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  1. Book: Treatment resistant depression

    Jha, Manish Kumar

    (Psychiatric clinics of North America ; volume 46, number 2 (June 2023))

    2023  

    Author's details editors Manish Kumar Jha, Madhukar H. Trivedi
    Series title Psychiatric clinics of North America ; volume 46, number 2 (June 2023)
    Collection
    Language English
    Size xiv Seiten, Seite 211-413
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT030348723
    ISBN 978-0-443-18252-5 ; 0-443-18252-3
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Selective Orexin Receptor Antagonists as Novel Augmentation Treatments for Major Depressive Disorder: Evidence for Safety and Efficacy From a Phase 2B Study of Seltorexant.

    Jha, Manish Kumar

    The international journal of neuropsychopharmacology

    2021  Volume 25, Issue 1, Page(s) 85–88

    Abstract: There is a large unmet need for effective treatment of major depressive disorder (MDD), an often chronic/recurrent disorder that affects 1 in 5 adults during their lifetime in the United States. Clinicians and individuals with MDD often rely on ... ...

    Abstract There is a large unmet need for effective treatment of major depressive disorder (MDD), an often chronic/recurrent disorder that affects 1 in 5 adults during their lifetime in the United States. Clinicians and individuals with MDD often rely on augmentation approaches given the low rate of remission with the initial antidepressant treatment. Therefore, the report by Savitz and colleagues on the safety and efficacy of seltorexant is of great interest because it provides initial evidence for the antidepressant potential of drugs targeting orexin neurotransmission. Findings of this study suggest that seltorexant 20 mg is more effective than placebo, especially in individuals with moderate or insomnia symptoms at baseline. Given that insomnia is a common feature of depression, orexin 2 receptor antagonists may serve as important new treatment alternatives for people with MDD.
    MeSH term(s) Adult ; Depressive Disorder, Major/drug therapy ; Humans ; Orexin Receptor Antagonists/adverse effects ; Pyrimidines/therapeutic use ; Pyrroles/therapeutic use ; Triazoles
    Chemical Substances Orexin Receptor Antagonists ; Pyrimidines ; Pyrroles ; Triazoles ; seltorexant (AIS8N3O50B)
    Language English
    Publishing date 2021-06-28
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1440129-0
    ISSN 1469-5111 ; 1461-1457
    ISSN (online) 1469-5111
    ISSN 1461-1457
    DOI 10.1093/ijnp/pyab078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pharmacotherapies for Treatment-Resistant Depression: How Antipsychotics Fit in the Rapidly Evolving Therapeutic Landscape.

    Jha, Manish K / Mathew, Sanjay J

    The American journal of psychiatry

    2023  Volume 180, Issue 3, Page(s) 190–199

    Abstract: One in three adults with major depressive disorder (MDD) do not experience clinically significant improvement after multiple sequential courses of antidepressants and have treatment-resistant depression (TRD). The presence of TRD contributes to the ... ...

    Abstract One in three adults with major depressive disorder (MDD) do not experience clinically significant improvement after multiple sequential courses of antidepressants and have treatment-resistant depression (TRD). The presence of TRD contributes to the morbidity and excess mortality associated with MDD and has been linked to significantly increased health care expenses. In the absence of a consensus definition of TRD, this report takes a broad approach by considering inadequate response to one or more courses of antidepressants and focuses on atypical antipsychotics that are approved by the U.S. Food and Drug Administration for treatment of depression (aripiprazole, brexpiprazole, cariprazine, extended-release quetiapine, and olanzapine-fluoxetine combination). While multiple acute-phase studies have demonstrated the efficacy of these medications in improving depressive symptoms, clinically meaningful improvement (i.e., remission) remains limited, with significant concerns about side effects (including weight gain, metabolic dysfunction, extrapyramidal symptoms, and tardive dyskinesia), especially with long-term use. With the rapidly evolving landscape of antidepressant treatments over the past few years, which has witnessed approval of rapid-acting antidepressants (e.g., esketamine nasal spray and dextromethorphan-bupropion combination) and several more in the late-stage pipeline (e.g., zuranolone and psilocybin), it remains to be seen whether the use of atypical antipsychotics will go the way of the older and rarely prescribed antidepressants (such as tricyclics and monoamine oxidase inhibitors). Pragmatic clinical trials are needed to compare the effectiveness of atypical antipsychotics with TRD-specific pharmacotherapies and neuromodulation treatments and to identify the optimal sequencing of these varied approaches for patients with MDD. When using atypical antipsychotics, clinicians and patients are encouraged to use a shared decision-making approach by personalizing treatment selection based on anticipated side effects, tolerability, cost, and feasibility.
    MeSH term(s) United States ; Adult ; Humans ; Antipsychotic Agents/therapeutic use ; Depressive Disorder, Major/drug therapy ; Depression ; Depressive Disorder, Treatment-Resistant/drug therapy ; Aripiprazole ; Drug-Related Side Effects and Adverse Reactions
    Chemical Substances Antipsychotic Agents ; Aripiprazole (82VFR53I78)
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.20230025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Treatment-Resistant Depression (TRD): Management Approaches in a Rapidly Evolving Therapeutic Landscape.

    Jha, Manish Kumar / Trivedi, Madhukar H

    The Psychiatric clinics of North America

    2023  Volume 46, Issue 2, Page(s) xiii–xiv

    MeSH term(s) Humans ; Depression ; Antidepressive Agents/therapeutic use ; Depressive Disorder, Treatment-Resistant/drug therapy
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 431518-2
    ISSN 1558-3147 ; 0193-953X
    ISSN (online) 1558-3147
    ISSN 0193-953X
    DOI 10.1016/j.psc.2023.03.014
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  5. Article: Life cycle of medical oxygen from production to consumption.

    Jha, Manish / Gaur, Nayanika

    Journal of family medicine and primary care

    2022  Volume 11, Issue 4, Page(s) 1231–1236

    Abstract: Oxygen is used extensively in illnesses involving respiratory system. In emergencies such as the one created by the flare of Covid-19, oxygen consumption has increased tremendously. This article aims to improve our understanding about the medical oxygen, ...

    Abstract Oxygen is used extensively in illnesses involving respiratory system. In emergencies such as the one created by the flare of Covid-19, oxygen consumption has increased tremendously. This article aims to improve our understanding about the medical oxygen, its production (air separation unit, pressure swing adsorption, oxygen concentrators), the supply chain, storage methods, and the final delivery system to the patient. This article also provides a comprehensive review on the additions in the medical infrastructure during the time of oxygen crisis in India along with the introduction of certain novel approaches towards oxygen production and conservation. We aim to minimize the panic among our readers by giving them an insight about the course behind the oxygen supply in that oxygen mask.
    Language English
    Publishing date 2022-03-18
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_956_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Paraquat poisoning with spontaneous pneumothorax in the era of online shopping.

    Jha, Manish / Gaur, Nayanika

    Journal of family medicine and primary care

    2022  Volume 11, Issue 1, Page(s) 357–359

    Abstract: This is a case of a 22-year-old male student who took paraquat as a substance abuse. He presented with flu-like symptoms and chest X-ray depicting changes of acute respiratory distress syndrome (ARDS). After looking at his purchase history in his cell ... ...

    Abstract This is a case of a 22-year-old male student who took paraquat as a substance abuse. He presented with flu-like symptoms and chest X-ray depicting changes of acute respiratory distress syndrome (ARDS). After looking at his purchase history in his cell phone, he was found to have purchased paraquat dichloride online and its use was later confirmed by his roommate. The patient developed respiratory distress with renal failure and succumbed to his condition after 11 days of hospital admission. This report highlights an important social issue of probable substance abuse with paraquat which is a commonly used contact herbicide in rural settings but not-so-common in urban population. Also, the report highlights the unusual complication sequalae of pneumothorax. The high mortality with this substance is because of the unavailability of an antidote and of its unscrutinized availability.
    Language English
    Publishing date 2022-01-31
    Publishing country India
    Document type Case Reports
    ZDB-ID 2735275-4
    ISSN 2278-7135 ; 2249-4863
    ISSN (online) 2278-7135
    ISSN 2249-4863
    DOI 10.4103/jfmpc.jfmpc_957_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Anti-Inflammatory Treatments for Major Depressive Disorder: What's on the Horizon?

    Jha, Manish Kumar

    The Journal of clinical psychiatry

    2019  Volume 80, Issue 6

    MeSH term(s) Anti-Inflammatory Agents/adverse effects ; Anti-Inflammatory Agents/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Antidepressive Agents/adverse effects ; Antidepressive Agents/therapeutic use ; Clinical Trials as Topic ; Cytokines/antagonists & inhibitors ; Depressive Disorder, Major/drug therapy ; Dietary Supplements ; Drug Therapy, Combination ; Forecasting ; Humans ; Surveys and Questionnaires
    Chemical Substances Anti-Inflammatory Agents ; Anti-Inflammatory Agents, Non-Steroidal ; Antidepressive Agents ; Cytokines
    Language English
    Publishing date 2019-06-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.18ac12630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Discontinuing Antidepressants: How Can Clinicians Guide Patients and Drive Research?

    Jha, Manish Kumar

    The Journal of clinical psychiatry

    2019  Volume 80, Issue 6

    Abstract: Recent media reports have refocused attention on the syndromic manifestation experienced by some patients as they discontinue their antidepressant medication ("discontinuation syndrome"). This attention has been accompanied by criticisms that mainstream ... ...

    Abstract Recent media reports have refocused attention on the syndromic manifestation experienced by some patients as they discontinue their antidepressant medication ("discontinuation syndrome"). This attention has been accompanied by criticisms that mainstream psychiatry has either ignored or minimized these symptoms and exposed patients to potentially harmful and addictive treatments. Yet, there has been very limited original research on the prevalence of discontinuation syndrome in the last decade. There is growing concern that labeling antidepressants as addictive may drive down the use of these medications and exacerbate the mental health crisis in which depression is often undiagnosed and undertreated. Hence, the onus of guiding patients through questions and concerns related to the use and discontinuation of antidepressants has fallen mainly on primary care and psychiatric clinicians. This report discusses some common decisional uncertainties relevant to antidepressant discontinuation and recommends a shared decision-making approach. Further, this report seeks to outline a roadmap for clinicians to drive research on this important yet understudied topic.
    MeSH term(s) Antidepressive Agents/adverse effects ; Antidepressive Agents/therapeutic use ; Clinical Decision-Making ; Decision Making, Shared ; Depressive Disorder, Major/diagnosis ; Depressive Disorder, Major/drug therapy ; Depressive Disorder, Major/psychology ; Humans ; Pharmaceutical Research ; Physician's Role ; Physician-Patient Relations ; Substance Withdrawal Syndrome/etiology ; Substance Withdrawal Syndrome/prevention & control ; Syndrome
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2019-11-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.19com13047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Choosing Between Ketamine and Electroconvulsive Therapy for Outpatients With Treatment-Resistant Depression-Advantage Ketamine?

    Mathew, Sanjay J / Jha, Manish K / Anand, Amit

    JAMA psychiatry

    2023  Volume 80, Issue 12, Page(s) 1187–1188

    MeSH term(s) Humans ; Ketamine/pharmacology ; Ketamine/therapeutic use ; Electroconvulsive Therapy ; Depression ; Outpatients ; Depressive Disorder, Major/drug therapy ; Depressive Disorder, Treatment-Resistant/therapy ; Treatment Outcome
    Chemical Substances Ketamine (690G0D6V8H)
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2023.3979
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  10. Article ; Online: Approach to Diagnosis and Management of Treatment-Resistant Depression.

    Rikhani, Karina / Vas, Collin / Jha, Manish Kumar

    The Psychiatric clinics of North America

    2023  Volume 46, Issue 2, Page(s) 247–259

    Abstract: Major depressive disorder is a chronic and recurrent illness that affects 20% of adults during their lifetime and is one of the leading causes of suicide in the United States. A systematic measurement-based care approach is the essential first step in ... ...

    Abstract Major depressive disorder is a chronic and recurrent illness that affects 20% of adults during their lifetime and is one of the leading causes of suicide in the United States. A systematic measurement-based care approach is the essential first step in the diagnosis and management of treatment-resistant depression (TRD) by promptly identifying individuals with depression and avoiding delays in treatment initiation. As comorbidities may be associated with poorer outcomes to commonly used antidepressants and increase risk of drug-drug interactions, their recognition and treatment is an essential component of management of TRD.
    MeSH term(s) Adult ; Humans ; United States ; Depression ; Depressive Disorder, Major/diagnosis ; Depressive Disorder, Major/drug therapy ; Antidepressive Agents/therapeutic use ; Comorbidity ; Depressive Disorder, Treatment-Resistant/diagnosis ; Depressive Disorder, Treatment-Resistant/drug therapy
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 431518-2
    ISSN 1558-3147 ; 0193-953X
    ISSN (online) 1558-3147
    ISSN 0193-953X
    DOI 10.1016/j.psc.2023.02.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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