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Article: ENO2 promotes anoikis resistance in anaplastic thyroid cancer by maintaining redox homeostasis.

Zhang, Yu / Ji, Xiaoyu / Wang, Yu

2024 Volume 13, Issue 2, Page(s) 209–224

Abstract: Background: Anoikis presents a significant barrier in the metastasis of cancer. As the most aggressive type of thyroid cancer, anaplastic thyroid cancer (ATC) exhibits a high risk of metastasis and is characterized by high mortality. Therefore, ... ...

Abstract	Background: Anoikis presents a significant barrier in the metastasis of cancer. As the most aggressive type of thyroid cancer, anaplastic thyroid cancer (ATC) exhibits a high risk of metastasis and is characterized by high mortality. Therefore, investigating the molecular mechanisms of anoikis resistance in ATC is important for devising therapeutic targets in clinical research. Methods: Differentially Expressed Genes were screened in ATC cells under attached and detached culture conditions with RNA-seq. Investigate the impact of enolase 2 (ENO2) on apoptosis and spheroid formation by gain and loss of function. Changes of reactive oxygen species (ROS), glutathione (GSH) and nicotinamide adenine dinucleotide phosphate (NADPH) were detected to assess redox balance. The transcriptional regulatory role of signal transducer and activator of transcription 1 (STAT1) on ENO2 was validated through Dual-Luciferase Reporter Gene Assay. Explore the impact of ENO2 expression on the formation of lung metastases in nude mice. Results: We found that the glycolysis process was activated in detached ATC cells. Several genes in the glycolysis process, particularly Conclusions: Stable expression of ENO2 and the maintenance of redox balance played a pivotal role in facilitating anoikis resistance of ATC.
Language	English
Publishing date	2024-02-23
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	3016969-0
ISSN	2227-8575 ; 2227-684X
ISSN (online)	2227-8575
ISSN	2227-684X
DOI	10.21037/gs-24-44
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Article: Effect of degraded flaxseed meals on the growth performance, nutrient digestibility, and health status of broilers.

Ji, Xiaoyu / Liu, Xiangyu / Wang, J / Liu, Ning

Animal bioscience

2024

Abstract: Objective: The present study evaluated the effect of flaxseed meal degraded by a protease, Lactobacillus plantarum, or both on the growth performance, nutrient digestibility, and health status of broilers.: Methods: There were four diets containing ... ...

Abstract	Objective: The present study evaluated the effect of flaxseed meal degraded by a protease, Lactobacillus plantarum, or both on the growth performance, nutrient digestibility, and health status of broilers. Methods: There were four diets containing flaxseed meals in its non-degraded form (control, CON), degraded with 3,000 U/kg of protease (ELM), 1.0×109 CFU/kg of Lactobacillus plantarum (FLM), or both (DLM). Each form of flaxseed meals was added at 15% of diet. A total of 480 yellow-feathered broilers at 22 d of age were distributed into 4 groups with 6 replicates of 20 chickens each. The feeding trial lasted for 42 d. Growth performance, apparent fecal digestibility (dry matter, energy, crude protein, and ash), and serum immunoglobins and antioxidases were determined at 42 and 63 d of age. Results: Results showed that ELM, FLM, and DLM increased (p<0.001) the contents of peptides and decreased (p<0.001) cyanogenic glycosides, compared to CON. The diets with degraded flaxseed meals increased (p<0.05) feed intake and body weight gain throughout the feeding trial, and the digestibility of energy, crude protein, and ash at the end of feeding trial. Furthermore, all degraded groups enhanced (p<0.05) broiler health status by increasing serum immunoglobulins A and G. Additinally, DLM showed more pronounced effects (p<0.05) on these parameters than ELM or FLM. Conclusion: Flaxseed meals degraded by enzymolysis, fermentation, or both had improved nutrition and application in broilers.
Language	English
Publishing date	2024-02-23
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2765-0189
ISSN	2765-0189
DOI	10.5713/ab.23.0416
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Article ; Online: Clinical and molecular features of progressive papillary thyroid microcarcinoma.

Wang, Zhiyuan / Ji, Xiaoyu / Zhang, Hao / Sun, Wei

International journal of surgery (London, England)

2024 Volume 110, Issue 4, Page(s) 2313–2322

Abstract: In recent decades, the prevalence of thyroid cancer has risen substantially, with papillary thyroid microcarcinoma (PTMC) constituting over 50% of cases. Although most PTMCs exhibit indolent growth and a favorable prognosis, some present an increased ... ...

Abstract	In recent decades, the prevalence of thyroid cancer has risen substantially, with papillary thyroid microcarcinoma (PTMC) constituting over 50% of cases. Although most PTMCs exhibit indolent growth and a favorable prognosis, some present an increased risk of recurrence and an unfavorable prognosis due to high-risk characteristics such as lymph node metastasis, extrathyroidal extension, and distant metastasis. The early identification of clinically progressing PTMC remains elusive. In this review, the authors summarize findings from PTMC progression-related literature, highlighting that factors such as larger tumor size, cervical lymph node metastasis, extrathyroidal extension, younger age, higher preoperative serum thyroid-stimulating hormone levels, family history, and obesity positively correlate with PTMC progression. The role of multifocality in promoting PTMC progression; however, remains contentious. Furthermore, recent studies have shed light on the impact of mutations, such as BRAF and TERT mutations, on PTMC progression. Researchers have identified several mRNAs, noncoding RNAs, and proteins associated with various features of PTMC progression. Some studies propose that peripheral and tumor tissue-infiltrating immune cells could serve as biomarkers for the clinical progression of PTMC. Collectively, these clinical and molecular features offer a rationale for the early detection and the development of precision theranostic strategies of clinically progressive PTMC.
MeSH term(s)	Humans ; Thyroid Neoplasms/genetics ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/diagnosis ; Carcinoma, Papillary/genetics ; Carcinoma, Papillary/pathology ; Disease Progression ; Prognosis ; Mutation ; Lymphatic Metastasis ; Biomarkers, Tumor/genetics
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1097/JS9.0000000000001117
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Article ; Online: A Comprehensive Review of Licorice: the Preparation, Chemical Composition, Bioactivities and Its Applications.

Ji, Xiaoyu / Liu, Ning / Huang, Shucheng / Zhang, Cai

The American journal of Chinese medicine

2024 , Page(s) 1–50

Abstract: Licorice ( ...

Abstract	Licorice (
Language	English
Publishing date	2024-05-08
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193085-0
ISSN	1793-6853 ; 0090-2942 ; 0192-415X
ISSN (online)	1793-6853
ISSN	0090-2942 ; 0192-415X
DOI	10.1142/S0192415X24500289
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Article: Integrated multiomics analysis and machine learning refine molecular subtypes and prognosis for muscle-invasive urothelial cancer.

Chu, Guangdi / Ji, Xiaoyu / Wang, Yonghua / Niu, Haitao

Molecular therapy. Nucleic acids

2023 Volume 33, Page(s) 110–126

Abstract: Muscle-invasive urothelial cancer (MUC), characterized by high aggressiveness and significant heterogeneity, is currently lacking highly precise individualized treatment options. We used a computational pipeline to synthesize multiomics data from MUC ... ...

Abstract	Muscle-invasive urothelial cancer (MUC), characterized by high aggressiveness and significant heterogeneity, is currently lacking highly precise individualized treatment options. We used a computational pipeline to synthesize multiomics data from MUC patients using 10 clustering algorithms, which were then combined with 10 machine learning algorithms to identify molecular subgroups of high resolution and develop a robust consensus machine learning-driven signature (CMLS). Through multiomics clustering, we identified three cancer subtypes (CSs) that are related to prognosis, with CS2 exhibiting the most favorable prognostic outcome. Subsequent screening enabled identification of 12 hub genes that constitute a CMLS with robust predictive power for prognosis. The low-CMLS group exhibited a more favorable prognosis and greater responsiveness to immunotherapy and was more likely to exhibit the "hot tumor" phenotype. The high-CMLS group had a poor prognosis and lower likelihood of benefitting from immunotherapy, but dasatinib and romidepsin may serve as promising treatments for them. Comprehensive analysis of multiomics data can offer important insights and further refine the molecular classification of MUC. Identification of CMLS represents a valuable tool for early prediction of patient prognosis and for screening potential candidates likely to benefit from immunotherapy, with broad implications for clinical practice.
Language	English
Publishing date	2023-06-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2662631-7
ISSN	2162-2531
ISSN	2162-2531
DOI	10.1016/j.omtn.2023.06.001
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Article: The Emerging Role of m6A Modification in Endocrine Cancer.

Ji, Xiaoyu / Wang, Zhiyuan / Sun, Wei / Zhang, Hao

Cancers

2023 Volume 15, Issue 4

Abstract: With the development of RNA modification research, N6-methyladenosine (m6A) is regarded as one of the most important internal epigenetic modifications of eukaryotic mRNA. It is also regulated by methylase, demethylase, and protein preferentially ... ...

Abstract	With the development of RNA modification research, N6-methyladenosine (m6A) is regarded as one of the most important internal epigenetic modifications of eukaryotic mRNA. It is also regulated by methylase, demethylase, and protein preferentially recognizing the m6A modification. This dynamic and reversible post-transcriptional RNA alteration has steadily become the focus of cancer research. It can increase tumor stem cell self-renewal and cell proliferation. The m6A-modified genes may be the primary focus for cancer breakthroughs. Although some endocrine cancers are rare, they may have a high mortality rate. As a result, it is critical to recognize the significance of endocrine cancers and identify new therapeutic targets that will aid in improving disease treatment and prognosis. We summarized the latest experimental progress in the m6A modification in endocrine cancers and proposed the m6A alteration as a potential diagnostic marker for endocrine malignancies.
Language	English
Publishing date	2023-02-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15041033
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Article ; Online: Unfolded protein response pathways in stroke patients: a comprehensive landscape assessed through machine learning algorithms and experimental verification.

Yu, Haiyang / Ji, Xiaoyu / Ouyang, Yang

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 759

Abstract: Background: The unfolding protein response is a critical biological process implicated in a variety of physiological functions and disease states across eukaryotes. Despite its significance, the role and underlying mechanisms of the response in the ... ...

Abstract	Background: The unfolding protein response is a critical biological process implicated in a variety of physiological functions and disease states across eukaryotes. Despite its significance, the role and underlying mechanisms of the response in the context of ischemic stroke remain elusive. Hence, this study endeavors to shed light on the mechanisms and role of the unfolding protein response in the context of ischemic stroke. Methods: In this study, mRNA expression patterns were extracted from the GSE58294 and GSE16561 datasets in the GEO database. The screening and validation of protein response-related biomarkers in stroke patients, as well as the analysis of the immune effects of the pathway, were carried out. To identify the key genes in the unfolded protein response, we constructed diagnostic models using both random forest and support vector machine-recursive feature elimination methods. The internal validation was performed using a bootstrapping approach based on a random sample of 1,000 iterations. Lastly, the target gene was validated by RT-PCR using clinical samples. We utilized two algorithms, CIBERSORT and MCPcounter, to investigate the relationship between the model genes and immune cells. Additionally, we performed uniform clustering of ischemic stroke samples based on expression of genes related to the UPR pathway and analyzed the relationship between different clusters and clinical traits. The weighted gene co-expression network analysis was conducted to identify the core genes in various clusters, followed by enrichment analysis and protein profiling for the hub genes from different clusters. Results: Our differential analysis revealed 44 genes related to the UPR pathway to be statistically significant. The integration of both machine learning algorithms resulted in the identification of 7 key genes, namely ATF6, EXOSC5, EEF2, LSM4, NOLC1, BANF1, and DNAJC3. These genes served as the foundation for a diagnostic model, with an area under the curve of 0.972. Following 1000 rounds of internal validation via randomized sampling, the model was confirmed to exhibit high levels of both specificity and sensitivity. Furthermore, the expression of these genes was found to be linked with the infiltration of immune cells such as neutrophils and CD8 T cells. The cluster analysis of ischemic stroke samples revealed three distinct groups, each with differential expression of most genes related to the UPR pathway, immune cell infiltration, and inflammatory factor secretion. The weighted gene co-expression network analysis showed that all three clusters were associated with the unfolded protein response, as evidenced by gene enrichment analysis and the protein landscape of each cluster. The results showed that the expression of the target gene in blood was consistent with the previous analysis. Conclusion: The study of the relationship between UPR and ischemic stroke can help to better understand the underlying mechanisms of the disease and provide new targets for therapeutic intervention. For example, targeting the UPR pathway by blocking excessive autophagy or inducing moderate UPR could potentially reduce tissue injury and promote cell survival after ischemic stroke. In addition, the results of this study suggest that the use of UPR gene expression levels as biomarkers could improve the accuracy of early diagnosis and prognosis of ischemic stroke, leading to more personalized treatment strategies. Overall, this study highlights the importance of the UPR pathway in the pathology of ischemic stroke and provides a foundation for future studies in this field.
MeSH term(s)	Humans ; Stroke/genetics ; Ischemic Stroke ; Algorithms ; Random Forest ; Biomarkers ; Antigens, Neoplasm ; RNA-Binding Proteins ; Exosome Multienzyme Ribonuclease Complex
Chemical Substances	Biomarkers ; EXOSC5 protein, human ; Antigens, Neoplasm ; RNA-Binding Proteins ; Exosome Multienzyme Ribonuclease Complex (EC 3.1.-)
Language	English
Publishing date	2023-10-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-04567-9
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Article: Three new species of

Wang, Zhi-Jie / Du, Yu-Zhou / Ji, Xiao-Yu

Biodiversity data journal

2023 Volume 11, Page(s) e112020

Abstract: Background: The genus : New information: Three new species ... ...

Abstract	Background: The genus New information: Three new species of
Language	English
Publishing date	2023-11-14
Publishing country	Bulgaria
Document type	Journal Article
ZDB-ID	2736709-5
ISSN	1314-2828
ISSN	1314-2828
DOI	10.3897/BDJ.11.e112020
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Article: Low-intensity pulsed ultrasound in obstetrics and gynecology: advances in clinical application and research progress.

Ji, Xiaoyu / Duan, Hua / Wang, Sha / Chang, Yanan

Frontiers in endocrinology

2023 Volume 14, Page(s) 1233187

Abstract: In the past decade, research on ultrasound therapy in obstetrics and gynecology has rapidly developed. Currently, high-intensity ultrasound has been widely used in clinical practice, while low-intensity ultrasound has gradually emerged as a new trend of ... ...

Abstract	In the past decade, research on ultrasound therapy in obstetrics and gynecology has rapidly developed. Currently, high-intensity ultrasound has been widely used in clinical practice, while low-intensity ultrasound has gradually emerged as a new trend of transitioning from pre-clinical research to clinical applications. Low-intensity pulsed ultrasound (LIPUS), characterized by a non-invasive low-intensity pulse wave stimulation method, employs its non-thermal effects to achieve safe, economical, and convenient therapeutic outcomes. LIPUS converts into biochemical signals within cells through pathways such as cavitation, acoustic flow, and mechanical stimulation, regulating molecular biological mechanisms and exerting various biological effects. The molecular biology mechanisms underlying the application of LIPUS in obstetrics and gynecology mainly include signaling pathways, key gene expression, angiogenesis, inflammation inhibition, and stem cell differentiation. LIPUS plays a positive role in promoting soft tissue regeneration, bone regeneration, nerve regulation, and changes in cell membrane permeability. LIPUS can improve the treatment benefit of premature ovarian failure, pelvic floor dysfunction, nerve damage caused by intrauterine growth restriction, ovariectomized osteoporosis, and incomplete uterine involution through the above biological effects, and it also has application value in the adjuvant treatment of malignant tumors such as ovarian cancer and cervical cancer. This study outlines the biological mechanisms and applications of LIPUS in treating various obstetric and gynecologic diseases, aiming to promote its precise application and provide a theoretical basis for its use in the field.
MeSH term(s)	Female ; Humans ; Pregnancy ; Bone Regeneration ; Cell Differentiation ; Gynecology ; Obstetrics ; Ultrasonic Waves
Language	English
Publishing date	2023-07-31
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1233187
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Article ; Online: Effects of Laminaria japonica polysaccharide and coumaric acid on pasting, rheological, retrogradation and structural properties of corn starch.

Xu, Ning / Yu, Pei / Zhang, Hui / Ji, Xiaoyu / Wu, Penghao / Zhang, Lei / Wang, Xiao

International journal of biological macromolecules

2024 Volume 263, Issue Pt 2, Page(s) 130343

Abstract: The aim of this study was to investigate the effects of Laminaria japonica polysaccharide (LJP) and coumaric acid (CA) on pasting, rheological, retrogradation and structural properties of corn starch (CS). Rapid viscosity analysis (RVA) revealed that LJP ...

Abstract	The aim of this study was to investigate the effects of Laminaria japonica polysaccharide (LJP) and coumaric acid (CA) on pasting, rheological, retrogradation and structural properties of corn starch (CS). Rapid viscosity analysis (RVA) revealed that LJP significantly increased the peak viscosity, trough viscosity, final viscosity, and setback viscosity of CS gel (p < 0.05) in a concentration-dependent manner. The addition of LJP and CA simultaneously caused the pasting of CS to need a greater temperature (from 75.53 °C to 78.75 °C), suggesting that LJP and CA made CS pasting more difficult. Dynamic viscoelasticity measurements found that all gels exhibited typical characteristics of weak gel. When compared to CS gel, 4 % LJP increased the viscosity and fluidity of gel and the simultaneous addition of LJP and CA reduced the elasticity. The steady shear results showed that the all gels were pseudoplastic fluids with shear-thinning behavior. In the meanwhile, the addition of LJP and CA enhanced the pseudoplasticity of CS-LJP-CA gel and improved its shear thinning. Furthermore, thermodynamic results showed that 8 % LJP promoted the retrogradation of CS gel and 2.0 % CA delayed the retrogradation of CS gel. Notably, on the 7th day of retrogradation, 2.0 % CA significantly decreased the retrogradation rate of CS-LJP by 19.31 % as compared to CS + 8 % LJP. Microstructure observation revealed that LJP made the honeycomb network structure of CS gel partially collapsed, and the surface of CS-LJP gel developed venation. Nevertheless, the structure of CS-LJP gel was clearly enhanced by adding CA. FT-IR spectra demonstrated that the addition of LJP or CA to CS did not result in the formation of a new distinctive peak in the system, suggesting the absence of a new group. Moreover, LF-NMR findings showed that LJP and CA strengthened the gel structure of CS and enhanced its capacity to retain water. This study not only provided a new insight into using LJP and CA to regulate the gel properties of CS, but also provided scientific strategy for developing starchy foods.
MeSH term(s)	Starch/chemistry ; Zea mays/chemistry ; Coumaric Acids ; Spectroscopy, Fourier Transform Infrared ; Polysaccharides/pharmacology ; Rheology ; Viscosity ; Gels/chemistry ; Edible Seaweeds ; Laminaria
Chemical Substances	Starch (9005-25-8) ; Coumaric Acids ; Polysaccharides ; Gels
Language	English
Publishing date	2024-02-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.130343
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