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Article ; Online: Generation Z's Health Information Avoidance Behavior: Insights From Focus Group Discussions.

Jia, Chenjin / Li, Pengcheng

2024 Volume 26, Page(s) e54107

Abstract: Background: Younger generations actively use social media to access health information. However, research shows that they also avoid obtaining health information online at times when confronted with uncertainty.: Objective: This study aims to examine ...

Abstract	Background: Younger generations actively use social media to access health information. However, research shows that they also avoid obtaining health information online at times when confronted with uncertainty. Objective: This study aims to examine the phenomenon of health information avoidance among Generation Z, a representative cohort of active web users in this era. Methods: Drawing on the planned risk information avoidance model, we adopted a qualitative approach to explore the factors related to information avoidance within the context of health and risk communication. The researchers recruited 38 participants aged 16 to 25 years for the focus group discussion sessions. Results: In this study, we sought to perform a deductive qualitative analysis of the focus group interview content with open, focused, and theoretical coding. Our findings support several key components of the planned risk information avoidance model while highlighting the underlying influence of cognition on emotions. Specifically, socioculturally, group identity and social norms among peers lead some to avoid health information. Cognitively, mixed levels of risk perception, conflicting values, information overload, and low credibility of information sources elicited their information avoidance behaviors. Affectively, negative emotions such as anxiety, frustration, and the desire to stay positive contributed to avoidance. Conclusions: This study has implications for understanding young users' information avoidance behaviors in both academia and practice.
MeSH term(s)	Humans ; Focus Groups ; Information Avoidance ; Health Behavior ; Communication
Language	English
Publishing date	2024-03-08
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1438-8871
ISSN (online)	1438-8871
ISSN	1438-8871
DOI	10.2196/54107
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Article ; Online: Antibacterial Chemodynamic Therapy: Materials and Strategies.

Jia, Chenyang / Wu, Fu-Gen

BME frontiers

2023 Volume 4, Page(s) 21

Abstract: The wide and frequent use of antibiotics in the treatment of bacterial infection can cause the occurrence of multidrug-resistant bacteria, which becomes a serious health threat. Therefore, it is necessary to develop antibiotic-independent treatment ... ...

Abstract	The wide and frequent use of antibiotics in the treatment of bacterial infection can cause the occurrence of multidrug-resistant bacteria, which becomes a serious health threat. Therefore, it is necessary to develop antibiotic-independent treatment modalities. Chemodynamic therapy (CDT) is defined as the approach employing Fenton and/or Fenton-like reactions for generating hydroxyl radical (•OH) that can kill target cells. Recently, CDT has been successfully employed for antibacterial applications. Apart from the common Fe-mediated CDT strategy, antibacterial CDT strategies mediated by other metal elements such as copper, manganese, cobalt, molybdenum, platinum, tungsten, nickel, silver, ruthenium, and zinc have also been proposed. Furthermore, different types of materials like nanomaterials and hydrogels can be adopted for constructing CDT-involved antibacterial platforms. Besides, CDT can introduce some toxic metal elements and then achieve synergistic antibacterial effects together with reactive oxygen species. Finally, CDT can be combined with other therapies such as starvation therapy, phototherapy, and sonodynamic therapy for achieving improved antibacterial performance. This review first summarizes the advancements in antibacterial CDT and then discusses the present limitations and future research directions in this field, hoping to promote the development of more effective materials and strategies for achieving potentiated CDT.
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2765-8031
ISSN (online)	2765-8031
DOI	10.34133/bmef.0021
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Article ; Online: Plants' emission behaviors under dual control of pollutant concentration and quantity.

Jia, Ce / Gong, Yazhen

Journal of environmental management

2023 Volume 347, Page(s) 119066

Abstract: Quantity-based and concentration-based limits are two common environmental permitting approaches utilized by government worldwide in environmental management. While existing literature is still unambiguous about roles played by quantity-based versus ... ...

Abstract	Quantity-based and concentration-based limits are two common environmental permitting approaches utilized by government worldwide in environmental management. While existing literature is still unambiguous about roles played by quantity-based versus concentration-based limits in environmental management, it becomes evident that relying exclusively on concentration-based or quantity-based limits to control plant emissions may not necessarily result in improved environmental quality. This paper leverages a unique opportunity arising from a recent reform in China's Pollutant Emission Permit System (PEPS) initiated in 2016 to analyze how the introduction of quantity-based limits in addition to concentration-based limits through the PEPS reform impact emissions at the plant level. Utilizing a unique plant-level continuous emission monitoring system data collected from Shaanxi Province (located in western China), the paper finds a significant reduction in air pollutant emissions as a result of the PEPS reform (nitrogen oxides (NOx) by 39%, sulfur dioxide (SO
MeSH term(s)	Air Pollution/analysis ; Environmental Pollutants/analysis ; Environmental Monitoring ; Air Pollutants/analysis ; Particulate Matter/analysis ; China
Chemical Substances	Environmental Pollutants ; Air Pollutants ; Particulate Matter
Language	English
Publishing date	2023-10-04
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.119066
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Article ; Online: Silymarin protects the rats against paraquat-induced acute kidney injury via Nrf2.

Jia, C / Zhang, Z / Wang, J / Nie, Z

Human & experimental toxicology

2022 Volume 41, Page(s) 9603271221074334

Abstract: Background: Paraquat (PQ) poisoning induces severe acute kidney injury and causes extremely high rate of death. In this study, we aimed to investigate the protective effects of silymarin on PQ-induced acute kidney injury and explore the underlying ... ...

Abstract	Background: Paraquat (PQ) poisoning induces severe acute kidney injury and causes extremely high rate of death. In this study, we aimed to investigate the protective effects of silymarin on PQ-induced acute kidney injury and explore the underlying mechanisms. Methods: A rat model was established through intraperitoneal injection of PQ. Rats were administrated with saline or silymarin for 3 days. Then, survival rate, physiological parameters, and renal injury score were evaluated. The apoptosis and oxidative stress in kidney tissues were determined through hematoxylin and eosin staining, quantitative reverse transcription polymerase chain reaction, Western blot, and enzyme-linked immunosorbent assays. Results: Silymarin administration could significantly increase the survival rate of PQ-poisoned rats. It was found that silymarin treatment improved renal function, decreased injury score in kidney tissues, and inhibited the apoptosis and oxidative stress in PQ-induced acute kidney injury through the activating the signaling pathway of Nrf2 and promoting its nuclear translocation. Conclusion: Silymarin exhibited a protective effect against PQ-induced kidney injury, suggesting that treatment with this flavonoid could be a potential therapeutic agent for the treatment of acute kidney injury.
MeSH term(s)	Acute Kidney Injury/chemically induced ; Acute Kidney Injury/prevention & control ; Animals ; Disease Models, Animal ; Herbicides/toxicity ; Male ; NF-E2-Related Factor 2/drug effects ; Paraquat/toxicity ; Protective Agents/administration & dosage ; Protective Agents/pharmacology ; Rats ; Rats, Wistar ; Silymarin/administration & dosage ; Silymarin/pharmacology
Chemical Substances	Herbicides ; NF-E2-Related Factor 2 ; Protective Agents ; Silymarin ; Paraquat (PLG39H7695)
Language	English
Publishing date	2022-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1027454-6
ISSN	1477-0903 ; 0144-5952 ; 0960-3271
ISSN (online)	1477-0903
ISSN	0144-5952 ; 0960-3271
DOI	10.1177/09603271221074334
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Article ; Online: Constitutive and evoked release of ATP in adult mouse olfactory epithelium.

Hayoz, Sébastien / Jia, Cuihong / Hegg, Colleen Cosgrove

Open life sciences

2024 Volume 19, Issue 1, Page(s) 20220811

Abstract: In adult olfactory epithelium (OE), ATP plays a role in constant cell turnover and post-injury neuroregeneration. We previously demonstrated that constitutive and ATP-evoked ATP release are present in neonatal mouse OE and underlie continuous cell turn- ... ...

Abstract	In adult olfactory epithelium (OE), ATP plays a role in constant cell turnover and post-injury neuroregeneration. We previously demonstrated that constitutive and ATP-evoked ATP release are present in neonatal mouse OE and underlie continuous cell turn-over and post-injury neuroregeneration, and that activation of purinergic P2X
Language	English
Publishing date	2024-01-16
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2817958-4
ISSN	2391-5412 ; 2391-5412
ISSN (online)	2391-5412
ISSN	2391-5412
DOI	10.1515/biol-2022-0811
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Article ; Online: Solving the time-dependent protein distributions for autoregulated bursty gene expression using spectral decomposition.

Wu, Bingjie / Holehouse, James / Grima, Ramon / Jia, Chen

The Journal of chemical physics

2024 Volume 160, Issue 7

Abstract: In this study, we obtain an exact time-dependent solution of the chemical master equation (CME) of an extension of the two-state telegraph model describing bursty or non-bursty protein expression in the presence of positive or negative autoregulation. ... ...

Abstract	In this study, we obtain an exact time-dependent solution of the chemical master equation (CME) of an extension of the two-state telegraph model describing bursty or non-bursty protein expression in the presence of positive or negative autoregulation. Using the method of spectral decomposition, we show that the eigenfunctions of the generating function solution of the CME are Heun functions, while the eigenvalues can be determined by solving a continued fraction equation. Our solution generalizes and corrects a previous time-dependent solution for the CME of a gene circuit describing non-bursty protein expression in the presence of negative autoregulation [Ramos et al., Phys. Rev. E 83, 062902 (2011)]. In particular, we clarify that the eigenvalues are generally not real as previously claimed. We also investigate the relationship between different types of dynamic behavior and the type of feedback, the protein burst size, and the gene switching rate.
MeSH term(s)	Stochastic Processes ; Proteins/genetics ; Proteins/metabolism ; Gene Regulatory Networks ; Gene Expression
Chemical Substances	Proteins
Language	English
Publishing date	2024-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0188455
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Article ; Online: Paeonol impacts ovarian cancer cell proliferation, migration, invasion and apoptosis via modulating the transforming growth factor beta/smad3 signaling pathway.

Chen, X M / Jia, C L / Zhu, Z Y

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society

2024 Volume 74, Issue 6

Abstract: Paeonol (2-hydroxy-4-methoxyphenylacetophenone) is a natural phenolic component isolated from the root bark of peony with multiple pharmacological activities and has been proven to have anti-cancer effects. The objective of this study is to investigate ... ...

Abstract	Paeonol (2-hydroxy-4-methoxyphenylacetophenone) is a natural phenolic component isolated from the root bark of peony with multiple pharmacological activities and has been proven to have anti-cancer effects. The objective of this study is to investigate the influence mechanism of paeonol on the proliferatory and apoptotic activities of ovarian cancer (OC) cells by modulating the transforming growth factor beta (TGF-β)/Smad3 pathway. The SKOV3 cells were pretreated with various concentrations of paeonol (0, 25, 50, 100, 200, 400 μg/mL) for 48 hours to determine the optimal experimental concentration of paeonol. Following this, the TGF-β overexpression vector was constructed and transfected into the SKOV3 cells. The assessment of cell proliferation, invasion, and migration was conducted through MTT, colony formation, flow cytometry, transwell, and wound-healing experiments. The detection of TGF-β/Smad3 pathway-related proteins and apoptosis-related proteins (B-cell lymphoma (Bcl-2) Bcl-2-associated X protein (Bax)) was performed using Western blot analysis. Paeonol exhibited a significant inhibitory effect on SKOV3 cell viability when administered at concentrations ranging from 50-400 μg/mL, with an IC
MeSH term(s)	Humans ; Female ; bcl-2-Associated X Protein ; Ovarian Neoplasms/metabolism ; Transforming Growth Factor beta/pharmacology ; Transforming Growth Factor beta/therapeutic use ; Apoptosis ; Signal Transduction ; Cell Proliferation ; Cell Line, Tumor ; Cell Movement ; Acetophenones
Chemical Substances	paeonol (3R834EPI82) ; bcl-2-Associated X Protein ; Transforming Growth Factor beta ; Acetophenones
Language	English
Publishing date	2024-02-07
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1125221-2
ISSN	1899-1505 ; 0867-5910 ; 0044-6033
ISSN (online)	1899-1505
ISSN	0867-5910 ; 0044-6033
DOI	10.26402/jpp.2023.6.06
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Article: Treatment of sexual dysfunction induced by hyperprolactinemia accompanied by reduced luteinizing hormone levels: A case report.

Liu, Tao / Jia, Chao / Li, Yan

Clinical case reports

2024 Volume 12, Issue 3, Page(s) e8432

Abstract: Key clinical message: Sexual dysfunction induced by hyperprolactinemia accompanied by reduced luteinizing hormone (LH) is common in anrology clinics. A low dose of bromocriptine is helpful for restoring penile erectile function and libido in patients.!## ...

Abstract	Key clinical message: Sexual dysfunction induced by hyperprolactinemia accompanied by reduced luteinizing hormone (LH) is common in anrology clinics. A low dose of bromocriptine is helpful for restoring penile erectile function and libido in patients. Abstract: Sexual dysfunction is closely related to hormonal disorders, of which prolactin (PRL) and luteinizing hormone (LH) disorders are common. How to treat sexual dysfunction induced by hyperprolactinemia accompanied by reduced LH levels is worth discussing. In this study, we aimed to present the case of a 35-year-old male patient with sexual dysfunction. The treatment process and physical and laboratory examination results were recorded. Before treatment, the PRL and LH levels in this patient were 31.27 ng/mL and 1.62 mIU/mL, respectively. The International Index of Erectile Function-5 (IIEF-5) score was initially 14 points. After regular treatment with low doses of bromocriptine and tadalafil, the hormonal disorder was corrected (PRL: 11.16 ng/mL and LH: 2.28 mIU/mL) and sexual function was recovered (IIEF-5: 23 points). This case report suggested a sufficient exposure to low-dose bromocriptine for such patients. Conversely, the exogenous supplementation of human chorionic gonadotropin may not be appropriate.
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.8432
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Article: Efficacy of medication for overactive bladder symptoms in 70 patients with Parkinson's disease.

Jia, Chunsong / Cui, Xin / Ou, Tongwen

Translational andrology and urology

2024 Volume 13, Issue 1, Page(s) 64–71

Abstract: Background: Managing overactive bladder (OAB) symptoms in Parkinson's disease (PD) is challenging. This study aimed to investigate the medical management of OAB symptoms in patients with PD.: Methods: Patients with OAB symptoms who were newly treated ...

Abstract	Background: Managing overactive bladder (OAB) symptoms in Parkinson's disease (PD) is challenging. This study aimed to investigate the medical management of OAB symptoms in patients with PD. Methods: Patients with OAB symptoms who were newly treated with tolterodine and/or tamsulosin were screened from a database of 187 PD patients. Before treatment, the Hoehn-Yahr scale, International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score (OABSS), and urodynamic evaluation were evaluated. On day 21 of treatment, the IPSS and OABSS were re-evaluated. The changes of these scores and urinary symptoms were analyzed. Results: Seventy patients with a mean age of 62.2±7.9 years and median Hoehn-Yahr stage of 2 (IQR 2-3) were enrolled. Tolterodine, tamsulosin, and tolterodine + tamsulosin were used in 43, 20, and 7 patients, respectively. The IPSS storage symptoms (9.4±3 Conclusions: Tolterodine and/or tamsulosin can significantly improve OAB symptoms in PD patients. Nocturia and urgency remain common after treatment.
Language	English
Publishing date	2024-01-23
Publishing country	China
Document type	Journal Article
ZDB-ID	2851630-8
ISSN	2223-4691 ; 2223-4691 ; 2223-4683
ISSN (online)	2223-4691
ISSN	2223-4691 ; 2223-4683
DOI	10.21037/tau-23-378
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Article ; Online: Turn Waste Golden Tide into Treasure: Bio-Adsorbent Synthesis for CO

Ying, Huijuan / Jia, Chenglin / Zeng, Ganning / Ai, Ning

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 6

Abstract: ... ...

Abstract	Converting
Language	English
Publishing date	2024-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29061345
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