Article ; Online: Functional characterization of the human Cdk10/Cyclin Q complex.
2022 Volume 12, Issue 3, Page(s) 210381
Abstract: Cyclin-dependent kinases (CDKs) are key players in cell cycle regulation and transcription. The CDK-family member Cdk10 is important for neural development and can act as a tumour suppressor, but the underlying molecular mechanisms are largely unknown. ... ...
Abstract | Cyclin-dependent kinases (CDKs) are key players in cell cycle regulation and transcription. The CDK-family member Cdk10 is important for neural development and can act as a tumour suppressor, but the underlying molecular mechanisms are largely unknown. Here, we provide an in-depth analysis of Cdk10 substrate specificity and function. Using recombinant Cdk10/CycQ protein complexes, we characterize RNA pol II CTD, c-MYC and RB1 as |
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MeSH term(s) | Cell Cycle ; Cell Division ; Cyclin-Dependent Kinases/genetics ; Cyclin-Dependent Kinases/metabolism ; Cyclins/metabolism ; Humans ; RNA Polymerase II/metabolism |
Chemical Substances | CCNQ protein, human ; Cyclins ; CDK10 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinases (EC 2.7.11.22) ; RNA Polymerase II (EC 2.7.7.-) |
Language | English |
Publishing date | 2022-03-16 |
Publishing country | England |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2630944-0 |
ISSN | 2046-2441 ; 2046-2441 |
ISSN (online) | 2046-2441 |
ISSN | 2046-2441 |
DOI | 10.1098/rsob.210381 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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