.18, p=.019), with emotional neglect as main contributor. Conclusion: These findings demonstrate a complex link between different types of childhood trauma and multidimensional frailty among older psychiatric patients. Regarding the three dimensions of frailty, social frailty seems most affected by childhood trauma. This may have been underestimated until now and should receive more attention in clinical care and future research.
MeSH term(s)	Aged ; Anxiety ; Cohort Studies ; Cross-Sectional Studies ; Frail Elderly ; Frailty/epidemiology ; Geriatric Assessment ; Humans ; Medically Unexplained Symptoms ; Surveys and Questionnaires
Language	English
Publishing date	2021-05-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	603162-6
ISSN	1872-6976 ; 0167-4943
ISSN (online)	1872-6976
ISSN	0167-4943
DOI	10.1016/j.archger.2021.104452
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Article ; Online: The long-term outcome of subthreshold depression in later life.

Jeuring, H W / Huisman, M / Comijs, H C / Stek, M L / Beekman, A T F

Psychological medicine

2016 Volume 46, Issue 13, Page(s) 2855–2865

Abstract: Background: Subthreshold depression (SUBD) in later life is common and important as prodromal state and prominent risk factor in the development of major depressive disorder (MDD). Indicated prevention can reduce the incidence of MDD among people with ... ...

Abstract	Background: Subthreshold depression (SUBD) in later life is common and important as prodromal state and prominent risk factor in the development of major depressive disorder (MDD). Indicated prevention can reduce the incidence of MDD among people with SUBD substantially, but needs to be targeted to those that are truly at risk of developing MDD. Method: N = 341 eligible participants with SUBD were included from the first (1992/1993), second (1995/1996) and third (1998/1999) cycle from the Longitudinal Aging Study Amsterdam (LASA) by using a two-stage screening design. LASA is an ongoing prospective cohort study in The Netherlands among the older population (55-85 years). At baseline (1992/1993) N = 3107 participants were interviewed and follow-up cycles were conducted every 3 years until 2008/2009, resulting in maximal 17 years of observational period. The proportion of people that developed MDD, remained SUBD, or recovered from SUBD was measured and Cox proportional regression analyses were performed to investigate 29 putative predictors of MDD and recovery from SUBD. Results: N = 153 (44.9%) recovered from SUBD, N = 138 (40.5%) remained chronically SUBD, and N = 50 (14.7%) developed MDD (incidence rate 15.1/1000 person-years). Women, high neuroticism, more chronic diseases, high body mass index, smoking and less social support predicted conversion to MDD. Men, low neuroticism and absence of pain predicted recovery from SUBD. Conclusions: Although older people with SUBD are clearly at risk of developing MDD, the majority did not, even after a long and thorough follow-up. Given the risk factors that were uncovered, targeting and prevention of MDD in those at very high risk is feasible.
MeSH term(s)	Aged ; Aged, 80 and over ; Aging ; Chronic Disease ; Depression/diagnosis ; Depression/epidemiology ; Depressive Disorder, Major/diagnosis ; Depressive Disorder, Major/epidemiology ; Disease Progression ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Netherlands/epidemiology ; Prodromal Symptoms ; Risk Factors ; Sex Factors
Language	English
Publishing date	2016-10
Publishing country	England
Document type	Journal Article
ZDB-ID	217420-0
ISSN	1469-8978 ; 0033-2917
ISSN (online)	1469-8978
ISSN	0033-2917
DOI	10.1017/S0033291716001549
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Zs.B 1003: Show issues

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Article: Persisterende subjectieve geheugen-klachten op middelbare leeftijd: diagnostiek en behandeling.

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Article ; Online: The impact of a history of child abuse on cognitive performance: a cross-sectional study in older patients with a depressive, anxiety, or somatic symptom disorder.

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Article ; Online: Course of frailty stratified by physical and mental multimorbidity patterns: a 5-year follow-up of 92,640 participants of the LifeLines cohort study.

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Article ; Online: Excess mortality in depressive and anxiety disorders: The Lifelines Cohort Study.

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Article ; Online: The tide has turned: incidence of depression declined in community living young-old adults over one decade.

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Article ; Online: Impact of childhood trauma on multidimensional frailty in older patients with a unipolar depressive-, anxiety- or somatic symptom disorder.

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Article ; Online: The long-term outcome of subthreshold depression in later life.

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