Article ; Online: Methylation of tumour suppressor genes in benign and malignant salivary gland tumours: a systematic review and meta-analysis.
Epigenetics
2022 Volume 17, Issue 12, Page(s) 1661–1676
Abstract: The aim of the present systematic review was to critically analyse the relationship between tumour suppressor genes (TSGs) promoter methylation, a potent mechanism of gene silencing, and the development of salivary gland tumours, as well as the possible ... ...
Abstract | The aim of the present systematic review was to critically analyse the relationship between tumour suppressor genes (TSGs) promoter methylation, a potent mechanism of gene silencing, and the development of salivary gland tumours, as well as the possible effect on clinical/histological characteristics. Review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) database (registration ID CRD42020218511). A comprehensive search of Web of Science, Scopus, PubMed, and Cochrane Central Register of Controlled Trials was performed utilizing relevant key terms, supplemented by a search of grey literature. Newcastle-Ottawa Quality Assessment Scale (NOQAS) was used for the quality assessment of included studies. Sixteen cross-sectional and 12 case-control studies were included in the review, predominantly dealing with methylation in TSGs related to DNA repair, cell cycle, and cell growth regulation and differentiation. Quantitative synthesis could be performed on P16 (inhibitor of cyclin-dependent kinase 4a), RASSF1A (Ras association domain family 1 isoform A) and MGMT (O6-methylguanine DNA methyltransferase) genes only. It showed that P16 and RASSF1A genes were more frequently methylated in salivary gland tumours compared to controls ( |
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MeSH term(s) | Humans ; Genes, Tumor Suppressor ; DNA Methylation ; Cross-Sectional Studies ; Salivary Gland Neoplasms/genetics ; Cyclin-Dependent Kinases ; DNA |
Chemical Substances | Cyclin-Dependent Kinases (EC 2.7.11.22) ; DNA (9007-49-2) |
Language | English |
Publishing date | 2022-03-24 |
Publishing country | United States |
Document type | Meta-Analysis ; Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't |
ISSN | 1559-2308 |
ISSN (online) | 1559-2308 |
DOI | 10.1080/15592294.2022.2052426 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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