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Article ; Online: Endoscopic Endonasal Surgery for Resection of a Pterygopalatine Fossa Malignant Peripheral Nerve Sheath Tumor: 2-Dimensional Operative Video.

Shah, Rahul S / Martinez-Devesa, Pablo / Jeyaretna, Deva S

2021 Volume 150, Page(s) 171

Abstract: The pterygopalatine fossa (PPF) is an inverted, pyramid-shaped space immediately behind the posterior wall of the maxillary sinus, and lesions arising here include juvenile angiofibromas, schwannomas, and, in exceptionally rare cases, malignant ... ...

Abstract	The pterygopalatine fossa (PPF) is an inverted, pyramid-shaped space immediately behind the posterior wall of the maxillary sinus, and lesions arising here include juvenile angiofibromas, schwannomas, and, in exceptionally rare cases, malignant peripheral nerve sheath tumors.
MeSH term(s)	Aged ; Female ; Humans ; Maxillary Sinus/surgery ; Neuroendoscopy/methods ; Neurofibrosarcoma/surgery ; Pterygopalatine Fossa/pathology ; Pterygopalatine Fossa/surgery ; Treatment Outcome
Language	English
Publishing date	2021-04-08
Publishing country	United States
Document type	Case Reports ; Video-Audio Media
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2021.03.132
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Zs.A 1159: Show issues

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Article: Recent advances in the development of oncolytic HSV-1 vectors: 'arming' of HSV-1 vectors and application of bacterial artificial chromosome technology for their construction.

Jeyaretna, Deva S / Kuroda, Toshihiko

Current opinion in molecular therapeutics

2007 Volume 9, Issue 5, Page(s) 447–466

Abstract: HSV-1 was one of the first oncolytic viruses to have been investigated for its therapeutic potential against cancer. Among the dozens of oncolytic HSV-1 vectors that have so far been reported, some carry transgenes, including interleukins, anti- ... ...

Abstract	HSV-1 was one of the first oncolytic viruses to have been investigated for its therapeutic potential against cancer. Among the dozens of oncolytic HSV-1 vectors that have so far been reported, some carry transgenes, including interleukins, anti-angiogenic peptides, and prodrug-converting enzymes. 'Arming' of HSV-1 with therapeutic transgenes such as these is expected to enhance its efficacy. HSV-1 is a 152-kb double-stranded DNA virus, and the generation of armed HSV usually takes several months to achieve by conventional homologous recombination methods. Recently, bacterial artificial chromosome (BAC)-based systems termed 'HSVQuik' and 'Flip-Flop HSV-BAC' were developed to enable the fast generation of recombinant HSV-1 vectors within weeks by using site-specific recombinases. These systems provide powerful tools for screening potential transgenes that might greatly enhance the efficacy of HSV-1 vectors. This review discusses the current state of research into the development of oncolytic HSV-1 vectors, and highlights the promise that armed oncolytic HSV-1 vectors might hold for the future.
MeSH term(s)	Animals ; Chromosomes, Artificial, Bacterial ; Genetic Engineering ; Genetic Vectors/chemical synthesis ; Herpesvirus 1, Human/genetics ; Humans ; Oncolytic Viruses/genetics
Language	English
Publishing date	2007-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2022273-7
ISSN	1464-8431
ISSN	1464-8431
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Zs.A 5272: Show issues

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Article ; Online: Oncolytic herpes simplex virus therapy for peripheral nerve tumors.

Jeyaretna, Deva S / Rabkin, Samuel D / Martuza, Robert L

Neurosurgical focus

2007 Volume 22, Issue 6, Page(s) E4

Abstract: Oncolytic viruses are one of many emerging cancer therapies. The surgical management of peripheral nerve tumors carries an inherent risk of damaging the nerves involved and so the search for novel therapies with reduced risk of morbidity continues. In ... ...

Abstract	Oncolytic viruses are one of many emerging cancer therapies. The surgical management of peripheral nerve tumors carries an inherent risk of damaging the nerves involved and so the search for novel therapies with reduced risk of morbidity continues. In this review the authors discuss the use of oncolytic herpes simplex virus (HSV) in the treatment of peripheral nerve tumors. Herpes simplex virus has a number of characteristics that make it a useful oncolytic vector, including its large, sequenced genome that can accommodate multiple transgenes, its lack of insertional mutagenesis, its ability to infect a wide array of cell types in various species, and the availability of well-established antiviral therapies to treat it. The efficacy of oncolytic HSV therapy against schwannomas and malignant peripheral nerve sheath tumors has been studied in multiple experimental models both in vitro and in vivo. The virus utilizes cell pathways unique to tumors to enhance its oncolytic efficacy, preferentially and effectively targeting and destroying peripheral nerve tumor cells without harming normal cells. This effect is augmented by transgenes expressing antiangiogenic factors, such as dominant-negative fibroblast growth factor receptor and platelet factor 4, and displays synergy with chemotherapy. Different oncolytic HSV vectors have been tested, including hrR3, G207, and G47D. In addition, new animal models have been developed to test the efficacy of oncolytic HSV therapy in peripheral nerve tumors. The safety of oncolytic HSV is well established and has been tested in nonhuman primates and in human clinical trials.
MeSH term(s)	Animals ; Genetic Vectors/therapeutic use ; Humans ; Oncolytic Virotherapy/methods ; Oncolytic Viruses/genetics ; Peripheral Nervous System Neoplasms/chemistry ; Peripheral Nervous System Neoplasms/genetics ; Peripheral Nervous System Neoplasms/therapy ; Peripheral Nervous System Neoplasms/virology ; Simplexvirus/genetics
Language	English
Publishing date	2007-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2026589-X
ISSN	1092-0684 ; 1092-0684
ISSN (online)	1092-0684
ISSN	1092-0684
DOI	10.3171/foc.2007.22.6.5
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Article ; Online: Solitary neurofibroma in the male breast.

Jeyaretna, Deva S / Oriolowo, Adewunmi / Smith, Mark E F / Watkins, Roger M

World journal of surgical oncology

2007 Volume 5, Page(s) 23

Abstract: Background: Neurofibroma of the male breast outside of neurofibromatosis is extremely rare with only one previous case having been reported.: Case presentation: A 48 year old male patient with a neurofibroma in the breast presenting with ... ...

Abstract	Background: Neurofibroma of the male breast outside of neurofibromatosis is extremely rare with only one previous case having been reported. Case presentation: A 48 year old male patient with a neurofibroma in the breast presenting with gynaecomastia is reported. Clinical and mammogram findings with fine needle aspiration cytology and full histology are presented. Conclusion: To our knowledge this is only the second case of a neurofibroma in a male breast in the English literature and the first report to include the mammographic findings.
MeSH term(s)	Breast Neoplasms, Male/pathology ; Humans ; Male ; Middle Aged ; Neurofibroma/pathology
Language	English
Publishing date	2007-02-27
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2118383-1
ISSN	1477-7819 ; 1477-7819
ISSN (online)	1477-7819
ISSN	1477-7819
DOI	10.1186/1477-7819-5-23
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Article ; Online: A case of elbow hyperextension leading to complete brachial artery rupture.

Jeyaretna, Deva S / Butler, Michael / David, Huw G / Walker, Alasdair J

World journal of emergency surgery : WJES

2007 Volume 2, Page(s) 6

Abstract: Background: To our knowledge there are no cases in the literature of traumatic vascular injury of the brachial artery by elbow hyperextension without elbow dislocation based on either clinical or radiological evidence.: Case presentation: We present ... ...

Abstract	Background: To our knowledge there are no cases in the literature of traumatic vascular injury of the brachial artery by elbow hyperextension without elbow dislocation based on either clinical or radiological evidence. Case presentation: We present the first case of complete brachial artery rupture resulting from a hyperextension injury to an elbow, without dislocation. The history, early assessment and operative treatment with figures are presented. Conclusion: We advocate prompt clinical assessment by orthopaedic and vascular teams and early surgical exploration and repair.
Language	English
Publishing date	2007-03-01
Publishing country	England
Document type	Journal Article
ISSN	1749-7922
ISSN (online)	1749-7922
DOI	10.1186/1749-7922-2-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Neuralgia of the glossopharyngeal and vagal nerves: long-term outcome following surgical treatment and literature review.

Kandan, Sri R / Khan, Sadaquate / Jeyaretna, Deva S / Lhatoo, Samden / Patel, Nikunj K / Coakham, Hugh B

British journal of neurosurgery

2010 Volume 24, Issue 4, Page(s) 441–446

Abstract: This study describes our experience in the surgical treatment of neuralgia of the glossopharyngeal and vagal nerves. Over the last 19 years, 21 patients underwent surgery. Their case notes were reviewed to obtain demographic information, clinical ... ...

Abstract	This study describes our experience in the surgical treatment of neuralgia of the glossopharyngeal and vagal nerves. Over the last 19 years, 21 patients underwent surgery. Their case notes were reviewed to obtain demographic information, clinical presentation, surgical findings and early results. All patients were then contacted by telephone for long-term results and complications. Independent analysis of results was carried out by a Neurology team. Ten patients had microvascular decompression (MVD). Four patients had MVD and nerve section. In the remaining seven patients, the glossopharyngeal and first two rootlets of the vagal nerve were sectioned. Nineteen (90%) of 21 patients experienced complete relief of pain immediately after surgery. The remaining patients reported an improvement in their symptoms. There were no mortalities. Four patients experienced short-term complications, which resolved. Two patients were left with a persistent hoarse voice. At follow-up (mean duration of 4 years), there was no recurrence in symptoms. In our experience, surgery is safe and effective for the treatment of vago-glossopharyngeal neuralgia.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Facial Pain/etiology ; Facial Pain/surgery ; Female ; Glossopharyngeal Nerve/physiopathology ; Glossopharyngeal Nerve/surgery ; Glossopharyngeal Nerve Diseases/physiopathology ; Glossopharyngeal Nerve Diseases/surgery ; Humans ; Male ; Middle Aged ; Neuralgia/physiopathology ; Neuralgia/surgery ; Treatment Outcome ; Vagus Nerve Diseases/physiopathology ; Vagus Nerve Diseases/surgery
Language	English
Publishing date	2010-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639029-8
ISSN	1360-046X ; 0268-8697
ISSN (online)	1360-046X
ISSN	0268-8697
DOI	10.3109/02688697.2010.487131
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Zs.A 2210: Show issues

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Article ; Online: Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model.

Cheema, Tooba A / Wakimoto, Hiroaki / Fecci, Peter E / Ning, Jianfang / Kuroda, Toshihiko / Jeyaretna, Deva S / Martuza, Robert L / Rabkin, Samuel D

Proceedings of the National Academy of Sciences of the United States of America

2013 Volume 110, Issue 29, Page(s) 12006–12011

Abstract: Glioblastoma (World Health Organization grade IV) is an aggressive adult brain tumor that is inevitably fatal despite surgery, radiation, and chemotherapy. Treatment failures are attributed to combinations of cellular heterogeneity, including a ... ...

Abstract	Glioblastoma (World Health Organization grade IV) is an aggressive adult brain tumor that is inevitably fatal despite surgery, radiation, and chemotherapy. Treatment failures are attributed to combinations of cellular heterogeneity, including a subpopulation of often-resistant cancer stem cells, aberrant vasculature, and noteworthy immune suppression. Current preclinical models and treatment strategies do not incorporate or address all these features satisfactorily. Herein, we describe a murine glioblastoma stem cell (GSC) model that recapitulates tumor heterogeneity, invasiveness, vascularity, and immunosuppressive microenvironment in syngeneic immunocompetent mice and should prove useful for a range of therapeutic studies. Using this model, we tested a genetically engineered oncolytic herpes simplex virus that is armed with an immunomodulatory cytokine, interleukin 12 (G47-mIL12). G47Δ-mIL12 infects and replicates similarly to its unarmed oncolytic herpes simplex virus counterpart in mouse 005 GSCs in vitro, whereas in vivo, it significantly enhances survival in syngeneic mice bearing intracerebral 005 tumors. Mechanistically, G47-mIL12 targets not only GSCs but also increases IFN-γ release, inhibits angiogenesis, and reduces the number of regulatory T cells in the tumor. The increased efficacy is dependent upon T cells, but not natural killer cells. Taken together, our findings demonstrate that G47Δ-mIL12 provides a multifaceted approach to targeting GSCs, tumor microenvironment, and the immune system, with resultant therapeutic benefit in a stringent glioblastoma model.
MeSH term(s)	Animals ; Blotting, Western ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Glioblastoma/therapy ; Glioblastoma/virology ; Immunohistochemistry ; Immunotherapy/methods ; Interleukin-12/metabolism ; Kaplan-Meier Estimate ; Mice ; Mice, Inbred C57BL ; Neoplastic Stem Cells ; Oncolytic Virotherapy/methods ; Simplexvirus/metabolism
Chemical Substances	Interleukin-12 (187348-17-0)
Language	English
Publishing date	2013-06-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1307935110
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Zs.A 1148: Show issues

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Article ; Online: A case of elbow hyperextension leading to complete brachial artery rupture

David Huw G / Butler Michael / Jeyaretna Deva S / Walker Alasdair J

World Journal of Emergency Surgery, Vol 2, Iss 1, p

2007 Volume 6

Abstract: Abstract Background To our knowledge there are no cases in the literature of traumatic vascular injury of the brachial artery by elbow hyperextension without elbow dislocation based on either clinical or radiological evidence. Case presentation We ... ...

Abstract	Abstract Background To our knowledge there are no cases in the literature of traumatic vascular injury of the brachial artery by elbow hyperextension without elbow dislocation based on either clinical or radiological evidence. Case presentation We present the first case of complete brachial artery rupture resulting from a hyperextension injury to an elbow, without dislocation. The history, early assessment and operative treatment with figures are presented. Conclusion We advocate prompt clinical assessment by orthopaedic and vascular teams and early surgical exploration and repair.
Keywords	Surgery ; RD1-811 ; Medicine ; R ; DOAJ:Surgery ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2007-03-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Solitary neurofibroma in the male breast

Smith Mark EF / Oriolowo Adewunmi / Jeyaretna Deva S / Watkins Roger M

World Journal of Surgical Oncology, Vol 5, Iss 1, p

2007 Volume 23

Abstract: Abstract Background Neurofibroma of the male breast outside of neurofibromatosis is extremely rare with only one previous case having been reported. Case presentation A 48 year old male patient with a neurofibroma in the breast presenting with ... ...

Abstract	Abstract Background Neurofibroma of the male breast outside of neurofibromatosis is extremely rare with only one previous case having been reported. Case presentation A 48 year old male patient with a neurofibroma in the breast presenting with gynaecomastia is reported. Clinical and mammogram findings with fine needle aspiration cytology and full histology are presented. Conclusion To our knowledge this is only the second case of a neurofibroma in a male breast in the English literature and the first report to include the mammographic findings.
Keywords	Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2007-02-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Combination of oncolytic herpes simplex viruses armed with angiostatin and IL-12 enhances antitumor efficacy in human glioblastoma models.

Zhang, Wei / Fulci, Giulia / Wakimoto, Hiroaki / Cheema, Tooba A / Buhrman, Jason S / Jeyaretna, Deva S / Stemmer Rachamimov, Anat O / Rabkin, Samuel D / Martuza, Robert L

Neoplasia (New York, N.Y.)

2013 Volume 15, Issue 6, Page(s) 591–599

Abstract: Oncolytic herpes simplex virus (oHSV) can potentially spread throughout the tumor, reach isolated infiltrating cells, kill them, and deliver anticancer agents. However, the host responds to oHSV by inducing intratumoral infiltration of macrophages that ... ...

Abstract	Oncolytic herpes simplex virus (oHSV) can potentially spread throughout the tumor, reach isolated infiltrating cells, kill them, and deliver anticancer agents. However, the host responds to oHSV by inducing intratumoral infiltration of macrophages that can engulf the virus, limiting the potential of this therapeutic strategy. Hypervascularity is a pathognomonic feature of glioblastoma (GBM) and is a promising therapeutic target. Antiangiogenic treatments have multiple benefits, including the capacity to increase oHSV efficacy by suppressing macrophage extravasation and infiltration into the tumor. Angiostatin is an antiangiogenic polypeptide, and interleukin-12 (IL-12) is an immunostimulatory cytokine with strong antiangiogenic effects. Clinical use of each has been limited by delivery issues and systemic toxicity. We tested a combination treatment strategy using oHSVs expressing angiostatin (G47Δ-mAngio) and IL-12 (G47Δ-mIL12) in two orthotopic human GBM models. Intratumoral injection of G47Δ-mAngio and G47Δ-mIL12 in mice bearing intracranial U87 or tumors derived from glioblastoma stem cells significantly prolonged survival compared to each armed oHSV alone. This was associated with increased antiangiogenesis and virus spread and decreased macrophages. These data support the paradigm of using oHSV expressing different antiangiogenic agents and show for the first time that oHSVs expressing angiostatin and IL-12 can improve efficacy in human GBM models.
MeSH term(s)	Angiogenesis Inhibitors/pharmacology ; Angiostatins/genetics ; Angiostatins/pharmacology ; Animals ; Brain Neoplasms/drug therapy ; Brain Neoplasms/metabolism ; Brain Neoplasms/virology ; Cell Line, Tumor ; Disease Models, Animal ; Female ; Glioblastoma/drug therapy ; Glioblastoma/metabolism ; Glioblastoma/virology ; Humans ; Injections, Intralesional ; Interleukin-12/genetics ; Interleukin-12/pharmacology ; Mice ; Mice, Nude ; Oncolytic Viruses/genetics ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Simplexvirus/genetics ; Vascular Endothelial Growth Factor A/metabolism ; Xenograft Model Antitumor Assays
Chemical Substances	Angiogenesis Inhibitors ; Platelet Endothelial Cell Adhesion Molecule-1 ; VEGFA protein, human ; Vascular Endothelial Growth Factor A ; Interleukin-12 (187348-17-0) ; Angiostatins (86090-08-6)
Language	English
Publishing date	2013-02-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1483840-0
ISSN	1476-5586 ; 1522-8002
ISSN (online)	1476-5586
ISSN	1522-8002
DOI	10.1593/neo.13158
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Zs.A 5203: Show issues

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