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Article ; Online: Hemopexin and α1-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction.

Lina Youssef / Lena Erlandsson / Bo Åkerström / Jezid Miranda / Cristina Paules / Francesca Crovetto / Fatima Crispi / Eduard Gratacos / Stefan R Hansson

PLoS ONE, Vol 15, Iss 9, p e

2020 Volume 0239030

Abstract: Hemopexin and α1-microglobulin act as scavengers to eliminate free heme-groups responsible for hemoglobin-induced oxidative stress. The present study evaluated maternal and fetal plasma concentrations of these scavengers in the different phenotypes of ... ...

Abstract	Hemopexin and α1-microglobulin act as scavengers to eliminate free heme-groups responsible for hemoglobin-induced oxidative stress. The present study evaluated maternal and fetal plasma concentrations of these scavengers in the different phenotypes of placenta-mediated disorders. Singleton pregnancies with normotensive fetal growth restriction [FGR] (n = 47), preeclampsia without FGR (n = 45) and preeclampsia with FGR (n = 51) were included prospectively as well as uncomplicated pregnancies (n = 49). Samples were collected at delivery and ELISA analysis was applied to measure the hemopexin and α1-microglobulin concentrations. In maternal blood in preeclampsia with and without FGR, hemopexin was significantly lower (p = 0.003 and p<0.001, respectively) and α1-microglobulin was significantly higher (p<0.001 in both) whereas no difference existed in normotensive FGR mothers compared to controls. In contrast, in fetal blood in growth restricted fetuses with and without preeclampsia, both hemopexin and α1-microglobulin were significantly lower (p<0.001 and p = 0.001 for hemopexin, p = 0.016 and p = 0.013 for α1-microglobulin, respectively) with no difference in fetuses from preeclampsia without FGR in comparison to controls. Thus, hemopexin and α1-microglobulin present significantly altered concentrations in maternal blood in the maternal disease -preeclampsia- and in cord blood in the fetal disease -FGR-, which supports their differential role in placenta-mediated disorders in accordance with the clinical presentation of these disorders.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction

Lina Youssef / Rui V. Simões / Jezid Miranda / María Luisa García-Martín / Cristina Paules / Francesca Crovetto / Nuria Amigó / Nicolau Cañellas / Eduard Gratacos / Fatima Crispi

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 11

Abstract: Abstract Preeclampsia (PE) and fetal growth restriction (FGR) are both placenta-mediated disorders with unclear pathogenesis. Metabolomics of maternal and fetal pairs might help in understanding these disorders. We recruited prospectively pregnancies ... ...

Abstract	Abstract Preeclampsia (PE) and fetal growth restriction (FGR) are both placenta-mediated disorders with unclear pathogenesis. Metabolomics of maternal and fetal pairs might help in understanding these disorders. We recruited prospectively pregnancies with normotensive FGR, PE without FGR, PE + FGR and uncomplicated pregnancies as controls. Nuclear magnetic resonance metabolomics were applied on plasma samples collected at delivery. Advanced lipoprotein, glycoprotein and choline profiling was performed using the Liposcale test. The software package Dolphin was used to quantify 24 low-molecular-weight metabolites. Statistical analysis comprised the comparison between each group of complicated pregnancies versus controls, considering 5% false discovery rate correction. Lipid profiles were altered in accordance with the clinical presentation of these disorders. Specifically, PE mothers and FGR fetuses (with or without FGR or PE, respectively) exhibited a pro-atherogenic and pro-inflammatory profile, with higher concentrations of triglycerides, remnant cholesterol (VLDL, IDL) and Glc/GalNAc-linked and lipid-associated glycoproteins compared to controls. Low-molecular-weight metabolites were extensively disturbed in preeclamptic mothers, with or without FGR. Growth restricted fetuses in the presence of PE showed changes in low-molecular-weight metabolites similar to their mothers (increased creatine and creatinine), while normotensive FGR fetuses presented scarce differences, consistent with undernutrition (lower isoleucine). Further research is warranted to clarify maternal and fetal adaptations to PE and FGR.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Embarazo heterotópico

César Mendivil / Rafael Padrón / Jezid Miranda / Glenda Silva

Revista Colombiana de Obstetricia y Ginecología, Vol 62, Iss 1, Pp 98-

diagnóstico ecográfico temprano, manejo con laparoscopia: Reporte de un caso y revisión de la literatura Laparoscopic management of heterotopic pregnancy following early ecographic diagnosis: a case report and literature review

2011 Volume 103

Abstract: Objetivo: realizar una revisión de la literatura acerca de los aspectos más importantes relacionados con el diagnóstico oportuno y el manejo del embarazo heterotópico. Materiales y métodos: se presenta un caso de un embarazo heterotópico diagnosticado ... ...

Abstract	Objetivo: realizar una revisión de la literatura acerca de los aspectos más importantes relacionados con el diagnóstico oportuno y el manejo del embarazo heterotópico. Materiales y métodos: se presenta un caso de un embarazo heterotópico diagnosticado por ultrasonografía, a quien se le realizó salpingectomía por laparoscopia y se continuó con la gestación intrauterina normal. Se realizó una revisión en las bases de datos MEDLINE y EMBASE, además de la base latinoamericana SciELO y libros de la especialidad. Conclusión: el diagnóstico del embarazo heterotópico es difícil debido a las diversas manifestaciones clínicas y a la existencia del embarazo intrauterino que continúa la producción de fracción Beta de la gonadotropina coriónica humana. La ecografía es un pilar importante en el diagnóstico e identificación temprana de esta patología. La laparoscopia surge como una alternativa segura en el manejo. Objective: reviewing the pertinent literature about the most important aspects related to early diagnosis and management of heterotopic pregnancy. Materials and methods: a case of heterotopic pregnancy is presented which was diagnosed by ultrasonography. The patient underwent laparoscopic salpingectomy and she continued normal intrauterine gestation. MEDLINE and EMBASE databases were reviewed, as well as the Latin-American SciELO database and books on the specialization. Conclusion: diagnosis of heterotopic pregnancy is difficult due to its diverse clinical manifestations and intrauterine pregnancy leading to human chorionic gonadotropin Beta fraction production being continued; echography is thus an important pillar in the early diagnosis and identification of this pathology. Laparoscopy emerges as a safe management alternative.
Keywords	embarazo heterotópico ; laparoscopia ; embarazo ectópico/diagnóstico ; embarazo ectópico/terapia ; heterotopic pregnancy ; laparoscopy ; ectopic pregnancy/diagnosis ; ectopic pregnancy/ therapy ; Gynecology and obstetrics ; RG1-991 ; Medicine ; R ; DOAJ:Gynecology and Obstetrics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	Spanish
Publishing date	2011-03-01T00:00:00Z
Publisher	Federación Colombiana de Asociaciones de Obstetricia y Ginecología
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Embarazo heterotópico

César Mendivil / Rafael Padrón / Jezid Miranda / Glenda Silva

Revista Colombiana de Obstetricia y Ginecología, Vol 62, Iss 1, Pp 98-

diagnóstico ecográfico temprano, manejo con laparoscopia: Reporte de un caso y revisión de la literatura

2011 Volume 103

Abstract	Objetivo: realizar una revisión de la literatura acerca de los aspectos más importantes relacionados con el diagnóstico oportuno y el manejo del embarazo heterotópico. Materiales y métodos: se presenta un caso de un embarazo heterotópico diagnosticado por ultrasonografía, a quien se le realizó salpingectomía por laparoscopia y se continuó con la gestación intrauterina normal. Se realizó una revisión en las bases de datos MEDLINE y EMBASE, además de la base latinoamericana SciELO y libros de la especialidad. Conclusión: el diagnóstico del embarazo heterotópico es difícil debido a las diversas manifestaciones clínicas y a la existencia del embarazo intrauterino que continúa la producción de fracción Beta de la gonadotropina coriónica humana. La ecografía es un pilar importante en el diagnóstico e identificación temprana de esta patología. La laparoscopia surge como una alternativa segura en el manejo.
Keywords	embarazo heterotópico ; laparoscopia ; embarazo ectópico/diagnóstico ; embarazo ectópico/terapia ; Gynecology and obstetrics ; RG1-991 ; Medicine ; R
Language	Spanish
Publishing date	2011-03-01T00:00:00Z
Publisher	Federación Colombiana de Obstetricia y Ginecología
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Embarazo heterotópico

César Mendivil / Rafael Padrón / Jezid Miranda / Glenda Silva

Revista Colombiana de Obstetricia y Ginecología, Vol 62, Iss 1, Pp 98-

diagnóstico ecográfico temprano, manejo con laparoscopia: Reporte de un caso y revisión de la literatura

2011 Volume 103

Abstract	Objetivo: realizar una revisión de la literatura acerca de los aspectos más importantes relacionados con el diagnóstico oportuno y el manejo del embarazo heterotópico. Materiales y métodos: se presenta un caso de un embarazo heterotópico diagnosticado por ultrasonografía, a quien se le realizó salpingectomía por laparoscopia y se continuó con la gestación intrauterina normal. Se realizó una revisión en las bases de datos MEDLINE y EMBASE, además de la base latinoamericana SciELO y libros de la especialidad. Conclusión: el diagnóstico del embarazo heterotópico es difícil debido a las diversas manifestaciones clínicas y a la existencia del embarazo intrauterino que continúa la producción de fracción Beta de la gonadotropina coriónica humana. La ecografía es un pilar importante en el diagnóstico e identificación temprana de esta patología. La laparoscopia surge como una alternativa segura en el manejo.
Keywords	embarazo heterotópico ; laparoscopia ; embarazo ectópico/diagnóstico ; embarazo ectópico/terapia ; Gynecology and obstetrics ; RG1-991 ; Medicine ; R
Language	Spanish
Publishing date	2011-03-01T00:00:00Z
Publisher	Federación Colombiana de Asociaciones de Obstetricia y Ginecología
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Embarazo heterotópico

César Mendivil / Rafael Padrón / Jezid Miranda / Glenda Silva

Revista Colombiana de Obstetricia y Ginecología, Vol 62, Iss 1, Pp 98-

diagnóstico ecográfico temprano, manejo con laparoscopia: Reporte de un caso y revisión de la literatura

2011 Volume 103

Abstract	Objetivo: realizar una revisión de la literatura acerca de los aspectos más importantes relacionados con el diagnóstico oportuno y el manejo del embarazo heterotópico. Materiales y métodos: se presenta un caso de un embarazo heterotópico diagnosticado por ultrasonografía, a quien se le realizó salpingectomía por laparoscopia y se continuó con la gestación intrauterina normal. Se realizó una revisión en las bases de datos MEDLINE y EMBASE, además de la base latinoamericana SciELO y libros de la especialidad. Conclusión: el diagnóstico del embarazo heterotópico es difícil debido a las diversas manifestaciones clínicas y a la existencia del embarazo intrauterino que continúa la producción de fracción Beta de la gonadotropina coriónica humana. La ecografía es un pilar importante en el diagnóstico e identificación temprana de esta patología. La laparoscopia surge como una alternativa segura en el manejo.
Keywords	embarazo heterotópico ; laparoscopia ; embarazo ectópico/diagnóstico ; embarazo ectópico/terapia ; Gynecology and obstetrics ; RG1-991 ; Medicine ; R
Language	Spanish
Publishing date	2011-03-01T00:00:00Z
Publisher	Federación Colombiana de Obstetricia y Ginecología
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Embarazo heterotópico

César Mendivil / Rafael Padrón / Jezid Miranda / Glenda Silva

Revista Colombiana de Obstetricia y Ginecología, Vol 62, Iss 1, Pp 98-

diagnóstico ecográfico temprano, manejo con laparoscopia: Reporte de un caso y revisión de la literatura

2011 Volume 103

Abstract	Objetivo: realizar una revisión de la literatura acerca de los aspectos más importantes relacionados con el diagnóstico oportuno y el manejo del embarazo heterotópico. Materiales y métodos: se presenta un caso de un embarazo heterotópico diagnosticado por ultrasonografía, a quien se le realizó salpingectomía por laparoscopia y se continuó con la gestación intrauterina normal. Se realizó una revisión en las bases de datos MEDLINE y EMBASE, además de la base latinoamericana SciELO y libros de la especialidad. Conclusión: el diagnóstico del embarazo heterotópico es difícil debido a las diversas manifestaciones clínicas y a la existencia del embarazo intrauterino que continúa la producción de fracción Beta de la gonadotropina coriónica humana. La ecografía es un pilar importante en el diagnóstico e identificación temprana de esta patología. La laparoscopia surge como una alternativa segura en el manejo.
Keywords	embarazo heterotópico ; laparoscopia ; embarazo ectópico/diagnóstico ; embarazo ectópico/terapia ; Gynecology and obstetrics ; RG1-991 ; Medicine ; R
Language	Spanish
Publishing date	2011-03-01T00:00:00Z
Publisher	Federación Colombiana de Obstetricia y Ginecología
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Embarazo heterotópico

César Mendivil / Rafael Padrón / Jezid Miranda / Glenda Silva

Revista Colombiana de Obstetricia y Ginecología, Vol 62, Iss 1, Pp 98-

diagnóstico ecográfico temprano, manejo con laparoscopia: Reporte de un caso y revisión de la literatura

2011 Volume 103

Abstract	Objetivo: realizar una revisión de la literatura acerca de los aspectos más importantes relacionados con el diagnóstico oportuno y el manejo del embarazo heterotópico. Materiales y métodos: se presenta un caso de un embarazo heterotópico diagnosticado por ultrasonografía, a quien se le realizó salpingectomía por laparoscopia y se continuó con la gestación intrauterina normal. Se realizó una revisión en las bases de datos MEDLINE y EMBASE, además de la base latinoamericana SciELO y libros de la especialidad. Conclusión: el diagnóstico del embarazo heterotópico es difícil debido a las diversas manifestaciones clínicas y a la existencia del embarazo intrauterino que continúa la producción de fracción Beta de la gonadotropina coriónica humana. La ecografía es un pilar importante en el diagnóstico e identificación temprana de esta patología. La laparoscopia surge como una alternativa segura en el manejo.
Keywords	embarazo heterotópico ; laparoscopia ; embarazo ectópico/diagnóstico ; embarazo ectópico/terapia ; Gynecology and obstetrics ; RG1-991 ; Medicine ; R
Language	Spanish
Publishing date	2011-03-01T00:00:00Z
Publisher	Federación Colombiana de Obstetricia y Ginecología
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hemopexin and α1-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction

Lina Youssef / Lena Erlandsson / Bo Åkerström / Jezid Miranda / Cristina Paules / Francesca Crovetto / Fatima Crispi / Eduard Gratacos / Stefan R. Hansson / Frank T. Spradley

PLoS ONE, Vol 15, Iss

2020 Volume 9

Abstract	Hemopexin and α1-microglobulin act as scavengers to eliminate free heme-groups responsible for hemoglobin-induced oxidative stress. The present study evaluated maternal and fetal plasma concentrations of these scavengers in the different phenotypes of placenta-mediated disorders. Singleton pregnancies with normotensive fetal growth restriction [FGR] (n = 47), preeclampsia without FGR (n = 45) and preeclampsia with FGR (n = 51) were included prospectively as well as uncomplicated pregnancies (n = 49). Samples were collected at delivery and ELISA analysis was applied to measure the hemopexin and α1-microglobulin concentrations. In maternal blood in preeclampsia with and without FGR, hemopexin was significantly lower (p = 0.003 and p<0.001, respectively) and α1-microglobulin was significantly higher (p<0.001 in both) whereas no difference existed in normotensive FGR mothers compared to controls. In contrast, in fetal blood in growth restricted fetuses with and without preeclampsia, both hemopexin and α1-microglobulin were significantly lower (p<0.001 and p = 0.001 for hemopexin, p = 0.016 and p = 0.013 for α1-microglobulin, respectively) with no difference in fetuses from preeclampsia without FGR in comparison to controls. Thus, hemopexin and α1-microglobulin present significantly altered concentrations in maternal blood in the maternal disease -preeclampsia- and in cord blood in the fetal disease -FGR-, which supports their differential role in placenta-mediated disorders in accordance with the clinical presentation of these disorders.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Interplay between Pathophysiological Pathways in Early-Onset Severe Preeclampsia Unveiled by Metabolomics

Lina Youssef / Francesca Crovetto / Rui Vasco Simoes / Jezid Miranda / Cristina Paules / Miquel Blasco / Marta Palomo / Héctor García-Calderó / Olga Tura-Ceide / Ana Paula Dantas / Virginia Hernandez-Gea / Pol Herrero / Núria Canela / Josep Maria Campistol / Joan Carles Garcia-Pagan / Maribel Diaz-Ricart / Eduard Gratacos / Fatima Crispi

Life, Vol 12, Iss 86, p

2022 Volume 86

Abstract: Introduction: Preeclampsia is a multi-system disorder unique to pregnancy responsible for a great part of maternal and perinatal morbidity and mortality. The precise pathogenesis of this complex disorder is still unrevealed. Methods: We examined the ... ...

Abstract	Introduction: Preeclampsia is a multi-system disorder unique to pregnancy responsible for a great part of maternal and perinatal morbidity and mortality. The precise pathogenesis of this complex disorder is still unrevealed. Methods: We examined the pathophysiological pathways involved in early-onset preeclampsia, a specific subgroup representing its most severe presentation, using LC-MS/MS metabolomic analysis based on multi-level extraction of lipids and small metabolites from maternal blood samples, collected at the time of diagnosis from 14 preeclamptic and six matched healthy pregnancies. Statistical analysis comprised multivariate and univariate approaches with the application of over representation analysis to identify differential pathways. Results: A clear difference between preeclamptic and control pregnancies was observed in principal component analysis. Supervised multivariate analysis using orthogonal partial least square discriminant analysis provided a robust model with goodness of fit (R 2 X = 0.91, p = 0.002) and predictive ability (Q 2 Y = 0.72, p < 0.001). Finally, univariate analysis followed by 5% false discovery rate correction indicated 82 metabolites significantly altered, corresponding to six overrepresented pathways: (1) aminoacyl-tRNA biosynthesis; (2) arginine biosynthesis; (3) alanine, aspartate and glutamate metabolism; (4) D-glutamine and D-glutamate metabolism; (5) arginine and proline metabolism; and (6) histidine metabolism. Conclusion: Metabolomic analysis focusing specifically on the early-onset severe form of preeclampsia reveals the interplay between pathophysiological pathways involved in this form. Future studies are required to explore new therapeutic approaches targeting these altered metabolic pathways in early-onset preeclampsia.
Keywords	early-onset preeclampsia ; fetal growth restriction ; LC-MS/MS ; maternal serum ; preeclampsia ; metabolomics ; Science ; Q
Subject code	572
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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