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  1. Article ; Online: Applications of Immunomagnetic Reduction Technology as a Biosensor in Therapeutic Evaluation of Chinese Herbal Medicine in Tauopathy Alleviation of an AD

    Su, Ming-Tsan / Lu, Chen-Wen / Wu, Wen-Jhen / Jheng, Yong-Sin / Yang, Shieh-Yueh / Chuang, Wu-Chang / Lee, Ming-Chung / Wu, Chung-Hsin

    Biosensors

    2022  Volume 12, Issue 10

    Abstract: Alzheimer's disease (AD) is the most common form of dementia. The most convincing biomarkers in the blood for AD are currently β-amyloid (Aβ) and Tau protein because amyloid plaques and neurofibrillary tangles are pathological hallmarks in the brains of ... ...

    Abstract Alzheimer's disease (AD) is the most common form of dementia. The most convincing biomarkers in the blood for AD are currently β-amyloid (Aβ) and Tau protein because amyloid plaques and neurofibrillary tangles are pathological hallmarks in the brains of patients with AD. The development of assay technologies in diagnosing early-stage AD is very important. The study of human AD subjects is hindered by ethical and technical limitations. Thus, many studies have therefore turned to AD animal models, such as
    MeSH term(s) Animals ; Humans ; tau Proteins ; Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Drosophila/metabolism ; Drugs, Chinese Herbal/therapeutic use ; Drosophila melanogaster/metabolism ; Tauopathies/drug therapy ; Amyloid beta-Peptides ; Biosensing Techniques ; Technology
    Chemical Substances tau Proteins ; Drugs, Chinese Herbal ; Amyloid beta-Peptides
    Language English
    Publishing date 2022-10-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios12100883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Neurotherapy of Yi-Gan-San, a Traditional Herbal Medicine, in an Alzheimer's Disease Model of

    Su, Ming-Tsan / Jheng, Yong-Sin / Lu, Chen-Wen / Wu, Wen-Jhen / Yang, Shieh-Yueh / Chuang, Wu-Chang / Lee, Ming-Chung / Wu, Chung-Hsin

    Plants (Basel, Switzerland)

    2022  Volume 11, Issue 4

    Abstract: Alzheimer's disease (AD), a main cause of dementia, is the most common neurodegenerative disease that is related to the abnormal accumulation of amyloid β (Aβ) proteins. Yi-Gan-San (YGS), a traditional herbal medicine, has been used for the management of ...

    Abstract Alzheimer's disease (AD), a main cause of dementia, is the most common neurodegenerative disease that is related to the abnormal accumulation of amyloid β (Aβ) proteins. Yi-Gan-San (YGS), a traditional herbal medicine, has been used for the management of neurodegenerative disorders and for the treatment of neurosis, insomnia and dementia. The aim of this study was to examine antioxidant capacity and cytotoxicity of YGS treatment by using 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays in vitro. We explored neuroprotective effects of YGS treatment in alleviating Aβ neurotoxicity of Drosophila melanogaster in vivo by comparing survival rate, climbing index, and Aβ expressions through retinal green fluorescent protein (GFP) expression, highly sensitive immunomagnetic reduction (IMR) and Western blotting assays. In the in vitro study, our results showed that scavenging activities of free radical and SH-SY5Y nerve cell viability were increased significantly (
    Language English
    Publishing date 2022-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11040572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Neurotherapy of Yi-Gan-San, a Traditional Herbal Medicine, in an Alzheimer’s Disease Model of Drosophila melanogaster by Alleviating Aβ42 Expression

    Su, Ming-Tsan / Jheng, Yong-Sin / Lu, Chen-Wen / Wu, Wen-Jhen / Yang, Shieh-Yueh / Chuang, Wu-Chang / Lee, Ming-Chung / Wu, Chung-Hsin

    Plants. 2022 Feb. 21, v. 11, no. 4

    2022  

    Abstract: Alzheimer’s disease (AD), a main cause of dementia, is the most common neurodegenerative disease that is related to the abnormal accumulation of amyloid β (Aβ) proteins. Yi-Gan-San (YGS), a traditional herbal medicine, has been used for the management of ...

    Abstract Alzheimer’s disease (AD), a main cause of dementia, is the most common neurodegenerative disease that is related to the abnormal accumulation of amyloid β (Aβ) proteins. Yi-Gan-San (YGS), a traditional herbal medicine, has been used for the management of neurodegenerative disorders and for the treatment of neurosis, insomnia and dementia. The aim of this study was to examine antioxidant capacity and cytotoxicity of YGS treatment by using 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays in vitro. We explored neuroprotective effects of YGS treatment in alleviating Aβ neurotoxicity of Drosophila melanogaster in vivo by comparing survival rate, climbing index, and Aβ expressions through retinal green fluorescent protein (GFP) expression, highly sensitive immunomagnetic reduction (IMR) and Western blotting assays. In the in vitro study, our results showed that scavenging activities of free radical and SH-SY5Y nerve cell viability were increased significantly (p < 0.01–0.05). In the in vivo study, Aβ₄₂-expressing flies (Aβ₄₂-GFP flies) and their WT flies (mCD8-GFP flies) were used as an animal model to examine the neurotherapeutic effects of YGS treatment. Our results showed that, in comparison with those Aβ₄₂ flies under sham treatments, Aβ₄₂ flies under YGS treatments showed a greater survival rate, better climbing speed, and lower Aβ₄₂ aggregation in Drosophila brain tissue (p < 0.01). Our findings suggest that YGS should have a beneficial alternative therapy for AD and dementia via alleviating Aβ neurotoxicity in the brain tissue.
    Keywords 2,2-diphenyl-1-picrylhydrazyl ; Drosophila melanogaster ; amyloid ; animal models ; antioxidant activity ; brain ; cell viability ; cytotoxicity ; disease models ; free radicals ; green fluorescent protein ; herbal medicines ; neurodegenerative diseases ; neurons ; neurotoxicity ; sleep disorders ; survival rate ; therapeutics
    Language English
    Dates of publication 2022-0221
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11040572
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Chinese Veterinary Medicine B307 Promotes Cardiac Performance and Skeletal Muscle Contraction via Enhancing Intracellular Calcium Levels and Neural Electrical Activity in Animal and Cell Models.

    Lien, Chia-Ying / Lu, Chen-Wen / Hsu, Chih-Hsiang / Chuang, Tai-Yuan / Su, Li-Yu / Wu, Wan-Jhen / Jheng, Yong-Sin / Lee, Ming-Chung / Wu, Chung-Hsin

    Evidence-based complementary and alternative medicine : eCAM

    2020  Volume 2020, Page(s) 9064824

    Abstract: The study mainly investigated the effects of Chinese veterinary medicine B307 in cardiac and motor functions in animal models of pigeons and mice. Related cellular mechanisms were also studied in the neuroblastoma cell model of SH-SY5Y. Cardiac functions ...

    Abstract The study mainly investigated the effects of Chinese veterinary medicine B307 in cardiac and motor functions in animal models of pigeons and mice. Related cellular mechanisms were also studied in the neuroblastoma cell model of SH-SY5Y. Cardiac functions of pigeons and mice were examined by using moorFLPI Laser color Doppler imager and M-mode echocardiography, and motor functions were examined by using muscle electrical stimulation and force recording in the isolated breast muscle. Intracellular calcium levels and electrical activity of SH-SY5Y cells were examined by using Fura 2-AM fluorescence and MED64 system separately. Our results
    Language English
    Publishing date 2020-10-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2020/9064824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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