LIVIVO - Search results -

Search results

Result 1 - 10 of total 437

Search options

Article ; Online: Author Correction: THBS1, a fatty acid-related metabolic gene, can promote the development of laryngeal cancer.

Ji, Fei-Hong / Qiu, Xin-Guang

2022 Volume 12, Issue 1, Page(s) 21532

Language	English
Publishing date	2022-12-13
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-25904-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: THBS1, a fatty acid-related metabolic gene, can promote the development of laryngeal cancer.

Ji, Fei-Hong / Qiu, Xin-Guang

Scientific reports

2022 Volume 12, Issue 1, Page(s) 18809

Abstract: Laryngeal cancer is the second most prevalent head and neck tumor and it is one of the most common malignancies of the upper respiratory tract. Fatty acid metabolism affects cancer cell biology in several ways, and alterations in fatty acid metabolism ... ...

Abstract	Laryngeal cancer is the second most prevalent head and neck tumor and it is one of the most common malignancies of the upper respiratory tract. Fatty acid metabolism affects cancer cell biology in several ways, and alterations in fatty acid metabolism are characteristic of both tumorigenesis and metastasis. Despite advances in laryngeal cancer diagnosis and treatment over the years, there has been no significant improvement in survival or mortality. Studying the role of fatty acid metabolism-related genes in laryngeal cancer will facilitate our search for valuable biomarkers to guide prognostic management and treatment selection. We constructed a prognostic risk score model for fatty acid metabolism-related genes by downloading and analyzing laryngeal cancers from the TCGA and GEO databases. We predicted survival outcomes of laryngeal cancer patients using a prognostic risk score model of fatty acid metabolism-related genes and analyzed the resistance of laryngeal cancer in different individuals to multiple drugs. In addition, the relationship between the prognostic risk score model and cellular infiltration characteristics of the tumor microenvironment were investigated. Through the prognostic risk scoring model, the genes with risk-prompting effect and related to prognosis were screened out for further research. Through the study of gene expression levels in the TCGA database, we screened out 120 differentially expressed fatty acid metabolism genes. LASSO-Cox and Cox regression analyses identified nine genes associated with prognosis to construct a prognostic risk score model for genes related to fatty acid metabolism. Both TCGA and GEO confirmed that samples in the high-risk score group had a worse prognosis than those in the low-risk score group. We found significant differences between the high-risk and low-risk groups for 22 drugs (P < 0.05). In addition, we found differences in immune cell infiltration between the different risk score groups. Finally, through the risk assessment model, combined with multiple databases, THBS1, a high-risk and prognosis-related gene, was screened. We also found that THBS1 could promote the migration, invasion and proliferation of laryngeal cancer cells by constructing THBS1 knockout cell lines. In our study, we identified key fatty acid-related genes differentially expressed in laryngeal carcinoma that can be used to adequately predict prognosis using a comprehensive bioinformatic experimental approach. It was also found that THBS1, a high-risk and prognosis-related gene, may regulate the occurrence and development of laryngeal cancer through fatty acid metabolism, which has further helped us to explore the role of fatty acid metabolism genes in laryngeal cancer.
MeSH term(s)	Humans ; Laryngeal Neoplasms/genetics ; Laryngeal Neoplasms/pathology ; Gene Expression Profiling ; Fatty Acids ; Prognosis ; Computational Biology ; Tumor Microenvironment/genetics
Chemical Substances	Fatty Acids
Language	English
Publishing date	2022-11-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-23500-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: [Effect of rhTPO and rhIL-11 on Thrombocytopenia after Chemotherapy in Leukemia].

Dai, Ji-Fei / Xia, Rui-Xiang

Zhongguo shi yan xue ye xue za zhi

2022 Volume 30, Issue 3, Page(s) 711–717

Abstract: Objective: To analyze and compare the efficacy of recombinant human thrombopoietin (rhTPO) and recombinant human interleukin-11 (rhIL-11) in the treatment of thrombocytopenia after chemotherapy in acute leukemia patients.: Methods: 180 patients with ... ...

Abstract	Objective: To analyze and compare the efficacy of recombinant human thrombopoietin (rhTPO) and recombinant human interleukin-11 (rhIL-11) in the treatment of thrombocytopenia after chemotherapy in acute leukemia patients. Methods: 180 patients with acute leukemia complicated with thrombocytopenia after chemotherapy in the First Affiliated Hospital of Anhui Medical University were analyzed retrospectively. Among them, 50 patients who treated with rhTPO and did not receive platelet transfusion were set as group A, 50 patients treated with rhTPO and receive platelet transfusion were set as group B, Forty patients treated with rhIL-11 without platelet transfusion were set as group C, Forty patients who treated with rhIL-11 and received platelet transfusion were set as group D. The duration of PLT below 20×10 Results: The duration of PLT<20×10 Conclusion: In the treatment of acute leukemia patients with thrombocytopenia after chemotherapy, compared with rhIL-11, rhTPO can significantly shorten the duration for patients in a status with extremely low levels of PLT and the recovery time of PLT to normal range. In addition, PLT transfusion cannot speed up the time for patients to raise platelets to a safe range, nor can it shorten the duration of low PLT levels, but it can reduce the incidence of high bleeding risk events.
MeSH term(s)	Humans ; Interleukin-11 ; Leukemia, Myeloid, Acute/drug therapy ; Platelet Count ; Recombinant Proteins/therapeutic use ; Retrospective Studies ; Thrombocytopenia ; Thrombopoietin/therapeutic use
Chemical Substances	Interleukin-11 ; Recombinant Proteins ; Thrombopoietin (9014-42-0) ; oprelvekin (HM5641GA6F)
Language	Chinese
Publishing date	2022-06-10
Publishing country	China
Document type	Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2022.03.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6603: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Mini review of photoacoustic clinical imaging: a noninvasive tool for disease diagnosis and treatment evaluation.

Liu, Huazhen / Wang, Ming / Ji, Fei / Jiang, Yuxin / Yang, Meng

Journal of biomedical optics

2024 Volume 29, Issue Suppl 1, Page(s) S11522

Abstract: Significance: Photoacoustic (PA) imaging is an imaging modality that integrates anatomical, functional, metabolic, and histologic insights. It has been a hot topic of medical research and draws extensive attention.: Aim: This review aims to explore ... ...

Abstract	Significance: Photoacoustic (PA) imaging is an imaging modality that integrates anatomical, functional, metabolic, and histologic insights. It has been a hot topic of medical research and draws extensive attention. Aim: This review aims to explore the applications of PA clinical imaging in human diseases, highlighting recent advancements. Approach: A systemic survey of the literature concerning the clinical utility of PA imaging was conducted, with a particular focus on its application in tumors, autoimmune diseases, inflammatory conditions, and endocrine disorders. Results: PA imaging is emerging as a valuable tool for human disease investigation. Information provided by PA imaging can be used for diagnosis, grading, and prognosis in multiple types of tumors including breast tumors, ovarian neoplasms, thyroid nodules, and cutaneous malignancies. PA imaging facilitates the monitoring of disease activity in autoimmune and inflammatory diseases such as rheumatoid arthritis, systemic sclerosis, arteritis, and inflammatory bowel disease by capturing dynamic functional alterations. Furthermore, its unique capability of visualizing vascular structure and oxygenation levels aids in assessing diabetes mellitus comorbidities and thyroid function. Conclusions: Despite extant challenges, PA imaging offers a promising noninvasive tool for precision disease diagnosis, long-term evaluation, and prognosis anticipation, making it a potentially significant imaging modality for clinical practice.
MeSH term(s)	Humans ; Skin Neoplasms ; Arthritis, Rheumatoid ; Spectrum Analysis ; Photoacoustic Techniques/methods
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1309154-2
ISSN	1560-2281 ; 1083-3668
ISSN (online)	1560-2281
ISSN	1083-3668
DOI	10.1117/1.JBO.29.S1.S11522
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4699: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Effect of IP-10/CXCR3 signaling pathway on rats with diabetic retinopathy.

Ji, Fei / Zhang, Hongjie / Ge, Qian

Cellular and molecular biology (Noisy-le-Grand, France)

2023 Volume 69, Issue 11, Page(s) 233–238

Abstract: This study aimed to investigate the effect of the interferon-inducible protein-10 (IP-10)/C-X-C motif chemokine receptor 3 (CXCR3) signaling pathway on rats with diabetic retinopathy. A total of 21 Sprague-Dawley rats were selected as the objects and ... ...

Abstract	This study aimed to investigate the effect of the interferon-inducible protein-10 (IP-10)/C-X-C motif chemokine receptor 3 (CXCR3) signaling pathway on rats with diabetic retinopathy. A total of 21 Sprague-Dawley rats were selected as the objects and divided into control (n=7), model (n=7) and inhibitor (n=7) groups. The rats in control group did not receive any treatment. The diabetic retinopathy model was established using streptozotocin and vascular endothelial growth factor in model group, while the rats in inhibitor group were treated with AMG 487, an inhibitor of the IP-10/CXCR3 signaling pathway, based on the treatment in model group. The changes in gene expression patterns in rats with diabetic retinopathy were screened by sequencing. After the differential genes were determined, the pathways mainly related to the complication were obtained via enrichment analysis. The expression of the IP-10/CXCR3 signaling pathway, the apoptotic cells and the expression of inflammatory molecules (IL-6, IL-12, TNF-α and IL-1β) in each group of rats were detected. It was shown in volcano plot that there were some differentially expressed genes (fold change >1.2, P<0.01) in retinal tissues of rats in control and model groups. Meanwhile, the heatmap displayed that there were great differences in the gene expression patterns between control and model groups, and the gene expressions of IP-10 and CXCR3 in model group were higher than those in control group (P<0.05). The differential genes in control and model groupwere enriched in such processes as the cAMP metabolic regulatory pathway, chemotaxis of immunocytes, proliferation of endothelial cells, response of cytokine receptors, apoptosis, mTOR signaling pathway and TGF-β-related signaling pathway. The mRNA expressions of IP-10 and CXCR3 in model group were higher than those in control group (P<0.05), while they were notably lower in inhibitor group than those in model group (P<0.05). Besides, the protein levels of IP-10 and CXCR3 were identical to the mRNA levels. The apoptotic cells were increased markedly in model group compared with those in control group (P<0.05) and inhibitor group (P<0.05). Model group exhibited higher expression levels of IL-6, TNF-α and IL-1β in retinal tissues than control group (P<0.05), while inhibitor group had distinctly lower expression levels of IL-6, TNF-α and IL-1β in retinal tissues than model group (P<0.05). The IP-10/CXCR3 signaling pathway can affect rats with diabetic retinopathy.
MeSH term(s)	Rats ; Animals ; Diabetic Retinopathy/genetics ; Tumor Necrosis Factor-alpha ; Chemokine CXCL10/genetics ; Endothelial Cells ; Interleukin-6 ; Vascular Endothelial Growth Factor A ; Rats, Sprague-Dawley ; Signal Transduction ; RNA, Messenger ; Diabetes Mellitus
Chemical Substances	Tumor Necrosis Factor-alpha ; Chemokine CXCL10 ; Interleukin-6 ; Vascular Endothelial Growth Factor A ; RNA, Messenger
Language	English
Publishing date	2023-11-15
Publishing country	France
Document type	Journal Article
ZDB-ID	1161779-2
ISSN	1165-158X ; 0145-5680
ISSN (online)	1165-158X
ISSN	0145-5680
DOI	10.14715/cmb/2023.69.11.35
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3812: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The characteristics of hearing loss in outpatients with tinnitus over the age of 60: a 11-year cross-sectional study.

Xia, Qingqing / Yang, Shiming / Ji, Fei

Acta oto-laryngologica

2023 Volume 143, Issue 9, Page(s) 753–758

Abstract: Background: Presbycusis with tinnitus has a significant impact on the quality of life of elderly patients, becoming a serious socioeconomic problem.: Objectives: We conducted an 11-year cross-sectional analysis of the audiometry results of elderly ... ...

Abstract	Background: Presbycusis with tinnitus has a significant impact on the quality of life of elderly patients, becoming a serious socioeconomic problem. Objectives: We conducted an 11-year cross-sectional analysis of the audiometry results of elderly patients with tinnitus from 2011 to 2021. Methods: 9642 patients aged 60 and over were divided into three groups: young-old (YO) (60-74), old-old (OO) (75-89), and longevous (LON) (90 and over). Pure-tone audiometry results of all patients were analyzed. Results: Among 9642 patients, the cases of female with tinnitus were more than male in all years. The hearing curve showed a typical age-related decline. Hearing level of air conduction in female declined significantly at low frequencies while that of male was worse at high frequencies in YO and OO groups. Compared with right, left hearing level of air conduction was significantly decreased at all frequencies except 0.125 kHz. Conclusions: When the chief complaint was tinnitus, women were likely to experience more distress than men. However, men suffered from more hearing loss than women, at least in high frequencies. The influence weight of presbycusis and tinnitus on the auditory cortices might be a possible reason for the lateral distinction of hearing loss at different ages.
MeSH term(s)	Aged ; Humans ; Male ; Female ; Middle Aged ; Tinnitus/epidemiology ; Cross-Sectional Studies ; Presbycusis/complications ; Presbycusis/epidemiology ; Outpatients ; Quality of Life ; Auditory Threshold ; Deafness ; Audiometry, Pure-Tone
Language	English
Publishing date	2023-11-08
Publishing country	England
Document type	Journal Article
ISSN	1651-2251
ISSN (online)	1651-2251
DOI	10.1080/00016489.2023.2259952
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ul II Zs 105: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book ; Online: Message-Passing Receiver for OCDM over Multi-Lag Multi-Doppler Channels

Liu, Yun / Ji, Fei / Wen, Miaowen / Qing, Hua

2024

Abstract: As a new candidate waveform for the next generation wireless communications, orthogonal chirp division multiplexing (OCDM) has attracted growing attention for its ability to achieve full diversity in uncoded transmission, and its robustness to narrow- ... ...

Abstract	As a new candidate waveform for the next generation wireless communications, orthogonal chirp division multiplexing (OCDM) has attracted growing attention for its ability to achieve full diversity in uncoded transmission, and its robustness to narrow-band interference or impulsive noise. Under high mobility channels with multiple lags and multiple Doppler-shifts (MLMD), the signal suffers doubly selective (DS) fadings in time and frequency domain, and data symbols modulated on orthogonal chirps are interfered by each other. To address the problem of symbol detection of OCDM over MLMD channel, under the assumption that path attenuation factors, delays, and Doppler shifts of the channel are available, we first derive the closed-form channel matrix in Fresnel domain, and then propose a low-complexity method to approximate it as a sparse matrix. Based on the approximated Fresnel-domain channel, we propose a message passing (MP) based detector to estimate the transmit symbols iteratively. Finally, under two MLMD channels (an underspread channel for terrestrial vehicular communication, and an overspread channel for narrow-band underwater acoustic communications), Monte Carlo simulation results and analysis are provided to validate its advantages as a promising detector for OCDM. Comment: 15 pages, 10 figures
Keywords	Computer Science - Information Theory ; Electrical Engineering and Systems Science - Signal Processing ; B.4.1
Subject code	003
Publishing date	2024-01-08
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A Reversible MnO

Wang, Jinhui / Zhou, Yiping / Lv, Ying / Feng, Ji-Fei / Wang, Zhuanpei / Cai, Guofa

Small (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e2310229

Abstract: Electrochromic technology offers exciting opportunities for smart applications such as energy-saving and interactive systems. However, achieving dual-band regulation together with the multicolor function is still an unmet challenge for electrochromic ... ...

Abstract	Electrochromic technology offers exciting opportunities for smart applications such as energy-saving and interactive systems. However, achieving dual-band regulation together with the multicolor function is still an unmet challenge for electrochromic devices. Herein, an ingenious electrochromic strategy based on reversible manganese oxide (MnO
Language	English
Publishing date	2024-01-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202310229
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Comparisons of Metastatic Patterns, Survival Outcomes and Tumor Immune Microenvironment Between Young and Non-Young Breast Cancer Patients.

Sun, Hengwen / Huang, Wei / Ji, Fei / Pan, Yi / Yang, Lu

Frontiers in cell and developmental biology

2022 Volume 10, Page(s) 923371

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-07-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2022.923371
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Real-Time Analysis of AKT Signaling Activities at Single-Cell Resolution Using Cyclic Peptide-Based Probes.

Ji, Fei / Wang, Siwen / Shao, Shiqun / Sarkar, Priyanka / Xue, Min

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2394, Page(s) 65–80

Abstract: Here we present a protocol for interrogating AKT signaling activities in living single cells, using a pair of cyclic peptide-based fluorescent probes. These probes are encapsulated in liposomes and delivered into cells, where they continuously report on ... ...

Abstract	Here we present a protocol for interrogating AKT signaling activities in living single cells, using a pair of cyclic peptide-based fluorescent probes. These probes are encapsulated in liposomes and delivered into cells, where they continuously report on AKT signaling activities through a Föster resonance energy transfer mechanism. We describe the use of a microwell chip to achieve single-cell resolution and demonstrate the procedure for on-chip immunostaining. Finally, we provide a method for data extraction, correction, and processing.
MeSH term(s)	Fluorescence Resonance Energy Transfer/methods ; Fluorescent Dyes/chemistry ; Peptides, Cyclic/chemistry ; Proto-Oncogene Proteins c-akt/analysis ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction
Chemical Substances	Fluorescent Dyes ; Peptides, Cyclic ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2022-01-30
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1811-0_5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED