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Article: The Role of Flaxseed in Improving Human Health.

Nowak, Wioletta / Jeziorek, Małgorzata

2023 Volume 11, Issue 3

Abstract: Flaxseed contains high amounts of biologically active components such as α-linolenic acid, lignans, and dietary fiber. Due to its numerous nutritional properties, flaxseed has been classified as a "superfood", that is, a food of natural origin with ... ...

Abstract	Flaxseed contains high amounts of biologically active components such as α-linolenic acid, lignans, and dietary fiber. Due to its numerous nutritional properties, flaxseed has been classified as a "superfood", that is, a food of natural origin with various bioactive components and many health-promoting benefits. Flaxseed consumption can be an important factor in the prevention of diseases, particularly related to nutrition. The regular consumption of flaxseed may help to improve lipid profile and lower blood pressure, fasting glucose, and insulin resistance index (HOMA-IR). Moreover, flaxseed is characterized by anticancer and antioxidant properties and can significantly reduce the intensity of symptoms associated with menopause, constipation, and mental fatigue, improve skin condition, and accelerate wound healing. In addition to its bioactive compounds, flaxseed also contains antinutrients such as cyanogenic glycosides (CGs), cadmium, trypsin inhibitors, and phytic acid that can reduce the bioavailability of essential nutrients and/or limit its health-promoting effects. Three common forms of flaxseed available for human consumption include whole flaxseed, ground flaxseed, and flaxseed oil. The bioavailability of ALA and lignans is also dependent on the form of flaxseed consumed. To ensure high bioavailability of its bioactive components, flaxseed should be consumed in the ground form.
Language	English
Publishing date	2023-01-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11030395
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Article: Development of New Predictive Equations for the Resting Metabolic Rate (RMR) of Women with Lipedema.

Jeziorek, Małgorzata / Wronowicz, Jakub / Janek, Łucja / Kujawa, Krzysztof / Szuba, Andrzej

Metabolites

2024 Volume 14, Issue 4

Abstract: This study aimed to develop a novel predictive equation for calculating resting metabolic rate (RMR) in women with lipedema. We recruited 119 women diagnosed with lipedema from the Angiology Outpatient Clinic at Wroclaw Medical University, Poland. RMR ... ...

Abstract	This study aimed to develop a novel predictive equation for calculating resting metabolic rate (RMR) in women with lipedema. We recruited 119 women diagnosed with lipedema from the Angiology Outpatient Clinic at Wroclaw Medical University, Poland. RMR was assessed using indirect calorimetry, while body composition and anthropometric measurements were conducted using standardized protocols. Due to multicollinearity among predictors, classical multiple regression was deemed inadequate for developing the new equation. Therefore, we employed machine learning techniques, utilizing principal component analysis (PCA) for dimensionality reduction and predictor selection. Regression models, including support vector regression (SVR), random forest regression (RFR), and k-nearest neighbor (kNN) were evaluated in Python's scikit-learn framework, with hyperparameter tuning via GridSearchCV. Model performance was assessed through mean absolute percentage error (MAPE) and cross-validation, complemented by Bland-Altman plots for method comparison. A novel equation incorporating body composition parameters was developed, addressing a gap in accurate RMR prediction methods. By incorporating measurements of body circumference and body composition parameters alongside traditional predictors, the model's accuracy was improved. The segmented regression model outperformed others, achieving an MAPE of 10.78%. The proposed predictive equation for RMR offers a practical tool for personalized treatment planning in patients with lipedema.
Language	English
Publishing date	2024-04-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo14040235
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Article: The role of nutrition in Alzheimer's disease.

Śliwińska, Sylwia / Jeziorek, Małgorzata

Roczniki Panstwowego Zakladu Higieny

2021 Volume 72, Issue 1, Page(s) 29–39

Abstract: The aging population is a significant social, medical and economic problem due to increasing prevalence of chronic diseases in elderly population. Alzheimer's disease (AD) is the most common form of dementia and the most common neurodegenerative disease. ...

Abstract	The aging population is a significant social, medical and economic problem due to increasing prevalence of chronic diseases in elderly population. Alzheimer's disease (AD) is the most common form of dementia and the most common neurodegenerative disease. It is characterized by a progressive deterioration of memory and cognitive function. So far, there is neither an effective prevention nor cure for dementia, so more and more attention is paid to the prevention of this group of diseases, particularly to the appropriate diet. Preventive intervention gives the best results if introduced before the first symptoms of dementia, i.e., around the age of 50. This is when the nutritional status, number of synapses, cognition, and neuropathological changes in the nervous system compensate each other, which increases the chances of staying healthy for a longer period of time. It has been proven that dietary habits, which lead to the development of cardiovascular and metabolic diseases, significantly increase the risk of dementia. On the other hand, a Mediterranean diet rich in antioxidants, fiber and omega-3 polyunsaturated fatty acids may have a protective effect on the neurodegenerative process. The beneficial effect of many nutrients on the course of AD has been demonstrated. These include: glutathione, polyphenols, curcumin, coenzyme Q10, vitamins B6, B12, folic acid, unsaturated fatty acids, lecithin, UA, caffeine and some probiotic bacteria. A diet rich in saturated fatty acids and branched-chain amino acids (BCAA) promotes the progression of dementia. Dietary intervention should be introduced as early as possible to minimize the risk of developing dementia. The Mediterranean and DASH diets have been documented to protect against AD. However, the MIND diet is reported to be much more effective in preventing cognitive decline/dementia than either the Mediterranean or DASH diets alone.
MeSH term(s)	Aged ; Alzheimer Disease/diet therapy ; Alzheimer Disease/prevention & control ; Diet ; Diet, Mediterranean ; Feeding Behavior ; Humans ; Neurodegenerative Diseases ; Nutritional Status
Language	English
Publishing date	2021-04-21
Publishing country	Poland
Document type	Journal Article
ZDB-ID	421739-1
ISSN	0035-7715
ISSN	0035-7715
DOI	10.32394/rpzh.2021.0154
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Article ; Online: Comparison of Actual and Predicted Resting Metabolic Rate in Women with Lipedema.

Jeziorek, Małgorzata / Szuba, Andrzej / Kujawa, Krzysztof / Regulska-Ilow, Bożena

Lymphatic research and biology

2023 Volume 21, Issue 3, Page(s) 244–252

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Female ; Basal Metabolism ; Lipedema/diagnosis ; Body Mass Index ; Energy Metabolism ; Calorimetry, Indirect/methods ; Body Composition
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2147953-7
ISSN	1557-8585 ; 1539-6851
ISSN (online)	1557-8585
ISSN	1539-6851
DOI	10.1089/lrb.2022.0084
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Article: The Effect of a Low-Carbohydrate, High-Fat Diet versus Moderate-Carbohydrate and Fat Diet on Body Composition in Patients with Lipedema.

Jeziorek, Małgorzata / Szuba, Andrzej / Kujawa, Krzysztof / Regulska-Ilow, Bożena

Diabetes, metabolic syndrome and obesity : targets and therapy

2022 Volume 15, Page(s) 2545–2561

Abstract: Introduction: Lipedema is a disorder characterized by an excessive accumulation of subcutaneous body fat, mainly bilateral and symmetrical accumulation of fat deposits, particularly in the lower extremities excluding feet. Pain (spontaneous or with ... ...

Abstract	Introduction: Lipedema is a disorder characterized by an excessive accumulation of subcutaneous body fat, mainly bilateral and symmetrical accumulation of fat deposits, particularly in the lower extremities excluding feet. Pain (spontaneous or with palpation) and increased capillary fragility with bruising are also part of clinical presentation. It is estimated to occur in approximately 11.0% of women worldwide. Management of obesity among patients with lipedema is a key component in its treatment. Purpose: The aim of this study was to compare effectiveness of two diets: low-carbohydrate-high-fat diet (LCHF) and medium-fat-medium-carbohydrate diet (MFMC) in body weight, body fat and limb circumference reduction in patients with lipedema. Material and methods: The studied women (n = 91) were divided into 2 groups and submitted to 1 of the 2 diets for 16 weeks. Anthropometric measurements such as body height [cm], body weight [kg], body fat percentage [%], body fat [kg], lean body mass [kg], and visceral fat level were collected at the beginning and end of the study. Results: We have not found any significant differences in anthropometric measurements at the baseline between groups. Body weight and all anthropometric parameters decreased significantly in both groups after 16 weeks of diets, excluding the circumference above the right ankle for the MFMC diet which did not change. The LCHF diet contributed to reduction of body weight (-8.2 ± 4.1 kg vs -2.1 ± 1.0 kg; p < 0.0001), body fat (-6.4 ± 3.2 kg vs 1.6 ± 0.8 kg; p < 0.0001), waist (-7.8 ± 3.9 cm vs -2.3 ± 1.1 cm; p < 0.0001), hips (-7.4 ± 3.7 cm vs -2.5 ± 1.3 cm; p < 0.0001), thighs and calves' circumferences compared with the MFMC diet. We observed reduction of pain in the extremities and mobility improvement in LCHF group (data not shown). Conclusion: The LCHF diet was more effective than MFMC in body weight, body fat and lower limb circumferences reduction.
Language	English
Publishing date	2022-08-22
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S377720
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Article ; Online: The Effect of a Low-Carbohydrate High-Fat Diet on Laboratory Parameters in Women with Lipedema in Comparison to Overweight/Obese Women.

Jeziorek, Małgorzata / Szuba, Andrzej / Sowicz, Monika / Adaszyńska, Agnieszka / Kujawa, Krzysztof / Chachaj, Angelika

Nutrients

2023 Volume 15, Issue 11

Abstract: The aim of this study was to evaluate alterations in blood parameters after a low-carbohydrate high-fat (LCHF) diet in women with lipedema in comparison to overweight or obese women. A total of 115 women were classified into two groups: the lipedema ... ...

Abstract	The aim of this study was to evaluate alterations in blood parameters after a low-carbohydrate high-fat (LCHF) diet in women with lipedema in comparison to overweight or obese women. A total of 115 women were classified into two groups: the lipedema group and the overweight/obesity group. Both study groups followed the caloric-restricted LCHF diet for 7 months. A total of 48 women completed the study. A reduction in body weight was observed in both study groups. A significant decrease in triglycerides and an increase in HDL-C concentrations were observed in both study groups. Despite the increase in the concentration of LDL-C observed in the lipedema group, changes in LDL-C differed between individual patients. Improvements in liver parameters, glucose tolerance, and a decrease in fasting insulin levels were observed, although they were less pronounced in the lipedema group than in the overweight/obesity group. Kidney and thyroid functions were similar before and after the LCHF diet in both groups. The LCHF diet may be a valuable nutritional strategy for lipedema and overweight/obese women, with a beneficial effect on weight, glucose profile, liver function, the concentration of triglycerides, and HDL-C and with no effect on kidney and thyroid function.
MeSH term(s)	Humans ; Female ; Overweight ; Cholesterol, LDL ; Diet, High-Fat/adverse effects ; Lipedema ; Weight Loss ; Obesity ; Triglycerides ; Glucose ; Carbohydrates ; Diet, Carbohydrate-Restricted
Chemical Substances	Cholesterol, LDL ; Triglycerides ; Glucose (IY9XDZ35W2) ; Carbohydrates
Language	English
Publishing date	2023-06-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15112619
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Article: Lymphoscintigraphic alterations in lower limbs in women with lipedema in comparison to women with overweight/obesity.

Chachaj, Angelika / Dudka, Ilona / Jeziorek, Małgorzata / Sowicz, Monika / Adaszyńska, Agnieszka / Szuba, Andrzej

Frontiers in physiology

2023 Volume 14, Page(s) 1099555

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-04-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2023.1099555
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Article: Mediterranean diet adherence among cosmetology students.

Jeziorek, Małgorzata / Szypowska, Alicja / Regulska-Ilow, Bożena

Roczniki Panstwowego Zakladu Higieny

2021 Volume 72, Issue 3, Page(s) 301–307

Abstract: Background: The Mediterranean diet (MD) is universally recognized as the healthiest model of nutrition whose beneficial effects help prevent many diet-related diseases.: Objective: The aim of the study was to assess cosmetology students' adherence to ...

Abstract	Background: The Mediterranean diet (MD) is universally recognized as the healthiest model of nutrition whose beneficial effects help prevent many diet-related diseases. Objective: The aim of the study was to assess cosmetology students' adherence to the Mediterranean Diet using the Mediterranean Diet Score (MDS). Material and methods: The study group consisted of 175 cosmetology students of the School of Physiotherapy whose dietary habits were assessed using a validated food frequency questionnaire (FFQ) consisting of 154 food and drink items representative of the diet during the last year. We analyzed data obtained from FFQ and calculated the average number of daily and/or weekly servings from each of the 9 MDS food groups (grains, vegetables, fruits/nuts, milk/dairy products, meat/meat products, legumes, alcohol, olive oil, fish). To obtain more reliable results, we analyzed other products consumed by study participants (sweets, beverages, eggs and potatoes). Study participants were assigned 0, 1 or 2 points for each MDS ingredient. Mediterranean diet adherence was assessed on a 17-point scale. Low adherence to MD was defined at 0-7 points, moderate at 8-10 points, and high at 11-17 points. Results: The mean MDS was 7.1 ± 2.3. Students who were assigned 11-17 points (n = 20) consumed significantly more vegetables, fruits, nuts, legumes, fish, olive oil and significantly less meat, meat products, milk, dairy, and sweets compared to study participants who were assigned the lowest number of points (n = 78). We reported significant differences in the amounts of consumed vegetables and sweets between participants who received 8-10 points (n = 77) and those who received 11-17 points. The higher MDS was significantly associated with the higher intakes of vegetables and dietary fiber. Conclusions: The dietary patterns of study group of Polish cosmetology students did not adhere to the MD recommendations.
MeSH term(s)	Animals ; Diet ; Diet, Mediterranean ; Feeding Behavior ; Fruit ; Humans ; Students ; Vegetables
Language	English
Publishing date	2021-09-23
Publishing country	Poland
Document type	Journal Article
ZDB-ID	421739-1
ISSN	0035-7715
ISSN	0035-7715
DOI	10.32394/rpzh.2021.0172
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Article: Assessment of eating and lifestyle habits among Polish cosmetology and physiotherapy students.

Szypowska, Alicja / Jeziorek, Małgorzata / Regulska-Ilow, Bożena

Roczniki Panstwowego Zakladu Higieny

2020 Volume 71, Issue 2, Page(s) 157–163

Abstract: Background: Proper nutritional behaviors are one of the most important factors shaping our health, as they influence people's physical and mental state. Good eating habits help prevent many chronic diseases, including cardiovascular disease, type II ... ...

Abstract	Background: Proper nutritional behaviors are one of the most important factors shaping our health, as they influence people's physical and mental state. Good eating habits help prevent many chronic diseases, including cardiovascular disease, type II diabetes, some types of cancer, and osteoporosis. The Polish population aged 20-34 years displays improper nutritional behaviors which may put them at risk of developing diet-dependent diseases in the future. There is a need to assess students' lifestyle, including their eating habits, as it would help adapt already existing education programs. Objective: We evaluated and compared eating habits and lifestyle of students studying cosmetology and physiotherapy in association with selected risk factors of civilization diseases. Material and methods: We used a standardized dietary questionnaire evaluating respondents' physical activity, smoking and dietary habits. The obtained results were compared with the recommendations from the Polish food-based dietary guidelines. We evaluated respondents' nutritional status based on their anthropometric measurements such as body weight, body height, hips and waist circumferences and then we estimated their body mass index (BMI) and waist hip ratio (WHR). Results: Students studying cosmetology and physiotherapy obtained on average 5.3 ±1.5 points based on their compliance with the nutritional recommendations. The academic youth did not meet principles of healthy nutrition according to the given recommendations. There were no significant differences in nutrition status between the faculties, except for products that provide complete protein. Conclusions: There is a need to increase nutritional awareness of academic youth, especially students of health-related faculties, because better knowledge on nutrition would help them choose healthier food options.
MeSH term(s)	Adult ; Attitude to Health ; Cross-Sectional Studies ; Diet/statistics & numerical data ; Exercise/psychology ; Feeding Behavior/psychology ; Female ; Food Preferences/psychology ; Health Behavior ; Humans ; Nutritional Status ; Poland ; Students/statistics & numerical data ; Young Adult
Language	English
Publishing date	2020-05-11
Publishing country	Poland
Document type	Journal Article
ZDB-ID	421739-1
ISSN	0035-7715
ISSN	0035-7715
DOI	10.32394/rpzh.2020.0111
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Article ; Online: The Benefits of Low-Carbohydrate, High-Fat (LCHF) Diet on Body Composition, Leg Volume, and Pain in Women with Lipedema.

Jeziorek, Małgorzata / Chachaj, Angelika / Sowicz, Monika / Adaszyńska, Agnieszka / Truszyński, Aleksander / Putek, Justyna / Kujawa, Krzysztof / Szuba, Andrzej

Journal of obesity

2023 Volume 2023, Page(s) 5826630

Abstract: This study aimed to assess the potential benefits of a low-carbohydrate, high-fat (LCHF) diet on body composition, leg volume, and pain reduction in women with lipedema compared to overweight or women with obesity. The study included 113 female ... ...

Abstract	This study aimed to assess the potential benefits of a low-carbohydrate, high-fat (LCHF) diet on body composition, leg volume, and pain reduction in women with lipedema compared to overweight or women with obesity. The study included 113 female participants, 56 with lipedema and 57 with overweight/obesity (BMI >25 kg/m
MeSH term(s)	Humans ; Female ; Overweight ; Diet, Carbohydrate-Restricted ; Lipedema ; Leg ; Obesity/complications ; Diet, High-Fat ; Pain ; Body Composition ; Weight Loss ; Carbohydrates
Chemical Substances	Carbohydrates
Language	English
Publishing date	2023-11-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573566-4
ISSN	2090-0716 ; 2090-0708
ISSN (online)	2090-0716
ISSN	2090-0708
DOI	10.1155/2023/5826630
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