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Article ; Online: Erratum for Versluis et al., "A Multiscale Spatiotemporal Model Including a Switch from Aerobic To Anaerobic Metabolism Reproduces Succession in the Early Infant Gut Microbiota".

Versluis, David M / Schoemaker, Ruud / Looijesteijn, Ellen / Muysken, Daniël / Jeurink, Prescilla V / Paques, Marcel / Geurts, Jan M W / Merks, Roeland M H

mSystems

2022 Volume 8, Issue 1, Page(s) e0115022

Language	English
Publishing date	2022-12-12
Publishing country	United States
Document type	Journal Article ; Published Erratum
ISSN	2379-5077
ISSN (online)	2379-5077
DOI	10.1128/msystems.01150-22
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Article: A Multiscale Spatiotemporal Model Including a Switch from Aerobic to Anaerobic Metabolism Reproduces Succession in the Early Infant Gut Microbiota.

Versluis, David M / Schoemaker, Ruud / Looijesteijn, Ellen / Muysken, Daniël / Jeurink, Prescilla V / Paques, Marcel / Geurts, Jan M W / Merks, Roeland M H

mSystems

2022 Volume 7, Issue 5, Page(s) e0044622

Abstract: The human intestinal microbiota starts to form immediately after birth and is important for the health of the host. During the first days, facultatively anaerobic bacterial species generally dominate, such ... ...

Abstract	The human intestinal microbiota starts to form immediately after birth and is important for the health of the host. During the first days, facultatively anaerobic bacterial species generally dominate, such as
MeSH term(s)	Infant ; Humans ; Infant, Newborn ; Gastrointestinal Microbiome ; Anaerobiosis ; Lactose/metabolism ; Bifidobacterium ; Microbiota ; Bacteria ; Enterobacteriaceae
Chemical Substances	Lactose (J2B2A4N98G)
Language	English
Publishing date	2022-09-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2379-5077
ISSN	2379-5077
DOI	10.1128/msystems.00446-22
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Article ; Online: Dietary Vitamin D Supplementation Is Ineffective in Preventing Murine Cow's Milk Allergy, Irrespective of the Presence of Nondigestible Oligosaccharides.

Kerperien, JoAnn / Veening-Griffioen, Désirée / Oja, Anna / Wehkamp, Tjalling / Jeurink, Prescilla V / Garssen, Johan / Knippels, Leon M J / Willemsen, Linette E M

International archives of allergy and immunology

2020 Volume 181, Issue 12, Page(s) 908–918

Abstract: Introduction: Cow's milk allergy (CMA) is one of the most common food allergies especially early in life. A mixture of nondigestible short-chain galacto-oligosaccharides, long-chain fructo-oligosaccharides, and pectin-derived acidic-oligosaccharides ( ... ...

Abstract	Introduction: Cow's milk allergy (CMA) is one of the most common food allergies especially early in life. A mixture of nondigestible short-chain galacto-oligosaccharides, long-chain fructo-oligosaccharides, and pectin-derived acidic-oligosaccharides (GFA) may reduce allergy development and allergic symptoms in murine CMA. Recently, vitamin D (VitD) has been suggested to have beneficial effects in reducing allergy as well. Objective: In this study, the immune modulatory effect on allergy prevention using the combination of GFA and VitD was investigated. Methods: Female C3H/HeOuJ mice were fed a control or GFA-containing diet with depleted, standard (1,000 IU/kg), or supplemented (5,000 IU/kg) VitD content for 2 weeks before and during whey sensitization (n = 10-15). Mice were sensitized 5 times intragastrically with PBS as a control, whey as cow's milk allergen, and/or cholera toxin as adjuvant on a weekly interval. One week after the last sensitization, mice were intradermally challenged in both ear pinnae and orally with whey, subsequently the acute allergic skin response and shock symptoms were measured. After 18 h, terminal blood samples, mesenteric lymph nodes, and spleens were collected. Whey-specific immunoglobulin (Ig) E and IgG1 levels were measured by means of ELISA. T cell subsets and dendritic cells (DCs) were studied using flow cytometry. Results: Additional VitD supplementation did not lower the allergic symptoms compared to the standard VitD diet. CMA mice fed the GFA diet supplemented with VitD (GFA VitD+) significantly decreased the acute allergic skin response of whey sensitized mice when compared to the CMA mice fed VitD (VitD+) group (p < 0.05). The effect of GFA was not improved by extra VitD supplementation even though the CMA mice fed the GFA VitD+ diet had a significantly increased percentage of CD103+ DCs compared to the VitD+ group (p < 0.05). The VitD-deprived mice showed a high percentage of severe shock and many reached the humane endpoint; therefore, these groups were not further analyzed. Conclusions: High-dose VitD supplementation in mice does not protect against CMA development in the presence or absence of GFA.
MeSH term(s)	Allergens/immunology ; Animals ; Cattle ; Dendritic Cells/immunology ; Diet ; Dietary Supplements ; Disease Models, Animal ; Female ; Humans ; Immunoglobulin E/metabolism ; Mice ; Mice, Inbred C3H ; Milk/immunology ; Milk Hypersensitivity/diet therapy ; Oligosaccharides/therapeutic use ; Skin/pathology ; T-Lymphocytes, Regulatory/immunology ; Vitamin D/therapeutic use
Chemical Substances	Allergens ; Oligosaccharides ; Vitamin D (1406-16-2) ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2020-08-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1108932-5
ISSN	1423-0097 ; 1018-2438
ISSN (online)	1423-0097
ISSN	1018-2438
DOI	10.1159/000509750
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Article ; Online: Evaluating Human Intestinal Cell Lines for Studying Dietary Protein Absorption.

Jochems, Paulus G M / Garssen, Johan / van Keulen, Antonius M / Masereeuw, Rosalinde / Jeurink, Prescilla V

Nutrients

2018 Volume 10, Issue 3

Abstract: With the global population rising, the need for sustainable and resource-efficiently produced proteins with nutritional and health promoting qualities has become urgent. Proteins are important macronutrients and are involved in most, if not all, ... ...

Abstract	With the global population rising, the need for sustainable and resource-efficiently produced proteins with nutritional and health promoting qualities has become urgent. Proteins are important macronutrients and are involved in most, if not all, biological processes in the human body. This review discusses these absorption mechanisms in the small intestine. To study intestinal transport and predict bioavailability, cell lines are widely applied as screening models and often concern Caco-2, HT-29, HT-29/MTX and T84 cells. Here, we provide an overview of the presence and activities of peptide- and amino acid transporters in these cell models. Further, inter-laboratory differences are discussed as well as the culture micro-environment, both of which may influence cell culture phenotype and performance. Finally, the value of new developments in the field, including culturing cells in 3-dimensional systems under shear stress (i.e., gut-on-chips), is highlighted. In particular, their suitability in screening novel food proteins and prediction of the nutritional quality needed for inclusion in the human diet of the future is addressed.
MeSH term(s)	Amino Acid Transport Systems/metabolism ; Biological Availability ; Caco-2 Cells ; Cadherins/metabolism ; Carrier Proteins/metabolism ; Cell Line, Tumor ; Cell Membrane Permeability ; Dietary Proteins/pharmacokinetics ; HT29 Cells ; Humans ; Intestinal Absorption/drug effects ; Intestines/cytology ; Intestines/drug effects ; Intestines/metabolism ; Membrane Transport Proteins/metabolism ; Nerve Tissue Proteins/metabolism ; Peptide Transporter 1/metabolism ; Peptides/metabolism
Chemical Substances	Amino Acid Transport Systems ; CDH17 protein, human ; Cadherins ; Carrier Proteins ; Dietary Proteins ; Membrane Transport Proteins ; Nerve Tissue Proteins ; Peptide Transporter 1 ; Peptides ; SLC15A1 protein, human ; SLC15A3 protein, human ; SLC15A4 protein, human
Language	English
Publishing date	2018-03-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu10030322
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Book ; Thesis: A mutildisciplinary study of allergy

Jeurink, Prescilla V

mouse models, immune modulation and lifestyle

2008

Author's details	Prescilla V. Jeurink
Language	English
Size	275 p. :, ill. (some col.) ;, 24 cm.
Publisher	s.n.
Publishing place	Wageningen
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Thesis (doctoral)--Wageningen Universiteit, 2008
Note	Summary in Dutch. ; "Propositions" ([1] p.) inserted. ; Vita.
ISBN	9789085049616 ; 908504961X
Database	NAL-Catalogue (AGRICOLA)

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Article: Evaluating Human Intestinal Cell Lines for Studying Dietary Protein Absorption

Jochems, Paulus G. M / Garssen, Johan / van Keulen, Antonius M / Masereeuw, Rosalinde / Jeurink, Prescilla V

Nutrients. 2018 Mar. 07, v. 10, no. 3

2018

Abstract	With the global population rising, the need for sustainable and resource-efficiently produced proteins with nutritional and health promoting qualities has become urgent. Proteins are important macronutrients and are involved in most, if not all, biological processes in the human body. This review discusses these absorption mechanisms in the small intestine. To study intestinal transport and predict bioavailability, cell lines are widely applied as screening models and often concern Caco-2, HT-29, HT-29/MTX and T84 cells. Here, we provide an overview of the presence and activities of peptide- and amino acid transporters in these cell models. Further, inter-laboratory differences are discussed as well as the culture micro-environment, both of which may influence cell culture phenotype and performance. Finally, the value of new developments in the field, including culturing cells in 3-dimensional systems under shear stress (i.e., gut-on-chips), is highlighted. In particular, their suitability in screening novel food proteins and prediction of the nutritional quality needed for inclusion in the human diet of the future is addressed.
Keywords	amino acid transporters ; bioavailability ; cell culture ; dietary protein ; health promotion ; human cell lines ; human nutrition ; models ; novel foods ; nutritive value ; peptides ; phenotype ; prediction ; screening ; shear stress ; small intestine
Language	English
Dates of publication	2018-0307
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu10030322
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Mutual influences of man-made pollutants and allergic manifestations

Jeurink, Prescilla V. / Damialis, Athanasios / Wichers, H.J. / Savelkoul, H.F.J.

APSTRACT: Applied Studies in Agribusiness and Commerce

2016 Volume 10, Issue 2-3

Abstract: The United Nations have projected the world population to reach 9.6 billion by 2050 and that, by then, over 50% of the world population will be living in urban areas. This continuing population growth and accompanying urbanization lead to serious ... ...

Abstract	The United Nations have projected the world population to reach 9.6 billion by 2050 and that, by then, over 50% of the world population will be living in urban areas. This continuing population growth and accompanying urbanization lead to serious concerns about clean water and food for all, but also about climate change and pollution. Soil and water pollution are directly affecting the crops grown for consumption, and air pollution is affecting our mucosal barriers in the respiratory and gastro-intestinal tract on a daily basis. This review provides an overview of the different types of pollution, and the health effects triggered by especially air pollution ranging from heart disease, pulmonary disease, cancer, to fatal respiratory infections. In addition, the differences in how pollution-induced effects are affecting different age-groups are discussed. Finally, the socio-economic causes and consequences (e.g. Quality of Life and Years of Life Losses versus medical care cost) of these pollution-induced diseases are debated.
Keywords	Life Science
Subject code	333
Language	English
Publishing country	nl
Document type	Article ; Online
ISSN	1789-221X
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Mechanisms underlying immune effects of dietary oligosaccharides

Jeurink, Prescilla V / van Esch, Betty CAM / Rijnierse, Anneke / Garssen, Johan / Knippels, Léon MJ

American journal of clinical nutrition. 2013 Aug., v. 98, no. 2

2013

Abstract: The WHO refers to human milk as the nutritional gold standard for term infants. Human milk contains many immunomodulatory compounds, including oligosaccharides. Human-milk oligosaccharides can serve as prebiotics because the nondigestible ... ...

Abstract	The WHO refers to human milk as the nutritional gold standard for term infants. Human milk contains many immunomodulatory compounds, including oligosaccharides. Human-milk oligosaccharides can serve as prebiotics because the nondigestible oligosaccharides present in human milk show a clear bifidogenic effect on the gut microbiota. Dietary oligosaccharide structures that have prebiotic effects similar to human-milk oligosaccharides include galacto-oligosaccharides, fructo-oligosaccharides, and pectin-derived acidic oligosaccharides. Both animal studies and human clinical trials showed that dietary intervention with these dietary oligosaccharides in early life could lead to the prevention of atopic dermatitis, food allergy, and allergic asthma. The immune-modulating effects of these oligosaccharides are likely assisted via alteration of the intestinal microbiota or in a microbiota-independent manner by direct interaction on immune cells or both. In this review, an overview of the prebiotic role of dietary oligosaccharides on the microbiota and the microbiota-independent immune modulation by these prebiotics is provided. In addition, recent publications that report on the pathways by which the oligosaccharides might exert their direct immunomodulatory effect are summarized.
Keywords	World Health Organization ; asthma ; atopic dermatitis ; breast milk ; clinical nutrition ; clinical trials ; food allergies ; fructooligosaccharides ; galactooligosaccharides ; humans ; immunomodulators ; infants ; intestinal microorganisms ; nutritional intervention ; prebiotics
Language	English
Dates of publication	2013-08
Size	p. 572S-577S.
Publishing place	American Society for Clinical Nutrition
Document type	Article
ZDB-ID	280048-2
ISSN	1938-3207 ; 0002-9165
ISSN (online)	1938-3207
ISSN	0002-9165
DOI	10.3945/ajcn.112.038596
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Development and validation of bioengineered intestinal tubules for translational research aimed at safety and efficacy testing of drugs and nutrients.

Jochems, Paulus G M / van Bergenhenegouwen, Jeroen / van Genderen, Anne Metje / Eis, Sophie T / Wilod Versprille, Livia J F / Wichers, Harry J / Jeurink, Prescilla V / Garssen, Johan / Masereeuw, Rosalinde

Toxicology in vitro : an international journal published in association with BIBRA

2019 Volume 60, Page(s) 1–11

Abstract: Currently used intestinal cell models have limited translational value, therefore, development of novel in vitro intestinal models that recapitulate the human in vivo setting more closely are of interest. Here, an advanced intestinal model was developed ... ...

Abstract	Currently used intestinal cell models have limited translational value, therefore, development of novel in vitro intestinal models that recapitulate the human in vivo setting more closely are of interest. Here, an advanced intestinal model was developed by the incorporation of physiological parameters, such as extracellular matrix (ECM) elements and shear stress, to cultured Caco-2 cells in a 3-dimensional environment. Caco-2 cells grown on ECM-coated hollow fiber membranes (HFM) under physiological shear stress show an improved phenotype, as demonstrated by the presence of enterocytes, goblet, Paneth, enteroendocrine and stem cells. Additionally, this model showed signs of an improved morphology due to the appearance of villi-like structures. Similar to epithelial cells grown on Transwells™, the current model remains easy to use, cost efficient and allows apical and basolateral access. The bioengineered intestinal tubule was validated by exposure to Clostridium difficile toxin A, the leading cause of healthcare-associated diarrhea. The loss of the tight junction network was supported by an increase in inulin-FITC leakage and the number of goblet cells increased, in agreement with clinical findings. In addition to toxicity screening, the bioengineered intestinal tubules are considered useful for drug and nutrient safety and efficacy testing.
MeSH term(s)	Bacterial Toxins/toxicity ; Caco-2 Cells ; Enterotoxins/toxicity ; Humans ; Intestinal Mucosa/drug effects ; Models, Biological ; Tissue Engineering ; Toxicity Tests/methods ; Translational Medical Research/methods
Chemical Substances	Bacterial Toxins ; Enterotoxins ; tcdA protein, Clostridium difficile
Language	English
Publishing date	2019-05-06
Publishing country	England
Document type	Journal Article
ZDB-ID	639064-x
ISSN	1879-3177 ; 0887-2333
ISSN (online)	1879-3177
ISSN	0887-2333
DOI	10.1016/j.tiv.2019.04.019
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Article ; Online: Mechanisms underlying immune effects of dietary oligosaccharides.

Jeurink, Prescilla V / van Esch, Betty C A M / Rijnierse, Anneke / Garssen, Johan / Knippels, Léon M J

The American journal of clinical nutrition

2013 Volume 98, Issue 2, Page(s) 572S–7S

Abstract	The WHO refers to human milk as the nutritional gold standard for term infants. Human milk contains many immunomodulatory compounds, including oligosaccharides. Human-milk oligosaccharides can serve as prebiotics because the nondigestible oligosaccharides present in human milk show a clear bifidogenic effect on the gut microbiota. Dietary oligosaccharide structures that have prebiotic effects similar to human-milk oligosaccharides include galacto-oligosaccharides, fructo-oligosaccharides, and pectin-derived acidic oligosaccharides. Both animal studies and human clinical trials showed that dietary intervention with these dietary oligosaccharides in early life could lead to the prevention of atopic dermatitis, food allergy, and allergic asthma. The immune-modulating effects of these oligosaccharides are likely assisted via alteration of the intestinal microbiota or in a microbiota-independent manner by direct interaction on immune cells or both. In this review, an overview of the prebiotic role of dietary oligosaccharides on the microbiota and the microbiota-independent immune modulation by these prebiotics is provided. In addition, recent publications that report on the pathways by which the oligosaccharides might exert their direct immunomodulatory effect are summarized.
MeSH term(s)	Animals ; Asthma/prevention & control ; Clinical Trials as Topic ; Dermatitis, Atopic/prevention & control ; Diet ; Food Hypersensitivity/prevention & control ; Gastrointestinal Tract/microbiology ; Humans ; Immunologic Factors/administration & dosage ; Infant ; Metagenome ; Milk, Human/chemistry ; Models, Animal ; Oligosaccharides/administration & dosage ; Prebiotics/analysis ; Prebiotics/microbiology ; Probiotics/administration & dosage ; Trisaccharides/administration & dosage
Chemical Substances	Immunologic Factors ; Oligosaccharides ; Prebiotics ; Trisaccharides ; fructooligosaccharide ; 4'-galactooligosaccharide (6587-31-1)
Language	English
Publishing date	2013-07-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	280048-2
ISSN	1938-3207 ; 0002-9165
ISSN (online)	1938-3207
ISSN	0002-9165
DOI	10.3945/ajcn.112.038596
Database	MEDical Literature Analysis and Retrieval System OnLINE

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