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Article ; Online: A case report of refractory angina in a patient with diabetes and apical hypertrophic cardiomyopathy.

Jex, Nicholas / Chowdhary, Amrit / Thirunavukarasu, Sharmaine / Levelt, Eylem

European heart journal. Case reports

2022 Volume 6, Issue 8, Page(s) ytac347

Abstract: Background: Using serial imaging over time, this case reviews the natural history of co-morbid Type two diabetes (T2D) and apical hypertrophic cardiomyopathy (HCM) and assesses the potential combined impact on myocardial structure and perfusion.: Case ...

Abstract	Background: Using serial imaging over time, this case reviews the natural history of co-morbid Type two diabetes (T2D) and apical hypertrophic cardiomyopathy (HCM) and assesses the potential combined impact on myocardial structure and perfusion. Case summary: A 59-year-old patient with concomitant T2D and an apical phenotype of HCM was seen over a 11-year period with a significant burden of anginal chest pain. Chest pain was refractory to anti-anginal medical therapy and persisted at on-going follow-up. Multi-modality imaging demonstrated significant deterioration in coronary microvascular function and increased myocardial scar burden despite unobstructed epicardial coronary arteries. Discussion: Comorbidity with T2D and apical HCM resulted in a significant increase in myocardial fibrosis and deterioration in coronary microvascular function.
Language	English
Publishing date	2022-08-16
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytac347
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Article ; Online: A 30-Year-Old Man With Primary Cardiac Angiosarcoma.

Jex, Nicholas / Farley, Jonathan / Thirunavukarasu, Sharmaine / Chowdhary, Amrit / Sengupta, Anshuman / Greenwood, John / Schlosshan, Dominik / Plein, Sven / Levelt, Eylem

JACC. Case reports

2021 Volume 3, Issue 6, Page(s) 944–949

Abstract: A previously fit and well 30-year-old man presented with palpitations, fever, and pleuritic chest pain. Multimodality imaging and histopathology confirmed the diagnosis of primary cardiac angiosarcoma. We present the details of the presentation, ... ...

Abstract	A previously fit and well 30-year-old man presented with palpitations, fever, and pleuritic chest pain. Multimodality imaging and histopathology confirmed the diagnosis of primary cardiac angiosarcoma. We present the details of the presentation, diagnostic process using multimodality imaging, and clinical management. (
Language	English
Publishing date	2021-05-12
Publishing country	Netherlands
Document type	Case Reports
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2021.03.009
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Article ; Online: Rationale and design of the randomised controlled cross-over trial: Cardiovascular effects of empaglifozin in diabetes mellitus.

Thirunavukarasu, Sharmaine / Brown, Louise Ae / Chowdhary, Amrit / Jex, Nicholas / Swoboda, Peter / Greenwood, John P / Plein, Sven / Levelt, Eylem

Diabetes & vascular disease research

2021 Volume 18, Issue 3, Page(s) 14791641211021585

Abstract: Background: Type 2 diabetes (T2D) is associated with an increased risk of cardiovascular (CV) disease. In patients with T2D and established CV disease, selective inhibitors of sodium-glucose cotransporter 2 (SGLT2) have been shown to decrease CV and all- ...

Abstract	Background: Type 2 diabetes (T2D) is associated with an increased risk of cardiovascular (CV) disease. In patients with T2D and established CV disease, selective inhibitors of sodium-glucose cotransporter 2 (SGLT2) have been shown to decrease CV and all-cause mortality, and heart failure (HF) admissions. Utilising CV magnetic resonance imaging (CMR) and continuous glucose monitoring (CGM) by FreeStyle Libre Pro Sensor, we aim to explore the mechanisms of action which give Empagliflozin, an SGLT2 inhibitor, its beneficial CV effects and compare these to the effects of dipeptidyl peptidase-4 inhibitor Sitagliptin. Methods: This is a single centre, open-label, cross-over trial conducted at the Leeds Teaching Hospitals NHS Trust. Participants are randomised for the order of treatment and receive 3 months therapy with Empagliflozin, and 3 months therapy with Sitagliptin sequentially. Twenty-eight eligible T2D patients with established ischaemic heart disease will be recruited. Patients undergo serial CMR scans on three visits. Discussion: The primary outcome measure is the myocardial perfusion reserve in remote myocardium. We hypothesise that Empaglifozin treatment is associated with improvements in myocardial blood flow and reductions in myocardial interstitial fibrosis, independent of CGM measured glycemic control in patients with T2D and established CV disease. Trial registration: This study has full research ethics committee approval (REC: 18/YH/0190) and data collection is anticipated to finish in December 2021. This study was retrospectively registered at https://doi.org/10.1186/ISRCTN82391603 and monitored by the University of Leeds. The study results will be submitted for publication within 6 months of completion.
MeSH term(s)	Benzhydryl Compounds/adverse effects ; Benzhydryl Compounds/therapeutic use ; Coronary Circulation/drug effects ; Cross-Over Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Dipeptidyl-Peptidase IV Inhibitors/adverse effects ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; England ; Fibrosis ; Glucosides/adverse effects ; Glucosides/therapeutic use ; Glycemic Control/adverse effects ; Humans ; Myocardial Ischemia/diagnostic imaging ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/physiopathology ; Myocardium/pathology ; Randomized Controlled Trials as Topic ; Sitagliptin Phosphate/adverse effects ; Sitagliptin Phosphate/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Time Factors ; Treatment Outcome
Chemical Substances	Benzhydryl Compounds ; Dipeptidyl-Peptidase IV Inhibitors ; Glucosides ; Sodium-Glucose Transporter 2 Inhibitors ; empagliflozin (HDC1R2M35U) ; Sitagliptin Phosphate (TS63EW8X6F)
Language	English
Publishing date	2021-06-25
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2250793-0
ISSN	1752-8984 ; 1479-1641
ISSN (online)	1752-8984
ISSN	1479-1641
DOI	10.1177/14791641211021585
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Article ; Online: Cardiac reverse remodeling in primary mitral regurgitation: mitral valve replacement vs. mitral valve repair.

Craven, Thomas P / Chew, Pei G / Dobson, Laura E / Gorecka, Miroslawa / Parent, Martine / Brown, Louise A E / Saunderson, Christopher E D / Das, Arka / Chowdhary, Amrit / Jex, Nicholas / Higgins, David M / Dall'Armellina, Erica / Levelt, Eylem / Schlosshan, Dominik / Swoboda, Peter P / Plein, Sven / Greenwood, John P

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

2023 Volume 25, Issue 1, Page(s) 43

Abstract: Background: When feasible, guidelines recommend mitral valve repair (MVr) over mitral valve replacement (MVR) to treat primary mitral regurgitation (MR), based upon historic outcome studies and transthoracic echocardiography (TTE) reverse remodeling ... ...

Abstract	Background: When feasible, guidelines recommend mitral valve repair (MVr) over mitral valve replacement (MVR) to treat primary mitral regurgitation (MR), based upon historic outcome studies and transthoracic echocardiography (TTE) reverse remodeling studies. Cardiovascular magnetic resonance (CMR) offers reference standard biventricular assessment with superior MR quantification compared to TTE. Using serial CMR in primary MR patients, we aimed to investigate cardiac reverse remodeling and residual MR post-MVr vs MVR with chordal preservation. Methods: 83 patients with ≥ moderate-severe MR on TTE were prospectively recruited. 6-min walk tests (6MWT) and CMR imaging including cine imaging, aortic/pulmonary through-plane phase contrast imaging, T1 maps and late-gadolinium-enhanced (LGE) imaging were performed at baseline and 6 months after mitral surgery or watchful waiting (control group). Results: 72 patients completed follow-up (Controls = 20, MVr = 30 and MVR = 22). Surgical groups demonstrated comparable baseline cardiac indices and co-morbidities. At 6-months, MVr and MVR groups demonstrated comparable improvements in 6MWT distances (+ 57 ± 54 m vs + 64 ± 76 m respectively, p = 1), reduced indexed left ventricular end-diastolic volumes (LVEDVi; - 29 ± 21 ml/m Conclusion: In primary MR, MVR with chordal preservation may offer comparable cardiac reverse remodeling and functional benefits at 6-months when compared to MVr. Larger, multicenter CMR studies are required, which if the findings are confirmed could impact future surgical practice.
MeSH term(s)	Humans ; Mitral Valve Insufficiency/diagnostic imaging ; Mitral Valve Insufficiency/surgery ; Mitral Valve Insufficiency/pathology ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Stroke Volume ; Predictive Value of Tests ; Ventricular Function, Right ; Fibrosis
Language	English
Publishing date	2023-07-27
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	1458034-2
ISSN	1532-429X ; 1097-6647
ISSN (online)	1532-429X
ISSN	1097-6647
DOI	10.1186/s12968-023-00946-9
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Article ; Online: Coronary microvascular function and visceral adiposity in patients with normal body weight and type 2 diabetes.

Chowdhary, Amrit / Thirunavukarasu, Sharmaine / Jex, Nicholas / Coles, Lauren / Bowers, Charles / Sengupta, Anshuman / Swoboda, Peter / Witte, Klaus / Cubbon, Richard / Xue, Hui / Kellman, Peter / Greenwood, John / Plein, Sven / Levelt, Eylem

Obesity (Silver Spring, Md.)

2022 Volume 30, Issue 5, Page(s) 1079–1090

Abstract: Objective: This study sought to assess whether diabetes affects coronary microvascular function in individuals with normal body weight.: Methods: Seventy-five participants (30 patients with type 2 diabetes [T2D] who were overweight [O-T2D], 15 ... ...

Abstract	Objective: This study sought to assess whether diabetes affects coronary microvascular function in individuals with normal body weight. Methods: Seventy-five participants (30 patients with type 2 diabetes [T2D] who were overweight [O-T2D], 15 patients with T2D who were lean [LnT2D], 15 healthy volunteers who were lean [LnHV], and 15 healthy volunteers who were overweight [O-HV]) without established cardiovascular disease were recruited. Participants underwent magnetic resonance imaging for assessment of subcutaneous, epicardial, and visceral adipose tissue areas, adenosine stress myocardial blood flow (MBF), and cardiac structure and function. Results: Stress MBF was reduced only in the O-T2D group (mean [SD], LnHV = 2.07 [0.47] mL/g/min, O-HV = 2.08 [0.42] mL/g/min, LnT2D = 2.16 [0.36] mL/g/min, O-T2D = 1.60 [0.28] mL/g/min; p ≤ 0.0001). Accumulation of visceral fat was evident in the LnT2D group at similar levels to the O-HV group (LnHV = 127 [53] cm Conclusions: Patients with T2D and normal body weight do not show alterations in global stress MBF, but they do show significant increases in visceral adiposity. Patients with T2D who were overweight and had no prior cardiovascular disease showed an increase in visceral adiposity and significant reductions in stress MBF.
MeSH term(s)	Adiposity ; Cardiovascular Diseases ; Diabetes Mellitus, Type 2/complications ; Humans ; Ideal Body Weight ; Obesity, Abdominal/complications ; Obesity, Abdominal/diagnostic imaging ; Overweight/complications ; Stroke Volume ; Ventricular Function, Left
Language	English
Publishing date	2022-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1002/oby.23413
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Article ; Online: Cardiac Adaptations to Acute Hemodynamic Stress in Function, Perfusion, and Energetics in Type 2 Diabetes With Overweight and Obesity.

Chowdhary, Amrit / Javed, Wasim / Thirunavukarasu, Sharmaine / Jex, Nicholas / Kotha, Sindhoora / Kellman, Peter / Swoboda, Peter / Greenwood, John P / Plein, Sven / Levelt, Eylem

Diabetes care

2022 Volume 45, Issue 12, Page(s) e176–e178

MeSH term(s)	Humans ; Overweight/complications ; Diabetes Mellitus, Type 2 ; Obesity ; Hemodynamics ; Perfusion
Language	English
Publishing date	2022-10-06
Publishing country	United States
Document type	Research Support, Non-U.S. Gov't ; Letter
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc22-0887
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Article ; Online: Cardiovascular magnetic resonance phenotyping of heart failure with mildly reduced ejection fraction.

Brown, Louise A E / Wahab, Ali / Ikongo, Eunice / Saunderson, Chirstopher E D / Jex, Nicholas / Thirunavukarasu, Sharmaine / Chowdhary, Amrit / Das, Arka / Craven, Thomas P / Levelt, Eylem / Dall'Armellina, Erica / Knott, Kristopher D / Greenwood, John P / Moon, James C / Xue, Hui / Kellman, Peter / Plein, Sven / Swoboda, Peter P

European heart journal. Cardiovascular Imaging

2022 Volume 24, Issue 1, Page(s) 38–45

Abstract: Aims: The 2016 European Society of Cardiology Heart Failure Guidelines defined a new category: heart failure with mid-range ejection fraction (HFmrEF) of 40-49%. This new category was highlighted as having limited evidence and research was advocated ... ...

Abstract	Aims: The 2016 European Society of Cardiology Heart Failure Guidelines defined a new category: heart failure with mid-range ejection fraction (HFmrEF) of 40-49%. This new category was highlighted as having limited evidence and research was advocated into underlying characteristics, pathophysiology, and diagnosis. We used multi-parametric cardiovascular magnetic resonance (CMR) to define the cardiac phenotype of presumed non-ischaemic HFmrEF. Methods and results: Patients (N = 300, 62.7 ± 13 years, 63% males) with a clinical diagnosis of heart failure with no angina symptoms, history of myocardial infarction, or coronary intervention were prospectively recruited. Patients underwent clinical assessment and CMR including T1 mapping, extracellular volume (ECV) mapping, late gadolinium enhancement, and measurement of myocardial blood flow at rest and maximal hyperaemia. Of 273 patients in the final analysis, 93 (34%) patients were categorized as HFmrEF, 46 (17%) as heart failure with preserved ejection fraction (HFpEF), and 134 (49%) as heart failure with reduced ejection fraction (HFrEF). Nineteen (20%) patients with HFmrEF had evidence of occult ischaemic heart disease. Diffuse fibrosis and hyperaemic myocardial blood flow were similar in HFmrEF and HFpEF, but HFmrEF showed significantly lower native T1 (1311 ± 32 vs. 1340 ± 45 ms, P < 0.001), ECV (24.6 ± 3.2 vs. 26.3 ± 3.1%, P < 0.001), and higher myocardial perfusion reserve (2.75 ± 0.84 vs. 2.28 ± 0.84, P < 0.001) compared with HFrEF. Conclusion: Patients with HFmrEF share most phenotypic characteristics with HFpEF, including the degree of microvascular impairment and fibrosis, but have a high prevalence of occult ischaemic heart disease similar to HFrEF. Further work is needed to confirm how the phenotype of HFmrEF responds to medical therapy.
MeSH term(s)	Male ; Female ; Humans ; Heart Failure ; Stroke Volume/physiology ; Contrast Media ; Prognosis ; Gadolinium ; Coronary Artery Disease ; Magnetic Resonance Spectroscopy ; Fibrosis
Chemical Substances	Contrast Media ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2022-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jeac204
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Article ; Online: Coexistent Diabetes Is Associated With the Presence of Adverse Phenotypic Features in Patients With Hypertrophic Cardiomyopathy.

Jex, Nicholas / Chowdhary, Amrit / Thirunavukarasu, Sharmaine / Procter, Henry / Sengupta, Anshuman / Natarajan, Pavithra / Kotha, Sindhoora / Poenar, Ana-Maria / Swoboda, Peter / Xue, Hui / Cubbon, Richard M / Kellman, Peter / Greenwood, John P / Plein, Sven / Page, Stephen / Levelt, Eylem

Diabetes care

2022 Volume 45, Issue 8, Page(s) 1852–1862

Abstract: Objective: Type 2 diabetes mellitus (T2DM) is associated with worsened clinical outcomes in hypertrophic cardiomyopathy (HCM) patients. We sought to investigate whether HCM patients with T2DM comorbidity exhibit adverse cardiac alterations in myocardial ...

Abstract	Objective: Type 2 diabetes mellitus (T2DM) is associated with worsened clinical outcomes in hypertrophic cardiomyopathy (HCM) patients. We sought to investigate whether HCM patients with T2DM comorbidity exhibit adverse cardiac alterations in myocardial energetics, function, perfusion, or tissue characteristics. Research design and methods: A total of 55 participants with concomitant HCM and T2DM (HCM-DM) (n = 20) or isolated HCM (n = 20) and healthy volunteers (HV) (n = 15) underwent 31P-MRS and cardiovascular MRI. The HCM groups were matched for HCM phenotype. Results: Mean ± SD European Society of Cardiology sudden cardiac death risk scores were comparable between the HCM groups (HCM 2.2 ± 1.5%, HCM-DM 1.9 ± 1.2%; P = not significant), and sarcomeric mutations were equally common. HCM-DM patients had the highest median NT-proBNP levels (HV 42 ng/L [interquartile range 35-66], HCM 298 ng/L [157-837], HCM-DM 726 ng/L [213-8,695]; P < 0.0001). Left ventricular (LV) ejection fraction, mass, and wall thickness were similar between the HCM groups. HCM-DM patients displayed a greater degree of fibrosis burden with higher scar percentage and lower global longitudinal strain compared with HCM patients. PCr/ATP (the relative concentrations of phosphocreatine and ATP) was significantly lower in the HCM-DM group than in both HCM and HV (HV 2.17 ± 0.49, HCM 1.93 ± 0.38, HCM-DM 1.54 ± 0.27; P = 0.002). In a similar pattern, stress myocardial blood flow was significantly lower in the HCM-DM group than in both HCM and HV (HV 2.06 ± 0.42 mL/min/g, HCM 1.74 ± 0.44 mL/min/g, HCM-DM 1.39 ± 0.42 mL/min/g; P = 0.002). Conclusions: We show for the first time that HCM-DM patients display greater reductions in myocardial energetics, perfusion, and contractile function and higher myocardial scar burden and serum NT-proBNP levels compared with patients with isolated HCM despite similar LV mass and wall thickness and presence of sarcomeric mutations. These adverse phenotypic features may be important components of the adverse clinical manifestation attributable to a combined presence of HCM and T2DM.
MeSH term(s)	Adenosine Triphosphate ; Cardiomyopathy, Hypertrophic/complications ; Cardiomyopathy, Hypertrophic/genetics ; Cicatrix ; Diabetes Mellitus, Type 2/complications ; Humans ; Phenotype
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2022-07-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc22-0083
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Article ; Online: Empagliflozin Treatment Is Associated With Improvements in Cardiac Energetics and Function and Reductions in Myocardial Cellular Volume in Patients With Type 2 Diabetes.

Thirunavukarasu, Sharmaine / Jex, Nicholas / Chowdhary, Amrit / Hassan, Imtiaz Ul / Straw, Sam / Craven, Thomas P / Gorecka, Miroslawa / Broadbent, David / Swoboda, Peter / Witte, Klaus K / Cubbon, Richard M / Xue, Hui / Kellman, Peter / Greenwood, John P / Plein, Sven / Levelt, Eylem

Diabetes

2021 Volume 70, Issue 12, Page(s) 2810–2822

Abstract: Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of major adverse cardiovascular (CV) events and hospitalization for heart failure (HF) in patients with type 2 diabetes (T2D). Using CV MRI (CMR) ... ...

Abstract	Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of major adverse cardiovascular (CV) events and hospitalization for heart failure (HF) in patients with type 2 diabetes (T2D). Using CV MRI (CMR) and
MeSH term(s)	Aged ; Benzhydryl Compounds/pharmacology ; Benzhydryl Compounds/therapeutic use ; Cell Size/drug effects ; Cohort Studies ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/pathology ; Diabetic Cardiomyopathies/pathology ; Diabetic Cardiomyopathies/prevention & control ; Energy Metabolism/drug effects ; Female ; Glucosides/pharmacology ; Glucosides/therapeutic use ; Heart/drug effects ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Myocardium/metabolism ; Myocardium/pathology ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; United Kingdom
Chemical Substances	Benzhydryl Compounds ; Glucosides ; empagliflozin (HDC1R2M35U)
Language	English
Publishing date	2021-10-05
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/db21-0270
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Article ; Online: Acute Microstructural Changes after ST-Segment Elevation Myocardial Infarction Assessed with Diffusion Tensor Imaging.

Das, Arka / Kelly, Christopher / Teh, Irvin / Stoeck, Christian T / Kozerke, Sebastian / Chowdhary, Amrit / Brown, Louise A E / Saunderson, Christopher E D / Craven, Thomas P / Chew, Pei G / Jex, Nicholas / Swoboda, Peter P / Levelt, Eylem / Greenwood, John P / Schneider, Jurgen E / Plein, Sven / Dall'Armellina, Erica

Radiology

2021 Volume 299, Issue 1, Page(s) 86–96

Abstract: Background Cardiac diffusion tensor imaging (cDTI) allows for in vivo characterization of myocardial microstructure. In cDTI, mean diffusivity and fractional anisotropy (FA)-markers of magnitude and anisotropy of diffusion of water molecules-are known to ...

Abstract	Background Cardiac diffusion tensor imaging (cDTI) allows for in vivo characterization of myocardial microstructure. In cDTI, mean diffusivity and fractional anisotropy (FA)-markers of magnitude and anisotropy of diffusion of water molecules-are known to change after myocardial infarction. However, little is known about regional changes in helix angle (HA) and secondary eigenvector angle (E2A), which reflects orientations of laminar sheetlets, and their association with long-term recovery of left ventricular ejection fraction (LVEF). Purpose To assess serial changes in cDTI biomarkers in participants following ST-segment elevation myocardial infarction (STEMI) and to determine their associations with long-term left ventricular remodeling. Materials and Methods In this prospective study, 30 participants underwent cardiac MRI (3 T) after STEMI at 5 days and 3 months after reperfusion (National Institute of Health Research study no. 33963 and Research Ethics no. REC17/YH/0062). Spin-echo cDTI with second-order motion-compensation (approximate duration, 13 minutes; three sections; 18 noncollinear diffusion-weighted scans with
MeSH term(s)	Anisotropy ; Diffusion Magnetic Resonance Imaging/methods ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; ST Elevation Myocardial Infarction/diagnostic imaging ; ST Elevation Myocardial Infarction/pathology ; Ventricular Remodeling
Language	English
Publishing date	2021-02-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.2021203208
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