Article ; Online: Shikonin prevents mice from heat stroke-induced death via suppressing a trigger IL-17A on the inflammatory and oxidative pathways.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2023 Volume 166, Page(s) 115346
Abstract: Heat stroke (HS) is the deadliest disease. Due to the complex pathogenesis of HS, lack of effective therapeutic drugs for clinical treatment. Shikonin (SK) is the main active compound of Radix Arnebiae, which was evaluated on the HS model (temperature: ( ... ...
Abstract | Heat stroke (HS) is the deadliest disease. Due to the complex pathogenesis of HS, lack of effective therapeutic drugs for clinical treatment. Shikonin (SK) is the main active compound of Radix Arnebiae, which was evaluated on the HS model (temperature: (41 ± 0.5) ℃, relative humidity: (60 ± 5) %) via pathological and biochemical approaches in vivo and in vitro. Upon the dose of 10 mg.kg |
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MeSH term(s) | Animals ; Mice ; Interleukin-17 ; Heat Stroke/drug therapy ; Naphthoquinones/pharmacology ; Naphthoquinones/therapeutic use ; Oxidative Stress |
Chemical Substances | Interleukin-17 ; shikonin (3IK6592UBW) ; Naphthoquinones |
Language | English |
Publishing date | 2023-08-27 |
Publishing country | France |
Document type | Journal Article |
ZDB-ID | 392415-4 |
ISSN | 1950-6007 ; 0753-3322 ; 0300-0893 |
ISSN (online) | 1950-6007 |
ISSN | 0753-3322 ; 0300-0893 |
DOI | 10.1016/j.biopha.2023.115346 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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