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Article ; Online: Large deflection analysis of circular piezoelectric micro-actuator with flexoelectric effect.

Ji, Xue

2023 Volume 13, Issue 1, Page(s) 19388

Abstract: At micro/nano scale, the stiffening effect and flexoelectric effect of strain gradient play important roles in the electromechanical coupling response of piezoelectric micro-components. In this paper, the large deflection bending problem of circular ... ...

Abstract	At micro/nano scale, the stiffening effect and flexoelectric effect of strain gradient play important roles in the electromechanical coupling response of piezoelectric micro-components. In this paper, the large deflection bending problem of circular piezoelectric micro-actuator is studied based on the extended linear dielectric theory. In addition to the piezoelectric effect, the flexoelectric effect, the stiffening effect of strain gradient and the high-order electric field effect of polarization gradient are introduced. According to the variational principle, a size-dependent model of circular piezoelectric micro-actuator is established to investigate its electromechanical coupling response. The contributions of piezoelectric effect and flexoelectric effect on large deflection behaviors of piezoelectric micro-actuator are revealed. It is hoped that the research results will be helpful to further understand the electromechanical coupling properties of piezoelectric micro-components and improve the control precision of piezoelectric micro-actuator.
Language	English
Publishing date	2023-11-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-45990-8
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Article ; Online: Diffusion Model of Lennard-Jones Fluids Based on the Radial Distribution Function.

Ji, Xiangfei

The journal of physical chemistry. B

2022 Volume 126, Issue 44, Page(s) 9008–9015

Abstract: In this paper, a theoretical model for diffusion in Lennard-Jones fluids over a larger density range is proposed. Instead of looking at molecular transport in real space, we treat molecular transport in radial distribution function space. Specifically, ... ...

Abstract	In this paper, a theoretical model for diffusion in Lennard-Jones fluids over a larger density range is proposed. Instead of looking at molecular transport in real space, we treat molecular transport in radial distribution function space. Specifically, the radial distribution function, which reflects the static properties of the system, is used to calculate the mean free path of molecules, a key physical quantity for diffusion modeling. Then, on the basis of the rarefied hard sphere gas diffusion model, and with consideration of the correction of collision frequency and backscattering effect caused by the higher density, the expression of self-diffusion coefficient in Lennard-Jones fluid is obtained. Molecular dynamics was used to simulate the diffusion in Lennard-Jones fluids in a wide range of reduced densities from 0.298 to 1.19 and reduced temperatures from 0.833 to 1.67. Except for small deviations at very high densities, the simulation results agree with the model predictions when the temperature is not too low.
Language	English
Publishing date	2022-10-27
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.2c04019
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Article ; Online: Prodrug Strategies for Critical Drug Developability Issues: Part II.

Ji, Xingyue

Current topics in medicinal chemistry

2022 Volume 21, Issue 32, Page(s) 2869

MeSH term(s)	Drug Development ; Prodrugs/pharmacology
Chemical Substances	Prodrugs
Language	English
Publishing date	2022-01-04
Publishing country	United Arab Emirates
Document type	Editorial
ZDB-ID	2064823-6
ISSN	1873-4294 ; 1568-0266
ISSN (online)	1873-4294
ISSN	1568-0266
DOI	10.2174/156802662132211215162732
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Article ; Online: Assessment of left ventricular systolic synchrony by peak strain dispersion in patients with systemic lupus erythematosus.

Ji, X / Zhang, X

European review for medical and pharmacological sciences

2022 Volume 26, Issue 8, Page(s) 2840–2846

Abstract: Objective: The aim of the study was to investigate the clinical value of the peak strain dispersion (PSD) in evaluating left ventricular (LV) systolic synchrony in patients with systemic lupus erythematosus (SLE).: Patients and methods: 58 SLE ... ...

Abstract	Objective: The aim of the study was to investigate the clinical value of the peak strain dispersion (PSD) in evaluating left ventricular (LV) systolic synchrony in patients with systemic lupus erythematosus (SLE). Patients and methods: 58 SLE patients without cardiovascular diseases and 60 healthy subjects were enrolled in the study. Both groups were examined by transthoracic two-dimensional echocardiography. Traditional parameters were measured by conventional echocardiography. Two-dimensional speckle tracking imaging (2D-STI) was used to analyze the PSD and LV global longitudinal strain (LVGLS). Related ultrasound and blood test results were analyzed and compared. Results: The PSD was significantly higher in SLE patients than in controls (p<0.05). The LVGLS was significantly lower in SLE patients than in controls (p<0.05). The PSD was negatively correlated with the LVGLS. Conclusions: LV systolic synchrony is impaired in patients with SLE disease. The PSD can be used as a new reliable index to evaluate LV systolic synchrony.
MeSH term(s)	Heart Ventricles/diagnostic imaging ; Humans ; Lupus Erythematosus, Systemic/diagnostic imaging ; Systole ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Function, Left
Language	English
Publishing date	2022-04-19
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202204_28614
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Article ; Online: Generalized bulk-boundary correspondence in periodically driven non-Hermitian systems.

Ji, Xiang / Yang, Xiaosen

Journal of physics. Condensed matter : an Institute of Physics journal

2024 Volume 36, Issue 24

Abstract: We present a pedagogical review of the periodically driven non-Hermitian systems, particularly on the rich interplay between the non-Hermitian skin effect and the topology. We start by reviewing the non-Bloch band theory of the static non-Hermitian ... ...

Abstract	We present a pedagogical review of the periodically driven non-Hermitian systems, particularly on the rich interplay between the non-Hermitian skin effect and the topology. We start by reviewing the non-Bloch band theory of the static non-Hermitian systems and discuss the establishment of its generalized bulk-boundary correspondence (BBC). Ultimately, we focus on the non-Bloch band theory of two typical periodically driven non-Hermitian systems: harmonically driven non-Hermitian system and periodically quenched non-Hermitian system. The non-Bloch topological invariants were defined on the generalized Brillouin zone and the real space wave functions to characterize the Floquet non-Hermtian topological phases. Then, the generalized BBC was established for the two typical periodically driven non-Hermitian systems. Additionally, we review novel phenomena in the higher-dimensional periodically driven non-Hermitian systems, including Floquet non-Hermitian higher-order topological phases and Floquet hybrid skin-topological modes. The experimental realizations and recent advances have also been surveyed. Finally, we end with a summarization and hope this pedagogical review can motivate further research on Floquet non-Hermtian topological physics.
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1472968-4
ISSN	1361-648X ; 0953-8984
ISSN (online)	1361-648X
ISSN	0953-8984
DOI	10.1088/1361-648X/ad2c73
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Article ; Online: Metabolic signatures of acute respiratory distress syndrome: COVID VS non-COVID.

Ji, Xiangming / Ji, Hong-Long

American journal of physiology. Lung cellular and molecular physiology

2024

Abstract: Acute respiratory distress syndrome (ARDS) is a fatal pulmonary disorder characterized by severe hypoxia and inflammation. Systemic and pulmonary infections are a leading cause of ARDS. The common respiratory pathogens include bacteria and virus, ... ...

Abstract	Acute respiratory distress syndrome (ARDS) is a fatal pulmonary disorder characterized by severe hypoxia and inflammation. Systemic and pulmonary infections are a leading cause of ARDS. The common respiratory pathogens include bacteria and virus, including Pseudomonas aeruginosa, Streptococcus aureus, Enterobacter species, coronavirus, influenza, and herpesviruses. COVID-19-associated ARDS is a new etiologic phenotype of the disease. The pathogenesis of ARDS caused by bacteria and viruses differs in host immune responses and lung mesenchymal injury. We postulate that both systemic and lung metabolomics of ARDS induced by virus may differ from those infected by other pathogens. This review aims to compare the metabolic signatures in blood and lung specimens. Both common and SARS-CoV-2-specific metabolomic signatures were comprehensively reviewed. The differences in metabolic profiles between COVID-19 and other etiology-associated ARDS may uncover new biomarkers, pathogenic mechanisms, druggable targets, and differential diagnosis.
Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1013184-x
ISSN	1522-1504 ; 1040-0605
ISSN (online)	1522-1504
ISSN	1040-0605
DOI	10.1152/ajplung.00266.2023
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Zs.A 2749: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Nonlinear electromechanical analysis of axisymmetric thin circular plate based on flexoelectric theory.

Ji, Xue

Scientific reports

2021 Volume 11, Issue 1, Page(s) 21762

Abstract: Flexoelectricity will dominate the electromechanical coupling of intelligent components in MEMS/NEMS due to its size-dependency. This paper focuses on investigating the flexoelectric responses of intelligent components of the circular plate type, which ... ...

Abstract	Flexoelectricity will dominate the electromechanical coupling of intelligent components in MEMS/NEMS due to its size-dependency. This paper focuses on investigating the flexoelectric responses of intelligent components of the circular plate type, which are commonly used in MEMS/NEMS. Utilizing Hamilton's principle, the nonlinear flexoelectric circular plate model is presented by combining von Kármán plate theory and flexoelectric theory. The equilibrium equations and all boundary conditions are obtained and then discretized. The nonlinear static bending of the simply supported axisymmetric flexoelectric circular plate is investigated by combining DQM and iteration method. The distributions of dimensionless bending deflection and electric potential are analyzed under different loads. Moreover, the nonlinear free vibration behaviors are also investigated by combining the Galerkin method and Lindstedt-Poincaré Method. The flexoelectric effect and stiffening effect of strain gradient are revealed. This paper will be helpful to promote the application of flexoelectric intelligent components of the circular plate type, which are encountered commonly in engineering.
Language	English
Publishing date	2021-11-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-01289-0
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Article ; Online: Prodrug Strategies for Critical Drug Developability Issues: Part I.

Ji, Xingyue

Current topics in medicinal chemistry

2021 Volume 21, Issue 24, Page(s) 2155–2156

Abstract: Drug development is a very time, capital, and labor-intensive process. It was anticipated that bringing a novel chemical entity to market would take over a billion dollars and around 14 years [1]. In addition, drug development is characterized by a very ... ...

Abstract	Drug development is a very time, capital, and labor-intensive process. It was anticipated that bringing a novel chemical entity to market would take over a billion dollars and around 14 years [1]. In addition, drug development is characterized by a very high attrition rate both in preclinical and clinical studies. It was reported that only 40% of drug candidates with the most drug-like properties could make their way into clinical trials, and only 10% of these can eventually reach FDA approval [2]. After analyzing the data from seven UK-based pharmaceutical companies from 1964 through 1985, Prentis et al. found that 39% of failure was attributed to poor pharmacokinetic (PK) profiles in humans, 29% was attributed to a lack of clinical efficacy, 21% was attributed to toxicity and adverse effects, and about 6% was attributed to commercial limitations [3]. When a drug candidate is identified with one of these issues (except the commercial limitations), normally, a new round of structureactivity or structure-property relationship (SAR/SPR) studies is carried out to generate a new chemical entity with improved profiles, and in most cases, such a process is time and labor-intensive. Alternatively, prodrug strategy can be leveraged to efficiently address associated drug developability issues without making enormous derivatives. Prodrug strategy has been demonstrated to be very successful and fruitful in drug development, with around 20% of approved drugs from 2008 through 2020 being clarified as prodrugs [4]. In recent years, prodrug strategy has also been leveraged to address the delivery issues associated with gasotransmitters, including NO, H2S, CO as well as SO2 [5-8]. In this thematic issue, six excellent reviews were included, focusing on varied prodrug strategies in addressing different drug developability issues associated with anticancer drugs, central nervous system (CNS) drugs, and gasotransmitters....
MeSH term(s)	Antineoplastic Agents ; Central Nervous System/drug effects ; Drug Development ; Gasotransmitters ; Humans ; Prodrugs
Chemical Substances	Antineoplastic Agents ; Gasotransmitters ; Prodrugs
Language	English
Publishing date	2021-12-01
Publishing country	United Arab Emirates
Document type	Editorial ; Introductory Journal Article
ZDB-ID	2064823-6
ISSN	1873-4294 ; 1568-0266
ISSN (online)	1873-4294
ISSN	1568-0266
DOI	10.2174/156802662124211104100228
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Article: [Effects of propofol on myelin basic protein expression in zebrafish at different developmental stages].

Guo, Z / Wang, Z / Zeng, L / Ji, X

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

2023 Volume 43, Issue 10, Page(s) 1810–1814

Abstract: Objective: To observe the effect of propofol on the expression of myelin basic protein (MBP) in developing zebrafish and explore the possible mechanisms.: Methods: A total of 180 zebrafish embryos at 6-48 h post-fertilization were randomly allocated ... ...

Abstract	Objective: To observe the effect of propofol on the expression of myelin basic protein (MBP) in developing zebrafish and explore the possible mechanisms. Methods: A total of 180 zebrafish embryos at 6-48 h post-fertilization were randomly allocated into 3 equal groups and raised in fresh water (control group), water containing dimethyl sulfoxide (DMSO group) and water containing 30 μg/mL propofol (propofol group). On 3, 4, 5, 6, 7, 10 d post-fertilization, the juvenile fish were collected for detection of mRNA and protein expressions of MBP using RT-qPCR and Western blotting. TUNEL assay and immunofluorescence assay were used to detect apoptosis of the oligodendrocytes of the fish at 3 d post-fertilization; RT-qPCR and Western blotting were performed to detect the expressions of apoptosis-related factors caspase-8, caspase-9 and caspase-3. Results: Compared with the control group, the fish with propofol exposure showed significantly decreased mRNA and protein expression of MBP at 3-7 d post-fertilization ( Conclusion: Propofol persistently inhibits MBP expression in developing zebrafish within a short term possibly by mediating apoptosis of the oligodendrocytes.
MeSH term(s)	Animals ; Apoptosis ; Caspase 3/metabolism ; Caspase 8/metabolism ; Caspase 9/metabolism ; Myelin Basic Protein/metabolism ; Propofol/pharmacology ; RNA, Messenger/metabolism ; Zebrafish/embryology
Chemical Substances	Caspase 3 (EC 3.4.22.-) ; Caspase 8 (EC 3.4.22.-) ; Caspase 9 (EC 3.4.22.-) ; Myelin Basic Protein ; Propofol (YI7VU623SF) ; RNA, Messenger
Language	Chinese
Publishing date	2023-11-28
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2250951-3
ISSN	1673-4254
ISSN	1673-4254
DOI	10.12122/j.issn.1673-4254.2023.10.21
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Article ; Online: Factors Associated with Self-Regulatory Fatigue in Chinese Older Patients with Coronary Heart Disease

Ji X / Yu H

Patient Preference and Adherence, Vol Volume 17, Pp 941-

A Cross-Sectional Survey

2023 Volume 949

Abstract: Xiaofu Ji, Hongyu Yu School of Nursing, Jinzhou Medical University, Jinzhou, Liaoning, People’s Republic of ChinaCorrespondence: Hongyu Yu, School of Nursing, Jinzhou Medical University, Jinzhou, Liaoning, People’s Republic of China, Tel +86 15941628522, ...

Abstract	Xiaofu Ji, Hongyu Yu School of Nursing, Jinzhou Medical University, Jinzhou, Liaoning, People’s Republic of ChinaCorrespondence: Hongyu Yu, School of Nursing, Jinzhou Medical University, Jinzhou, Liaoning, People’s Republic of China, Tel +86 15941628522, Email 838821920@qq.comPurpose: To identify important determinants of self-regulatory fatigue in older adults with coronary heart disease based on demographics, health literacy, and health empowerment factors.Patients and Methods: A total of 201 older patients with coronary heart disease (CHD) from First Affiliated Hospital of Jinzhou Medical University by cluster sampling method. Demographic Questionnaire, the Health Literacy Management Scale (HLSCP), the Patient Perception Empowerment Scale (PPES), and the Self-Regulatory Fatigue Scale (SRF-S) were used to collect the data.Results: The coronary heart disease elderly scored 44.20± 6.98 points in self-regulatory fatigue. The results showed that residence, monthly household income, hospitalized times of CHD since illness, health literacy and health empowerment were significant determinants of self-regulatory fatigue (p< 0.001). Self-regulatory fatigue was negatively correlated with health literacy (r=− 0.639, P< 0.01) and health empowerment (r=− 0.580, P< 0.01).Conclusion: Residence, monthly household income, hospitalized times of CHD since illness influence self-regulatory fatigue among coronary heart disease patients. Health literacy and health empowerment were independent predictors of self-regulatory among coronary heart disease patients.Keywords: coronary heart disease, older adults, health literacy, health empowerment, self-regulatory fatigue
Keywords	coronary heart disease ; older adults ; health literacy ; health empowerment ; self-regulatory fatigue ; Medicine (General) ; R5-920
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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